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1. 发明授权

US07320984B2 Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group 有权
标题翻译：尿频或尿失禁的补救措施或预防措施以及含有氮杂环基的吗啡喃衍生物
公开(公告)号：US07320984B2
公开(公告)日：2008-01-22
申请号：US10530664
申请日：2003-10-08
申请人： Naoki Izumimoto , Koji Kawai , Kuniaki Kawamura , Morihiro Fujimura , Toshikazu Komagata
发明人： Naoki Izumimoto , Koji Kawai , Kuniaki Kawamura , Morihiro Fujimura , Toshikazu Komagata
IPC分类号： A61K31/485 , C07D489/00
CPC分类号： C07D489/08
摘要： The invention provides a morphinan derivative of the Formula (I): wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y and Z are valence bonds, —C(═O)— or the like; X is C2-C5 carbon chain (one of the carbon atoms may be substituted by oxygen, sulfur or nitrogen) constituting a part of the ring structure, or the like; (R4)k is substituted or non-substituted benzene fused ring, carbonyl group or the like; R9 is hydrogen or the like; R10 and R11 are bound to represent —O—, or the like, and R6 is hydrogen or the like or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a therapeutic or prophylactic agent for urinary frequency or urinary incontinence, comprising as an effective ingredient the morphinan derivative or the pharmaceutically acceptable acid addition salt thereof; a method for therapy or prophylaxis of the diseases.
摘要翻译：本发明提供式（I）的吗啡喃衍生物：其中R 1是甲基，环丙基甲基等; R 2和R 3是羟基，甲氧基，乙酰氧基等; Y和Z都是价键，-C（-O） - 等; X是C 2 -C 5 -C 5碳链（其中一个碳原子可以被氧，硫或氮取代）构成环结构的一部分等 ; （R 4）k是取代或未取代的苯稠环，羰基等; R 9是氢等; R 10和R 11结合表示-O-等，R 6是氢等或其药学上可接受的其酸加成盐。本发明还提供了用于尿频或尿失禁的治疗或预防剂，其包含吗啡喃衍生物或其药学上可接受的酸加成盐作为有效成分; 一种治疗或预防疾病的方法。

2. 发明申请

US20060000222A1 Apparatus for producing slush nitrogen and method for producing the same 失效
标题翻译：硫化氮生产装置及其制造方法
公开(公告)号：US20060000222A1
公开(公告)日：2006-01-05
申请号：US11165528
申请日：2005-06-23
申请人： Kuniaki Kawamura , Akito Machida , Masamitsu Ikeuchi , Kazuhiro Hattori , Kouichi Matsuo , Hideharu Yanagi
发明人： Kuniaki Kawamura , Akito Machida , Masamitsu Ikeuchi , Kazuhiro Hattori , Kouichi Matsuo , Hideharu Yanagi
IPC分类号： F25B19/00 , F17C5/00 , F25C1/00
CPC分类号： F25J1/0015 , F25C1/00 , F25D3/10 , F25J1/0221 , F25J1/0251 , F25J1/0276 , F25J2205/20 , F25J2205/30 , F25J2205/90 , F25J2210/42 , F25J2240/60
摘要： Liquid nitrogen is filled in a low temperature vessel; an ejector that sucks liquid nitrogen by blowing a cooling agent (liquid or gas) such as low temperature helium gas or liquid helium of pressure higher than in the space within the vessel is disposed in the vessel; the liquid nitrogen blown with the cooling agent is cooled by the cooling agent to become fine particles of solid nitrogen which fall down; and gas in a space of the vessel is discharged out of the vessel so as to maintain the pressure of the space higher than the atmospheric pressure. A gaseous phase of liquid nitrogen in an adiabatic vessel is depressurized to vaporize nitrogen in a liquid phase so that a temperature of the nitrogen is reached to the triple point of nitrogen by lowering temperature thereby and solid nitrogen is produced by keeping at the triple point, and that the produced solid nitrogen is transformed into slush by stirring the content of the adiabatic vessel. In a method for cooling a super conductive body in which a material showing a state of super conductance in the vicinity of the temperature of liquid nitrogen or of the temperature liquid nitrogen and solid nitrogen coexist is used, a method for cooling a super conductive body characterized in that the super conductive body is immersed in slush nitrogen held in an adiabatic vessel, and that the body is contacted with slush nitrogen to cool.
摘要翻译：液氮填充在低温容器中; 喷射器通过吹送诸如低温氦气或低于容器内的空间的压力的液氦的冷却剂（液体或气体）而吸入液氮; 用冷却剂吹入的液氮被冷却剂冷却，成为脱落的固体氮的细小颗粒; 并且将容器的空间中的气体排出容器，以保持空间的压力高于大气压力。将绝热容器中的氮气的气相减压以使液相中的氮气蒸发，由此通过降低温度将氮气的温度达到氮的三重点，从而通过保持三相点产生固体氮，并且通过搅拌绝热容器的内容物将所产生的固体氮转变成泥浆。在使用在液氮温度或液氮附近存在超导状态的材料和固体氮共存的超导电体的冷却方法中，使用超导电体的冷却方法，因为超导体被浸入保持在绝热容器中的冰冷的氮气中，并且使主体与冷却氮气接触以冷却。

3. 发明授权

US06803366B2 Agent for improving learning or memory 失效
标题翻译：改善学习或记忆的代理
公开(公告)号：US06803366B2
公开(公告)日：2004-10-12
申请号：US10148489
申请日：2002-05-30
申请人： Kuniaki Kawamura , Hiroshi Nagase , Noriyuki Hirano , Junzo Kamei
发明人： Kuniaki Kawamura , Hiroshi Nagase , Noriyuki Hirano , Junzo Kamei
IPC分类号： A61K314375
CPC分类号： C07D471/04 , A61K31/4738 , A61K31/4745 , A61K31/498
摘要： Disclosed is an agent for improving learning and/or memory, which is useful for therapy of dementia accompanying disorder of memory due to a cerebrovascular disease, neurodegenerative disease such as Alzheimer's disease, endocrine disease, nutritional or metabolic disorder, infectious disease, drug addiction or the like. The agent for improving learning and/or memory according to the present invention comprises as an effective ingredient an isoquinoline derivative having a specific structure, such as (4aR, 12aR)-2-methyl-4a-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a-octahydro-quinoline[2,3-g]isoquinoline or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了一种用于改善学习和/或记忆的药剂，其用于治疗由于脑血管疾病，神经变性疾病如阿尔茨海默病，内分泌疾病，营养或代谢障碍，感染性疾病，药物成瘾引起的记忆障碍的痴呆症类似。根据本发明的用于改善学习和/或记忆的药剂包括作为有效成分的具有特定结构的异喹啉衍生物，例如（4aR，12aR）-2-甲基-4a-（3-羟基苯基）-1,2 ，3,4,4a，5,12,12a-八氢 - 喹啉[2,3-g]异喹啉或其药学上可接受的盐。

4. 发明授权

US06316461B1 Antipruritic 有权
标题翻译：止痒药
公开(公告)号：US06316461B1
公开(公告)日：2001-11-13
申请号：US09615540
申请日：2000-07-13
申请人： Hiroshi Nagase , Jun Utsumi , Takashi Endoh , Toshiaki Tanaka , Junzo Kamei , Kuniaki Kawamura
发明人： Hiroshi Nagase , Jun Utsumi , Takashi Endoh , Toshiaki Tanaka , Junzo Kamei , Kuniaki Kawamura
IPC分类号： A61K31485
CPC分类号： A61K31/541 , A61K31/40 , A61K31/4025 , A61K31/435 , A61K31/485 , A61K31/5377 , C07D489/00 , C07D489/08
摘要： This invention provides an antipruritc comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.
摘要翻译：本发明提供了含有鸦片类κ受体激动剂作为有效成分的止痒剂，新的吗啡喃季铵盐衍生物和新的吗啡喃-N-氧化物衍生物，其可用于治疗与某些疾病并发的瘙痒。

5. 发明授权

US06177438B1 Morphinan derivatives and pharmaceutical use thereof 失效
标题翻译：吗啡衍生物及其药物用途
公开(公告)号：US06177438B1
公开(公告)日：2001-01-23
申请号：US08754750
申请日：1996-11-21
申请人： Hiroshi Nagase , Jun Hayakawa , Kuniaki Kawamura , Koji Kawai , Takashi Endoh
发明人： Hiroshi Nagase , Jun Hayakawa , Kuniaki Kawamura , Koji Kawai , Takashi Endoh
IPC分类号： C07D49108
CPC分类号： C07D489/08 , C07D489/00
摘要： A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example, and an analgesic, diuretic, antitussive and brain cell protector having its derivative or its salt as the active ingredient are described. The compound of the present invention possesses strong analgesic activity, diuretic action and antitussive action as a highly selective &kgr;-opioid agonist, allowing it to be used as a useful analgesic, diuretic and antitussive. On the other hand, the compound of the present invention also possesses remarkable cerebro-neuroprotective activity, thus allowing it be used as a useful cerebro-neuroprotective agents.
摘要翻译：描述了以其衍生物或其盐作为活性成分代表的吗啡喃衍生物或其药学上可接受的酸加成盐和镇痛药，利尿剂，镇咳药和脑细胞保护剂。本发明化合物具有强的止痛活性，利尿作用和镇咳作用作为高度选择性的κ-阿片样物质激动剂，使其可用作有用的止痛剂，利尿剂和镇咳药。另一方面，本发明的化合物也具有显着的脑血管保护作用，因此可用作有用的脑血管保护剂。

6. 发明授权

US5939551A Process for producing 4a-aryldecahydroisoquinoline derivatives 失效
标题翻译：制备4a-芳基十氢异喹啉衍生物的方法
公开(公告)号：US5939551A
公开(公告)日：1999-08-17
申请号：US000121
申请日：1998-04-06
申请人： Hiroshi Nagase , Kuniaki Kawamura , Koji Ohshima , Koji Kawai
发明人： Hiroshi Nagase , Kuniaki Kawamura , Koji Ohshima , Koji Kawai
IPC分类号： C07D217/04 , C07D217/16 , C07D491/10 , C07D491/113
CPC分类号： C07D217/04 , C07D217/16 , C07D491/10
摘要： The present invention provides a novel process for producing 4a-aryldecahydroisoquinoline compounds. The process is especially useful for preparing 4a-trans-6-oxo-aryldecahydroisoquinoline compounds.
摘要翻译： PCT No.PCT / JP96 / 01272 Sec。 371日期：1998年4月6日 102（e）1998年4月6日PCT PCT 1996年5月15日PCT公布。出版物WO97 / 43263 日期：1997年11月20日本发明提供了一种生产4a-芳基十氢异喹啉化合物的新方法。该方法对于制备4a-反式-6-氧代 - 芳基十氢异喹啉化合物特别有用。

7. 发明申请

US20070299100A1 Analgesic 有权
标题翻译：止痛药
公开(公告)号：US20070299100A1
公开(公告)日：2007-12-27
申请号：US11667136
申请日：2005-11-04
申请人： Naoki Izumimoto , Kuniaki Kawamura , Toshikazu Komagata , Tadatoshi Hashimoto , Hiroshi Nagabukuro
发明人： Naoki Izumimoto , Kuniaki Kawamura , Toshikazu Komagata , Tadatoshi Hashimoto , Hiroshi Nagabukuro
IPC分类号： A61K31/44 , A61P29/00 , C07D221/28
CPC分类号： C07D489/08 , A61K31/485
摘要： An analgesic which may be applied to wide variety of pain from various causes is disclosed. The analgesic comprises as an effective ingredient a specific morphinan derivative having a nitrogen containing heterocyclic group, such as compound 1:
摘要翻译：公开了可以应用于各种原因的多种疼痛的止痛剂。止痛剂包含具有含氮杂环基的具体吗啡喃衍生物作为有效成分，例如化合物1：

8. 发明申请

US20070006599A1 APPARATUS AND METHOD FOR COOLING SUPER CONDUCTIVE BODY 失效
标题翻译：用于冷却超导体的装置和方法
公开(公告)号：US20070006599A1
公开(公告)日：2007-01-11
申请号：US11532527
申请日：2006-09-16
申请人： Kuniaki KAWAMURA , Akito MACHIDA , Masamitsu IKEUCHI , Kazuhiro HATTORI , Kouichi MATSUO , Hideharu YANAGI
发明人： Kuniaki KAWAMURA , Akito MACHIDA , Masamitsu IKEUCHI , Kazuhiro HATTORI , Kouichi MATSUO , Hideharu YANAGI
IPC分类号： F17C5/00 , F25D23/12
CPC分类号： F25J1/0015 , F25C1/00 , F25D3/10 , F25J1/0221 , F25J1/0251 , F25J1/0276 , F25J2205/20 , F25J2205/30 , F25J2205/90 , F25J2210/42 , F25J2240/60
摘要： Liquid nitrogen is filled in a low temperature vessel; an ejector that sucks liquid nitrogen by blowing a cooling agent (liquid or gas) such as low temperature helium gas or liquid helium of pressure higher than in the space within the vessel is disposed in the vessel; the liquid nitrogen blown with the cooling agent is cooled by the cooling agent to become fine particles of solid nitrogen which fall down; and gas in a space of the vessel is discharged out of the vessel so as to maintain the pressure of the space higher than the atmospheric pressure. A gaseous phase of liquid nitrogen in an adiabatic vessel is depressurized to vaporize nitrogen in a liquid phase so that the temperature of the nitrogen reaches the triple point of nitrogen by lowering the temperature to thereby produce solid nitrogen by keeping the temperature at the triple point, and that the produced solid nitrogen is transformed into slush by stirring the content of the adiabatic vessel. A super conductive body formed of a material exhibiting a state of super conductance in the vicinity of the temperature of liquid nitrogen or of the temperature where liquid nitrogen and solid nitrogen coexist can be cooled by immersing the body in slush nitrogen held in an adiabatic vessel or flowing in an adiabatic pipe.
摘要翻译：液氮填充在低温容器中; 喷射器通过吹送诸如低温氦气或低于容器内的空间的压力的液氦的冷却剂（液体或气体）而吸入液氮; 用冷却剂吹入的液氮被冷却剂冷却，成为脱落的固体氮的细小颗粒; 并且将容器的空间中的气体排出容器，以保持空间的压力高于大气压力。将绝热容器中的氮气气相减压以使液相中的氮气蒸发，使得氮气的温度通过降低温度而达到氮的三重点，从而通过将温度保持在三重点来产生固体氮，并且通过搅拌绝热容器的内容物将所产生的固体氮转变成泥浆。在液氮温度附近或液氮和固态氮共存的温度下表现出超导状态的材料形成的超导体可以通过将本体浸入保持在绝热容器中的冰冷氮气中来冷却，或在绝热管中流动。

9. 发明申请

US20060094741A1 Remedies for neuropathic pain and model animals of neuropathic pain 有权
标题翻译：神经性疼痛和模型动物的神经性疼痛的补救措施
公开(公告)号：US20060094741A1
公开(公告)日：2006-05-04
申请号：US11206489
申请日：2005-08-18
申请人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
发明人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
IPC分类号： A61K31/4745 , A61K49/00 , C07D471/04
CPC分类号： A61K31/485 , A61K31/4745 , C07D489/08
摘要： The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.
摘要翻译：本发明涉及神经性疼痛治疗剂，其含有作为活性成分的通式（I）表示的化合物或其药理学上可接受的酸加成盐：（其中R 1，R 2， R 2，R 3，R 4，R 5，R 6，R 6， A +和B B具有与说明书中描述的那些相同的定义）和通过给予（+） - 4a-（3- 羟基苯基）-2-甲基-1,2,3,4,4a，5,12,12a-八氢 - 反 - 喹啉并[2,3-g]异喹啉。本发明使得可以进行神经性疼痛的药物治疗。也可以评价化合物对神经性疼痛的治疗作用。

10. 发明授权

US06889520B2 Inter-region thermal complementary system by distributed cryogenic and thermal devices 失效
标题翻译：分布式低温和热装置的区域间互补系统
公开(公告)号：US06889520B2
公开(公告)日：2005-05-10
申请号：US10416487
申请日：2001-12-12
申请人： Makoto Sano , Kuniaki Kawamura , Junji Matsuda , Katsumi Fujima , Takanori Kudo , Youichi Kawazu , Choiku Yoshikawa , Syuji Fukano
发明人： Makoto Sano , Kuniaki Kawamura , Junji Matsuda , Katsumi Fujima , Takanori Kudo , Youichi Kawazu , Choiku Yoshikawa , Syuji Fukano
IPC分类号： F25D17/02 , F25B27/00 , F25D11/00
CPC分类号： F25D17/02 , F24F2005/0039
摘要： The object of the invention is to provide a thermal complementary (combination of heat supply and heat discharge) system which can complement heat without the restriction of area of a region to be supplied with heat. An endless multiplex helical loop is formed to complement the heat produced in a region such as plants and regional facilities on a reciprocal basis, and the water is not circulated forcibly but achieves heat transfer in the helical loop.Liquid or slurry-like water is sealed in the annular endless channel (endless loop) without forcibly circulated. Therefore, loop diameter of the annular endless channel, that means the area of the region, is not limited. The water forms temperature zones in the endless helical loop, the temperature being different per each component loop. Distributed cryogenic sources and thermal sources are thermally connected to said multiplex helical loop so that heat (i.e. water) can be taken in or discharged to or from said cryogenic or thermal sources. As the water needs not be forcibly circulated, the power for forcibly circulating the water is eliminated resulting in reduced running cost. Refrigerating apparatuses, heat source apparatuses, etc. distributed in the region are effectively utilized and also central control of energy supply through the multiplex helical loops is made possible.
摘要翻译：本发明的目的是提供一种热互补（组合的热供应和放热）系统，其可以补充热量，而不受限于供热区域的面积。形成一个无休止的多路复用螺旋回路，以互补的方式补充在诸如工厂和区域设施之类的区域产生的热量，水不会被强制循环，而是在螺旋回路中实现热传递。液体或浆状水被密封在环形环形通道（无限循环）中，而不会被强制循环。因此，环形环形通道的环径，即区域的面积不受限制。水在环形螺旋环中形成温度区，每个组分环的温度不同。分布式低温源和热源热连接到所述多路螺旋回路，使得热（即水）可以被吸入或从所述低温或热源排出。由于水不需要强制循环，所以强制循环水的功率被消除，导致运行成本降低。有效利用分布在该区域的制冷装置，热源装置等，并且也可以通过多路复用螺旋回路进行能量供给的集中控制。

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