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1. 发明申请

US20110303396A1 HEAT EXCHANGER, OUTDOOR UNIT AND REFRIGERATION APPARATUS 审中-公开
标题翻译：热交换器，户外单元和制冷装置
公开(公告)号：US20110303396A1
公开(公告)日：2011-12-15
申请号：US13202660
申请日：2010-02-23
申请人： Yoshito Ishida , Keiji Iwasaki , Kenichi Masaki , Hideo Sugimoto , Yoshinori Azuma , Shoji Morii
发明人： Yoshito Ishida , Keiji Iwasaki , Kenichi Masaki , Hideo Sugimoto , Yoshinori Azuma , Shoji Morii
IPC分类号： F28F13/00
CPC分类号： F24F1/16 , F24F1/48 , F24F1/50 , F24F1/68 , F24F13/30
摘要： A heat pump chiller includes a casing having a compressor, etc. inside thereof and four flat-plate shaped air heat exchangers disposed on side surfaces of the casing and extending vertically. Two air heat exchangers constitute a first heat exchanger body and a second heat exchanger body. Respective heat exchanger bodies are positioned with end parts extending toward outside of the air heat exchangers to be close to each other.
摘要翻译：一种热泵冷水机构，其具有在其内部具有压缩机等的壳体，以及四个平板形的空气热交换器，其设置在壳体的侧面上并垂直延伸。两个空气热交换器构成第一热交换器主体和第二热交换器主体。相应的热交换器主体被定位成使得端部朝向空气热交换器的外部延伸以彼此靠近。

2. 发明申请

US20080113019A1 COMPOSITION FOR CAPSULE COATING 审中-公开
标题翻译：胶囊涂料组合物
公开(公告)号：US20080113019A1
公开(公告)日：2008-05-15
申请号：US11951678
申请日：2007-12-06
申请人： Hideo Satokawa , Kiyonori Furuta , Keiji Iwasaki
发明人： Hideo Satokawa , Kiyonori Furuta , Keiji Iwasaki
IPC分类号： A61K9/48
CPC分类号： A61K9/4891 , A23L29/212 , A23L29/281 , A23P10/30 , A61K9/4816 , A61K47/36
摘要： The present invention provides a composition that is suitable for producing a plant-derived, practical capsule shell sheet having both sufficient strength and elongation as a capsule shell, superior adhesiveness and transparency, and a low burden on a drying step. The present invention also provides a capsule shell sheet obtained using the composition and a capsule preparation process. The composition of the present invention contains vegetable polysaccharides and a polyglutamic acid.
摘要翻译：本发明提供一种适用于生产具有作为胶囊壳具有足够的强度和伸长率的植物来源的实用的胶囊壳片的组合物，优异的粘合性和透明性，以及干燥步骤的低负担。本发明还提供使用该组合物和胶囊制备方法获得的胶囊壳片。本发明的组合物含有植物多糖和聚谷氨酸。

3. 发明申请

US20070099888A1 Inflammation Inhibitor Comprising Zinc Salt of Acylamino Acid 审中-公开
标题翻译：包含酰氨基酸锌盐的炎症抑制剂
公开(公告)号：US20070099888A1
公开(公告)日：2007-05-03
申请号：US11610736
申请日：2006-12-14
申请人： Keiji Iwasaki , Manabu Kitazawa , Yoshinobu Takino
发明人： Keiji Iwasaki , Manabu Kitazawa , Yoshinobu Takino
IPC分类号： A61K31/555 , A61K31/315
CPC分类号： A61K31/315 , A61K8/27 , A61K8/44 , A61K31/198 , A61K31/20 , A61K31/4172 , A61K31/555 , A61Q19/08
摘要： An inflammation inhibitor for the skin is provided containing a zinc salt of an acylamino acid and further, a cosmetic containing the inflammation inhibitor.
摘要翻译：提供了含有酰氨基酸的锌盐的皮肤的炎症抑制剂，还含有含有炎症抑制剂的化妆品。

4. 发明授权

US06552061B1 Amino acid derivatives and anti-inflammatory agents 失效
标题翻译：氨基酸衍生物和抗炎剂
公开(公告)号：US06552061B1
公开(公告)日：2003-04-22
申请号：US09285390
申请日：1999-04-02
申请人： Manabu Kitazawa , Keiji Iwasaki , Eiji Shiojiri
发明人： Manabu Kitazawa , Keiji Iwasaki , Eiji Shiojiri
IPC分类号： C07C22928
CPC分类号： C07D233/64 , C07C229/14 , C07C229/22 , C07C229/34 , C07C237/06 , C07C237/20 , C07D207/28
摘要： Provided are an anti-inflammatory agent containing, as an active ingredient, at least one selected from amino acid derivatives represented by formula (I) wherein Ar represents an optionally substituted 2-hydroxyaryl group, n is 0 or 1, R2 represents a hydrogen atom or a side chain of an &agr;-amino acid or &bgr;-amino acid, X represents —O— or —NH—, R1 represents a hydrogen atom or a group that forms, together with R2 and an adjacent atoms, a cyclic structure of pyroglutamic acid, and R3 represents a hydrogen atom, an alkyl group having from 1 to 22 carbon atoms or an alkenyl group having from 2 to 22 carbon atoms, and salts thereof, and toiletries or skin external products containing the same. The anti-inflammatory agent of the invention inhibits expression of an inflammatory protein and activation of a gene transcription control factor that participates therein, and exhibits a good feeling upon use and a safety.
摘要翻译：提供含有选自由式（I）表示的氨基酸衍生物中的至少一种作为活性成分的抗炎剂，其中Ar表示任选取代的2-羟基芳基，n为0或1，R 2表示氢原子或α-氨基酸或β-氨基酸的侧链，X表示-O-或-NH-，R1表示氢原子或与R2和相邻原子一起形成焦谷氨酸的环状结构的基团酸，R3表示氢原子，具有1至22个碳原子的烷基或具有2至22个碳原子的烯基，以及其盐，以及含有它们的化妆品或皮肤外用产品。本发明的抗炎剂抑制炎症蛋白的表达和参与其中的基因转录控制因子的活化，并且在使用时表现出良好的感觉和安全性。

5. 发明授权

US4773890A Slidable-type homokinetic (universal) tripod joint 失效
标题翻译：滑动式同型动力（通用）三脚架接头
公开(公告)号：US4773890A
公开(公告)日：1988-09-27
申请号：US33285
申请日：1987-04-02
申请人： Keiji Iwasaki , Yukimitsu Yamamoto , Masao Kato , Mikio Banno
发明人： Keiji Iwasaki , Yukimitsu Yamamoto , Masao Kato , Mikio Banno
IPC分类号： F16D3/20 , F16D3/205
CPC分类号： F16D3/2055 , Y10S464/905
摘要： A slidable-type homokinetic tripod joint includes an outer member formed with track grooves, a tripod member having three trunnions and mounted in the outer member with the trunnions on the tripod member received in the track grooves in the outer member, and a spherical roller rotatably mounted on each trunnion. Each track groove is formed at each side with a guide surface for the spherical roller. The spherical roller is kept in contact with the roller guide surface at two points. This decreases unbalanced load and the turning moment acting on the spherical roller and decreases the friction force causing vibration.
摘要翻译：可滑动式的同轴三脚架接头包括形成有轨道槽的外部构件，具有三个耳轴并且安装在外部构件中的三脚架构件，其中三通架构件上的耳轴容纳在外部构件的轨道槽中，并且可旋转地安装在每个耳轴上。每个轨道槽在每一侧形成有用于球面滚子的引导表面。球面滚子在两点处与滚子引导面保持接触。这减少了不平衡载荷和作用在球面滚子上的转矩，并降低了引起振动的摩擦力。

6. 发明授权

US06914075B2 Cystine derivative and agent for suppressing activation of inflammatory factors 失效
标题翻译：胱氨酸衍生物和抑制炎症因子活化的药剂
公开(公告)号：US06914075B2
公开(公告)日：2005-07-05
申请号：US10632959
申请日：2003-08-04
申请人： Takashi Nakano , Manabu Kitazawa , Keiji Iwasaki , Kazutami Sakamoto
发明人： Takashi Nakano , Manabu Kitazawa , Keiji Iwasaki , Kazutami Sakamoto
IPC分类号： A23L1/30 , A23L1/305 , A61K8/00 , A61K8/30 , A61K8/44 , A61K31/137 , A61K31/198 , A61P1/04 , A61P1/18 , A61P9/00 , A61P9/02 , A61P11/00 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/30 , A61P27/02 , A61P29/00 , A61P37/04 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q5/02 , A61Q17/04 , A61Q19/00 , C07C323/58 , A61K31/225 , C07C229/00
CPC分类号： C07C323/58 , A23L33/10
摘要： The present invention provides cystine derivatives, which may be in a free form, a salt form, a solvate form. The cystine derivatives of the present invention may be used to suppress activation of inflammatory factors. Accordingly, the present invention provides: compositions containing the cystine derivatives; a method for suppressing the activation of inflammatory factors by administering the composition; a method for preventing, ameliorating and/or therapeutically treating diseases, skin injuries or disorders involved in the activation of inflammatory factors by administering the composition; a method for preventing, delaying, ameliorating and/or therapeutically treating skin change via aging or aesthetically unfavorable skin change as induced or promoted by inflammatory factors by administering the composition; and pharmaceutical agents containing the cystine derivatives.
摘要翻译：本发明提供胱氨酸衍生物，其可以是游离形式，盐形式，溶剂合物形式。本发明的胱氨酸衍生物可用于抑制炎症因子的活化。因此，本发明提供：含有胱氨酸衍生物的组合物; 通过施用该组合物来抑制炎症因子的活化的方法; 通过施用组合物来预防，改善和/或治疗疾病，皮肤损伤或参与炎性因子活化的病症的方法; 一种通过施用该组合物来预防，延缓，改善和/或治疗由炎症因子诱导或促进的衰老或美学上不利的皮肤变化来治疗皮肤变化的方法; 和含有胱氨酸衍生物的药剂。

7. 发明授权

US06703031B1 Cysteine derivatives 失效
标题翻译：半胱氨酸衍生物
公开(公告)号：US06703031B1
公开(公告)日：2004-03-09
申请号：US09806937
申请日：2001-06-14
申请人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
发明人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
IPC分类号： A61K700
CPC分类号： C07C323/60 , A61K8/02 , A61K8/0212 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/411 , A61K8/447 , A61K8/45 , A61K8/46 , A61K8/494 , A61K8/60 , A61K8/63 , A61K8/676 , A61K8/678 , A61K8/86 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , A61Q19/10 , Y10S514/844 , Y10S514/847
摘要： Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.
摘要翻译：本发明的目的是提供能够抑制细胞毒性蛋白质的表达和基因转录调节因子的活化的氧化应激抑制剂，其采用这种细胞毒性蛋白质的这种表达，并且在使用和安全性方面表现出良好的感觉; 提供一种预防，延缓，减轻或治疗由于老化引起的皮肤变化或由氧化应激引起或促进的不期望的美容皮肤变化的方法; 并且提供包含氧化应激抑制剂作为有效成分的外用化妆品组合物或皮肤病学制剂，并且为了这些目的，使用氧化应激抑制剂，其包含作为有效成分的至少一种选自半胱氨酸或胱氨酸衍生物及其盐。

8. 发明授权

US5594012A Amino acid derivatives and anti-active oxygen agents 失效
标题翻译：氨基酸衍生物和抗活性氧剂
公开(公告)号：US5594012A
公开(公告)日：1997-01-14
申请号：US284668
申请日：1994-10-06
申请人： Manabu Kitazawa , Keiji Iwasaki
发明人： Manabu Kitazawa , Keiji Iwasaki
IPC分类号： C07C215/50 , C07C229/14 , C07C229/22 , C07C229/24 , C07C229/36 , C07C237/06 , C07C251/24 , C07C259/06 , C07C279/14 , C07C309/13 , C07C309/14 , C07C323/58 , C07D209/14 , C07D209/20 , C07D213/66 , C07D233/54 , C07D233/64 , C07D401/12 , A61K31/44 , C07C251/18 , C07D215/50
CPC分类号： C07D213/66 , C07C215/50 , C07C229/14 , C07C229/22 , C07C229/24 , C07C229/36 , C07C237/06 , C07C251/24 , C07C259/06 , C07C279/14 , C07C309/13 , C07C309/14 , C07C323/58 , C07D209/14 , C07D209/20 , C07D233/64 , C07D401/12 , C07C2102/26 , Y10S514/844
摘要： A novel anti-active oxygen agent which comprises as active ingredient an amino acid derivative represented by the following general formula (I): ##STR1## wherein Ar represents a 2-hydroxyphenyl, 2-hydroxy-1-naphthyl or pyridyl group, and one or more of the hydrogen atoms attached to the aromatic ring of these groups may be substituted with a halogen atom, or an alkyl, hydroxyl, hydroxyalkyl, nitro, alkoxyl or carboxyl group; R represents the side chain of an amino acid; X represents --CH.sub.2 --NH-- or --CH.dbd.N--; Y represents a hydrogen atom, --COOR.sup.1, --SO.sub.3 H, --CON(R.sup.2)R.sup.3, --CONHCH(R.sup.5)COOR.sup.4 or --CH.sub.2 OH (where each of R.sup.1 to R.sup.4 represents a hydrogen atom or an alkyl group, and R.sup.5 represents the side chain of an amino acid); and n represents an integer of 0 or 1;or its salt,and which inhibits generation of active oxygen species, has a high safety and can be prepared at relatively low costs.
摘要翻译： PCT No.PCT / JP93 / 01842 Sec。 371日期：1994年10月6日 102（e）日期1994年10月6日PCT 1993年12月20日PCT PCT。出版物WO94 / 14755 日期：1994年7月7日一种新型抗活性氧剂，其包含作为活性成分的由以下通式（I）表示的氨基酸衍生物：壬基，2-羟基-1-萘基或吡啶基，以及一种或多种与这些基团的芳香环连接的氢原子可以被卤素原子或烷基，羟基，羟烷基，硝基，烷氧基或羧基取代; R表示氨基酸的侧链; X表示-CH 2 -NH-或-CH = N-; Y表示氢原子，-COOR 1，-SO 3 H，-CON（R 2）R 3，-CONHCH（R 5）COOR 4或-CH 2 OH（其中，R 1〜R 4各自表示氢原子或烷基，R 5表示侧链的氨基酸）; n表示0或1的整数; 或其盐，并且其抑制活性氧的产生具有高安全性并且可以以相对低的成本制备。

9. 发明授权

US4786270A Homokinetic tripod joint 失效
标题翻译：人体动物三脚架关节
公开(公告)号：US4786270A
公开(公告)日：1988-11-22
申请号：US46322
申请日：1987-05-06
申请人： Keiji Iwasaki
发明人： Keiji Iwasaki
IPC分类号： B60K17/30 , F16D3/205 , F16D3/20
CPC分类号： F16D3/2055 , F16D2003/2026 , Y10S464/905
摘要： A homokinetic tripod type universal joint including a tripod member having three trunnions, with a roller rotatably mounted on each trunnion is mounted in an outer member. The roller consists of an inside ring and an outside ring wherein contact is established between a spherical outer periphery of the inside ring and a cylindrical inner periphery of the outside ring. The outside ring is guided in a direction parallel with the axis of the outer member by guide surfaces provided internally of grooves formed on the outer member. This arrangement helps to reduce sliding resistance, temperature rise and vibrations due to induced thrust.
摘要翻译：包括具有三个耳轴的三脚架构件和可旋转地安装在每个耳轴上的滚子的同轴三脚架型万向接头安装在外部构件中。辊由内圈和外圈构成，其中在内圈的球形外周和外圈的圆柱形内周之间建立接触。通过设置在外部构件上形成的槽内部的引导表面，外环在与外部构件的轴线平行的方向上被引导。这种布置有助于减少滑动阻力，温度上升和由于诱导推力引起的振动。

10. 发明授权

US07375085B1 Melanocyte-stimulating hormone inhibitors 有权
标题翻译：促黑细胞激素抑制剂
公开(公告)号：US07375085B1
公开(公告)日：2008-05-20
申请号：US09926391
申请日：2000-04-25
申请人： Eiji Shiojiri , Yoshinobu Takino , Hiromi Chujou , Kazutami Sakamoto , Chiori Ijichi , Yuzuru Eto , Keiji Iwasaki
发明人： Eiji Shiojiri , Yoshinobu Takino , Hiromi Chujou , Kazutami Sakamoto , Chiori Ijichi , Yuzuru Eto , Keiji Iwasaki
IPC分类号： C07K5/08 , A61K38/00
CPC分类号： C07K5/0812 , A61K38/00
摘要： In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having a 50% inhibitory concentration of cAMP production (IC50) of 100 nM or less, which composition can prevent pigmentation, or can prevent, improve or recover from immune abnormality or immunodeficiency, or regulate body weight by appetite control, and also can be used as cosmetics or external preparations for the skin, and in addition, can be produced easily, and are excellent in the stability during storage.
摘要翻译：在本说明书中公开了一种黑素细胞刺激激素抑制组合物，其包含作为活性成分的具有某个萘基的二肽或三肽衍生物或其盐，或具有50％抑制性的黑素细胞刺激激素抑制化合物 cAMP产生浓度（IC 50）为100nM以下，该组合物可以防止色素沉积，或者可以防止，改善或恢复免疫异常或免疫缺陷，或通过食欲控制来调节体重，并且还可以用作化妆品或外用制剂并且另外可以容易地制造，并且在保存期间的稳定性优异。

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