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1. 发明授权

US5952422A Polyurethane pressure-sensitive adhesives 失效
标题翻译：聚氨酯压敏粘合剂
公开(公告)号：US5952422A
公开(公告)日：1999-09-14
申请号：US768735
申请日：1996-12-18
申请人： Tak-lung Chang , Sheng-hung Kuo , Kishore Shah , Agis Kydonieus
发明人： Tak-lung Chang , Sheng-hung Kuo , Kishore Shah , Agis Kydonieus
IPC分类号： A61L15/58 , A61L24/04 , C08G18/10 , C08G18/48 , C08G18/72 , C08G18/82 , C09J175/04 , C09J175/08 , C08J3/00 , C08G18/00 , C08K3/20 , C08L75/00
CPC分类号： C09J175/08 , A61L15/58 , A61L24/046 , C08G18/10 , C08G18/4837 , C08G18/725 , C08G2170/40 , C08G2220/00
摘要： Method for forming a polyurethane based adhesive composition in which a reaction mixture of at least one NCO-terminated prepolymer and a polyhydroxy compound is heated at a temperature and for a length of time sufficient to provide a gel content of from about 30 to 42% by weight and a molecular weight of extractables of at least about 45,000. Polyurethane based adhesives prepared by the method and medical devices employing the same are also disclosed.
摘要翻译：用于形成聚氨酯基粘合剂组合物的方法，其中将至少一种NCO-封端的预聚物和多羟基化合物的反应混合物在足以使凝胶含量为约30至42％的温度和长度的温度下加热，重量和至少约45,000的可提取物的分子量。还公开了通过该方法制备的聚氨酯类粘合剂和使用其的医疗装置。

2. 发明授权

US5910536A Polyurethane pressure-sensitive adhesives 失效
标题翻译：聚氨酯压敏粘合剂
公开(公告)号：US5910536A
公开(公告)日：1999-06-08
申请号：US772217
申请日：1996-12-19
申请人： Agis Kydonieus , Kishore Shah , Aruna Nathan
发明人： Agis Kydonieus , Kishore Shah , Aruna Nathan
IPC分类号： C08F290/06 , C08F2/50 , C08G18/10 , C08G18/67 , C08G18/81 , C09J175/14 , C09J175/16 , C08J3/00 , C08J3/28 , C08K3/20 , C08L75/00
CPC分类号： C09J175/16 , C08G18/10 , C08G18/6715 , C08G18/672 , C08G18/8116 , C08G2170/40
摘要： Methods for producing poly�urethane-(meth)acrylate!-based adhesives in which an isocyanate-terminated prepolymer is reacted to convert the isocyanate terminal groups into groups capable of cross-linking with each other, excess isocyanate groups are quenched with an isocyanate group quenching compound and the resulting prepolymer is then irradiated or heated to form the polyurethane-based adhesives, and adhesives produced thereby. Alternatively, a hydroxyl-terminated prepolymer is reacted with a reagent having isocyanate and methacrylate groups to form a prepolymer which is then irradiated or heated.
摘要翻译：使异氰酸酯封端的预聚物反应以将异氰酸酯端基转化为能够交联的基团的聚[氨基甲酸酯 - （甲基）丙烯酸酯]基粘合剂的制备方法，过量的异氰酸酯基团用异氰酸酯基团然后将淬火化合物和所得预聚物照射或加热以形成聚氨酯基粘合剂，以及由此制备的粘合剂。或者，羟基封端的预聚物与具有异氰酸酯和甲基丙烯酸酯基团的试剂反应以形成预聚物，然后将其预辐射或加热。

3. 发明授权

US06179818B2 Ostomy bags and vessels for biological materials 失效
标题翻译：造口袋和生物材料容器
公开(公告)号：US06179818B2
公开(公告)日：2001-01-30
申请号：US08338917
申请日：1994-11-14
申请人： Agis Kydonieus , Cuilian Lin , Kishore Shah , Leslie Klem
发明人： Agis Kydonieus , Cuilian Lin , Kishore Shah , Leslie Klem
IPC分类号： A61F1315
CPC分类号： A61F5/445 , A61L28/0007 , A61L28/0034
摘要： The invention provides a vessel for biological materials comprising a multilayer polymeric barrier material that has very low permeability to small molecules, such as water and oxygen, high flexibility and softness, and is resistant to tearing. The invention is particularly useful for forming vessels that receive biological fluids, such as ostomy bags and bags for storing blood, blood products, and IV solutions. The vessel comprises a flexible, multilayer, polymeric barrier material comprising (1) a first sandwich polymer layer, (2) at least one sandwiched, oriented liquid crystal polymer layer, and (3) a second sandwich polymer layer, the first and second sandwich layers disposed to sandwich the liquid crystal layer therebetween.
摘要翻译：本发明提供了一种用于生物材料的容器，其包括对小分子（例如水和氧）具有非常低的渗透性，高柔性和柔软性并且耐撕裂性的多层聚合物阻隔材料。本发明特别可用于形成容纳生物流体的血管，例如造口袋和用于储存血液的血袋，血液制品和IV溶液。该容器包括柔性多层聚合物阻挡材料，其包含（1）第一夹层聚合物层，（2）至少一个夹层取向液晶聚合物层和（3）第二夹层聚合物层，第一和第二夹层设置在其间夹着液晶层的层。

4. 发明授权

US5310559A Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer 失效
标题翻译：用于控制释放和递送至包含含丙烯酸烷基酯共聚物的速率控制构件的药理学活性剂的哺乳动物组织的装置
公开(公告)号：US5310559A
公开(公告)日：1994-05-10
申请号：US964478
申请日：1992-10-21
申请人： Kishore Shah , Agis Kydonieus
发明人： Kishore Shah , Agis Kydonieus
IPC分类号： A61K9/70 , A61K31/21 , A61M31/00 , A61F13/00
CPC分类号： A61K9/703 , A61K31/21 , A61K9/7053 , A61K9/7084 , A61M31/002
摘要： Described is a device for the controlled release and delivery to mammalian tissue of a pharmacologically active agent comprising:(i) an impermeable backing member;(ii) a control membrane lamina consisting essentially of a first polymeric composition of matter which consists essentially of at least one C.sub.2 -C.sub.4 lower olefin-C.sub.1 -C.sub.8 alkyl acrylate and/or methacrylate copolymer having 2-90% by weight of alkyl acrylate and/or methacrylate monomeric units, taken alone, or taken further together with in intimate admixture, a second polymeric composition consisting essentially of a C.sub.2 -C.sub.4 polyalkylene corresponding to the C.sub.2 -C.sub.4 lower alkylene of said copolymer, said second polymeric composition being compatible with said first polymeric composition of matter; and(iii) a pharmacologically active agent reservoir maintained there between comprising said pharmacologically active agent and a carrier therefor and, optionally, one or more excipients and/or enhancers; and(iv) means for maintaining said device in pharmacologically active agent transmitting relationship to the mammalian tissue to be treated.
摘要翻译：描述了用于控制释放和递送到哺乳动物组织的药理活性剂的装置，包括：（i）不可渗透的背衬构件; （ii）主要由物质的第一聚合物组合物组成的对照膜层，其主要由至少一种具有2-90重量％的丙烯酸烷基酯的丙烯酸C 2 -C 4低级烯烃-C 1 -C 8烷基酯和/或甲基丙烯酸酯共聚物组成，或独立地取代或以紧密混合物进一步取代，第二聚合物组合物基本上由对应于所述共聚物的C 2 -C 4低级亚烷基的C 2 -C 4聚亚烷基组成，所述第二聚合物组合物与所述物质的第一聚合物组成; 和（iii）保持在其间的药理学活性剂储存器，其包含所述药理活性剂及其载体，以及任选的一种或多种赋形剂和/或增强剂; 和（iv）用于将所述装置维持在与要治疗的哺乳动物组织发生关系的药理活性剂中的装置。

5. 发明授权

US5591820A Polyurethane pressure-sensitive adhesives 失效
标题翻译：聚氨酯压敏粘合剂
公开(公告)号：US5591820A
公开(公告)日：1997-01-07
申请号：US437069
申请日：1995-05-09
申请人： Agis Kydonieus , Ladislav Bastar , Kishore Shah , Khosrow Jamshidi , Tak-lung Chang , Sheng-hung Kuo
发明人： Agis Kydonieus , Ladislav Bastar , Kishore Shah , Khosrow Jamshidi , Tak-lung Chang , Sheng-hung Kuo
IPC分类号： A61K9/70 , A61F13/02 , A61L15/16 , A61L15/22 , A61L15/26 , A61L15/42 , A61L15/58 , A61L31/06 , A61L31/14 , C09J175/00 , C09J175/08 , C08G18/30
CPC分类号： A61L31/148 , A61L31/06 , C08G18/4804 , C08G18/73 , C08G18/76 , C09J175/08 , Y10S528/905 , Y10T428/31551
摘要： Pressure-sensitive adhesives which possess absorptivity and/or permeability properties to remove transepidermal water loss and/or other bodily fluids that come into contact with the adhesive, in combination with a fine balance of cohesion and adhesion properties, can be formulated by controlling the crosslinking of a polyurethane polymer having excess hydroxyl functionality, a glass transition temperature of less than about 0.degree. C., a moisture absorption of at least about 20% of its weight and/or a moisture vapor transmission rate of at least about 300 grams/meter.sup.2 /24 hours measured at 37.degree. C. and a 90% relative humidity gradient. Adhesives of these polymers possess a peel adhesion to human skin of between about 0.3 and 4 newtons/cm width of the polymer or adhesive.
摘要翻译：具有吸收性和/或渗透性能以去除经表皮水分流失的粘合剂和/或与粘合剂接触的其它体液以及内聚力和粘合性质的良好平衡的压敏粘合剂可以通过控制交联的具有过量羟基官能团的聚氨酯聚合物，玻璃化转变温度低于约0℃，其吸湿率至少为其重量的约20％和/或至少约300克/米2的湿气透过率 / 24小时，在37℃和90％相对湿度梯度下测量。这些聚合物的粘合剂对聚合物或粘合剂的宽度约为0.3-4牛顿/厘米，具有对人体皮肤的剥离粘合性。

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