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1. 发明申请

US20110135370A1 PRINT DEVICE, TRANSPORT UNIT, TRANSPORT ROLLER AND METHOD OF PRODUCING THE TRANSPORT ROLLER 审中-公开
标题翻译：打印设备，运输单元，运输滚子和生产运输滚子的方法
公开(公告)号：US20110135370A1
公开(公告)日：2011-06-09
申请号：US12959594
申请日：2010-12-03
申请人： Kenji MATSUYAMA , Kenji AOYAGI , Ryoji UESUGI , Koichi SAITO
发明人： Kenji MATSUYAMA , Kenji AOYAGI , Ryoji UESUGI , Koichi SAITO
IPC分类号： B41J13/02 , B23P19/04
CPC分类号： B23P15/00 , B21C37/0815 , B21D5/10 , B65H27/00 , B65H2402/80 , B65H2404/111 , B65H2601/254 , Y10T29/49826
摘要： A print device including a transport roller for transporting a recording medium in which a pair of end surfaces of a metallic plate faces each other so as to be molded in a cylindrical shape, wherein at least one end surface of the pair of end surfaces includes a first portion which comes into plane contact with the other end surface of the pair of end surfaces at an outer periphery surface side of the transport roller, and a second portion which has a gap between the second portion and the other end surface at an inner periphery surface side thereof.
摘要翻译：一种打印装置，包括用于传送其中金属板的一对端面彼此面对的记录介质的输送辊，以便被模制成圆柱形，其中所述一对端表面的至少一个端表面包括在输送辊的外周面侧与一对端面的另一端面平面接触的第一部分和在第二部分和第二部分之间在第二部分和另一个端面之间具有间隙的第二部分其表面侧。

2. 发明申请

US20090214388A1 METHOD FOR MANUFACTURING THE SCALE, SCALE, AND ENCODER-EQUIPPED APPARATUS 审中-公开
标题翻译：制造尺寸，尺寸和编码器设备的方法
公开(公告)号：US20090214388A1
公开(公告)日：2009-08-27
申请号：US12371441
申请日：2009-02-13
申请人： Koichi Saito , Shinichi Tonami , Kenji Matsuyama , Nagamitsu Takashima
发明人： Koichi Saito , Shinichi Tonami , Kenji Matsuyama , Nagamitsu Takashima
IPC分类号： G01N21/00 , B32B38/04
CPC分类号： B41J11/007 , B32B2038/042 , B41J11/008 , B41J2202/21 , Y10T156/1062
摘要： [Object] To provide a method for manufacturing a scale having an improved abrasion resistance, the scale, and an encoder having the same.[Solving Means] A scale base material 17 is arranged on the upper surface of a mount 26. A pattern base material 18′ as a material of pattern portions 18 are laminated on the upper surface of the scale base material 17. In this laminated state, the pattern base material 18′ is punched toward the scale base material 17 via a press work. Accordingly, the punched pattern base material 18′ is embedded and held in a thickness of the scale base material 17, and the pattern portions 18 are formed.
摘要翻译：本发明提供一种制造具有改进的耐磨性，氧化皮，以及具有这种规格的编码器的标尺的方法。 [解决方案]在基座26的上表面上设置刻度基材17.作为图案部18的材料的图案基材18'层叠在标尺基材17的上表面上。在该层叠状态，图案基材18'经由压力加工冲压到标尺基材17上。因此，冲压图案基材18'被嵌入并保持在刻度基材17的厚度上，形成图案部分18。

3. 发明申请

US20090201353A1 METAL PLATE MEMBER, A FILTER, A LIQUID JET HEAD, A LIQUID JET APPARATUS AND A METHOD OF MANUFACTURING A METAL PLATE MEMBER 审中-公开
标题翻译：金属板构件，过滤器，液体喷射头，液体喷射装置和制造金属板构件的方法
公开(公告)号：US20090201353A1
公开(公告)日：2009-08-13
申请号：US12363627
申请日：2009-01-30
申请人： Shinichi Tonami , Koichi Saito , Kenji Matsuyama
发明人： Shinichi Tonami , Koichi Saito , Kenji Matsuyama
IPC分类号： B41J2/175
CPC分类号： B41J2/17563
摘要： A metal plate member used as a filter for a liquid ejecting head or the like is a metal plate member with a plurality of through bores perforated therethrough, and on the surface thereof, pressure imprints by pressing a pressing member are formed.
摘要翻译：用作液体喷射头等的过滤器的金属板构件是具有穿过其的多个通孔的金属板构件，并且在其表面上形成通过按压构件的压力压印。

4. 发明申请

US20090084314A1 SPRING MEMBER, LIQUID CARTRIDGE INCLUDING THE SPRING MEMBER, AND RECORDING APPARATUS INCLUDING THE LIQUID CARTRIDGE 审中-公开
标题翻译：弹簧构件，包括弹簧构件的液体盒，以及包括液体盒的记录装置
公开(公告)号：US20090084314A1
公开(公告)日：2009-04-02
申请号：US12212189
申请日：2008-09-17
申请人： Kenji Matsuyama
发明人： Kenji Matsuyama
IPC分类号： B05C5/02
CPC分类号： B41J2/17523 , B41J2/17513 , B41J2/17556 , B41J2/17596
摘要： A spring member made by a simplified working process in which mistakes in assembling work are prevented, a liquid cartridge using the spring member, and a recording apparatus with the liquid cartridge are provided. A particular member of a spring member 1 is configured as a cap body 3 having an opening toward an elastic member and a sealing surface 3a at an end. An edge portion the opening is integrated with the elastic member 2. The cap body 3 includes a protruding piece 39 that protrudes from the edge portion of the opening of the cap body 3 toward the elastic member 2.
摘要翻译：提供了通过简化的工作过程制造的弹簧构件，其中防止组装工作中的错误，使用弹簧构件的液体盒和具有液体盒的记录装置。弹簧构件1的特定构件被构造成具有朝向弹性构件的开口的盖体3和端部的密封表面3a。开口的边缘部分与弹性构件2成一体。盖主体3包括从盖主体3的开口的边缘部朝向弹性构件2突出的突出件39。

5. 发明授权

US4927565A 5-substituted amino-4-hydroxy-pentenoic acid derivatives and their use 失效
公开(公告)号：US4927565A
公开(公告)日：1990-05-22
申请号：US133642
申请日：1987-12-16
申请人： Seiichi Tanaka , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Hajime Morishima , Kenji Matsuyama
发明人： Seiichi Tanaka , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Hajime Morishima , Kenji Matsuyama
IPC分类号： A61K38/00 , C07K5/02 , C07K5/062 , C07K5/065
CPC分类号： C07K5/06026 , C07K5/0207 , C07K5/06078 , A61K38/00 , Y10S530/86
摘要： A 5-substituted amino-4-hydroxy-pentenoic acid or its salt represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 which may be the same or different is a hydrogen atom, a lower alkyl group, an aralkyl group, a lower alkoxycarbonyl group, an aryloxycarbonyl group, an aralkyloxycarbonyl group or a lower alkanoyl group which may be substituted by from one to three substituents selected from the group consisting of an amino group, a hydroxyl group, a carboxyl group, an aryloxy group, an aralkyloxycarbonylamino group, a lower alkoxycarbonylamino group and a ##STR2## group (wherein each of X.sup.1 and X.sup.2 which may be the same or different is a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, or X.sup.1 and X.sup.2 form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may further contain a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom) and which may further contain a double bond in its carbon chain, each of R.sup.3, R.sup.4 and R.sup.6 which may be the same or different is a hydrogen atom, a lower alkyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group, an aralkyl group or a residue of an acidic neutral or basic amino acid, R.sup.5 is a hydrogen atom or a lower alkyl group, R.sup.7 is a hydrogen atom, a lower alkyl, cycloalkyl, cycloalkylalkyl or aralkyl group which may be substituted by one or two hydroxyl groups or a residue of an acidic, neutral or basic amino acid, R.sup.8 is a hydroxymethyl group or a --CO--R.sup.9 group (wherein R.sup.9 is a hydroxyl group, a --OY group (wherein Y is a lower alkyl group, an aryl group, an aralkyl group, a lower alkoxyalkyl group, a lower alkanoyloxyalkyl group, a lower alkoxycarbonyloxyalkyl group, or a 1-phthalidyl group) or ##STR3## group (wherein each of Y.sup.1 and Y.sup.2 which may be the same or different is a hydrogen atom, a lower alkyl group, an aryl group, an aralkyl group or a cycloalkyl group, or Y.sup.1 and Y.sup.2 form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may further contain a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom), and each of n and m which may be the same or different is 0 or 1.

6. 发明授权

US4743609A Indole derivatives having gastric and antisecretory and cytoprotective properties, and pharmaceutical preparations containing same 失效
标题翻译：具有胃和抗分泌和细胞保护性质的吲哚衍生物和含有它们的药物制剂
公开(公告)号：US4743609A
公开(公告)日：1988-05-10
申请号：US827898
申请日：1986-02-10
申请人： Masaaki Hosoi , Fumio Nakano , Kenji Matsuyama , Hiroshi Takeshita , Kenji Niiyama , Susumu Nakagawa
发明人： Masaaki Hosoi , Fumio Nakano , Kenji Matsuyama , Hiroshi Takeshita , Kenji Niiyama , Susumu Nakagawa
IPC分类号： C07D401/12 , C07D401/14 , A61K31/405
CPC分类号： C07D401/12 , C07D401/14
摘要： This invention provides a class of new indole derivatives which are useful as medicinal compounds having a mild inhibitory effect on the gastric acid secretion as well as a remarkably cytoprotective effects on gastric muscosa, and which are represented by the general formula: ##STR1##
摘要翻译：本发明提供了一类新的吲哚衍生物，其可用作对胃酸分泌具有温和抑制作用的药物化合物以及对胃肌肉的显着的细胞保护作用，其通过以下通式表示：

7. 发明申请

US20080131978A1 Method of Detecting Analyte Using Magnetic Beads 审中-公开
标题翻译：使用磁珠检测分析物的方法
公开(公告)号：US20080131978A1
公开(公告)日：2008-06-05
申请号：US10587996
申请日：2005-02-02
申请人： Mariko Fujimura , Kenji Matsuyama , Katsuya Watanabe
发明人： Mariko Fujimura , Kenji Matsuyama , Katsuya Watanabe
IPC分类号： G01N33/553
CPC分类号： G01N33/54326
摘要： A novel method of detecting and measuring the presence or amount of an analyte in a sample with high sensitivity and good simplicity is provided.A method of detecting an analyte, which comprises binding the analyte to a labeled specific binding substance to form a conjugate and detecting a magnetic signal from the conjugate to detect the analyte, wherein the labeled specific binding material comprises a substance capable of specifically binding to the analyte, a spacer and particular magnetic beads, and wherein the specific binding substance is coupled to the magnetic beads via the spacer.
摘要翻译：提供了一种以高灵敏度和良好的简便性检测和测量样品中分析物的存在或量的新方法。一种检测分析物的方法，其包括将分析物与标记的特异性结合物质结合以形成缀合物并检测来自缀合物的磁信号以检测分析物，其中标记的特异性结合材料包含能够特异性结合分析物，间隔物和特定磁珠，并且其中所述特异性结合物质经由所述间隔物偶联到所述磁珠上。

8. 发明授权

US5481036A N-acylamino acid derivatives and their use 失效
标题翻译： N-酰基氨基酸衍生物及其用途
公开(公告)号：US5481036A
公开(公告)日：1996-01-02
申请号：US179195
申请日：1994-01-10
申请人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
发明人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
IPC分类号： A61K31/195 , A61K31/535 , C07C59/66 , C07C317/00 , C07C317/44 , C07C323/43 , C07D207/08 , C07D211/14 , C07D215/12 , C07D233/54 , C07D239/38 , C07D257/04 , C07D265/30 , C07D285/12 , C07D285/125 , C07D295/084 , C07D295/12 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/18 , C07C321/00
CPC分类号： C07D207/08 , C07C323/00 , C07C323/43 , C07C59/66 , C07D211/14 , C07D215/12 , C07D233/64 , C07D239/38 , C07D257/04 , C07D285/125 , C07D295/084 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/1856
摘要： An N-acylamino acid derivative of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.6 is hydrogen lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from to 4 hetero atoms; each of R.sup.3 and R.sup.5 is hydrogen or lower alkyl; A is --CH(OH)--(CH.sub.2).sub.q R.sup.7 wherein R.sup.7 is hydrogen, lower alkyl, cycloalkyl, cyloalkylalkyl, aryl, aralkyl, a monocyclic or bicyclic heterocyclic group containing from to 4 hereto atoms or --E--R.sup.10 wherein E is --S(O).sub.i -- wherein i is 0, 1 or 2, oxygen, --NR.sup.11 -- wherein R.sup.11 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl, or ##STR2## wherein each of R.sup.12 and R.sup.13 is hydrogen, lower alkyl cycloalkyl, cycloalkylalkyl, aryl or aralkyl, and R.sup.10 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms provided that when R.sup.10 is hydrogen, i is 0, and a is an integer of from 0 to 5; or --CH.sub.2 --CHR.sup.8 --CO--R.sup.9 wherein R.sup.8 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms, and R.sup.9 is hydroxyl, --OX wherein X is alkyl, aryl, lower alkoxycarbonyloxyalkyl or 1-phthalidyl, or --N(Y.sup.1) (Y.sup.2) wherein each of Y.sup.1 and Y.sup.2 is hydrogen, lower alkyl, aryl, aralkyl or cycloalkyl, or Y and.sup.1 and Y.sup.2 form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may contain a further hereto atom; m is 0, 1 or 2; and n is an integer of from 1 to 5, provided that when R.sup.1 is hydrogen, m is 0; or a salt thereof, which is useful as hypotensive drugs.
摘要翻译：下式的N-酰基氨基酸衍生物：其中R 1，R 2，R 4和R 6各自为氢低级烷基，环烷基，环烷基烷基，芳基，芳烷基或含有4个杂原子的单环或双环杂环基原子 R 3和R 5各自为氢或低级烷基; A是-CH（OH） - （CH 2）q R 7，其中R 7是氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基，含有至4原子的单环或双环杂环基或-E-R 10，其中E是-S （O）i-其中i是0,1或2，氧，-NR 11 - ，其中R 11是氢，低级烷基，环烷基，环烷基烷基，芳基或芳烷基，或者其中R 12和R 13各自是氢，环烷基，环烷基烷基，芳基或芳烷基，R 10为含有1至4个杂原子的氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或单环或双环杂环基，条件是当R 10为氢时，i为0，是从0到5的整数; 或-CH 2 -CHR 8 -CO-R 9，其中R 8是氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或含有1至4个杂原子的单环或双环杂环基，并且R 9是羟基，，芳基，低级烷氧基羰氧基烷基或1-苯酞基，或-N（Y1）（Y2），其中Y1和Y2各自为氢，低级烷基，芳基，芳烷基或环烷基，或Y和1和Y2与相邻的氮原子一起形成可含有其它原子的5-或6-元杂环基; m为0,1或2; 且n为1至5的整数，条件是当R 1为氢时，m为0; 或其盐，其可用作降压药物。

9. 发明授权

US5122523A N-acylamino acid derivatives and their pharmaceutical compositions 失效
标题翻译： N-亚氨基酸衍生物及其药物组合物
公开(公告)号：US5122523A
公开(公告)日：1992-06-16
申请号：US240725
申请日：1988-09-06
申请人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
发明人： Hajime Morishima , Yutaka Koike , Masato Nakano , Shugo Atsuumi , Seiichi Tanaka , Kenji Matsuyama
IPC分类号： A61K31/195 , A61K31/535 , C07C59/66 , C07C317/00 , C07C317/44 , C07C323/43 , C07D207/08 , C07D211/14 , C07D215/12 , C07D233/54 , C07D239/38 , C07D257/04 , C07D265/30 , C07D285/12 , C07D285/125 , C07D295/084 , C07D295/12 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/18
CPC分类号： C07D207/08 , C07C323/00 , C07C323/43 , C07C59/66 , C07D211/14 , C07D215/12 , C07D233/64 , C07D239/38 , C07D257/04 , C07D285/125 , C07D295/084 , C07D295/125 , C07D295/13 , C07D295/24 , C07D307/38 , C07D319/18 , C07D401/12 , C07F7/1856
摘要： An N-acylamino acid derivative of the formula: ##STR1## wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.

10. 发明授权

US5380921A Aminophosponic acid derivative 失效
标题翻译：氨基磷酸衍生物
公开(公告)号：US5380921A
公开(公告)日：1995-01-10
申请号：US55872
申请日：1993-05-04
申请人： Kiyofumi Ishikawa , Takehiro Fukami , Takashi Hayama , Kenji Matsuyama , Kazuhito Noguchi , Mitsuo Yano
发明人： Kiyofumi Ishikawa , Takehiro Fukami , Takashi Hayama , Kenji Matsuyama , Kazuhito Noguchi , Mitsuo Yano
IPC分类号： A61K31/66 , A61K31/675 , A61K38/00 , A61P9/08 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , C07F9/38 , C07F9/40 , C07K5/06 , C12N9/99 , C07F9/08
CPC分类号： C07K5/06191 , C07F9/3808 , A61K38/00
摘要： There are provided novel aminophosphonic acid derivatives of the general formula [I]: ##STR1## wherein n is an integer of 2 or 3; R.sup.1 is a phenyl, naphthyl, indolyl, benzothienyl, benzofuryl or benzoxazolyl group which may have 1 to 3 substituents selected from the group consisting of hydroxyl and lower alkyloxy groups, or a hydrogen atom; R.sup.2 is a lower alkyl group, a benzyl group, a 4-hydroxybenzyl group, a 3-indolylmethyl group or a .beta.-phenethyl group; and A is an optional residue of an amino acid selected from the group consisting of tryptophane, tyrosine, phenylalanine, homophenylalanine, naphthylalanine or N.sup..omega. -nitroarginine, and their pharmaceutically acceptable salts. The compounds according to the present invention and their pharmaceutically acceptable salts exhibit an inhibitory activity against endothelin-converting enzyme, and are expected to be useful as a drug treating various diseases with which endothelin is concerned.
摘要翻译：提供了通式[I]的新型氨基膦酸衍生物：其中n为2或3的整数; R1是可以具有1至3个选自羟基和低级烷氧基或氢原子的取代基的苯基，萘基，吲哚基，苯并噻吩基，苯并呋喃基或苯并恶唑基; R2是低级烷基，苄基，4-羟基苄基，3-吲哚基甲基或β-苯乙基; A是任选的氨基酸残基，其选自色氨酸，酪氨酸，苯丙氨酸，高苯丙氨酸，萘丙氨酸或N，ω-硝基精氨酸，及其药学上可接受的盐。根据本发明的化合物及其药学上可接受的盐表现出对内皮素转化酶的抑制活性，并且预期可用作治疗涉及内皮素的各种疾病的药物。

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