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1. 发明授权

US06900030B2 Device for monitoring cells 有权
标题翻译：用于监控单元的设备
公开(公告)号：US06900030B2
公开(公告)日：2005-05-31
申请号：US10116777
申请日：2002-04-04
申请人： J. Bruce Pitner , John Jacob Hemperly , Richard D. Guarino , Magdalena Wodnicka , David T. Stitt , Gregory J. Burrell , Timothy G. Foley, Jr. , Patrick Shawn Beaty
发明人： J. Bruce Pitner , John Jacob Hemperly , Richard D. Guarino , Magdalena Wodnicka , David T. Stitt , Gregory J. Burrell , Timothy G. Foley, Jr. , Patrick Shawn Beaty
IPC分类号： C12Q1/04 , C12Q1/18
CPC分类号： C12Q1/18 , C12Q1/04 , C12Q2304/44 , G06F19/00 , Y02A90/26
摘要： The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.
摘要翻译：本发明涉及基于其消耗溶解氧的能力来检测和评价真核细胞和/或原核细胞的代谢活性的方法。该方法利用了发光检测系统，其利用某些化合物的发光发射对氧的存在的敏感性，其以浓度依赖性方式猝灭（减少）化合物的发光发射。呼吸真核细胞和/或原核细胞将影响浸入其中的液体培养基的氧浓度。因此，本发明提供了一种方便的系统，用于通过确定它们对存在的介质的氧浓度的影响来收集关于真核细胞和/或原核细胞的存在，鉴定，定量和细胞毒活性的信息。

2. 发明授权

US6017695A Nucleic acids encoding human cell adhesion molecule 失效
标题翻译：编码人细胞粘附分子的核酸
公开(公告)号：US6017695A
公开(公告)日：2000-01-25
申请号：US40741
申请日：1993-03-26
申请人： Robert Alan Reid , John Jacob Hemperly
发明人： Robert Alan Reid , John Jacob Hemperly
IPC分类号： C07K16/00 , C07H21/04 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/2839 , C07K14/70503 , C07K16/2803 , C07K2319/00
摘要： A human brain glycoprotein homologous to the mouse F3 and the chicken contactin/F11 adhesion molecules, nucleic acid sequences encoding the human brain glycoprotein and antibodies directed against the human brain glycoprotein.
摘要翻译：与小鼠F3和鸡接触蛋白/ F11粘附分子同源的人脑糖蛋白，编码人脑糖蛋白的核酸序列和针对人脑糖蛋白的抗体。

3. 发明授权

US5688916A Human cell adhesion molecule 失效
标题翻译：人细胞粘附分子
公开(公告)号：US5688916A
公开(公告)日：1997-11-18
申请号：US408093
申请日：1995-03-21
申请人： Robert Alan Reid , John Jacob Hemperly
发明人： Robert Alan Reid , John Jacob Hemperly
IPC分类号： C07K16/00 , C07H21/04 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/577 , A61K38/00
CPC分类号： C07K16/2839 , C07K14/70503 , C07K16/2803 , C07K2319/00
摘要： A human brain glycoprotein homologous to the mouse F3 and the chicken contactin/F11 adhesion molecules, nucleic acid sequences encoding the human brain glycoprotein and antibodies directed against the human brain glycoprotein.
摘要翻译：与小鼠F3和鸡接触蛋白/ F11粘附分子同源的人脑糖蛋白，编码人脑糖蛋白的核酸序列和针对人脑糖蛋白的抗体。

4. 发明授权

US5681931A Human restrictin 失效
标题翻译：人类限制
公开(公告)号：US5681931A
公开(公告)日：1997-10-28
申请号：US404781
申请日：1995-03-15
申请人： Robert Alan Reid , Rhonda Lucille Ackley , John Jacob Hemperly
发明人： Robert Alan Reid , Rhonda Lucille Ackley , John Jacob Hemperly
IPC分类号： C07K14/47
CPC分类号： C07K14/47
摘要： Human restrictin proteins and nucleic acid sequences encoding them are provided. Antibodies which recognize human restrictin in human brain are disclosed. In the human brain, restrictin occurs as two major polypeptides of 180 and 160 kD located in fiber tracts. These polypeptides are similar to those seen in rat brain. Surprisingly, restrictin has also been found in the peripheral nerves of rats and humans. The antibodies also detect a 170 kD polypeptide in MATRIGEL, an extracellular matrix product of rat EHS sarcoma cells widely used as a tissue culture substrate. Monoclonal antibodies to human restrictin and assays using the human restrictin protein, antibodies and DNA sequences are also provided.
摘要翻译：提供人类限制蛋白和编码它们的核酸序列。公开了在人脑中识别人类限制蛋白的抗体。在人脑中，限制蛋白作为位于纤维束中的180和160kD的两个主要多肽发生。这些多肽类似于在大鼠脑中看到的那些。令人惊讶的是，在大鼠和人的周围神经中也发现了限制蛋白。该抗体还检测了广泛用作组织培养基质的大鼠EHS肉瘤细胞的细胞外基质产物MATRIGEL中的170kD多肽。还提供了人类限制性蛋白的单克隆抗体和使用人类限制蛋白的抗体和DNA序列的测定。

5. 发明授权

US07338778B2 Luminescent method for determining cell oxygen consumption 有权
标题翻译：用于确定细胞氧消耗的发光方法
公开(公告)号：US07338778B2
公开(公告)日：2008-03-04
申请号：US10957802
申请日：2004-10-04
申请人： J. Bruce Pitner , John Jacob Hemperly , Richard D. Guarino , Magdalena Wodnicka , David T. Stitt , Gregory J. Burrell , Timothy G. Foley, Jr. , Patrick Shawn Beaty
发明人： J. Bruce Pitner , John Jacob Hemperly , Richard D. Guarino , Magdalena Wodnicka , David T. Stitt , Gregory J. Burrell , Timothy G. Foley, Jr. , Patrick Shawn Beaty
IPC分类号： C12Q1/04
CPC分类号： C12Q1/18 , C12Q1/04 , C12Q2304/44 , G06F19/00 , Y02A90/26
摘要： The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.
摘要翻译：本发明涉及基于其消耗溶解氧的能力来检测和评价真核细胞和/或原核细胞的代谢活性的方法。该方法利用了发光检测系统，其利用某些化合物的发光发射对氧的存在的敏感性，其以浓度依赖性方式猝灭（减少）化合物的发光发射。呼吸真核细胞和/或原核细胞将影响浸入其中的液体培养基的氧浓度。因此，本发明提供了一种方便的系统，用于通过确定它们对存在的介质的氧浓度的影响来收集关于真核细胞和/或原核细胞的存在，鉴定，定量和细胞毒活性的信息。

6. 发明授权

US06967086B2 Method for determining the presence or absence of respiring cells on a three-dimensional scaffold 有权
标题翻译：用于确定在三维支架上存在或不存在呼吸细胞的方法
公开(公告)号：US06967086B2
公开(公告)日：2005-11-22
申请号：US10109475
申请日：2002-03-28
申请人： Richard David Guarino , John Jacob Hemperly , Catherine A. Spargo , Andrea Liebmann-Vinson , Mohammad A. Heidaran
发明人： Richard David Guarino , John Jacob Hemperly , Catherine A. Spargo , Andrea Liebmann-Vinson , Mohammad A. Heidaran
IPC分类号： C12Q1/04 , C12Q1/18
CPC分类号： C12Q1/04 , B33Y80/00 , C12Q1/18 , C12Q2304/44
摘要： The invention provides a method and apparatus for determining the presence or absence of respiring cells, involving combining a three-dimensional biomimetic scaffold and cells onto a sensor composition.
摘要翻译：本发明提供了一种用于确定呼吸细胞的存在或不存在的方法和装置，其涉及将三维仿生支架和细胞组合到传感器组合物上。

7. 发明申请

US20050191613A1 Device for monitoring cells 有权
公开(公告)号：US20050191613A1
公开(公告)日：2005-09-01
申请号：US10957802
申请日：2004-10-04
申请人： J. Bruce Pitner , John Jacob Hemperly , Richard Guarino , Magdalena Wodnicka , David Stitt , Gregory Burrell , Timothy Foley , Patrick Shawn Beaty
发明人： J. Bruce Pitner , John Jacob Hemperly , Richard Guarino , Magdalena Wodnicka , David Stitt , Gregory Burrell , Timothy Foley , Patrick Shawn Beaty
IPC分类号： C12Q1/04 , C12Q1/18 , C12Q1/00
CPC分类号： C12Q1/18 , C12Q1/04 , C12Q2304/44 , G06F19/00 , Y02A90/26
摘要： The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.

8. 发明授权

US5667978A Antibody to the neural cell adhesion molecule and methods of use 失效
公开(公告)号：US5667978A
公开(公告)日：1997-09-16
申请号：US642288
申请日：1996-05-03
申请人： Duane David Bronson , John Jacob Hemperly
发明人： Duane David Bronson , John Jacob Hemperly
IPC分类号： A61B17/06 , A61K38/00 , C07K14/705 , C07K16/28 , C12P21/04 , A61K39/395 , A61B17/04 , G01N33/53
CPC分类号： C07K14/70503 , C07K16/2803 , A61B17/06166 , A61K38/00 , Y10S435/96 , Y10S530/839
摘要： The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on nerve cells of both the central and peripheral nervous systems, and is useful for enhancing neurite outgrowth in in vitro studies and for improving nerve regeneration and repair in vivo.

9. 发明授权

US5739289A Monoclonal antibody to human cell adhesion molecule 失效
标题翻译：人类细胞粘附分子的单克隆抗体
公开(公告)号：US5739289A
公开(公告)日：1998-04-14
申请号：US714901
申请日：1996-09-17
申请人： Robert Alan Reid , John Jacob Hemperly
发明人： Robert Alan Reid , John Jacob Hemperly
IPC分类号： C07K16/00 , C07H21/04 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/2839 , C07K14/70503 , C07K16/2803 , C07K2319/00
摘要： A human brain glycoprotein homologous to the mouse F3 and the chicken contactin/F11 adhesion molecules, nucleic acid sequences encoding the human brain glycoprotein and antibodies directed against the human brain glycoprotein.
摘要翻译：与小鼠F3和鸡接触蛋白/ F11粘附分子同源的人脑糖蛋白，编码人脑糖蛋白的核酸序列和针对人脑糖蛋白的抗体。

10. 发明授权

US5651969A Antibody to the neural cell adhesion molecule and methods of use 失效
标题翻译：抗体对神经细胞粘附分子的使用和使用方法
公开(公告)号：US5651969A
公开(公告)日：1997-07-29
申请号：US642374
申请日：1996-05-03
申请人： Duane David Bronson , John Jacob Hemperly
发明人： Duane David Bronson , John Jacob Hemperly
IPC分类号： A61B17/06 , A61K38/00 , C07K14/705 , C07K16/28 , C12P21/04 , A61K39/395 , A61B17/04 , A61B17/08
CPC分类号： C07K14/70503 , C07K16/2803 , A61B17/06166 , A61K38/00 , Y10S435/96 , Y10S530/839
摘要： The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on nerve cells of both the central and peripheral nervous systems, and is useful for enhancing neurite outgrowth in in vitro studies and for improving nerve regeneration and repair in vivo.
摘要翻译：本发明提供了抗N-CAM单克隆抗体，其增强而不是抑制体外和体内神经突向外生长。抗体对中枢和周围神经系统的神经细胞具有积极的调节作用，并且可用于在体外研究中增强神经突生长，并用于改善体内神经再生和修复。

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