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    • 2. 发明授权
    • Automated system and method for simultaneously performing a plurality of signal-based assays
    • 用于同时执行多个基于信号的测定的自动系统和方法
    • US07427380B2
    • 2008-09-23
    • US10836425
    • 2004-05-03
    • John A. McNeilMichael Anthony AkongDonald James MierzeskiGonul VelicelebiDavid Philip Karlton
    • John A. McNeilMichael Anthony AkongDonald James MierzeskiGonul VelicelebiDavid Philip Karlton
    • B01L3/00
    • G01N35/0099B01J2219/00315B01J2219/00585B01J2219/00659B01J2219/00689B01J2219/00695B01J2219/00702C40B60/14G01N33/5302G01N33/5304G01N35/0092G01N35/028G01N35/1065G01N2035/00752G01N2035/0093Y10T436/115831
    • An automated detection system includes a robotic fluid handling system for performing a plurality of assays; a detection system for imaging the assays as they are performed; and a computer control, data acquisition, and data analysis system for controlling the operation of the fluid-handling and detection system and for collecting and analyzing imaging data. The automated detection system comprises a pipettor for simultaneously distributing a predetermined amount of a liquid and a signal-generating element to each of the plurality of wells; an excitation source for simultaneously exposing the wells to excitation radiation; a detector for simultaneously detecting signal emitted from each of the wells over a period of time comprising a single imager for optically imaging the plurality of wells simultaneously; and computerized controller for simultaneously coordinating the pipettor, the excitation source, and the detector. Further, a method for performing simultaneous assays includes the steps of simultaneously distributing a predetermined amount of a liquid solution to each of a plurality of samples, simultaneously exposing the wells to excitation radiation, simultaneously detecting signals emitted from the wells using a detector comprising a single imaging means, and simultaneously controlling and coordinating the distribution, excitation, and detection using a computerized controller.
    • 一种自动化检测系统,包括用于执行多个测定的机器人流体处理系统; 用于在进行测定时对分析进行成像的检测系统; 以及用于控制流体处理和检测系统的操作并用于收集和分析成像数据的计算机控制,数据采集和数据分析系统。 该自动检测系统包括移液器,用于同时将预定量的液体和信号产生元件分配到多个孔中的每一个; 用于同时将阱暴露于激发辐射的激发源; 检测器,用于同时检测在一段时间内从每个孔发射的信号,包括单个成像器,用于同时对多个孔进行光学成像; 和计算机控制器,用于同时协调移液器,激发源和检测器。 此外,用于执行同时测定的方法包括以下步骤:将预定量的液体溶液分配到多个样品中的每一个,同时将孔暴露于激发辐射,同时使用检测器检测从孔发射的信号,所述检测器包括单个 成像装置,并且使用计算机控制器同时控制和协调分布,激励和检测。
    • 3. 发明授权
    • Flash economizer
    • 闪光节能器
    • US4732590A
    • 1988-03-22
    • US7609
    • 1987-01-28
    • John A. McNeil
    • John A. McNeil
    • F22D1/18B01D51/00
    • F22D1/18
    • A flash economizer employing an enclosed upright container has upper, intermediate and lower chambers for flashing pressurized blowdown effluent in the nature of moisture-contaminated steam. It is constructed to initially separate and remove pure steam in its upper so-called flashing chamber and to thereafter maximize, principally in the intermediate chamber, an indirect transfer of heat from the remaining heat-containing condensate or water to a clean effluent, such as make-up water. An upwardly spiraled tubing array positioned about and along the intermediate chamber receives the clean effluent and advances it in an upwardly spiraled counterclockwise path therealong, while the heat-containing condensate is directed in a downflow, counter or clockwise-spiraled path along the tubing array. The tubing array is carried by an enclosing support structure that defines a spiral downflow path for the heated condensate therealong and therabout. Enlarged inlet and outlet tubing members extend into and along the lower and into the intermediate chamber in a spaced relation with respect to each other, with the outlet or return tubing member extending along an inner periphery of the tubing array and along a substantially central supporting structure about which the array extends within the intermediate chamber. Downflow of heated condensate is proportioned to maintain a full spiral downflow within the enclosing structure along the tubing array while providing a central downflow along the inside of the central supporting structure.
    • 使用封闭的直立容器的闪蒸节能器具有用于在潮湿污染的蒸汽的性质中闪蒸加压排污流出物的上部,中间和下部室。 它被构造成在其上部所谓的闪蒸室中首先分离并除去纯蒸汽,然后主要在中间室中最大限度地将热量从剩余的含水冷凝物或水间接转移到清洁的流出物,例如 化妆水。 围绕并沿着中间室定位的向上旋转的管道阵列接收干净的流出物,并沿着其沿着向上旋转的逆时针路径前进,同时含冷凝物沿着管道阵列被引导在下流,逆向或顺时针旋转的路径中。 管道阵列由封闭的支撑结构承载,该支撑结构限定了用于其上的加热的冷凝物的螺旋下降流动路径和热管。 扩大的入口管和出口管构件相对于彼此以间隔开的关系延伸进入并沿着下部和下部中间室,其中出口或回流管构件沿着管道阵列的内周延伸并沿着基本上中心的支撑结构 阵列围绕该阵列在中间室内延伸。 加热的冷凝物的下流成比例,以沿着管道阵列保持封闭结构内的完全螺旋下降流动,同时沿中心支撑结构的内部提供中心向下流动。
    • 4. 发明授权
    • Method and apparatus for aligning a diffraction grating for tuning the
output of a laser
    • 用于对准用于调谐激光器的输出的衍射光栅的方法和装置
    • US4815820A
    • 1989-03-28
    • US860930
    • 1986-05-08
    • John A. McNeilRobin A. Reeder
    • John A. McNeilRobin A. Reeder
    • G02B7/00G02B5/18H01S20060101H01S3/08H01S3/086H01S3/1055G02B27/44G01J3/18H01S3/10
    • H01S3/08009G02B5/1828G02B7/003H01S3/086Y10S359/90
    • A method and improved apparatus for aligning a diffraction grating, as, for example, one used in tuning the output of a laser. The total angular misalignment .epsilon. between the incident and diffracted beams is a function of three angles: the tuning angle .theta.16, the angle of tilt .beta. between the plane of the grating 15 and the tuning rotational axis, and the angle .alpha. between the grating lines and the projection of the turning rotational axis in the plane of the grating 15. The present invention provides a method of aligning the diffraction grating so that the residual alignment error is very small over the desired range of tuning angle .theta. 16, by adjusting only .alpha. or only .beta. to zero at two reference tuning angles .theta..sub.0 and .theta..sub.1. Knowledge of the value of either .alpha. or .beta. is not necessary. For a CO.sub.2 laser tuned over the wavelength range 9.11 to 10.88 .mu.m, calculations show that the present method grating alignment results in a residual angular misalignment error .epsilon. of less than 60 .mu.rads, when .alpha. is close to 12,000 .mu.rads and .beta. is equal to 10,000 .mu.rads. Since adjustment of only .alpha. or .beta. is necessary in minimizing the total misalignment, an improved apparatus for aligning diffraction gratings consists of providing means for adjusting only one of the two angles .alpha. and .beta. in addition to the tuning angle .theta..
    • 用于对准衍射光栅的方法和改进的装置,例如用于调谐激光器的输出的方法和改进的装置。 入射光束和衍射光束之间的总角度偏移ε是三个角度的函数:调谐角度θ16,光栅15的平面与调谐旋转轴线之间的倾斜角β以及光栅线之间的角度α 以及旋转旋转轴在光栅15的平面中的投影。本发明提供了一种使衍射光栅对准的方法,使得在调谐角度θ16的期望范围上的残留对准误差非常小,仅通过调节α 或者在两个参考调谐角θ0和θ1处仅β为零。对于α或β的值的知识是不必要的。 对于在9.11至10.88μm波长范围内调谐的CO2激光器,计算表明,当Alpha方法接近12,000μA,并且β等于时,本方法光栅对准会产生小于60μA的残余角度偏移误差ε 至10,000亩。 由于仅使α或β的调整对于最小化总体未对准是必要的,所以用于对准衍射光栅的改进的装置包括提供除了调谐角θ之外仅调整α和β两个角度之一的装置。
    • 6. 发明授权
    • Method and apparatus for protecting vehicles and personnel against incoming projectiles
    • 保护车辆和人员防止入射弹的方法和装置
    • US07954411B2
    • 2011-06-07
    • US11660246
    • 2006-04-26
    • Jefferson E OdhnerJohn A. McNeilGeoffrey P. Smyton
    • Jefferson E OdhnerJohn A. McNeilGeoffrey P. Smyton
    • B64D1/04
    • F41H11/02F41H5/007F42B30/00
    • A projector of multiple skewed light planes or sheets is located adjacent a vehicle to be protected and detectors are arranged to detect the penetration of the light sheets by an incoming object, with the time intervals between the piercing of the planes defining the path of the incoming object and its expected impact time. An array of bullet-firing barrels is arranged to project bullets in an iron curtain under control of a fire control module that fires a round in a barrel above the projected flight path such that the round impacts the nose of the object and disables it. It is thus the piercing of the skewed light sheets that provides information as to the impact point of the object as well as its time of arrival so that a round can be fired to intercept the object as it arrives at the iron curtain.
    • 多个倾斜的光平面或片材的投影仪位于待保护的车辆附近,并且检测器被布置成检测入射物体对光片的穿透,其中穿透平面之间的时间间隔限定入射的路径 对象及其预期的影响时间。 安排了一批发射炮弹,在火焰控制模块的控制下,在铁窗帘中投射子弹,该火焰控制模块在投影飞行路径上方的枪管中圆形闪光,使得圆形物撞击物体的鼻部并将其禁用。 因此,倾斜的光片的穿透提供了关于物体的撞击点及其到达时间的信息,使得当物体到达铁幕时可以发射圆形以拦截物体。
    • 8. 发明授权
    • Flash economizer for variable loads
    • 闪存经济学家可变负载
    • US3693324A
    • 1972-09-26
    • US3693324D
    • 1972-02-09
    • JOHN A MCNEIL
    • MCNEIL JOHN A
    • F22B3/04B01D19/00
    • F22B3/04
    • Apparatus is provided for separting out pure flash or dry steam from a blowdown effluent discharge and, at the same time, for recovering a maximum amount of heat from and cooling the liquid content of the effluent to enable directly discharging the liquid into a natural body of water. The apparatus has an elongated main chamber-defining container or vessel provided with a vortex outlet for the steam in its upper area, an intermediate separation area, a heat exchange coil and baffle assembly within a bottom liquid collecting area, and pressure-sensitive trap means connected between lower and intermediate areas within the container for maintaining an effective and efficient operation under variable pressures and flow rates of introduction of the effluent.
    • 提供了用于从排污流出物排出的纯闪蒸或干蒸汽分离的装置,同时用于从流出物中回收最大量的热量并冷却流出物的液体含量,以使液体直接排放到 水。 该装置具有细长的主室限定容器或容器,该容器或容器设置有用于其上部区域中的蒸汽的涡流出口,在底部液体收集区域内的中间分离区域,热交换盘管和挡板组件以及压敏捕集装置 连接在容器内的下部和中间区域之间,用于在不同的压力和流出物的引入流速下保持有效和有效的操作。
    • 9. 发明授权
    • Flash economizer
    • 闪电经济
    • US3668838A
    • 1972-06-13
    • US3668838D
    • 1970-12-07
    • DALPH C MCNEILJOHN A MCNEIL
    • MCNEIL DALPH CMCNEIL JOHN A
    • B01D3/06F22B3/04B01D19/00
    • F22B3/04B01D3/06Y02P70/34
    • Apparatus and procedure are provided for, in one device or apparatus unit, effectively separating out pure flash or steam from a blow-down discharge and simultaneously effectively recovering heat from the blow-down discharge and, particularly from the more dense portions thereof. Flash separation is accomplished in an upper portion of an enclosed elongated container, condensate recovery and circulation are accomplished in a lower portion, and pressure reduction and heat recovery are principally accomplished in a baffle arch area below the flash separation. The liquid or condensate as discharged from the container has a minimized temperature such that it can be directly discharged into a sewage system without tempering it with and wasting added cooling water. A maximized efficiency of cooling and heat recovery are accomplished in the same container with an efficient to a maximum recovery of pure steam or flash.
    • 提供了一种设备和程序,用于在一个设备或设备单元中,有效地从吹出排放物中分离出纯闪蒸或蒸汽,并同时有效地从吹出排放中回收热量,特别是从其更致密的部分回收热量。 在封闭的细长容器的上部完成闪蒸分离,冷凝物回收和循环在下部完成,减压和热回收主要在闪蒸分离之下的挡板拱区中实现。 从容器排出的液体或冷凝物具有最小化的温度,使得其可以直接排放到污水系统中,而不会使其回火并浪费添加的冷却水。 冷却和热回收的最大化效率在相同的容器中实现,有效地最大限度地回收纯蒸汽或闪蒸。