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1. 发明授权

US06581889B2 Flexible stabilizer arm for forcibly holding an object against a surface 失效
标题翻译：柔性稳定臂，用于强制将物体靠在表面上
公开(公告)号：US06581889B2
公开(公告)日：2003-06-24
申请号：US09758585
申请日：2001-01-10
申请人： Kenneth W. Carpenter , Michelle Fourmont , Kazuo Sasamine
发明人： Kenneth W. Carpenter , Michelle Fourmont , Kazuo Sasamine
IPC分类号： F16M1300
CPC分类号： F16M13/022 , A61B17/02 , A61B90/50 , A61B2017/00243 , A61B2017/0243 , A61B2090/571 , F16M11/40 , F21V21/32
摘要： A flexible stabilizer arm assembly is provided that can be positioned in a desired three-dimensional attitude and then fixed in place to forceably hold an object against an undulating surface. In one embodiment, the invention assembly comprises a mounting base for attachment of the arm to a stationary fixture, a flexible arm of multiple articulated elongate links rotatably joined to adjacent links, a freely rotatable turret joint at the distal end of the arm that is adapted to attach an appendage in freely rotatable fashion to the distal end of the arm. Once positioned, a tightening mechanism is actuated to fix the attitude of the arm with respect to the mounting base. Optionally, the appendage is a two-tined foot adapted for holding a surgical instrument, such as a suction body, against a beating heart. The flexible arm, which ranges up to 12 inches in length, can withstand an undulating force exerted against the distal end of up to 20 pounds while remaining in the fixed position. To stabilize the arm under these conditions, the arm preferably comprises multiple articulated elongate links and a joining piece that substantially increases the friction fit of the arm to the mounting base so as to withstand a counter-force of up to 150 pounds.
摘要翻译：提供了柔性稳定器臂组件，其可以被定位在期望的三维姿态中，然后固定在适当位置以将物体可靠地抵靠起伏的表面保持。在一个实施例中，本发明组件包括用于将臂连接到固定固定装置的安装基座，可旋转地连接到相邻连杆的多个铰接细长连接件的柔性臂，在臂的远端处可自由旋转的转台接头，以可自由旋转的方式将附件附接到臂的远端。一旦定位，致动紧固机构以相对于安装基座固定臂的姿态。任选地，附件是适于将手术器械（例如吸入体）保持在跳动心脏上的双凹脚。长度可达12英寸的柔性臂可以在保持在固定位置的同时承受高达20磅的远端作用的波浪力。为了在这些条件下稳定臂，臂优选地包括多个铰接的细长连杆和连接件，其大大增加了臂与安装基座的摩擦配合，以承受高达150磅的反作用力。

2. 发明授权

US06796963B2 Flexible tissue injection catheters with controlled depth penetration 有权
标题翻译：灵活的组织注射导管，具有受控的深度穿透
公开(公告)号：US06796963B2
公开(公告)日：2004-09-28
申请号：US10000786
申请日：2001-10-23
申请人： Kenneth W. Carpenter , Michelle Fourmont , E. Thomas Malphus , Kazuo Sasamine , Hong Li
发明人： Kenneth W. Carpenter , Michelle Fourmont , E. Thomas Malphus , Kazuo Sasamine , Hong Li
IPC分类号： A61M500
CPC分类号： A61M25/0612 , A61B2090/062 , A61M25/0084 , A61M2025/0008 , A61M2025/0089 , A61M2202/0413 , A61M2205/75 , A61M2202/0021
摘要： The invention tissue injection catheters are designed to facilitate injection of a therapeutic or diagnostic agent to an interior body cavity, especially the myocardium or epicardium of the heart with precisely controlled depth penetration. The invention injection catheters, which include mechanisms for precisely controlling the length of needle tip exposed for tissue penetration, are designed to be used in an assemblage with a sterile container and delivery actuator for reinjection of autologous cell-containing fluids, such as autologous bone marrow aspirate. In preferred embodiments, the assemblage is designed to be hand-held. When used in such an assemblage, the invention catheters are particularly useful as a gene delivery device to effect angiogenesis of ischemic areas of the heart.
摘要翻译：本发明的组织注射导管被设计成便于将治疗剂或诊断剂注射到内部体腔，特别是具有精确控制的深度穿透的心脏的心肌或心外膜。本发明的注射导管包括用于精确控制暴露于组织穿透的针尖的长度的机构，被设计成与无菌容器和用于再注射含自体细胞的流体例如自体骨髓的输送致动器组合使用吸气在优选实施例中，组合被设计为手持式。当用于这种组合时，本发明的导管特别可用作用于实现心脏缺血区域血管生成的基因递送装置。

3. 发明授权

US06796957B2 Sterile aspiration/reinjection systems 有权
标题翻译：无菌抽吸/回注系统
公开(公告)号：US06796957B2
公开(公告)日：2004-09-28
申请号：US10004525
申请日：2001-10-23
申请人： Kenneth W. Carpenter , Michelle Fourmont , E. Thomas Malphus , Kazuo Sasamine , Hong Li
发明人： Kenneth W. Carpenter , Michelle Fourmont , E. Thomas Malphus , Kazuo Sasamine , Hong Li
IPC分类号： A61M3100
CPC分类号： A61M25/0084 , A61B2090/062 , A61M2025/0089 , A61M2202/0413 , A61M2205/75 , Y10S977/916 , A61M2202/0021
摘要： The invention provides systems containing a sterile container for aspiration, filtering, treating and reinjection into a subject of a bodily fluid in a sterile environment. The systems are particularly designed to facilitate transfection of cells within the sterile container by gene therapy molecules and reinjection of the transfected cells into the donor at controlled depth in precisely controlled volumes such as is useful for revascularization of ischemic cardiac tissue. For injection, a pressure actuator, preferably hand-held, applies force to liquids held within the sterile container in precisely controlled increments, thereby expressing liquids through a hollow needle or injection catheter in precisely controlled microvolumes. The invention systems include a hand-held injection device with audible cues that correspond to an operator-selected injection volume and/or audible cues that correspond to needle penetration depth selected by the operator.
摘要翻译：本发明提供了包含用于在无菌环境中吸入，过滤，处理和再注入体液的受试者的无菌容器的系统。该系统特别设计用于通过基因治疗分子促进无菌容器内的细胞的转染，并以受精的控制体积（例如对于缺血性心脏组织的血运重建有用）将被转染的细胞重新注入受控深度的供体。对于注射，优选手持式压力致动器以精确控制的增量对保持在无菌容器内的液体施加力，从而通过中空针或注射导管在精确控制的微量体积中表达液体。本发明系统包括手持式注射装置，其具有对应于操作者选择的注射体积和/或对应于由操作者选择的穿刺深度的可听到的线索的可听到的提示。

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