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1. 发明申请

US20130196987A1 MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS 审中-公开
标题翻译：大环化合物作为药物有用
公开(公告)号：US20130196987A1
公开(公告)日：2013-08-01
申请号：US13663857
申请日：2012-10-30
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： C07D405/12 , C07D491/044 , C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds, methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis.
摘要翻译：本发明提供了化合物，其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管生成的疾病的方法。

2. 发明申请

US20060247448A1 Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物
公开(公告)号：US20060247448A1
公开(公告)日：2006-11-02
申请号：US10507067
申请日：2003-03-07
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmanage , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmanage , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： C07D313/08
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
摘要翻译：本发明提供具有式（I）的化合物：另外提供其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R 1，R 11，X，Y，Z和n如本文所定义。

3. 发明授权

US5134111A Naphthalene derivative 失效
标题翻译：萘衍生物
公开(公告)号：US5134111A
公开(公告)日：1992-07-28
申请号：US451468
申请日：1989-12-15
申请人： Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/51 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68 , C07C69/157 , C07F7/18
CPC分类号： C07F7/1852 , C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/298 , C07C45/30 , C07C45/305 , C07C45/513 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68
摘要： A naphthalene derivative having the formula is new and useful for medicine. ##STR1## [wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;R.sup.3 and R.sup.4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxy group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;R.sup.5 represents a group of the formula, --OR.sup.7, (wherein R.sup.7 represents a hydrogen atom or a lower alkyl group), or a group of the formula ##STR2## (wherein R.sup.8 and R.sup.9 are the same or different and represent a hydrogen atom or a lower alkyl group, or R.sup.8 and R.sup.9 can form, along with the nitrogen atom bonded with R.sup.8 and R.sup.9, a ring which may contain an oxygen atom);R.sup.6 independently represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, an amino group, an arylalkyl group, or an aryl group; andm is 0 or an integer of from 1 to 2, and n is 0 or an integer of from 1 to 4.]

4. 发明授权

US08329742B2 Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物
公开(公告)号：US08329742B2
公开(公告)日：2012-12-11
申请号：US12839873
申请日：2010-07-20
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/355 , C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译：本发明提供了使用具有式（I）的化合物在治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，t，X，Y，Z和n 如本文所定义。

5. 发明申请

US20110144101A1 MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS 有权
标题翻译：大环化合物作为药物有用
公开(公告)号：US20110144101A1
公开(公告)日：2011-06-16
申请号：US12839873
申请日：2010-07-20
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/5377 , A61K31/335 , A61K31/4184 , A61P29/00 , A61P37/00 , A61P17/06 , A61P11/06 , A61P35/00 , A61P1/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译：本发明提供了使用具有式（I）的化合物在治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，t，X，Y，Z和n 如本文所定义。

6. 发明授权

US07648917B2 Manufacturing method of solid-state imaging device 有权
标题翻译：固态成像装置的制造方法
公开(公告)号：US07648917B2
公开(公告)日：2010-01-19
申请号：US11857590
申请日：2007-09-19
申请人： Kai Yoshitsugu , Kenichi Chiba
发明人： Kai Yoshitsugu , Kenichi Chiba
IPC分类号： H01L21/44 , H01L21/301 , H01L21/461
CPC分类号： H01L27/14689 , H01L27/14609 , H01L29/6653 , H01L29/6656 , H01L29/66575 , H01L29/78
摘要： A manufacturing method of a solid-state imaging device includes: forming a first and second insulating films having different properties on a silicon substrate such that they cover sides of gate electrodes formed on the silicon substrate; subjecting the second insulating film to selective etching, and forming sidewalls on the sides of the gate electrode; subjecting the gate electrode having the sidewalls formed to ion implantation; covering the gate electrode having the sidewalls formed and forming a third insulating film on the silicon substrate; covering with a mask material part of the gate electrodes covered with the third insulating film, and subjecting the substrate to etching to remove exposed third insulating film; and, after removing the mask material, forming a metal film capable of forming a silicide on the silicon substrate such that the metal film covers the gate electrodes and the third insulating film to form a silicide layer.
摘要翻译：固态成像装置的制造方法包括：在硅衬底上形成具有不同性质的第一和第二绝缘膜，使得它们覆盖形成在硅衬底上的栅电极的侧面; 对所述第二绝缘膜进行选择性蚀刻，并在所述栅电极的侧面上形成侧壁; 对具有形成的侧壁的栅电极进行离子注入; 覆盖形成有侧壁的栅电极，并在硅衬底上形成第三绝缘膜; 覆盖由第三绝缘膜覆盖的栅电极的掩模材料部分，并对基板进行蚀刻以去除暴露的第三绝缘膜; 并且在去除掩模材料之后，在硅衬底上形成能够形成硅化物的金属膜，使得金属膜覆盖栅电极和第三绝缘膜以形成硅化物层。

7. 发明授权

US08097486B2 Method for producing a solid-state imaging element 有权
标题翻译：固体摄像元件的制造方法
公开(公告)号：US08097486B2
公开(公告)日：2012-01-17
申请号：US12656925
申请日：2010-02-19
申请人： Hideo Kido , Kazuichiro Itonaga , Kai Yoshitsugu , Kenichi Chiba
发明人： Hideo Kido , Kazuichiro Itonaga , Kai Yoshitsugu , Kenichi Chiba
IPC分类号： H01L21/00
CPC分类号： H01L27/14689 , H01L31/0224
摘要： There is provided a solid-state imaging element having a light receiving part generating charges by light irradiation, and a source/drain region of a transistor, both formed in a semiconductor layer. The solid-state imaging element includes a non-silicided region including the light receiving part, in which surfaces of the source/drain region and a gate electrode of the transistor are not silicided; and a silicided region in which the surfaces of the source/drain region and the gate electrode of the transistor are silicided. The non-silicided region has a sidewall formed on a side surface of the gate electrode of the transistor, a hydrogen supply film formed to cover the semiconductor layer, the gate electrode, and the sidewall, and a salicide block film formed on the hydrogen supply film to prevent silicidation. The silicided region has a sidewall formed on the side surface of the gate electrode of the transistor.
摘要翻译：提供了一种固态成像元件，其具有通过光照射产生电荷的光接收部分和形成在半导体层中的晶体管的源极/漏极区域。固体摄像元件包括：包含光接收部分的非硅化区域，其中源极/漏极区域和晶体管的栅电极的表面不被硅化; 以及其中晶体管的源极/漏极区域和栅极电极的表面被硅化的硅化区域。非硅化区域具有形成在晶体管的栅电极的侧表面上的侧壁，形成为覆盖半导体层，栅极电极和侧壁的氢供应膜，以及形成在氢源上的自对准硅化物阻挡膜电影防止硅化。硅化区具有形成在晶体管的栅电极的侧表面上的侧壁。

8. 发明申请

US20100167450A1 Solid-state imaging element and method for producing the same 有权
标题翻译：固态成像元件及其制造方法
公开(公告)号：US20100167450A1
公开(公告)日：2010-07-01
申请号：US12656925
申请日：2010-02-19
申请人： Hideo Kido , Kazuichiro Itonaga , Kai Yoshitsugu , Kenichi Chiba
发明人： Hideo Kido , Kazuichiro Itonaga , Kai Yoshitsugu , Kenichi Chiba
IPC分类号： H01L31/18
CPC分类号： H01L27/14689 , H01L31/0224
摘要： There is provided a solid-state imaging element having a light receiving part generating charges by light irradiation, and a source/drain region of a transistor, both formed in a semiconductor layer. The solid-state imaging element includes a non-silicided region including the light receiving part, in which surfaces of the source/drain region and a gate electrode of the transistor are not silicided; and a silicided region in which the surfaces of the source/drain region and the gate electrode of the transistor are silicided. The non-silicided region has a sidewall formed on a side surface of the gate electrode of the transistor, a hydrogen supply film formed to cover the semiconductor layer, the gate electrode, and the sidewall, and a salicide block film formed on the hydrogen supply film to prevent silicidation. The silicided region has a sidewall formed on the side surface of the gate electrode of the transistor.
摘要翻译：提供了一种固态成像元件，其具有通过光照射产生电荷的光接收部分和形成在半导体层中的晶体管的源极/漏极区域。固体摄像元件包括：包含光接收部分的非硅化区域，其中源极/漏极区域和晶体管的栅电极的表面不被硅化; 以及其中晶体管的源极/漏极区域和栅极电极的表面被硅化的硅化区域。非硅化区域具有形成在晶体管的栅电极的侧表面上的侧壁，形成为覆盖半导体层，栅极电极和侧壁的氢供应膜，以及形成在氢源上的自对准硅化物阻挡膜电影防止硅化。硅化区具有形成在晶体管的栅电极的侧表面上的侧壁。

9. 发明申请

US20080237666A1 Solid-state imaging element and method for producing the same 有权
标题翻译：固态成像元件及其制造方法
公开(公告)号：US20080237666A1
公开(公告)日：2008-10-02
申请号：US12076792
申请日：2008-03-24
申请人： Hideo Kido , Kazuichiro Itonaga , Kai Yoshitsugu , Kenichi Chiba
发明人： Hideo Kido , Kazuichiro Itonaga , Kai Yoshitsugu , Kenichi Chiba
IPC分类号： H01L31/062 , H01L31/18
CPC分类号： H01L27/14689 , H01L31/0224
摘要： There is provided a solid-state imaging element having a light receiving part generating charges by light irradiation, and a source/drain region of a transistor, both formed in a semiconductor layer. The solid-state imaging element includes a non-silicided region including the light receiving part, in which surfaces of the source/drain region and a gate electrode of the transistor are not silicided; and a silicided region in which the surfaces of the source/drain region and the gate electrode of the transistor are silicided. The non-silicided region has a sidewall formed on a side surface of the gate electrode of the transistor, a hydrogen supply film formed to cover the semiconductor layer, the gate electrode, and the sidewall, and a salicide block film formed on the hydrogen supply film to prevent silicidation. The silicided region has a sidewall formed on the side surface of the gate electrode of the transistor.
摘要翻译：提供了一种固态成像元件，其具有通过光照射产生电荷的光接收部分和形成在半导体层中的晶体管的源极/漏极区域。固体摄像元件包括：包含光接收部分的非硅化区域，其中源极/漏极区域和晶体管的栅电极的表面不被硅化; 以及其中晶体管的源极/漏极区域和栅极电极的表面被硅化的硅化区域。非硅化区域具有形成在晶体管的栅电极的侧表面上的侧壁，形成为覆盖半导体层，栅极电极和侧壁的氢供应膜，以及形成在氢源上的自对准硅化物阻挡膜电影防止硅化。硅化区具有形成在晶体管的栅电极的侧表面上的侧壁。

10. 发明授权

US5789446A Therapeutic agent for treating joint diseases associated with arthritis 失效
标题翻译：用于治疗与关节炎相关的关节疾病的治疗剂
公开(公告)号：US5789446A
公开(公告)日：1998-08-04
申请号：US877459
申请日：1997-06-17
申请人： Akiyoshi Uchiyama , Kenzo Muramoto , Kenichi Chiba , Takashi Yamanaka , Isao Yamatsu
发明人： Akiyoshi Uchiyama , Kenzo Muramoto , Kenichi Chiba , Takashi Yamanaka , Isao Yamatsu
IPC分类号： A61K31/19 , A61K31/20
CPC分类号： A61K31/19 , A61K31/20
摘要： To provide a treating or ameliorating agent for joint diseases accompanied with arthritis, preferably, a rheumatoid arthritis or ameliorating agent, which exerts excellent pharmaceutical effects. The active ingredient is a quinone derivative represented by the following general formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein n is 0 or an integer of 1 to 12 and R is a methyl or methoxy group.
摘要翻译：提供伴随关节炎的关节疾病的治疗或改善剂，优选类风湿性关节炎或改善剂，其具有优异的药效。活性成分是由以下通式（I）表示的醌衍生物或其药理学上可接受的盐：其中n为0或1〜12的整数，R为甲基或甲氧基。

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