专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06703031B1 Cysteine derivatives 失效
标题翻译：半胱氨酸衍生物
公开(公告)号：US06703031B1
公开(公告)日：2004-03-09
申请号：US09806937
申请日：2001-06-14
申请人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
发明人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
IPC分类号： A61K700
CPC分类号： C07C323/60 , A61K8/02 , A61K8/0212 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/411 , A61K8/447 , A61K8/45 , A61K8/46 , A61K8/494 , A61K8/60 , A61K8/63 , A61K8/676 , A61K8/678 , A61K8/86 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , A61Q19/10 , Y10S514/844 , Y10S514/847
摘要： Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.
摘要翻译：本发明的目的是提供能够抑制细胞毒性蛋白质的表达和基因转录调节因子的活化的氧化应激抑制剂，其采用这种细胞毒性蛋白质的这种表达，并且在使用和安全性方面表现出良好的感觉; 提供一种预防，延缓，减轻或治疗由于老化引起的皮肤变化或由氧化应激引起或促进的不期望的美容皮肤变化的方法; 并且提供包含氧化应激抑制剂作为有效成分的外用化妆品组合物或皮肤病学制剂，并且为了这些目的，使用氧化应激抑制剂，其包含作为有效成分的至少一种选自半胱氨酸或胱氨酸衍生物及其盐。

2. 发明授权

US06552061B1 Amino acid derivatives and anti-inflammatory agents 失效
标题翻译：氨基酸衍生物和抗炎剂
公开(公告)号：US06552061B1
公开(公告)日：2003-04-22
申请号：US09285390
申请日：1999-04-02
申请人： Manabu Kitazawa , Keiji Iwasaki , Eiji Shiojiri
发明人： Manabu Kitazawa , Keiji Iwasaki , Eiji Shiojiri
IPC分类号： C07C22928
CPC分类号： C07D233/64 , C07C229/14 , C07C229/22 , C07C229/34 , C07C237/06 , C07C237/20 , C07D207/28
摘要： Provided are an anti-inflammatory agent containing, as an active ingredient, at least one selected from amino acid derivatives represented by formula (I) wherein Ar represents an optionally substituted 2-hydroxyaryl group, n is 0 or 1, R2 represents a hydrogen atom or a side chain of an &agr;-amino acid or &bgr;-amino acid, X represents —O— or —NH—, R1 represents a hydrogen atom or a group that forms, together with R2 and an adjacent atoms, a cyclic structure of pyroglutamic acid, and R3 represents a hydrogen atom, an alkyl group having from 1 to 22 carbon atoms or an alkenyl group having from 2 to 22 carbon atoms, and salts thereof, and toiletries or skin external products containing the same. The anti-inflammatory agent of the invention inhibits expression of an inflammatory protein and activation of a gene transcription control factor that participates therein, and exhibits a good feeling upon use and a safety.
摘要翻译：提供含有选自由式（I）表示的氨基酸衍生物中的至少一种作为活性成分的抗炎剂，其中Ar表示任选取代的2-羟基芳基，n为0或1，R 2表示氢原子或α-氨基酸或β-氨基酸的侧链，X表示-O-或-NH-，R1表示氢原子或与R2和相邻原子一起形成焦谷氨酸的环状结构的基团酸，R3表示氢原子，具有1至22个碳原子的烷基或具有2至22个碳原子的烯基，以及其盐，以及含有它们的化妆品或皮肤外用产品。本发明的抗炎剂抑制炎症蛋白的表达和参与其中的基因转录控制因子的活化，并且在使用时表现出良好的感觉和安全性。

3. 发明授权

US07105570B2 Cysteine derivatives 有权
公开(公告)号：US07105570B2
公开(公告)日：2006-09-12
申请号：US10323930
申请日：2002-12-20
申请人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
发明人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
IPC分类号： A61K31/195 , A61K31/22
CPC分类号： C07C323/60 , A61K8/02 , A61K8/0212 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/411 , A61K8/447 , A61K8/45 , A61K8/46 , A61K8/494 , A61K8/60 , A61K8/63 , A61K8/676 , A61K8/678 , A61K8/86 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , A61Q19/10 , Y10S514/844 , Y10S514/847
摘要： Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

4. 发明授权

US06602492B2 Cysteine derivatives 有权
公开(公告)号：US06602492B2
公开(公告)日：2003-08-05
申请号：US10051099
申请日：2002-01-22
申请人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
发明人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
IPC分类号： A61K742
CPC分类号： C07C323/60 , A61K8/02 , A61K8/0212 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/411 , A61K8/447 , A61K8/45 , A61K8/46 , A61K8/494 , A61K8/60 , A61K8/63 , A61K8/676 , A61K8/678 , A61K8/86 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , A61Q19/10 , Y10S514/844 , Y10S514/847
摘要： Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

5. 发明授权

US07375085B1 Melanocyte-stimulating hormone inhibitors 有权
标题翻译：促黑细胞激素抑制剂
公开(公告)号：US07375085B1
公开(公告)日：2008-05-20
申请号：US09926391
申请日：2000-04-25
申请人： Eiji Shiojiri , Yoshinobu Takino , Hiromi Chujou , Kazutami Sakamoto , Chiori Ijichi , Yuzuru Eto , Keiji Iwasaki
发明人： Eiji Shiojiri , Yoshinobu Takino , Hiromi Chujou , Kazutami Sakamoto , Chiori Ijichi , Yuzuru Eto , Keiji Iwasaki
IPC分类号： C07K5/08 , A61K38/00
CPC分类号： C07K5/0812 , A61K38/00
摘要： In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having a 50% inhibitory concentration of cAMP production (IC50) of 100 nM or less, which composition can prevent pigmentation, or can prevent, improve or recover from immune abnormality or immunodeficiency, or regulate body weight by appetite control, and also can be used as cosmetics or external preparations for the skin, and in addition, can be produced easily, and are excellent in the stability during storage.
摘要翻译：在本说明书中公开了一种黑素细胞刺激激素抑制组合物，其包含作为活性成分的具有某个萘基的二肽或三肽衍生物或其盐，或具有50％抑制性的黑素细胞刺激激素抑制化合物 cAMP产生浓度（IC 50）为100nM以下，该组合物可以防止色素沉积，或者可以防止，改善或恢复免疫异常或免疫缺陷，或通过食欲控制来调节体重，并且还可以用作化妆品或外用制剂并且另外可以容易地制造，并且在保存期间的稳定性优异。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式