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1. 发明授权

US07288608B2 Degradable thiol-ene polymers 有权
标题翻译：可降解的硫醇聚合物
公开(公告)号：US07288608B2
公开(公告)日：2007-10-30
申请号：US10269916
申请日：2002-10-10
申请人： Christopher Bowman , Kristi Anseth , Bilge Hacioglu , Charlie Nuttelman
发明人： Christopher Bowman , Kristi Anseth , Bilge Hacioglu , Charlie Nuttelman
IPC分类号： C08G81/00
CPC分类号： C08L89/00 , A01N25/04 , A61K47/34 , A61L27/16 , A61L27/18 , A61L27/38 , A61L27/52 , A61L27/54 , A61L2300/62 , C05G3/0029 , C05G3/0076 , C08G75/045 , C08G81/00 , C08G81/027 , C08G2261/126 , C08J3/075 , C08J2329/04 , C08J2367/04 , C08J2371/02 , C08L71/02 , C08L81/02 , C08L2205/05 , Y10S524/916 , Y10S525/936 , C08L83/00 , C08L2666/22
摘要： A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.
摘要翻译：公开了一种硫醇烯聚合物材料。该材料通过具有硫醇和烯烃部分的反应物的光聚合产生。该材料可以包含包封的组分，包括细胞。此外，可以通过使聚合物材料与诸如蛋白质的组分反应来衍生该材料。

2. 发明授权

US5314673A Process for the conversion of N.sub.2 O 失效
标题翻译： N2O转化工艺
公开(公告)号：US5314673A
公开(公告)日：1994-05-24
申请号：US836566
申请日：1992-02-18
申请人： Kristi Anseth , Theodore A. Koch
发明人： Kristi Anseth , Theodore A. Koch
IPC分类号： B01D53/86 , B01D53/94 , B01J23/755 , B01J8/00 , C01B17/00 , C01B21/00
CPC分类号： B01D53/8628 , B01J23/755 , Y02C20/10
摘要： A process for the conversion of nitrous oxide (N.sub.2 O) to nitrogen and oxygen by treating the gas with a catalyst of cobalt oxide and nickel oxide on a zirconia support at a temperature of at least about 280 degrees C.
摘要翻译：通过在至少约280℃的温度下用氧化钴和氧化镍在氧化锆载体上处理气体来将一氧化二氮（N 2 O）转化为氮和氧的方法。

3. 发明申请

US20140343225A1 HYDROGELS AND METHODS FOR PRODUCING AND USING THE SAME 审中-公开
标题翻译：水凝胶及其制造方法和使用方法
公开(公告)号：US20140343225A1
公开(公告)日：2014-11-20
申请号：US14257544
申请日：2014-04-21
申请人： Kristi Anseth , Brian Polizzotti , Cole DeForest
发明人： Kristi Anseth , Brian Polizzotti , Cole DeForest
IPC分类号： C08F289/00 , C08K3/20
CPC分类号： C08F289/00 , C08J3/075 , C08K3/20 , Y10T428/24802
摘要： The present invention relates to hydrogels and methods for producing and using the same. In particular, some embodiments of the invention relate to hydrogels and methods for patterning the same.
摘要翻译：本发明涉及水凝胶及其制造和使用方法。特别地，本发明的一些实施方案涉及水凝胶及其图案化方法。

4. 发明申请

US20140038826A1 COVALENTLY CROSS LINKED HYDROGELS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：共同的交联水合物及其制备方法和使用方法
公开(公告)号：US20140038826A1
公开(公告)日：2014-02-06
申请号：US13981885
申请日：2012-01-27
申请人： Kristi Anseth , Ben Fairbanks , Christopher Bowman
发明人： Kristi Anseth , Ben Fairbanks , Christopher Bowman
IPC分类号： A61L27/22 , A61L27/18 , A61L27/52
CPC分类号： A61L27/18 , A61L27/22 , A61L27/52 , A61L27/54 , A61L2430/02 , A61L2430/06 , A61L2430/34 , C08F38/00 , C08G75/045 , C08G75/12 , C08J3/075 , C08J2300/16 , C08J2300/20 , C08J2371/02 , C08L81/02 , C08L101/02 , C08L101/16 , C12N5/0068
摘要： A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol functional groups. The alkyne moiety, internal or terminal, may react with one or two thiols. Degradable monomers may be used to form degradable polymers.
摘要翻译：公开了一种硫醇聚合物材料及其制备方法。该材料通过具有炔和硫醇官能团的单体的自由基介导的聚合产生。内部或末端的炔基部分可与一个或两个硫醇反应。可降解单体可用于形成可降解聚合物。

5. 发明授权

US08519086B2 Degradable thiol-ene polymers 有权
公开(公告)号：US08519086B2
公开(公告)日：2013-08-27
申请号：US12556640
申请日：2009-09-10
申请人： Christopher Bowman , Kristi Anseth , Blige Hacioglu , Charlie Nuttelman
发明人： Christopher Bowman , Kristi Anseth , Blige Hacioglu , Charlie Nuttelman
IPC分类号： C08G75/04 , C08G81/00
CPC分类号： C08L89/00 , A01N25/04 , A61K47/34 , A61L27/16 , A61L27/18 , A61L27/38 , A61L27/52 , A61L27/54 , A61L2300/62 , C05G3/0029 , C05G3/0076 , C08G75/045 , C08G81/00 , C08G81/027 , C08G2261/126 , C08J3/075 , C08J2329/04 , C08J2367/04 , C08J2371/02 , C08L71/02 , C08L81/02 , C08L2205/05 , Y10S524/916 , Y10S525/936 , C08L83/00 , C08L2666/22
摘要： A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.

6. 发明申请

US20060066006A1 Fabrication of 3d photopolymeric devices 审中-公开
标题翻译： 3d光聚合器件的制造
公开(公告)号：US20060066006A1
公开(公告)日：2006-03-30
申请号：US10521635
申请日：2003-07-21
申请人： K. Haraldsson , J Hutchison , Christopher Bowman , Kristi Anseth
发明人： K. Haraldsson , J Hutchison , Christopher Bowman , Kristi Anseth
IPC分类号： B29C35/08 , B29C41/02 , B29C41/22
CPC分类号： B82Y10/00 , B82Y40/00 , G03F7/0002 , G03F7/0035 , G03F7/0037 , G03F7/2014
摘要： A process and apparatus for making polymeric layers. A layer of liquid (20) including a photopolymerizable precursor is formed between a substrate (17) and a photomask (12). A reaction chamber is formed by a base (15), side walls (16) and photomask (12) polymerizes one or more regions of the liquid layer (20) to form a polymeric layer.
摘要翻译：用于制备聚合物层的方法和设备。在基板（17）和光掩模（12）之间形成包含可光聚合的前体的液体层（20）。反应室由基底（15）形成，侧壁（16）和光掩模（12）聚合液体层（20）的一个或多个区域以形成聚合物层。

7. 发明申请

US20050192371A1 Preparation and use of photopolymerized microparticles 审中-公开
标题翻译：光聚合微粒的制备和应用
公开(公告)号：US20050192371A1
公开(公告)日：2005-09-01
申请号：US11070506
申请日：2005-03-02
申请人： Theodore Randolph , Kristi Anseth , Jennifer Owens , Corinne Lengsfeld
发明人： Theodore Randolph , Kristi Anseth , Jennifer Owens , Corinne Lengsfeld
IPC分类号： A61K9/16 , C08F2/06 , C08F2/18 , C08F2/46 , C08K3/00
CPC分类号： A61K9/1635 , A61K9/1694 , C08F2/06 , C08F2/18 , C08F2/46 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989
摘要： Methods of forming crosslinked polymer particles in situ from polymer precursors such as monomers or oligomers, comprising exposing a composition comprising at least one polymer precursor, a solvent or solvent mixture, and an antisolvent or antisolvent mixture to photoradiation under conditions whereby particles are formed are provided. The polymer precursor may be photosensitive, or a separate polymerization initiator may be used. In a preferred embodiment, the polymer precursor is insoluble in the antisolvent or antisolvent mixture and the solvent or solvent mixture is soluble in the antisolvent or antisolvent mixture at the concentrations used. Crosslinked polymer particles and crosslinked polymer particles comprising a polymer and a bioactive material are also provided. The polymer may be erodable, and the polymer particles formed may be used in a variety of applications, including controlled release of bioactive materials such as drugs. Polymer particles formed using the methods of the invention have low residual solvent levels and high additive encapsulation efficiencies. The processes of the invention allow control of particle size and morphology, use low operating temperatures and are useful for efficient bulk production.
摘要翻译：提供从聚合物前体如单体或低聚物原位形成交联聚合物颗粒的方法，包括将包含至少一种聚合物前体，溶剂或溶剂混合物的组合物以及抗溶剂或抗溶剂混合物暴露于形成颗粒的条件下进行光引发。聚合物前体可以是光敏的，或者可以使用单独的聚合引发剂。在优选的实施方案中，聚合物前体不溶于抗溶剂或抗溶剂混合物，溶剂或溶剂混合物可以以所使用的浓度溶于抗溶剂或抗溶剂混合物。还提供了交联聚合物颗粒和包含聚合物和生物活性材料的交联聚合物颗粒。聚合物可能是可侵蚀的，并且形成的聚合物颗粒可以用于各种应用中，包括诸如药物的生物活性材料的控制释放。使用本发明方法形成的聚合物颗粒具有低的残留溶剂水平和高的添加剂包封效率。本发明的方法允许控制颗粒尺寸和形态，使用低的操作温度，并且可用于高效批量生产。

8. 发明授权

US06403672B1 Preparation and use of photopolymerized microparticles 失效
标题翻译：光聚合微粒的制备和应用
公开(公告)号：US06403672B1
公开(公告)日：2002-06-11
申请号：US09451481
申请日：1999-11-30
申请人： Theodore Randolph , Kristi Anseth , Jennifer L. Owens , Corinne Lengsfeld
发明人： Theodore Randolph , Kristi Anseth , Jennifer L. Owens , Corinne Lengsfeld
IPC分类号： C08F246
CPC分类号： A61K9/1694 , A61K9/1635 , C08F2/06 , C08F2/18 , C08F2/46
摘要： Methods of forming polymer particles in situ from polymer precursors such as monomers or oligomers, comprising exposing a composition comprising at least one polymer precursor, a solvent or solvent mixture, and an antisolvent or antisolvent mixture to photoradiation under conditions whereby particles are formed are provided. The polymer precursor may be photosensitive, or a separate polymerization initiator may be used. In a preferred embodiment, the polymer precursor is insoluble in the antisolvent or antisolvent mixture and the solvent or solvent mixture is soluble in the antisolvent or antisolvent mixture at the concentrations used. Polymer particles comprising a polymer and a bioactive material are also provided. The polymer may be erodable, and the polymer particles formed may be used in a variety of applications, including controlled release of bioactive materials such as drugs. Polymer particles formed using the methods of the invention have low residual solvent levels and high additive encapsulation efficiencies. The processes of the invention allow control of particle size and morphology, use low operating temperatures and are useful for efficient bulk production.
摘要翻译：提供从聚合物前体例如单体或低聚物原位形成聚合物颗粒的方法，其包括将包含至少一种聚合物前体，溶剂或溶剂混合物的组合物以及抗溶剂或抗溶剂混合物暴露于形成颗粒的条件下进行光引发。聚合物前体可以是光敏的，或者可以使用单独的聚合引发剂。在优选的实施方案中，聚合物前体不溶于抗溶剂或抗溶剂混合物，溶剂或溶剂混合物可以以所使用的浓度溶于抗溶剂或抗溶剂混合物。还提供了包含聚合物和生物活性材料的聚合物颗粒。聚合物可能是可侵蚀的，并且形成的聚合物颗粒可以用于各种应用中，包括诸如药物的生物活性材料的控制释放。使用本发明方法形成的聚合物颗粒具有低的残留溶剂水平和高的添加剂包封效率。本发明的方法允许控制颗粒尺寸和形态，使用低的操作温度，并且可用于高效批量生产。

9. 发明授权

US08703904B2 Hydrogels and methods for producing and using the same 有权
标题翻译：水凝胶及其制造和使用方法
公开(公告)号：US08703904B2
公开(公告)日：2014-04-22
申请号：US12678920
申请日：2008-09-18
申请人： Brian Polizzotti , Kristi Anseth , Benjamin Fairbanks , Cole DeForest
发明人： Brian Polizzotti , Kristi Anseth , Benjamin Fairbanks , Cole DeForest
IPC分类号： A61K38/00
CPC分类号： C08F289/00 , C08J3/075 , C08K3/20 , Y10T428/24802
摘要： The present invention relates to hydrogels and methods for producing and using the same. In particular, some embodiments of the invention relate to hydrogels and methods for patterning the same.
摘要翻译：本发明涉及水凝胶及其制造和使用方法。特别地，本发明的一些实施方案涉及水凝胶及其图案化方法。

10. 发明授权

US07625580B1 Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering 失效
标题翻译：用于药物递送和组织工程的半互穿或互穿聚合物网络
公开(公告)号：US07625580B1
公开(公告)日：2009-12-01
申请号：US09724382
申请日：2000-11-28
申请人： Robert S. Langer , Jennifer Elisseeff , Kristi Anseth , Derek Sims
发明人： Robert S. Langer , Jennifer Elisseeff , Kristi Anseth , Derek Sims
IPC分类号： A61K2/02
CPC分类号： A61L27/50 , A61L27/38 , A61L27/3817 , A61L27/3852 , A61L27/52 , A61L2400/06 , A61L2430/06
摘要： Compositions for tissue engineering and drug delivery have been developed based on solutions of two or more polymers which form semi-interpenetrating or interpenetrating polymer networks upon exposure to active species following injection at a site in a patient in need thereof. The polymers crosslink to themselves but not to each other; semi-interpenetrating networks are formed when only one of the polymers crosslink. The resulting viscous solutions retain the biologically active molecules or cells at the site of injection until release or tissue formation, respectfully, occurs.As a result of studies conducted with polymer-cell suspensions forming interpenetrating polymer networks, it has been determined that polymer solutions can be formulated wherein the active species is provided by exposure of the polymer solution to an exogenous source of active species, typically electromagnetic radiation, preferably light. Studies demonstrate that light will penetrate through skin, body fluids (such as synovial fluid) and membranes and polymerize the polymer solutions. The polymer solutions can be crosslinked ionically or covalently, to form a hydrogel, semi-interpenetrating polymer network or an interpenetrating polymer network.
摘要翻译：已经开发了用于组织工程和药物递送的组合物，其基于在需要其的患者的部位注射后暴露于活性物质时形成半互穿或互穿聚合物网络的两种或更多种聚合物的溶液。聚合物自身交联而不是彼此交联; 当只有一种聚合物交联时，形成半互穿网络。所得粘稠溶液将生物活性分子或细胞保留在注射部位，直到发生释放或组织形成。作为通过形成互穿聚合物网络的聚合物 - 细胞悬浮液进行的研究的结果，已经确定可以配制聚合物溶液，其中通过将聚合物溶液暴露于外源性活性物质（通常是电磁辐射）来提供活性物质，最好是光。研究表明，光将穿透皮肤，体液（如滑液）和膜，并聚合聚合物溶液。聚合物溶液可以离子交换或共价交联，以形成水凝胶，半互穿聚合物网络或互穿聚合物网络。

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