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1. 发明授权

US09074241B2 Methods employing non-coding RNA expression assays 有权
标题翻译：采用非编码RNA表达测定法的方法
公开(公告)号：US09074241B2
公开(公告)日：2015-07-07
申请号：US13145208
申请日：2010-01-19
申请人： Jacinto Peter Estibeiro , John Francis Gordon , Christopher Robert Hillier , Vincent O'Brien
发明人： Jacinto Peter Estibeiro , John Francis Gordon , Christopher Robert Hillier , Vincent O'Brien
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6809 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207
摘要： There is disclosed a method comprising the steps of: carrying out a plurality of expression assays, each expression assay comprising the steps of: carrying out an intervention on a biological system, measuring an expression profile of non-coding RNAs in the biological system resulting from the intervention, and storing an expression data set derived from the measured expression profile, the said expression assays concerning either or both a plurality of different interventions and a plurality of different biological systems; and analysing the resulting expression data sets to determine correlations between the effect on the expression profile of non-coding RNAs of the respective intervention in groups of two or more expression assays concerning either or both different interventions or different biological systems.
摘要翻译：公开了一种方法，其包括以下步骤：进行多个表达测定，每个表达测定法包括以下步骤：对生物系统进行干预，测量由生物系统产生的生物系统中非编码RNA的表达谱干预，以及存储从测量的表达谱导出的表达数据集，所述表达测定涉及多种不同干预中的一种或两种，以及多种不同的生物系统; 并分析所得到的表达数据集，以确定对于两种或更多种不同介入或不同生物系统之一或两种表达测定的组中相应干预的非编码RNA的表达谱的影响之间的相关性。

2. 发明授权

US06476907B1 Apparatus and method for carrying out histological analysis of specimens 失效
标题翻译：用于进行标本组织学分析的仪器和方法
公开(公告)号：US06476907B1
公开(公告)日：2002-11-05
申请号：US09665481
申请日：2000-09-20
申请人： John Francis Gordon
发明人： John Francis Gordon
IPC分类号： G01N2100
CPC分类号： G01N21/253 , B01J2219/00536 , G01N21/64 , G01N35/00069 , G01N35/025 , G01N2035/0458
摘要： A system for conducting a histological inspection of a biological specimen supported on or in a substrate which may be provided in the form of an optically transparent disc. The disc is mounted for rotation about its central axis while a light source and detector are provided for rotation in an arc crossing the surface of the disc. The source is arranged above the disc and one or more detectors is arranged above and/or below the disc with the optical disc being provided with position and tracking encoded information which interrupts the passage of the light beam when the beam passes over it, thus allowing the scan to be aligned relative to the disc and specimen. The specimen supported on or in the disk can be displayed on a computer display using the position and tracking information.
摘要翻译：用于进行支撑在基板上或基板上的生物样本的组织学检查的系统，其可以以光学透明盘的形式提供。盘被安装成围绕其中心轴线旋转，同时提供光源和检测器用于在与盘的表面交叉的弧中旋转。源设置在光盘上方，并且一个或多个检测器布置在光盘的上方和/或下方，其中光盘被设置有位置和跟踪编码信息，当信号束通过时中断光束的通过，从而允许扫描将相对于盘和样品进行对准。可以使用位置和跟踪信息在计算机显示器上显示支撑在磁盘上或磁盘上的样本。

3. 发明授权

US06256088B1 Apparatus and method for carrying out analysis of samples 失效
标题翻译：用于进行样品分析的装置和方法
公开(公告)号：US06256088B1
公开(公告)日：2001-07-03
申请号：US09156475
申请日：1998-09-18
申请人： John Francis Gordon
发明人： John Francis Gordon
IPC分类号： G01N2103
CPC分类号： G01N21/253 , B01J2219/00536 , G01N21/64 , G01N35/00069 , G01N35/025 , G01N2035/0458
摘要： A system for conducting an optical inspection of a biological, chemical, or biochemical sample supported by an optically transparent disc. The disc is mounted for rotation about its central axis while a light source and detector are mounted on an arm for rotation in an arc crossing the surface of the disc. The source is arranged above the disc and the detector is arranged below the disc with the optical axes provided with a calibration marking which interrupts the passage of the light beam when the beam passes over it, thus allowing the scan to be aligned relative to the disc. The optical properties of the sample supported on the substrate can be automatically and rapidly inspected by analyzing the output of the light detector.
摘要翻译：用于对由光学透明盘支撑的生物，化学或生化样品进行光学检查的系统。盘被安装成围绕其中心轴线旋转，而光源和检测器安装在臂上以在与盘的表面交叉的弧中旋转。源设置在盘的上方，并且检测器被布置在盘的下方，其中光轴设置有校准标记，当光束通过时，该标记中断光束的通过，从而允许扫描相对于盘对准。通过分析光检测器的输出可以自动快速地检查支撑在基板上的样品的光学性质。

4. 发明申请

US20110312524A1 METHODS EMPLOYING NON-CODING RNA EXPRESSION ASSAYS 有权
标题翻译：使用非编码RNA表达测定法的方法
公开(公告)号：US20110312524A1
公开(公告)日：2011-12-22
申请号：US13145208
申请日：2010-01-19
申请人： Jacinto Peter Estibeiro , John Francis Gordon , Christopher Robert HIllier , Vincent O'brien
发明人： Jacinto Peter Estibeiro , John Francis Gordon , Christopher Robert HIllier , Vincent O'brien
IPC分类号： C40B30/04 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6876 , C12Q1/6809 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207
摘要： There is disclosed a method comprising the steps of: carrying out a plurality of expression assays, each expression assay comprising the steps of: carrying out an intervention on a biological system, measuring an expression profile of non-coding RNAs in the biological system resulting from the intervention, and storing an expression data set derived from the measured expression profile, the said expression assays concerning either or both a plurality of different interventions and a plurality of different biological systems; and analysing the resulting expression data sets to determine correlations between the effect on the expression profile of non-coding RNAs of the respective intervention in groups of two or more expression assays concerning either or both different interventions or different biological systems.
摘要翻译：公开了一种方法，其包括以下步骤：进行多个表达测定，每个表达测定法包括以下步骤：对生物系统进行干预，测量由生物系统产生的生物系统中非编码RNA的表达谱干预，以及存储从测量的表达谱导出的表达数据集，所述表达测定涉及多种不同干预中的一种或两种，以及多种不同的生物系统; 并分析所得到的表达数据集，以确定对于两种或更多种不同介入或不同生物系统之一或两种表达测定的组中相应干预的非编码RNA的表达谱的影响之间的相关性。

5. 发明申请

US20090068064A1 APPARATUS AND METHOD FOR CONDUCTING ASSAYS 审中-公开
标题翻译：用于导电测定的装置和方法
公开(公告)号：US20090068064A1
公开(公告)日：2009-03-12
申请号：US12140691
申请日：2008-06-17
申请人： John Francis Gordon
发明人： John Francis Gordon
IPC分类号： G01N21/75 , B01L3/00
CPC分类号： B01L3/50855 , B01L3/5027 , B01L3/5085 , B01L3/5088 , B01L2200/025 , B01L2200/0642 , B01L2300/021 , B01L2300/0803 , B01L2300/165 , B01L2400/0406 , G01N33/5304 , G01N2035/0451 , Y10T436/111666 , Y10T436/2575
摘要： A multi-well assay plate structure (54) and assay apparatus and a method for performing chemical biochemical assays is described. The multi-well assay plate structure (54) defines a relatively shallow substantially enclosed space (71) above a plurality of wells (76), with the enclosed space (71) having an inlet (72) and an outlet (22) separate from the inlet. Fluid introduced via the inlet (72) flows into the space (71) and/or wells (76) by displacing air. Withdrawal of the fluid via the inlet (72) or outlet leaves fluid in the wells (76) allowing various tests to be performed. Various embodiments of the structure are described. The preferred arrangement embodies the structure on a transparent plastic disk which can be used with automatic fluid handling apparatus (80) and the results assessed using optical assessment apparatus (81). The apparatus can be used to perform a variety of assays but, in particular, biochemical/chemical assay, immunoassays and genetic (DNA) assays and it can be used in a laboratory for multiple sample testing or at a point-of-care, i.e. in a surgery or clinic.
摘要翻译：描述了多孔测定板结构（54）和测定装置以及用于进行化学生物化学测定的方法。多孔分析板结构（54）在多个孔（76）上方限定相对浅的基本上封闭的空间（71），其中封闭空间（71）具有入口（72）和与入口。通过入口（72）引入的流体通过排出空气而流入空间（71）和/或井（76）。通过入口（72）或出口抽出流体可以在孔（76）中排出流体，从而允许执行各种测试。描述该结构的各种实施例。优选的布置体现在可与自动流体处理装置（80）一起使用的透明塑料盘上的结构，并且使用光学评估装置（81）评估结果。该装置可用于进行各种测定，特别是生物化学/化学测定，免疫测定和遗传（DNA）测定，并且可用于实验室用于多次样品测试或在点护理，即在手术或诊所。

6. 发明授权

US07083920B2 Surface assembly for immobilizing DNA capture probes in genetic assays using enzymatic reactions to generate signal in optical bio-discs and methods relating thereto 失效
公开(公告)号：US07083920B2
公开(公告)日：2006-08-01
申请号：US10150702
申请日：2002-05-17
申请人： Martina Elisabeth Werner , Ramon Magpantay Valencia , John Francis Gordon
发明人： Martina Elisabeth Werner , Ramon Magpantay Valencia , John Francis Gordon
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/005 , B01J2219/00536 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00617 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502753 , B01L3/545 , B01L2300/0806 , B01L2400/0409 , C40B40/06 , C40B50/14 , C40B60/14 , G01N35/00069 , Y10S977/924
摘要： The present invention relates to methods and systems for the detection of specific sequences of nucleic acids or oligonucleotides. It relates more particularly to a conjugated enzyme based assay system utilizing reflective and/or transmissive optical bio-discs for detection of specific sequences of nucleic acids. In the assay according to the present invention, an enzyme reaction is used to detect the presence of an analyte (DNA or RNA) in a microchannel in an optical bio-disc. The analyte is immobilized by hybridization with a specific capture probe on a capture layer on the surface and the signal that is generated is localized and specific. The signal can be in the form of a pellet, a fluorescent product, and/or a colored product, and can be detected and quantified by an optical bio-disc reader utilized in conjunction with the inventions hereof. This assay is thus quantitative in nature.

7. 发明授权

US07026131B2 Methods and apparatus for blood typing with optical bio-discs 失效
公开(公告)号：US07026131B2
公开(公告)日：2006-04-11
申请号：US10298263
申请日：2002-11-15
申请人： Susan Newcomb Hurt , John Francis Gordon , Kevin Robert McIntyre
发明人： Susan Newcomb Hurt , John Francis Gordon , Kevin Robert McIntyre
IPC分类号： G01N33/567
CPC分类号： G01N33/80 , Y10T436/106664
摘要： This invention relates to clinical diagnostic assays, related optical bio-discs, and a disc-reading apparatus. The invention is directed to methods and apparatuses for performing immunohematology assays using an optical bio-disc analysis system. The invention is further directed to an optical bio-disc for performing an immunohematologic assay including a substrate having encoded information associated therewith. The encoded information may be readable by a disc drive assembly to control rotation of the disc. The disc may also include at least one target zone or capture zone associated with the substrate. The target zone is disposed at a predetermined location relative to a center of the substrate. The disc further includes a plurality of capture antibodies immobilized within the target zone, a flow channel, fluidic circuit, or analysis chamber associated with the target zone, and an input site in fluid communication with the analysis chamber.

8. 发明授权

US06992769B2 Apparatus and method for carrying out analysis of samples using semi-reflective beam radiation inspection 失效
标题翻译：使用半反射光束辐射检测进行样品分析的装置和方法
公开(公告)号：US06992769B2
公开(公告)日：2006-01-31
申请号：US09991429
申请日：2001-11-16
申请人： John Francis Gordon
发明人： John Francis Gordon
IPC分类号： G01N21/03 , G01N21/29
CPC分类号： G01N35/025 , B01J2219/00536 , G01N21/253 , G01N21/64 , G01N35/00069 , G01N2035/0458
摘要： An apparatus and method for carrying out analysis of samples using semi-reflective beam radiation inspection in association with an optical disk and an optical reader has an optically transparent substrate having a semi-reflective layer which reflects a portion of the beam of light to form a reflected beam and transmits a portion of the beam of light to form a transmitted beam. The semi-reflective layer includes optically readable encoded information to be read by the reader for controlling the scanning of the reader relative the disk, the encoded information providing modulation of the reflected beam. The disk includes a sample support surface positioned to be scanned by the reader on which the biological, chemical or biochemical sample may be located for optical inspection with the transmitted beam.
摘要翻译：使用与光盘和光学读取器相关联的半反射光束辐射检查来进行样品分析的装置和方法具有光学透明基板，该基板具有半反射层，该半反射层反射光束的一部分以形成反射光束并透射光束的一部分以形成透射光束。半反射层包括由读取器读取的用于控制读取器相对于盘的扫描的光学可读编码信息，编码信息提供反射光束的调制。盘包括样品支撑表面，其被读取器扫描，生物，化学或生物化学样品可以在其上定位，以便用透射光束进行光学检查。

9. 发明授权

US06327031B1 Apparatus and semi-reflective optical system for carrying out analysis of samples 失效
标题翻译：用于进行样品分析的仪器和半反射光学系统
公开(公告)号：US06327031B1
公开(公告)日：2001-12-04
申请号：US09665930
申请日：2000-09-20
申请人： John Francis Gordon
发明人： John Francis Gordon
IPC分类号： G01N2103
CPC分类号： G01N35/025 , B01J2219/00536 , G01N21/253 , G01N21/64 , G01N35/00069 , G01N2035/0458
摘要： An optical disk for use in conducting an optical inspection of a biological, chemical or biochemical sample in association with an optical reader capable of scanning and reading optical disks with a beam of light has an optically transparent substrate having a semi-reflective layer which reflects a portion of the beam of light to form a reflected beam and transmits a portion of the beam of light to form a transmitted beam. The semi-reflective layer includes optically readable encoded information to be read by the reader for controlling the scanning of the reader relative the disk, the encoded information providing modulation of the reflected beam. The disk includes a sample support surface positioned to be scanned by the reader and on which the biological, chemical or biochemical sample may be located for optical inspection with the transmitted beam.
摘要翻译：用于与能够用光束扫描和读取光盘的光学读取器相关联地进行生物，化学或生物化学样品的光学检查的光盘具有光学透明的基板，其具有半反射层，其反射光束的一部分以形成反射光束并透射光束的一部分以形成透射光束。半反射层包括由读取器读取的用于控制读取器相对于盘的扫描的光学可读编码信息，编码信息提供反射光束的调制。盘包括样品支撑表面，其被定位成由读取器扫描，生物，化学或生物化学样品可以位于该样品支撑表面上，用于与透射光束进行光学检查。

10. 发明授权

US07087203B2 Methods and apparatus for blood typing with optical bio-disc 失效
标题翻译：用光学生物盘进行血型分析的方法和装置
公开(公告)号：US07087203B2
公开(公告)日：2006-08-08
申请号：US09988850
申请日：2001-11-19
申请人： John Francis Gordon , Susan Newcomb Hurt , David Samuel Cohen
发明人： John Francis Gordon , Susan Newcomb Hurt , David Samuel Cohen
IPC分类号： C12M1/34
CPC分类号： G01N33/80 , Y10T436/111666
摘要： This invention relates to clinical diagnostic assays and related optical bio-discs and a disc-reading apparatus. The invention is directed to a method for determining the blood cell type of an individual.
摘要翻译：本发明涉及临床诊断测定和相关的光学生物盘和盘读取装置。本发明涉及一种用于确定个体血细胞类型的方法。

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