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1. 发明授权

US08506905B2 Method of forming bilayer membrane by contact between amphipathic monolayers and apparatus therefor 有权
标题翻译：通过两亲性单层之间的接触形成双层膜的方法及其设备
公开(公告)号：US08506905B2
公开(公告)日：2013-08-13
申请号：US11997058
申请日：2006-07-26
申请人： Shoji Takeuchi , Hiroaki Suzuki , Kei Funakoshi
发明人： Shoji Takeuchi , Hiroaki Suzuki , Kei Funakoshi
IPC分类号： B01L3/00 , G01N1/16 , G01N31/20 , B01D11/00 , B01D35/00
CPC分类号： G01N33/92 , B01L3/502769 , G01N33/68
摘要： The present invention provides simple and an accurate apparatuses for forming bilayer membranes by the contact of amphipathic monolayers. In one apparatus, amphipathic monolayers are brought into contact and fused by controlling the pressure of liquids introduced from microchannels forming an intersection containing a chamber. In another apparatus, the chamber includes a number of compartments and at least one construction portion. In this apparatus, a droplet is formed within each compartment and contact of amphipatic monolayers is accomplished by adjusting the size of the droplets.
摘要翻译：本发明提供了通过两亲性单层接触形成双层膜的简单且准确的装置。在一个装置中，通过控制从形成包含室的交点的微通道引入的液体的压力，使两亲性单层接触并熔融。在另一装置中，腔室包括多个隔间和至少一个结构部分。在该装置中，在每个室内形成液滴，并通过调节液滴的尺寸来实现两相单层的接触。

2. 发明申请

US20100147450A1 METHOD OF FORMING BILAYER MEMBRANE BY CONTACT BETWEEN AMPHIPATHIC MONOLAYERS AND APPARATUS THEREFOR 有权
标题翻译：通过大孔单体与其设备之间的接触形成双层膜的方法
公开(公告)号：US20100147450A1
公开(公告)日：2010-06-17
申请号：US11997058
申请日：2006-07-26
申请人： Shoji Takeuchi , Hiroaki Suzuki , Kei Funakoshi
发明人： Shoji Takeuchi , Hiroaki Suzuki , Kei Funakoshi
IPC分类号： B29C65/70 , B32B37/02 , B32B38/00
CPC分类号： G01N33/92 , B01L3/502769 , G01N33/68
摘要： The present invention provides a simple and an accurate method of forming a bilayer membrane by the contact of amphipathic monolayers and an apparatus therefor. The method is characterized in that the organic solvent (2) containing lipid molecules is introduced into a first microchannel (1) formed on a substrate (5). A liquid (4) immiscible with the organic solvent (2) containing lipid molecules is introduced into a second microchannel (3), which crosses the first microchannel (1) from both sides to form an intersection, from both ends of the second microchannel (3) toward the intersection. Amphipathic monolayers (2A) opposing each other are formed at the interfaces between the liquid (4) and the organic solvent (2), and finally a lipid bilayer membrane (2B) is obtained by bringing the amphipathic monolayers (2A) into contact and fusing, by the contact of the interfaces of the liquid (4) introduced from the both ends of the second microchannel (3) with the control of the pressure of the liquid (4) using syringe pumps.
摘要翻译：本发明提供了通过两亲性单层接触形成双层膜的简单且精确的方法及其装置。该方法的特征在于，将含有脂质分子的有机溶剂（2）引入到形成在基板（5）上的第一微通道（1）中。将含有脂质分子的有机溶剂（2）不混溶的液体（4）被引入第二微通道（3），第二微通道（3）从两侧穿过第一微通道（1）以形成交叉点，从第二微通道 3）朝向十字路口。在液体（4）和有机溶剂（2）之间的界面处形成彼此相对的两亲性单层（2A），最后通过使两亲性单层（2A）接触和融合获得脂质双层膜（2B）通过从第二微通道（3）的两端引入的液体（4）的界面与使用注射泵的液体（4）的压力的控制接触。

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