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1. 发明申请

US20090246873A1 SCAFFOLD FOR TISSUE ENGINEERING AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译：组织工程SCAFFOLD及其生产方法
公开(公告)号：US20090246873A1
公开(公告)日：2009-10-01
申请号：US12415285
申请日：2009-03-31
申请人： Katsushi YAMAMOTO , Katsuyuki Yamanaka , Youko Suda , Yuhiro Sakai , Tadashi Kaneko
发明人： Katsushi YAMAMOTO , Katsuyuki Yamanaka , Youko Suda , Yuhiro Sakai , Tadashi Kaneko
IPC分类号： C12N5/06
CPC分类号： A61L27/56 , A61L27/18 , C08L67/04
摘要： To provide a scaffold for tissue engineering which consists of a bioabsorbable polymer material to be absorbed in a biotissue, and holds strength of the whole scaffold while having a porosity proper for culturing cells inside thereof as well, a method for producing the scaffold for tissue engineering includes steps of dissolving a bioabsorbable polymer material with an organic solvent, drying the solution so as to produce a porous bioabsorbable polymer material having a porosity of 50 to 99%, covering the porous bioabsorbable polymer material with a bioabsorbable polymer material having a thickness of 0.01 to 5 mm, pores of 10 to 3000 μm diameter, a fracture strength of 0.05 to 0.15 MPa, and a volume of 15 to 90% with respect to the whole scaffold.
摘要翻译：提供一种用于组织工程的支架，其由吸收在生物组织中的生物可吸收聚合物材料组成，并且保持整个支架的强度同时具有适合于在其内部培养细胞的孔隙度，一种用于组织工程支架的生产方法包括将生物可吸收聚合物材料与有机溶剂一起溶解的步骤，干燥该溶液以产生孔隙率为50至99％的多孔生物可吸收聚合物材料，用具有厚度为0.01的生物可吸收聚合物材料覆盖多孔生物可吸收聚合物材料至5mm，孔径为10-3000μm直径，断裂强度为0.05-0.15MPa，体积相对于整个支架为15-90％。

2. 发明申请

US20090228027A1 BONE TISSUE REGENERATION SHEET AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译：骨组织再生片及其生产方法
公开(公告)号：US20090228027A1
公开(公告)日：2009-09-10
申请号：US12401121
申请日：2009-03-10
申请人： Katsuyuki YAMANAKA , Katsushi YAMAMOTO , Youko SUDA , Yuhiro SAKAI , Tadashi KANEKO
发明人： Katsuyuki YAMANAKA , Katsushi YAMAMOTO , Youko SUDA , Yuhiro SAKAI , Tadashi KANEKO
IPC分类号： A61B17/08 , C12N11/02
CPC分类号： C12N5/0655 , A61L27/18 , A61L27/3817 , A61L27/3821 , A61L27/3834 , A61L27/3847 , A61L27/3895 , A61L27/58 , A61L2430/02 , C12N2500/84 , C12N2506/1353 , C12N2533/40
摘要： To provide a bone tissue regeneration sheet having a cortical bone tissue layer of 200 μm or more in thickness, the bone tissue regeneration sheet is produced by seeding chondroblast or stem cells for differentiating to chondrocyte on one side of a porous bioabsorbable polymer sheet, taking the seeded porous body into a culture medium, applying centrifugal force of 100 to 1000 G to the culture medium for a predetermined time so as to aggregate the chondroblast or the stem cells for differentiating to chondrocyte, culturing the aggregated cells in a culture medium not containing serum but containing one or two or more kinds selected from ascorbic acid, an ascorbic acid derivative, and dexamethasone without applying centrifugal force to form a chondrocyte layer having a thickness of 200 μm or more.
摘要翻译：为了提供具有厚度为200μm以上的皮层骨组织层的骨组织再生片，通过将成软骨细胞或干细胞接种到多孔生物可吸收性聚合物片的一面上来分化为软骨细胞来生产骨组织再生片，将多孔体接种到培养基中，向培养液中施加100〜1000G的离心力达预定时间，以将软骨细胞或干细胞聚集成软骨细胞，在不含血清的培养基中培养聚集的细胞但含有选自抗坏血酸，抗坏血酸衍生物和地塞米松中的一种或两种以上，而不施加离心力，形成厚度为200μm以上的软骨细胞层。

3. 发明授权

US08518432B2 Block-shaped scaffold for tissue engineering and production method thereof 有权
标题翻译：用于组织工程的块状支架及其制造方法
公开(公告)号：US08518432B2
公开(公告)日：2013-08-27
申请号：US12488862
申请日：2009-06-22
申请人： Katsushi Yamamoto , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
发明人： Katsushi Yamamoto , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
IPC分类号： A01N25/34
CPC分类号： A61L27/58 , A61L27/18 , A61L27/56 , C08L67/04
摘要： A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 μm diameter with a solution, where a biodegradable polymer is dissolved with an organic solvent, freezing, drying it to remove the solvent, pulverizing thus obtained intermediate product, dissolving it with a liquid, where the biodegradable polymer is not dissolved, to remove the particle-shaped material taking thus obtained intermediate product into a mold, and pressing and heating it, the scaffold having ununiform and continuous holes occupying 20 to 80% in a cross-section area in a three-dimensional network structure having a small hole structure with 5 to 50 μm diameter, elastic coefficient being 0.1 to 2.5 MPa, and volume change being 95 to 105% when dipping it in water for 24 hours.
摘要翻译：具有改善的形状稳定性和较小体积变化的用于组织工程的块状支架是通过以下步骤产生的：将具有100至2000μm直径的颗粒状材料与溶解有生物可降解聚合物的溶液近似均匀混合用有机溶剂冷冻，干燥除去溶剂，粉碎由此获得的中间产物，将其溶解在生物可降解聚合物不溶解的液体中，以将得到的中间产物的颗粒状材料除去到模具中，并且对其进行加压加压，在具有5〜50μm直径的小孔结构的三维网状结构体的横截面积中占据20〜80％不均匀连续的支架的弹性系数为0.1〜2.5MPa ，当将其浸入水中24小时时，体积变化为95至105％。

4. 发明申请

US20090299475A1 BONE GRAFT SUBSTITUTE 审中-公开
标题翻译：骨髓替代品
公开(公告)号：US20090299475A1
公开(公告)日：2009-12-03
申请号：US12475831
申请日：2009-06-01
申请人： Katsushi YAMAMOTO , Katsuyuki YAMANAKA , Yuhiro SAKAI , Youko SUDA , Tadashi KANEKO
发明人： Katsushi YAMAMOTO , Katsuyuki YAMANAKA , Yuhiro SAKAI , Youko SUDA , Tadashi KANEKO
IPC分类号： A61F2/28
CPC分类号： A61L27/12 , A61L27/227 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： To provide a bone graft substitute having an appropriate absorption period in a living body and high osteoconductivity, the bone graft substitute contains a carbonate apatite and an osteoinductive factor, the osteoinductive factor is preferably at least one kind selected from a group including BMP (a bone morphogenetic protein), GDF (a growth differentiation factor), TGF-β (a transformation growth factor), FGF (a fibroblast growth factor), IGF (an insulin-like growth factor), PDGF (a platelet-derived growth factor), BDNF (a brain-derived nerve growth factor), and NGF (a nerve growth factor), and the bone graft substitute has open pores, preferably having a diameter of 50 to 1000 μm and/or a diameter of 0.001 to 5 μm, with porosity of 20 to 80%.
摘要翻译：为了提供在生物体中具有适当的吸收期和高的骨传导性的骨移植物替代物，骨移植物替代物含有碳酸磷灰石和骨诱导因子，骨诱导因子优选为选自包括BMP（骨骼）形态发生蛋白），GDF（生长分化因子），TGF-β（转化生长因子），FGF（成纤维细胞生长因子），IGF（胰岛素样生长因子），PDGF（血小板衍生生长因子） BDNF（脑源性神经生长因子）和NGF（神经生长因子），骨移植物替代物具有开孔，优选直径为50〜1000μm，直径为0.001〜5μm，孔隙率为20〜80％。

5. 发明申请

US20090261492A1 BLOCK-SHAPED SCAFFOLD FOR TISSUE ENGINEERING AND PRODUCTION METHOD THEREOF 有权
标题翻译：用于组织工程的块状SCAFFOLD及其生产方法
公开(公告)号：US20090261492A1
公开(公告)日：2009-10-22
申请号：US12488862
申请日：2009-06-22
申请人： Katsushi Yamamoto , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
发明人： Katsushi Yamamoto , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
IPC分类号： B29B9/12
CPC分类号： A61L27/58 , A61L27/18 , A61L27/56 , C08L67/04
摘要： A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 μm diameter with a solution, where a biodegradable polymer is dissolved with an organic solvent, freezing, drying it to remove the solvent, pulverizing thus obtained intermediate product, dissolving it with a liquid, where the biodegradable polymer is not dissolved, to remove the particle-shaped material taking thus obtained intermediate product into a mold, and pressing and heating it, the scaffold having ununiform and continuous holes occupying 20 to 80% in a cross-section area in a three-dimensional network structure having a small hole structure with 5 to 50 μm diameter, elastic coefficient being 0.1 to 2.5 MPa, and volume change being 95 to 105% when dipping it in water for 24 hours.
摘要翻译：具有改善的形状稳定性和较小体积变化的用于组织工程的块状支架是通过以下步骤产生的：将具有100至2000μm直径的颗粒状材料与溶解有生物可降解聚合物的溶液近似均匀混合用有机溶剂冷冻，干燥除去溶剂，粉碎由此获得的中间产物，将其溶解在生物可降解聚合物不溶解的液体中，以将得到的中间产物的颗粒状材料除去到模具中，并且对其进行加压加压，在具有5〜50μm直径的小孔结构的三维网状结构体的横截面积中占据20〜80％不均匀连续的支架的弹性系数为0.1〜2.5MPa ，当将其浸入水中24小时时，体积变化为95至105％。

6. 发明申请

US20090186412A1 POROUS CELL SCAFFOLD AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译：多孔细胞SCAFFOLD及其生产方法
公开(公告)号：US20090186412A1
公开(公告)日：2009-07-23
申请号：US12356769
申请日：2009-01-21
申请人： Katsuyuki Yamanaka , Youko Suda , Katsushi Yamamoto , Yuhiro Sakai , Tadashi Kaneko
发明人： Katsuyuki Yamanaka , Youko Suda , Katsushi Yamamoto , Yuhiro Sakai , Tadashi Kaneko
IPC分类号： C12N5/02
CPC分类号： C12N5/0655 , C12N5/0062 , C12N5/0653 , C12N5/0654 , C12N2533/30 , C12N2533/40
摘要： For easily seeding cells in its scaffold, a porous cell scaffold is produced by steps of filling a guiding solution with kinematic viscosity being 50 to 450% of that of a culture medium, in a whole continuous small hole structure having hole diameters of 5 to 3200 μm and an average hole diameter of 50 to 1500 μm, of a sheet-shaped or block-shaped scaffold having a thickness of 2 mm or more, supplying thereafter a culture medium with cells being suspended to an upper side of the scaffold, sucking the guiding solution from a lower side of the scaffold by low suction force, and entering thereby the culture medium with cells being suspended into the whole small hole structure, where a water absorber such as a filter paper is preferably used for sucking the guiding solution by low suction force.
摘要翻译：为了容易地在其支架中接种细胞，通过以孔径为5至3200的整个连续的小孔结构填充具有培养基的运动粘度为50至450％的引导溶液的步骤来生产多孔细胞支架平均孔径为50〜1500μm的片状或块状支架，其厚度为2mm以上，向培养基供给细胞悬浮于支架的上侧，吸附通过低抽吸力从支架的下侧引导溶液，并由此进入细胞悬浮在整个小孔结构中的培养基，其中优选使用诸如滤纸的吸水剂用于以低的速度吸引引导溶液吸力。

7. 发明申请

US20070233277A1 BIOABSORBABLE TUBE AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译：可生物管及其生产方法
公开(公告)号：US20070233277A1
公开(公告)日：2007-10-04
申请号：US11694043
申请日：2007-03-30
申请人： Katsushi YAMAMOTO , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
发明人： Katsushi YAMAMOTO , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
IPC分类号： A61F2/02 , F26B5/06
CPC分类号： A61B17/1128 , A61B2017/00004 , A61L27/18 , A61L27/50 , A61L27/58 , C08L67/04
摘要： To provide an organism absorbency tube for regenerating nerve tissue and a production method thereof, where the low cost tube can produce easier than a conventional one, various kinds of the different thickness tubes, inner diameters and outer shapes can be easily formed. The tube produces by drying polymer solvent to form sheet-like organism absorbency polymer material; cylindrically rolling thus material to form an overlapped sheet part; heat or solvent meld sealing at least a portion around an end edge on the outer peripheral side thereof. Or a two layers structure tube produces by freeze-drying polymer solvent to form the material; cylindrically rolling thus material; non-freeze-drying polymer solvent to form the high material; cylindrically wrapping thus material around the freeze-dried polymer material to form the sheet part; and heat or solvent meld sealing at least a portion around an edge on the outer peripheral side thereof.
摘要翻译：为了提供用于再生神经组织的生物体吸收管及其制造方法，其中低成本管可以比常规生产更容易制造，可以容易地形成各种不同厚度的管，内径和外形。管通过干燥聚合物溶剂生成片状生物体吸收性聚合物材料; 圆柱滚动，从而形成重叠的片部分; 热或溶剂在其外周侧的端缘周围的至少一部分进行熔融密封。或者通过冷冻干燥聚合物溶剂形成两层结构管来形成材料; 圆柱滚动如此材料; 非冷冻干燥聚合物溶剂形成高材料; 在冷冻干燥的聚合物材料周围圆周包裹这样的材料以形成片材部分; 并且在其外周侧上的边缘周围的至少一部分进行热或溶剂的熔融密封。

8. 发明申请

US20060030627A1 Bioabsorbable granular porous bone filling material and production method thereof 审中-公开
标题翻译：生物可吸收颗粒多孔骨填充材料及其制备方法
公开(公告)号：US20060030627A1
公开(公告)日：2006-02-09
申请号：US11188696
申请日：2005-07-26
申请人： Katsushi Yamamoto , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
发明人： Katsushi Yamamoto , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
IPC分类号： A61K47/00
CPC分类号： A61L27/58 , A61L27/18 , A61L27/56 , A61L2430/02 , C08L67/04
摘要： A bioabsorbable granular porous bone filling material having a particle diameter 100 to 3000 μm used for filling a defect part after removing a lesion, or grafting a self bone, and for reinforcing or filling a jawbone when embedding a dental implant, is produced such that the polymer material containing a particle-shaped material and having the small hole structure with the hole diameter of 5 to 50 μm is made by mixing the particle-shaped material having a diameter of 100 to 2000 μm with a solution, where the bioabsorbable polymer is dissolved with an organic solvent, the particle-shaped material being not dissolved with this organic solvent but dissolved with a liquid not dissolving the bioabsorbable polymer, freezing it, drying it to remove the organic solvent, pulverizing the produced material, dissolving the particle-shaped material with the liquid to be removed, and sieving it.
摘要翻译：产生具有100-3000μm的粒径的生物可吸收的颗粒状多孔骨填充材料，其用于在移除病变之后填充缺陷部分，或移植自体骨骼，以及用于在嵌入牙植入物时加强或填充颚骨。通过将直径为100〜2000μm的直径为100〜2000μm的颗粒状材料与生物体吸收性聚合物溶解的溶液混合，制成含有粒径为5〜50μm的小孔结构的粒状材料的高分子材料使用有机溶剂，颗粒状材料不与该有机溶剂溶解，但用不溶于生物可吸收性聚合物的液体溶解，冷冻，干燥除去有机溶剂，粉碎生成的材料，使颗粒状材料溶解将液体除去，并筛分。

9. 发明申请

US20060083771A1 Block-shaped scaffold for tissue engineering and production method thereof 审中-公开
公开(公告)号：US20060083771A1
公开(公告)日：2006-04-20
申请号：US11241997
申请日：2005-10-04
申请人： Katsushi Yamamoto , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
发明人： Katsushi Yamamoto , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
IPC分类号： A61F2/00
CPC分类号： A61L27/58 , A61L27/18 , A61L27/56 , C08L67/04
摘要： A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 μm diameter with a solution, where a biodegradable polymer is dissolved with an organic solvent, freezing, drying it to remove the solvent, pulverizing thus obtained intermediate product, dissolving it with a liquid, where the biodegradable polymer is not dissolved, to remove the particle-shaped material taking thus obtained intermediate product into a mold, and pressing and heating it, the scaffold having ununiform and continuous holes occupying 20 to 80% in a cross-section area in a three-dimensional network structure having a small hole structure with 5 to 50 μm diameter, elastic coefficient being 0.1 to 2.5 MPa, and volume change being 95 to 105% when dipping it in water for 24 hours.

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