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1. 发明授权

US07794706B2 Bioactive wound dressings and implantable devices and methods of use 失效
标题翻译：生物活性伤口敷料和植入式装置及使用方法
公开(公告)号：US07794706B2
公开(公告)日：2010-09-14
申请号：US11796267
申请日：2007-04-26
申请人： Kenneth W. Carpenter , William G. Turnell , Kristin M. DeFife , Kathryn A. Grako , Ramaz Katsarava
发明人： Kenneth W. Carpenter , William G. Turnell , Kristin M. DeFife , Kathryn A. Grako , Ramaz Katsarava
IPC分类号： C12N11/08
CPC分类号： A61F13/00012 , A61F13/069 , A61F2013/00221 , A61F2013/0054 , A61F2013/0091 , A61F2013/00927 , A61K35/22 , A61K35/28 , A61K35/30
摘要： The present invention provides wound dressings, optionally surgically implantable, containing biodegradable, polymers and hydrogels having allogenic or autologous precursor cells, such as stem cells and progenitor cells dispersed within. Alternatively, the wound dressings can have conditioned medium obtained from the precursor cells dispersed within. The wound dressings promote tissue restoration processes at a site of application or implantation. Additional bioactive agents can also be dispersed within the polymer/hydrogel matrix, which can be formulated to biodegrade at a controlled rate by adjusting the composition. Methods are also provided for using such biodegradable wound dressings as a delivery device or carrier for the precursor cells, conditioned medium and bioactive agents, or as coatings on implantable medical devices, to promote tissue restoration at a lesion site.
摘要翻译：本发明提供了包含可生物降解的，具有同种异体或自体前体细胞的生物可降解的聚合物和水凝胶的伤口敷料，任选地可手术植入，例如分散在其中的干细胞和祖细胞。或者，伤口敷料可以具有从分散在其中的前体细胞获得的条件培养基。伤口敷料在应用或植入部位促进组织修复过程。另外的生物活性剂也可以分散在聚合物/水凝胶基质内，其可以通过调节组合物以受控的速率配制成生物降解。还提供了使用这种可生物降解的伤口敷料作为用于前体细胞，条件培养基和生物活性剂的递送装置或载体或作为可植入医疗装置上的涂层来促进病变部位的组织恢复的方法。

2. 发明授权

US5735872A Stent 失效
标题翻译：支架
公开(公告)号：US5735872A
公开(公告)日：1998-04-07
申请号：US720714
申请日：1996-10-02
申请人： Kenneth W. Carpenter , Leo R. Roucher, Jr. , Eugene J. Jung, Jr. , Erich H. Wolf , Thomas A. Steinke
发明人： Kenneth W. Carpenter , Leo R. Roucher, Jr. , Eugene J. Jung, Jr. , Erich H. Wolf , Thomas A. Steinke
IPC分类号： A61F2/82 , A61F2/92 , A61M29/00
CPC分类号： A61F2/93 , A61F2/958
摘要： The present invention is a stent for insertion into an artery or other vessel. The stent is formed from a series of tubular shaped bands each formed with a first end which overlaps a second end. The overlap between the first and second ends is variable and allows each band to move between a contracted configuration and a fully expanded configuration which are within the elastic limits of the band. Each band includes a plurality of receivers and a first tab on a first edge of the band to secure each band at or near the fully expanded configuration and allow the stent to conform to the contours of the vessel. The bands are distributed along a substantially common axis to form a tube interconnected by a pair of elongated strips. In use, the stent is placed over a balloon catheter and compressed to adopt the contracted configuration. The stent is maintained in the contracted configuration by a retainer. The balloon catheter and stent are then advanced through a placement catheter to a target site where the balloon is partially inflated to free the stent for expansion to an equilibrium configuration. The balloon may then be more fully inflated to further expand any of the bands in the stent to suit the needs of the patient. The balloon is then deflated and removed, leaving the expanded stent to support that target site.
摘要翻译：本发明是用于插入动脉或其他血管的支架。支架由一系列管状带形成，每个管状带形成有与第二端重叠的第一端。第一和第二端之间的重叠是可变的，并且允许每个带在收缩构型和处于该带的弹性极限内的完全展开构型之间移动。每个带包括多个接收器和在带的第一边缘上的第一接头，以将每个带固定在完全展开的构型处或附近，并允许支架符合容器的轮廓。带沿着基本上共同的轴线分布以形成通过一对细长带相互连接的管。在使用中，将支架放置在气囊导管上并压缩以采用收缩构造。支架通过保持器保持在收缩构型中。气球导管和支架然后通过放置导管前进到目标部位，其中气囊被部分充气以释放支架用于扩张至平衡构型。然后，气球可以被更充分地充气以进一步扩张支架中的任何带以满足患者的需要。然后将气囊放气并除去，留下扩张的支架以支持该靶位点。

3. 发明授权

US08163269B2 Bioactive stents for type II diabetics and methods for use thereof 失效
标题翻译： II型糖尿病患者的生物活性支架及其使用方法
公开(公告)号：US08163269B2
公开(公告)日：2012-04-24
申请号：US11098891
申请日：2005-04-04
申请人： Kenneth W. Carpenter , William G. Turnell , Kristin M. DeFife , Kathryn A. Grako
发明人： Kenneth W. Carpenter , William G. Turnell , Kristin M. DeFife , Kathryn A. Grako
IPC分类号： A61M36/14 , A61K51/00
CPC分类号： A61L27/56 , A61F2/82 , A61F2250/0068 , A61L27/34 , A61L31/10 , C07K16/18 , C07K16/28 , C08L89/00
摘要： The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand that specifically captures progenitors of endothelial cells (PECs) from the circulating blood to promote endogenous formation of healthy endothelium in Type II diabetics. In one embodiment, the bioligand is a peptide that specifically binds to an integrin receptor on PECs. The invention also provides methods for using such vascular stents and other implantable devices to promote vascular healing in Type II diabetics, for example following mechanical intervention.
摘要翻译：本发明基于以下发现：血管支架或其它可植入医疗装置可以涂覆有可生物降解的生物相容性聚合物，其附着有特异性捕获来自循环血液的内皮细胞祖细胞（PEC）的生物配偶体，以促进内源性形成 II型糖尿病患者的健康内皮。在一个实施方案中，生物配体是特异性结合PEC上的整联蛋白受体的肽。本发明还提供了使用这种血管支架和其它可植入装置来促进II型糖尿病患者的血管愈合的方法，例如在机械干预之后。

4. 发明申请

US20080288057A1 Bioactive Stents For Type II Diabetics and Methods for Use Thereof 审中-公开
标题翻译： II型糖尿病患者的生物活性支架及其使用方法
公开(公告)号：US20080288057A1
公开(公告)日：2008-11-20
申请号：US11885791
申请日：2006-04-04
申请人： Kenneth W. Carpenter , William G. Turnell , Kristin M. Defife , Kathryn A. Grako
发明人： Kenneth W. Carpenter , William G. Turnell , Kristin M. Defife , Kathryn A. Grako
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： C07K16/18 , A61F2/82 , A61F2250/0068 , C07K16/28
摘要： The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand that specifically captures progenitors of endothelial cells (PECs) from the circulating blood to promote endogenous formation of healthy endothelium in Type II diabetics. In one embodiment, the bioligand is a peptide that specifically binds to an integrin receptor on PECs. The invention also provides methods for using such vascular stents and other implantable devices to promote vascular healing in Type II diabetics, for example following mechanical intervention.
摘要翻译：本发明基于以下发现：血管支架或其它可植入医疗装置可以涂覆有可生物降解的生物相容性聚合物，其附着有特异性捕获来自循环血液的内皮细胞祖细胞（PEC）的生物配偶体，以促进内源性形成 II型糖尿病患者的健康内皮。在一个实施方案中，生物配体是特异性结合PEC上的整联蛋白受体的肽。本发明还提供了使用这种血管支架和其它可植入装置来促进II型糖尿病患者的血管愈合的方法，例如在机械干预之后。

5. 发明授权

US06796957B2 Sterile aspiration/reinjection systems 有权
标题翻译：无菌抽吸/回注系统
公开(公告)号：US06796957B2
公开(公告)日：2004-09-28
申请号：US10004525
申请日：2001-10-23
申请人： Kenneth W. Carpenter , Michelle Fourmont , E. Thomas Malphus , Kazuo Sasamine , Hong Li
发明人： Kenneth W. Carpenter , Michelle Fourmont , E. Thomas Malphus , Kazuo Sasamine , Hong Li
IPC分类号： A61M3100
CPC分类号： A61M25/0084 , A61B2090/062 , A61M2025/0089 , A61M2202/0413 , A61M2205/75 , Y10S977/916 , A61M2202/0021
摘要： The invention provides systems containing a sterile container for aspiration, filtering, treating and reinjection into a subject of a bodily fluid in a sterile environment. The systems are particularly designed to facilitate transfection of cells within the sterile container by gene therapy molecules and reinjection of the transfected cells into the donor at controlled depth in precisely controlled volumes such as is useful for revascularization of ischemic cardiac tissue. For injection, a pressure actuator, preferably hand-held, applies force to liquids held within the sterile container in precisely controlled increments, thereby expressing liquids through a hollow needle or injection catheter in precisely controlled microvolumes. The invention systems include a hand-held injection device with audible cues that correspond to an operator-selected injection volume and/or audible cues that correspond to needle penetration depth selected by the operator.
摘要翻译：本发明提供了包含用于在无菌环境中吸入，过滤，处理和再注入体液的受试者的无菌容器的系统。该系统特别设计用于通过基因治疗分子促进无菌容器内的细胞的转染，并以受精的控制体积（例如对于缺血性心脏组织的血运重建有用）将被转染的细胞重新注入受控深度的供体。对于注射，优选手持式压力致动器以精确控制的增量对保持在无菌容器内的液体施加力，从而通过中空针或注射导管在精确控制的微量体积中表达液体。本发明系统包括手持式注射装置，其具有对应于操作者选择的注射体积和/或对应于由操作者选择的穿刺深度的可听到的线索的可听到的提示。

6. 发明申请

US20110137406A1 BIOACTIVE STENTS FOR TYPE II DIABETICS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：用于II型糖尿病的生物手术及其使用方法
公开(公告)号：US20110137406A1
公开(公告)日：2011-06-09
申请号：US12912440
申请日：2010-10-26
申请人： Kenneth W. Carpenter , William G. Turnell , Kristin M. DeFife , Kathryn A. Grako
发明人： Kenneth W. Carpenter , William G. Turnell , Kristin M. DeFife , Kathryn A. Grako
IPC分类号： A61F2/82
CPC分类号： C07K16/18 , A61F2/82 , A61F2250/0068 , A61L27/34 , A61L27/56 , A61L31/10 , C07K16/28 , C08L89/00
摘要： The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand that specifically captures progenitors of endothelial cells (PECs) from the circulating blood to promote endogenous formation of healthy endothelium in Type II diabetics. In one embodiment, the bioligand is a peptide that specifically binds to an integrin receptor on PECs. The invention also provides methods for using such vascular stents and other implantable devices to promote vascular healing in Type II diabetics, for example following mechanical intervention.
摘要翻译：本发明基于以下发现：血管支架或其它可植入医疗装置可以涂覆有可生物降解的生物相容性聚合物，其附着有特异性捕获来自循环血液的内皮细胞祖细胞（PEC）的生物配偶体，以促进内源性形成 II型糖尿病患者的健康内皮。在一个实施方案中，生物配体是特异性结合PEC上的整联蛋白受体的肽。本发明还提供了使用这种血管支架和其它可植入装置来促进II型糖尿病患者的血管愈合的方法，例如在机械干预之后。

7. 发明授权

US06231585B1 Device for stabilizing a treatment site and method of use 失效
标题翻译：用于稳定治疗部位和使用方法的装置
公开(公告)号：US06231585B1
公开(公告)日：2001-05-15
申请号：US09328526
申请日：1999-06-09
申请人： Masao Takahashi , Elazer E. Edelman , Kenneth W. Carpenter
发明人： Masao Takahashi , Elazer E. Edelman , Kenneth W. Carpenter
IPC分类号： A61M2900
CPC分类号： A61B17/02 , A61B17/0218 , A61B2017/00243 , A61B2017/00252 , A61B2017/0243 , A61B2017/306
摘要： The present invention provides stabilizing devices and methods of use for temporarily remotely immobilizing a local area of tissue, such as a local area of tissue on a beating heart, or other internal organ, to thereby permit minimally-invasive or robotic surgery thereon. The invention stabilizing device, which is coupled to a vacuum source, features an elastomeric suction body mounted on the steerable tip of a rod-like instrument, such as a steerable catheter. The flexible or steerable tip and elongate suction channel are sized for introduction into an interior body cavity via a small surgical opening. A steering mechanism mounted at the proximal end of the device is used to coil the elongate tip and suction channel into a ring- or horseshoe-shape within the body cavity. Preferably, the suction channel has a flexible, spreadable outer rim portion which is designed to flatten and spread outwardly against the surface of the treatment site as air is withdrawn from the coiled suction channel to distribute the pressure against the treatment site while maximizing the suction field. The suction body is manufactured of a soft, compliant material, such as an elastomeric polymer, to allow the suction channel to be transformed into the coiled conformation without deformation sufficient to defeat its purpose of use, i.e., clinging to the surface of a treatment site under partial vacuum.
摘要翻译：本发明提供了用于临时远程地固定组织局部区域（例如跳动心脏上的组织的局部区域）或其他内部器官的稳定装置和方法，从而允许其上进行微创或机器人手术。耦合到真空源的发明稳定装置的特征在于安装在诸如可导向导管的杆状器械的可转向尖端上的弹性抽吸体。该柔性或可操纵的尖端和细长的吸入通道的尺寸适于通过小的手术开口引入到内部体腔中。安装在装置的近端处的转向机构用于将细长末端和抽吸通道线圈成体腔内的环形或马蹄形。优选地，吸入通道具有柔性的可展开的外缘部分，其被设计成在处理部位的表面上向外平坦化并向外展开，因为空气从盘旋抽吸通道排出，以将压力分配到治疗部位上，同时最大化吸入场。吸入体由柔软的柔顺材料制成，例如弹性体聚合物，以允许吸入通道转化成卷曲结构，而不会产生足够的变形，以破坏其使用目的，即粘附于治疗部位的表面在部分真空下。

8. 发明授权

US5643314A Self-expanding stent 失效
标题翻译：自扩张支架
公开(公告)号：US5643314A
公开(公告)日：1997-07-01
申请号：US557725
申请日：1995-11-13
申请人： Kenneth W. Carpenter , Leo R. Roucher, Jr. , Eugene J. Jung, Jr.
发明人： Kenneth W. Carpenter , Leo R. Roucher, Jr. , Eugene J. Jung, Jr.
IPC分类号： A61F2/82 , A61F2/92 , A61M29/00
CPC分类号： A61F2/82 , A61F2/92 , A61F2/958
摘要： The present invention provides a self-expanding stent for insertion into an artery or other internal vessel. The stent is formed from a series of radial bands each formed with overlapping first and second ends. The overlap between the first and second ends is variable, allowing each band to move between a contracted configuration and an expanded configuration. The first and second ends of each band are both formed to include a tab which is folded to hold the first and second end against the band. The bands are distributed along a common axis to form a cylinder and interconnected by a pair of elongated strips. In use, the stent is placed over a balloon catheter and compressed to adopt the contracted configuration. The balloon catheter and stent are then advanced through a placement catheter and to a target site where the balloon is partially inflated to free the stent for self-expansion. The balloon may then be more fully inflated to further expand any of the radial bands in the stent. The balloon is then deflated and removed, leaving the expanded stent to support that target site.
摘要翻译：本发明提供一种用于插入动脉或其他内部血管的自扩张支架。支架由一系列径向带形成，每个径向带形成有重叠的第一和第二端。第一和第二端之间的重叠是可变的，允许每个带在收缩配置和扩展配置之间移动。每个带的第一和第二端都形成为包括折叠片，以将第一和第二端保持抵靠带。带沿着公共轴线分布以形成圆柱体并且通过一对细长条带互连。在使用中，将支架放置在气囊导管上并压缩以采用收缩构造。气囊导管和支架然后通过放置导管前进到靶部位，其中气囊被部分充气以释放支架以进行自我扩张。然后可以使球囊充分充气以进一步扩张支架中的任何径向带。然后将气囊放气并除去，留下扩张的支架以支持该靶位点。

9. 发明申请

US20090022772A1 BIOABSORBABLE ELASTOMERIC ARTERIAL SUPPORT DEVICE AND METHODS OF USE 审中-公开
标题翻译：生物可塑性弹性体支架装置及其使用方法
公开(公告)号：US20090022772A1
公开(公告)日：2009-01-22
申请号：US12058603
申请日：2008-03-28
申请人： Kenneth W. Carpenter , Zaza D. Gomurashvili
发明人： Kenneth W. Carpenter , Zaza D. Gomurashvili
IPC分类号： A61K9/00 , C08G63/44 , A61P43/00
CPC分类号： A61L31/148 , A61K47/6957 , A61L31/06 , A61L31/146 , C08L77/12
摘要： The invention provides bioabsorbable elastomeric arterial support devices fabricated using elastomeric polymer networks and semi-interpenetrating networks in which a linear polymer is crosslinked by ester or alpha-amino-acid containing cross-linkers that polymerize upon exposure to active species. The invention devices are designed for implant into curved segments of artery and can be expanded during arterial implant and cross-linked in vivo in the expanded state to restore a clogged artery to extended function. The invention devices are useful for in vivo implant in diseased arteries and for delivery of a variety of therapeutic molecules in a time release fashion to surrounding tissues to reduce or eliminate arterial response to implant of the device.
摘要翻译：本发明提供使用弹性体聚合物网络和半互穿网络制造的生物可吸收弹性体动脉支持装置，其中线性聚合物通过酯或含有α-氨基酸的交联剂在暴露于活性物质时聚合而交联。本发明装置被设计用于植入到动脉的弯曲部分中，并且可以在动脉植入期间扩张并且在膨胀状态下在体内交联以将阻塞的动脉恢复到延伸的功能。本发明装置可用于在患病动脉中的体内植入和以时间释放方式将各种治疗分子递送至周围组织以减少或消除对装置植入的动脉反应。

10. 发明授权

US06796963B2 Flexible tissue injection catheters with controlled depth penetration 有权
标题翻译：灵活的组织注射导管，具有受控的深度穿透
公开(公告)号：US06796963B2
公开(公告)日：2004-09-28
申请号：US10000786
申请日：2001-10-23
申请人： Kenneth W. Carpenter , Michelle Fourmont , E. Thomas Malphus , Kazuo Sasamine , Hong Li
发明人： Kenneth W. Carpenter , Michelle Fourmont , E. Thomas Malphus , Kazuo Sasamine , Hong Li
IPC分类号： A61M500
CPC分类号： A61M25/0612 , A61B2090/062 , A61M25/0084 , A61M2025/0008 , A61M2025/0089 , A61M2202/0413 , A61M2205/75 , A61M2202/0021
摘要： The invention tissue injection catheters are designed to facilitate injection of a therapeutic or diagnostic agent to an interior body cavity, especially the myocardium or epicardium of the heart with precisely controlled depth penetration. The invention injection catheters, which include mechanisms for precisely controlling the length of needle tip exposed for tissue penetration, are designed to be used in an assemblage with a sterile container and delivery actuator for reinjection of autologous cell-containing fluids, such as autologous bone marrow aspirate. In preferred embodiments, the assemblage is designed to be hand-held. When used in such an assemblage, the invention catheters are particularly useful as a gene delivery device to effect angiogenesis of ischemic areas of the heart.
摘要翻译：本发明的组织注射导管被设计成便于将治疗剂或诊断剂注射到内部体腔，特别是具有精确控制的深度穿透的心脏的心肌或心外膜。本发明的注射导管包括用于精确控制暴露于组织穿透的针尖的长度的机构，被设计成与无菌容器和用于再注射含自体细胞的流体例如自体骨髓的输送致动器组合使用吸气在优选实施例中，组合被设计为手持式。当用于这种组合时，本发明的导管特别可用作用于实现心脏缺血区域血管生成的基因递送装置。

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