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1. 发明申请

US20130245025A1 Compounds that modulate intracellular calcium 审中-公开
公开(公告)号：US20130245025A1
公开(公告)日：2013-09-19
申请号：US13733795
申请日：2013-01-03
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： C07D333/38 , C07D471/04 , C07D417/12 , C07D409/12 , C07D495/04 , C07D413/12 , C07D491/048
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

2. 发明申请

US20110166159A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 失效
公开(公告)号：US20110166159A1
公开(公告)日：2011-07-07
申请号：US13050356
申请日：2011-03-17
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/497 , C07D409/04 , A61K31/381 , C07D401/04 , A61K31/4436 , C07D403/04 , A61K31/506 , A61K31/405 , A61K31/4184 , C07D417/14 , A61K31/428 , C07D401/14 , A61K31/4709 , A61K31/4155 , A61K31/4535 , A61P1/00 , A61P19/02 , A61P3/10 , A61P25/28 , A61P17/06 , A61P37/06 , A61P7/06
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

3. 发明授权

US07906553B2 Substituted thiophene modulators of intracellular calcium 有权
标题翻译：细胞内钙的取代噻吩调节剂
公开(公告)号：US07906553B2
公开(公告)日：2011-03-15
申请号：US12548189
申请日：2009-08-26
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/38
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds of Formula (I) having the structure: where A, J, R1, R4, Z and X are described herein; and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译：本文描述了具有以下结构的式（I）的化合物：其中A，J，R 1，R 4，Z和X在本文中描述; 和含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

4. 发明授权

US07820397B2 Methods of modulating and identifying agents that modulate intracellular calcium 有权
标题翻译：调节和鉴定调节细胞内钙的药物的方法
公开(公告)号：US07820397B2
公开(公告)日：2010-10-26
申请号：US12388791
申请日：2009-02-19
申请人： Jack Roos , Kenneth A. Stauderman , Gonul Velicelebi , Paul J. Digregorio , Kari Lynn Ohlsen
发明人： Jack Roos , Kenneth A. Stauderman , Gonul Velicelebi , Paul J. Digregorio , Kari Lynn Ohlsen
IPC分类号： G01N33/53 , C12P21/02 , C07K14/435 , A61K33/06
CPC分类号： G01N33/6872 , C07K14/47 , G01N2500/10
摘要： Methods are provided for identifying agents that modulate intracellular calcium. Also provided are methods of modulating calcium within cells and methods of identifying proteins involved in modulating intracellular calcium.
摘要翻译：提供了用于鉴定调节细胞内钙的试剂的方法。还提供了调节细胞内钙的方法以及鉴定参与调节细胞内钙的蛋白质的方法。

5. 发明申请

US20090137659A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 有权
标题翻译：调节细胞内钙的化合物
公开(公告)号：US20090137659A1
公开(公告)日：2009-05-28
申请号：US12192812
申请日：2008-08-15
申请人： Gonul VELICELEBI , Kenneth A. STAUDERMAN , David P.M. PLEYNET , Song CHENG , Jeffrey P. WHITTEN
发明人： Gonul VELICELEBI , Kenneth A. STAUDERMAN , David P.M. PLEYNET , Song CHENG , Jeffrey P. WHITTEN
IPC分类号： A61K31/381 , C12N5/06 , C07D409/12 , C07D333/36
CPC分类号： C07D333/68 , A61K31/00 , A61K31/405
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译：本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

6. 发明申请

US20070031814A1 Methods of modulating and identifying agents that modulate intracellular calcium 有权
标题翻译：调节和鉴定调节细胞内钙的药物的方法
公开(公告)号：US20070031814A1
公开(公告)日：2007-02-08
申请号：US10547720
申请日：2004-03-03
申请人： Jack Roos , Kenneth Stauderman , Gonul Velicelebi , Paul Digregorio , Kari Ohlsen
发明人： Jack Roos , Kenneth Stauderman , Gonul Velicelebi , Paul Digregorio , Kari Ohlsen
IPC分类号： G01N33/20 , C12Q1/00
CPC分类号： G01N33/6872 , C07K14/47 , G01N2500/10
摘要： Methods are provided for identifying agents that modulate intracellular calcium. Also provided are methods of modulating calcium within cells and methods of identifying proteins involved in modulating intracellular calcium.
摘要翻译：提供了用于鉴定调节细胞内钙的试剂的方法。还提供了调节细胞内钙的方法以及鉴定参与调节细胞内钙的蛋白质的方法。

7. 发明授权

US08507269B2 Calcium channel proteins and uses thereof 有权
标题翻译：钙通道蛋白及其用途
公开(公告)号：US08507269B2
公开(公告)日：2013-08-13
申请号：US12127729
申请日：2008-05-27
申请人： Kenneth A. Stauderman , Jack Roos , Gonul Velicelebi
发明人： Kenneth A. Stauderman , Jack Roos , Gonul Velicelebi
IPC分类号： C12N5/00
CPC分类号： G01N33/5008 , G01N33/5076 , G01N33/6872 , G01N2333/705
摘要： Described herein are compositions and uses thereof related to Ca2+ release-activated Ca2+ (CRAC) channel activity. Also described herein CRAC channel modulators for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译：本文描述了与Ca 2+释放激活的Ca2 +（CRAC）通道活性相关的组合物和用途。本文还描述了用于治疗将受益于SOC通道活性抑制的疾病或病症的CRAC通道调节剂。

8. 发明申请

US20120289587A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 有权
公开(公告)号：US20120289587A1
公开(公告)日：2012-11-15
申请号：US13553726
申请日：2012-07-19
申请人： Gonul Velicelebi , Kenneth A. Stauderman , David P.M. Pleynet , Soan Cheng , Jeffrey P. Whitten
发明人： Gonul Velicelebi , Kenneth A. Stauderman , David P.M. Pleynet , Soan Cheng , Jeffrey P. Whitten
IPC分类号： A61K31/381 , A61P13/12 , A61P27/02 , A61P1/16 , A61P11/00 , A61P19/02 , A61P17/06 , A61P1/00 , A61P9/00 , A61P17/00 , A61P21/00 , A61P11/02 , A61P15/02 , A61P19/10 , A61P37/06 , A61P3/10 , A61P37/00 , A61P21/04 , A61P7/06 , A61P11/06 , A61P25/00 , A61P29/00
CPC分类号： C07D333/68 , A61K31/00 , A61K31/405
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

9. 发明申请

US20100261725A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 有权
标题翻译：调节细胞内钙的化合物
公开(公告)号：US20100261725A1
公开(公告)日：2010-10-14
申请号：US12548189
申请日：2009-08-26
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/498 , C07D263/54 , A61K31/423 , C07D471/04 , A61K31/437 , C07D491/048 , A61K31/4355 , C07D495/04 , A61K31/381 , C07D333/36 , C07D217/00 , A61K31/47 , C07D277/62 , A61K31/428 , C07D241/36 , C07D285/06 , A61K31/433 , A61P37/06 , A61P29/00
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译：本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

10. 发明授权

US07427380B2 Automated system and method for simultaneously performing a plurality of signal-based assays 失效
标题翻译：用于同时执行多个基于信号的测定的自动系统和方法
公开(公告)号：US07427380B2
公开(公告)日：2008-09-23
申请号：US10836425
申请日：2004-05-03
申请人： John A. McNeil , Michael Anthony Akong , Donald James Mierzeski , Gonul Velicelebi , David Philip Karlton
发明人： John A. McNeil , Michael Anthony Akong , Donald James Mierzeski , Gonul Velicelebi , David Philip Karlton
IPC分类号： B01L3/00
CPC分类号： G01N35/0099 , B01J2219/00315 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , C40B60/14 , G01N33/5302 , G01N33/5304 , G01N35/0092 , G01N35/028 , G01N35/1065 , G01N2035/00752 , G01N2035/0093 , Y10T436/115831
摘要： An automated detection system includes a robotic fluid handling system for performing a plurality of assays; a detection system for imaging the assays as they are performed; and a computer control, data acquisition, and data analysis system for controlling the operation of the fluid-handling and detection system and for collecting and analyzing imaging data. The automated detection system comprises a pipettor for simultaneously distributing a predetermined amount of a liquid and a signal-generating element to each of the plurality of wells; an excitation source for simultaneously exposing the wells to excitation radiation; a detector for simultaneously detecting signal emitted from each of the wells over a period of time comprising a single imager for optically imaging the plurality of wells simultaneously; and computerized controller for simultaneously coordinating the pipettor, the excitation source, and the detector. Further, a method for performing simultaneous assays includes the steps of simultaneously distributing a predetermined amount of a liquid solution to each of a plurality of samples, simultaneously exposing the wells to excitation radiation, simultaneously detecting signals emitted from the wells using a detector comprising a single imaging means, and simultaneously controlling and coordinating the distribution, excitation, and detection using a computerized controller.
摘要翻译：一种自动化检测系统，包括用于执行多个测定的机器人流体处理系统; 用于在进行测定时对分析进行成像的检测系统; 以及用于控制流体处理和检测系统的操作并用于收集和分析成像数据的计算机控制，数据采集和数据分析系统。该自动检测系统包括移液器，用于同时将预定量的液体和信号产生元件分配到多个孔中的每一个; 用于同时将阱暴露于激发辐射的激发源; 检测器，用于同时检测在一段时间内从每个孔发射的信号，包括单个成像器，用于同时对多个孔进行光学成像; 和计算机控制器，用于同时协调移液器，激发源和检测器。此外，用于执行同时测定的方法包括以下步骤：将预定量的液体溶液分配到多个样品中的每一个，同时将孔暴露于激发辐射，同时使用检测器检测从孔发射的信号，所述检测器包括单个成像装置，并且使用计算机控制器同时控制和协调分布，激励和检测。

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