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    • 8. 发明授权
    • Asymmetric bidentate silanes
    • 不对称双齿硅烷
    • US5869724A
    • 1999-02-09
    • US879541
    • 1997-06-20
    • Joseph J. KirklandJohn B. Adams, Jr.
    • Joseph J. KirklandJohn B. Adams, Jr.
    • B01D15/08B01J20/32C07F7/10C08K9/06
    • C07F7/10B01D15/08B01D15/20B01J20/286B01J20/3227B01J20/3257B01J20/3259C08K9/06Y10T428/2991Y10T428/2993Y10T428/2995Y10T428/2996Y10T428/2998Y10T428/31663
    • The present invention provides asymmetric bidentate silane reagents from modifying the surface of liquid chromatography supports, the supports and methods of making and using the same. When bonded to the surface of a support material, the resulting modified support material provides improved properties, such as better separations and more stable support materials, especially when used in liquid chromatography. These bidentate silanes have the general structure: R.sub.1 SiMe(NMe.sub.2)--(CH.sub.2).sub.n --SiMeR.sub.2 (NMe.sub.2). R.sub.1 is an alkyl group having from 1 to 30 carbon atoms, and R.sub.2 is an alkyl group having from 8 to 18 carbon atoms. R.sub.1 is a different alkyl group than R.sub.2. Me is a methyl group, and n has a value 2 or 3. In certain embodiments, R.sub.2 includes at least one functional group. When reacted with a silica surface, the resulting modified surface has a structure: PSiO--�R.sub.1 SiMe--(CH.sub.2).sub.n --SiMeR!--OSiP. PSiO is a surface reacted silica.
    • 本发明提供了改变液相色谱支架表面的不对称双齿硅烷试剂,其制备和使用方法。 当结合到支撑材料的表面时,所得到的改性载体材料提供改进的性能,例如更好的分离和更稳定的载体材料,特别是当用于液相色谱时。 这些二齿硅烷具有通式结构:R1SiMe(NMe2) - (CH2)n-SiMeR2(NMe2)。 R1是具有1至30个碳原子的烷基,R2是具有8至18个碳原子的烷基。 R1是不同于R2的烷基。 Me是甲基,n的值为2或3.在某些实施方案中,R 2包括至少一个官能团。 当与二氧化硅表面反应时,得到的改性表面具有以下结构:PSiO- [R 1 SiMe-(CH 2)n -SiMeR] -OSiP。 PSiO是表面反应二氧化硅。