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1. 发明授权

US08496941B2 Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same 有权
标题翻译：用于产生多能干细胞的载体和使用其制备多能干细胞的方法
公开(公告)号：US08496941B2
公开(公告)日：2013-07-30
申请号：US12792580
申请日：2010-06-02
申请人： Mahito Nakanishi , Ken Nishimura , Manami Ohtaka , Masayuki Sano
发明人： Mahito Nakanishi , Ken Nishimura , Manami Ohtaka , Masayuki Sano
IPC分类号： A61K39/12 , A61K39/155 , C12N5/00 , C12N15/00 , C12N15/86
CPC分类号： C12N5/0696 , C12N15/1131 , C12N15/86 , C12N15/8775 , C12N15/8776 , C12N2310/14 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2760/18843
摘要： Stem cell reprogramming genes cloned into a single sustained expression-type Sendai viral vector are shown to reprogram differentiated somatic cells into induced pluripotent stem (iPS) cells without integration of vector sequences into the host cell's genome. The genes are transduced into normal differentiated somatic cells via infection with recombinant Sendai virus. After expression of the reprogramming genes and subsequent induction of pluripotency, the vector genome RNA including the reprogramming genes is removed from the cell to establish an iPS cell that is genetically identical to the parent somatic differentiated cell thus reducing the risk of tumorigenic transformation caused by random integration of vector sequences into the host genome. The method promises to provide safe, autologous iPS cells that can be used for human cell replacement and regeneration therapeutic applications.
摘要翻译：克隆到单一持续表达型仙台病毒载体中的干细胞重编程基因显示将分化的体细胞重编程为诱导多能干细胞（iPS）细胞，而不将载体序列整合到宿主细胞的基因组中。通过感染重组仙台病毒将基因转导入正常分化的体细胞。在重编程基因表达和随后的多能性诱导之后，从细胞中除去包括重编程基因的载体基因组RNA以建立与亲本体细胞分化细胞遗传相同的iPS细胞，从而降低由随机引起的致瘤转化的风险将载体序列整合到宿主基因组中。该方法有望提供可用于人类细胞替代和再生治疗应用的安全的自体iPS细胞。

2. 发明授权

US07547489B2 Electrochemical device 失效
标题翻译：电化学装置
公开(公告)号：US07547489B2
公开(公告)日：2009-06-16
申请号：US10540862
申请日：2003-12-09
申请人： Ken Nishimura , Naoto Arai , Toru Oshima , Fumio Daio , Munehisa Ikoma , Hideo Kaiya
发明人： Ken Nishimura , Naoto Arai , Toru Oshima , Fumio Daio , Munehisa Ikoma , Hideo Kaiya
IPC分类号： H01M10/50
CPC分类号： H01M10/0525 , H01M2/34 , H01M2/348 , H01M4/667 , H01M4/70 , H01M6/42 , H01M10/0436 , H01M10/0587 , H01M10/42 , H01M2200/106 , Y02T10/7011
摘要： An electrochemical device having an electrode plate assembly that includes: (a) at least one first electrode; (b) at least one second electrode; and (c) a separator interposed between the first electrode and the second electrode, the electrode plate assembly including a PTC device. The use of the electrochemical device according to this invention makes it possible to efficiently manufacture secondary batteries with a simple structure, a high reliability and a high electrical capacity.
摘要翻译：一种具有电极板组件的电化学装置，包括：（a）至少一个第一电极; （b）至少一个第二电极; 和（c）介于所述第一电极和所述第二电极之间的隔板，所述电极板组件包括PTC器件。根据本发明的电化学装置的使用使得可以以简单的结构，高可靠性和高电容有效地制造二次电池。

3. 发明授权

US07525398B2 Acoustically communicating data signals across an electrical isolation barrier 有权
标题翻译：在电隔离屏障之间进行声学传播数据信号
公开(公告)号：US07525398B2
公开(公告)日：2009-04-28
申请号：US11252845
申请日：2005-10-18
申请人： Ken Nishimura , John D. Larson, III , Stephen R. Gilbert
发明人： Ken Nishimura , John D. Larson, III , Stephen R. Gilbert
IPC分类号： H03H9/50 , H03H9/54 , H04L27/00 , H03K9/02 , H03K7/02 , H03K7/06
CPC分类号： H04L27/10 , H04B11/00 , H04L27/18
摘要： In one aspect, a data communication system includes a modulator, an integrated acoustic data coupler, and a demodulator. The modulator modulates a carrier signal having a frequency in an operating frequency range in response to an input data signal and provides the modulated carrier signal at a modulator output. The integrated acoustic data coupler includes an acoustically resonant structure that has one or more acoustic resonant frequencies in the operating frequency range. The acoustically resonant structure includes a first thin film electro-acoustic transducer electrically coupled to the modulator output, a second thin film electro-acoustic transducer, and a substrate. The substrate supports, acoustically couples, and provides an electrical isolation barrier between the first and second thin film electro-acoustic transducers. The demodulator has a demodulator input coupled to the second thin film electro-acoustic transducer and is operable to generate an output data signal from an input signal received at the demodulator input.
摘要翻译：在一个方面，数据通信系统包括调制器，集成声学数据耦合器和解调器。调制器响应于输入数据信号调制具有在工作频率范围内的频率的载波信号，并在调制器输出端提供经调制的载波信号。集成声学数据耦合器包括在工作频率范围内具有一个或多个声学谐振频率的声学共振结构。声学共振结构包括电耦合到调制器输出的第一薄膜电声换能器，第二薄膜电声换能器和基底。衬底支撑，声耦合，并且在第一和第二薄膜电声换能器之间提供电隔离屏障。解调器具有耦合到第二薄膜电声换能器的解调器输入，并且可操作以从在解调器输入处接收的输入信号产生输出数据信号。

4. 发明申请

US20080042960A1 Systems And Method For Displaying Images With Reduced Power Consumption 有权
标题翻译：降低功耗显示图像的系统和方法
公开(公告)号：US20080042960A1
公开(公告)日：2008-02-21
申请号：US11853651
申请日：2007-09-11
申请人： Ken Nishimura , Ian Hardcastle , Pierre Mertz , Rene Helbing , Charels Hoke , Barry Bronson
发明人： Ken Nishimura , Ian Hardcastle , Pierre Mertz , Rene Helbing , Charels Hoke , Barry Bronson
IPC分类号： G09G3/36
CPC分类号： G02F1/141 , G02F1/133553 , G02F2001/133769
摘要： A method and a system for displaying images are provided. In the method, a pixel is provided that includes a layer of ferroelectric material and a layer of liquid crystal material. A first electric field is momentarily applied to the pixel to electrically polarize the ferroelectric layer to a first polarization. The first polarization is then used to maintain the liquid crystal material in a first orientation corresponding to a first apparent brightness of the pixel.
摘要翻译：提供了一种用于显示图像的方法和系统。在该方法中，提供了包括铁电材料层和液晶材料层的像素。瞬时施加第一电场至像素以将铁电体层电极化为第一极化。然后使用第一偏振来将液晶材料保持在与像素的第一表观亮度相对应的第一取向。

5. 发明申请

US20070086274A1 Acoustically communicating data signals across an electrical isolation barrier 有权
标题翻译：在电隔离屏障之间进行声学传播数据信号
公开(公告)号：US20070086274A1
公开(公告)日：2007-04-19
申请号：US11252845
申请日：2005-10-18
申请人： Ken Nishimura , John Larson , Stephen Gilbert
发明人： Ken Nishimura , John Larson , Stephen Gilbert
IPC分类号： B06B1/06 , H04B1/02 , G08B1/00
CPC分类号： H04L27/10 , H04B11/00 , H04L27/18
摘要： In one aspect, a data communication system includes a modulator, an integrated acoustic data coupler, and a demodulator. The modulator modulates a carrier signal having a frequency in an operating frequency range in response to an input data signal and provides the modulated carrier signal at a modulator output. The integrated acoustic data coupler includes an acoustically resonant structure that has one or more acoustic resonant frequencies in the operating frequency range. The acoustically resonant structure includes a first thin film electro-acoustic transducer electrically coupled to the modulator output, a second thin film electro-acoustic transducer, and a substrate. The substrate supports, acoustically couples, and provides an electrical isolation barrier between the first and second thin film electro-acoustic transducers. The demodulator has a demodulator input coupled to the second thin film electro-acoustic transducer and is operable to generate an output data signal from an input signal received at the demodulator input.
摘要翻译：在一个方面，数据通信系统包括调制器，集成声学数据耦合器和解调器。调制器响应于输入数据信号调制具有在工作频率范围内的频率的载波信号，并在调制器输出端提供经调制的载波信号。集成声学数据耦合器包括在工作频率范围内具有一个或多个声学谐振频率的声学共振结构。声学共振结构包括电耦合到调制器输出的第一薄膜电声换能器，第二薄膜电声换能器和基底。衬底支撑，声耦合，并且在第一和第二薄膜电声换能器之间提供电隔离屏障。解调器具有耦合到第二薄膜电声换能器的解调器输入，并且可操作以从在解调器输入处接收的输入信号产生输出数据信号。

6. 发明申请

US20060097738A1 UNIVERSAL TEST FIXTURE 失效
标题翻译：通用测试仪器
公开(公告)号：US20060097738A1
公开(公告)日：2006-05-11
申请号：US10975140
申请日：2004-10-28
申请人： Charles Hoke , Ken Nishimura
发明人： Charles Hoke , Ken Nishimura
IPC分类号： G01R31/02
CPC分类号： G01R1/07385 , G01R1/07328 , G01R1/07335
摘要： A universal fixture for testing a device, such as a bare printed circuit board, includes a plurality of addressable contact points. Each of the contact points includes a switch connected to a conductor capable of creating an electrical connection to the device. To obtain a measurement of a target on the device, two of the contact points on the universal fixture are selected based on the position of the target on the device relative to the contact points.
摘要翻译：用于测试诸如裸印刷电路板的设备的通用夹具包括多个可寻址的接触点。每个接触点包括连接到能够产生与设备的电连接的导体的开关。为了获得设备上的目标的测量，通用夹具上的两个接触点是根据目标在设备上相对于接触点的位置来选择的。

7. 发明申请

US20060043265A1 Differential color sensor without filters 有权
标题翻译：不带滤光片的差分彩色传感器
公开(公告)号：US20060043265A1
公开(公告)日：2006-03-02
申请号：US10919593
申请日：2004-08-16
申请人： Ken Nishimura
发明人： Ken Nishimura
IPC分类号： H01J40/14
CPC分类号： H01L27/1443 , G01J3/50 , G01J2003/466 , H01L31/101
摘要： A semiconductor color sensor implemented without the use of color filters. Fabricating photodiodes using different semiconductor materials provide photodiodes with different sensitivities vs. wavelengths. A first embodiment uses photodiodes with different junction depths. A shallow junction depth produces a photodiode with its sensitivity peak in shorter wavelengths, while a deeper junction depth produces a photodiode with its sensitivity peak in longer wavelengths. Amorphous as well as crystalline structures may be used. A second embodiment uses photodiodes with different materials, such as Silicon-Germanium (SiGe) which has a longer wavelength peak sensitivity, and Silicon (Si) which has a shorter wavelength peak sensitivity in comparison. More than two photodiodes having different wavelength sensitivities may be used. Sensing current ratios between pairs of diodes allows color balance to be maintained.
摘要翻译：实现了不使用滤色器的半导体颜色传感器。使用不同的半导体材料制造光电二极管提供具有不同灵敏度与波长的光电二极管。第一实施例使用具有不同结深度的光电二极管。浅结深产生具有较短波长的灵敏度峰值的光电二极管，而较深的结深度产生具有较长波长的灵敏度峰值的光电二极管。可以使用非晶态以及晶体结构。第二实施例使用具有不同材料的光电二极管，例如具有较长波长峰值灵敏度的硅锗（SiGe）和具有较短波长峰值灵敏度的硅（Si）。可以使用具有不同波长灵敏度的两个以上的光电二极管。二极管之间的感应电流比可以保持色彩平衡。

8. 发明申请

US20050128457A1 Defect mitigation in spatial light modulator used for dynamic photolithography 失效
标题翻译：用于动态光刻的空间光调制器中的缺陷减轻
公开(公告)号：US20050128457A1
公开(公告)日：2005-06-16
申请号：US10736724
申请日：2003-12-15
申请人： Ken Nishimura , Dale Schroeder , Charles Hoke
发明人： Ken Nishimura , Dale Schroeder , Charles Hoke
IPC分类号： G03F7/20 , G03B27/54
CPC分类号： G03F7/70466 , G03F7/70291
摘要： A spatial light modulator for use in a photolithography system includes light modulation elements configured to photolithographically transfer an image onto a substrate using an optical oversampling technique to reduce defects in the transferred image. A first set of the light modulation elements is operable to photolithographically transfer a portion of the image onto an area of a substrate, and a second set of the light modulation elements is operable to photolithographically transfer the portion of the image onto the area of the substrate. The spatial light modulator further includes memory elements in communication with respective light modulation elements for storing data representing the portion of the image.
摘要翻译：用于光刻系统的空间光调制器包括配置为使用光学过采样技术将图像光刻地转印到衬底上的光调制元件，以减少转印图像中的缺陷。第一组光调制元件可操作以将图像的一部分光刻地传送到衬底的区域上，并且第二组光调制元件可操作以光刻地将图像的一部分转印到衬底的区域上。空间光调制器还包括与相应的光调制元件通信的存储元件，用于存储表示图像的该部分的数据。

9. 发明申请

US20050128367A1 Liquid crystal cell that resists degradation from exposure to radiation 失效
标题翻译：防止暴露于辐射降解的液晶单元
公开(公告)号：US20050128367A1
公开(公告)日：2005-06-16
申请号：US10736090
申请日：2003-12-15
申请人： Charles Hoke , Peter Robrish , Rene Helbing , Ken Nishimura
发明人： Charles Hoke , Peter Robrish , Rene Helbing , Ken Nishimura
IPC分类号： G02F1/13 , G02F1/1333 , G02F1/1341 , G03F20060101 , G03F7/20
CPC分类号： G02F1/133371 , G02F1/1333 , G02F1/1341 , G03F7/70291
摘要： Embodiments of the invention involve UV resistant liquid crystal cells. One embodiment of the invention is to increase the volume of the liquid crystal material that is stored inside the cell. For example, trenches may be used to provide reservoirs that hold the additional liquid crystal material. Another embodiment of the invention uses an inorganic alignment layer in the cell, instead of using an organic material as the alignment layer. A further embodiment of the invention uses a pump to circulate liquid crystal material through the cell. The inventive cell can be used as a SLM in photolithographic imaging systems.
摘要翻译：本发明的实施方案涉及耐UV液晶单元。本发明的一个实施例是增加存储在电池内部的液晶材料的体积。例如，可以使用沟槽来提供保持附加液晶材料的储存器。本发明的另一个实施方案使用细胞中的无机取向层，而不是使用有机材料作为取向层。本发明的另一实施例使用泵将液晶材料循环通过电池。本发明的电池可以用作光刻成像系统中的SLM。

10. 发明授权

US06873804B2 Image sensing device 有权
标题翻译：图像传感装置
公开(公告)号：US06873804B2
公开(公告)日：2005-03-29
申请号：US09922643
申请日：2001-08-07
申请人： Hidekazu Shimomura , Ken Nishimura
发明人： Hidekazu Shimomura , Ken Nishimura
IPC分类号： G03G15/01 , H04N1/047 , H04N1/113 , H04N1/12 , G03G15/00
CPC分类号： H04N1/0473 , G03G15/0194 , G03G2215/0161 , H04N1/1135 , H04N1/12 , H04N2201/0471 , H04N2201/04722
摘要： An image sensing device includes: a light source, a recording member on which an image is formed and conveyed in one direction, illumination system for causing a light beam emitted from the light source to obliquely illuminate the recording member and, imaging system for condensing specularly reflected light from the image on the recording member and causing the reflected light to travel to a surface of a photodetector, so that the image sensing device obtains positional information of the image on the recording member on the basis of a signal obtained by the photodetector. When the amount of displacement of the recording member in a vertical direction during conveyance of the recording member is d, an angle between the optical axis of the imaging system and a normal to the recording member is θ (degrees), and resolution of the image formed on the recording member is R (dpi), the components are set so that d·tan θ
摘要翻译：图像感测装置包括：光源，在其上形成图像并沿一个方向传送的记录部件，用于使从光源发射的光束倾斜地照射记录部件的照明系统，以及镜面聚光成像系统来自记录部件上的图像的反射光并使反射光行进到光电检测器的表面，使得图像感测装置基于由光电检测器获得的信号获得记录部件上的图像的位置信息。当在记录部件传送期间记录部件在垂直方向上的位移量为d时，成像系统的光轴与记录部件的法线之间的角度为θ（度），图像的分辨率在记录部件上形成的是R（dpi），这些部件被设定成

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