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1. 发明申请

US20120061259A1 BIOSENSOR AND USAGE THEREOF 有权
标题翻译：生物传感器及其使用
公开(公告)号：US20120061259A1
公开(公告)日：2012-03-15
申请号：US13320903
申请日：2010-05-24
申请人： Jinn-Nan Lin , Chia-Lin Wang , Ziyi Zhang
发明人： Jinn-Nan Lin , Chia-Lin Wang , Ziyi Zhang
IPC分类号： G01N27/327 , G01N33/50
CPC分类号： G01N33/5438 , C12Q1/005 , G01N27/3272
摘要： A biosensor for quantifying an analyte in a sample and usage thereof are provided. The biosensor includes an insulative substrate, a cover, a sample supply port, an electrode system including at least a working electrode, a counter electrode and a third electrode, and a reaction layer at least formed over the working electrode. The third electrode, used for estimating whether the amount of the sample is sufficient, is disposed nearer to the sample supply port than the counter electrode is. Whether the amount of the added sample is sufficient is estimated by comparing the electrical current value detected between the working electrode and the counter electrode with the electrical current value detected between the working electrode and the third electrode. This invention has a simple structure and produces accurate measurements.
摘要翻译：提供了用于量化样品中的分析物的生物传感器及其用途。生物传感器包括绝缘基板，盖子，样品供给口，至少包括工作电极，对电极和第三电极的电极系统以及至少在工作电极上形成的反应层。用于估计样品量是否足够的第三电极设置得比对电极更靠近样品供给口。通过将检测到的工作电极和对电极之间的电流值与在工作电极和第三电极之间检测到的电流值进行比较来估计添加样品的量是否足够。本发明具有简单的结构并产生精确的测量。

2. 发明授权

US07803636B2 Devices for analyte assays with built-in result reporting using recognizable symbols 有权
标题翻译：使用可识别符号的内置结果报告的分析物测定装置
公开(公告)号：US07803636B2
公开(公告)日：2010-09-28
申请号：US11936742
申请日：2007-11-07
申请人： Fei Gao , Shujiang Wu , Huikang Chen , DengFeng Xiong , Jinn-nan Lin , James McMenamy
发明人： Fei Gao , Shujiang Wu , Huikang Chen , DengFeng Xiong , Jinn-nan Lin , James McMenamy
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , Y10S436/808 , Y10S436/81
摘要： The present invention provides devices, methods and kits for detecting the presence of an analyte in a liquid sample. The invention provides devices having a positive control area covered with an opaque, movable material, such as an ink, dye, or other material, that is moved on the device by the flow of liquid sample, thereby exposing the positive control area underneath. Using the interaction of colored signals from the positive control area and the analyte binding area, a recognizable symbol is revealed on the device that correlates with the test results, and appears as the test is conducted.
摘要翻译：本发明提供用于检测液体样品中分析物的存在的装置，方法和试剂盒。本发明提供了具有被不透明的可移动材料（例如墨水，染料或其他材料）覆盖的正面控制区域的装置，其通过液体样品流动在装置上移动，从而暴露下面的正面控制区域。使用来自阳性对照区域和分析物结合区域的彩色信号的相互作用，在与测试结果相关的设备上显示可识别的符号，并且在进行测试时出现。

3. 发明申请

US20060134804A1 Devices and methods for analyte assays with built-in result reporting using recognizable symbols 有权
标题翻译：使用可识别符号的内置结果报告的分析物测定的设备和方法
公开(公告)号：US20060134804A1
公开(公告)日：2006-06-22
申请号：US11016371
申请日：2004-12-17
申请人： Fei Gao , Shujiang Wu , Huikang Chen , DengFeng Xiong , Jinn-nan Lin , James McMenamy
发明人： Fei Gao , Shujiang Wu , Huikang Chen , DengFeng Xiong , Jinn-nan Lin , James McMenamy
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , Y10S436/808 , Y10S436/81
摘要： The present invention provides devices, methods and kits for detecting the presence of an analyte in a liquid sample. The invention provides devices having a positive control area covered with an opaque, movable material, such as an ink, dye, or other material, that is moved on the device by the flow of liquid sample, thereby exposing the positive control area underneath. Using the interaction of colored signals from the positive control area and the analyte binding area, a recognizable symbol is revealed on the device that correlates with the test results, and appears as the test is conducted.
摘要翻译：本发明提供用于检测液体样品中分析物的存在的装置，方法和试剂盒。本发明提供了具有被不透明的可移动材料（例如墨水，染料或其他材料）覆盖的正面控制区域的装置，其通过液体样品流动在装置上移动，从而暴露下面的正面控制区域。使用来自阳性对照区域和分析物结合区域的彩色信号的相互作用，在与测试结果相关的设备上显示可识别的符号，并且在进行测试时出现。

4. 发明申请

US20060040258A1 Water-soluble conjugates and methods of preparation 审中-公开
标题翻译：水溶性偶联物及其制备方法
公开(公告)号：US20060040258A1
公开(公告)日：2006-02-23
申请号：US10924738
申请日：2004-08-23
申请人： Huiyan Guo , Lorraine Bautista , Zurong Wu , Jinn-nan Lin
发明人： Huiyan Guo , Lorraine Bautista , Zurong Wu , Jinn-nan Lin
IPC分类号： C12Q1/70 , G01N33/53 , G01N33/554 , G01N33/569
CPC分类号： G01N33/532
摘要： The present invention provides water-soluble conjugates and methods of using them in diagnostic and detection assays. Devices for performing detection and quantitation assays are also provided. In various embodiments the conjugates are useful in immunoassays and later flow assays. The invention also provides methods of preparing the conjugates that result in higher yields and higher sensitivities for the assays.
摘要翻译：本发明提供水溶性缀合物及其在诊断和检测测定中的使用方法。还提供了用于进行检测和定量测定的装置。在各种实施方案中，缀合物可用于免疫测定和随后的流式测定。本发明还提供了制备结合物的方法，其导致更高的产率和更高的敏感性。

5. 发明授权

US08834702B2 Biosensor and usage thereof 有权
标题翻译：生物传感器及其用途
公开(公告)号：US08834702B2
公开(公告)日：2014-09-16
申请号：US13320903
申请日：2010-05-24
申请人： Jinn-Nan Lin , Chia-Lin Wang , Ziyi Zhang
发明人： Jinn-Nan Lin , Chia-Lin Wang , Ziyi Zhang
IPC分类号： G01N27/327 , G01N33/543 , C12Q1/00
CPC分类号： G01N33/5438 , C12Q1/005 , G01N27/3272
摘要： A biosensor for quantifying an analyte in a sample and usage thereof are provided. The biosensor includes an insulative substrate, a cover, a sample supply port, an electrode system including at least a working electrode, a counter electrode and a third electrode, and a reaction layer at least formed over the working electrode. The third electrode, used for estimating whether the amount of the sample is sufficient, is disposed nearer to the sample supply port than the counter electrode is. Whether the amount of the added sample is sufficient is estimated by comparing the electrical current value detected between the working electrode and the counter electrode with the electrical current value detected between the working electrode and the third electrode. This invention has a simple structure and produces accurate measurements.
摘要翻译：提供了用于量化样品中的分析物的生物传感器及其用途。生物传感器包括绝缘基板，盖子，样品供给口，至少包括工作电极，对电极和第三电极的电极系统以及至少在工作电极上形成的反应层。用于估计样品量是否足够的第三电极设置得比对电极更靠近样品供给口。通过将检测到的工作电极和对电极之间的电流值与在工作电极和第三电极之间检测到的电流值进行比较来估计添加样品的量是否足够。本发明具有简单的结构并产生精确的测量。

6. 发明授权

US07297502B2 Devices and methods for analyte assays with built-in result reporting using recognizable symbols 有权
标题翻译：使用可识别符号的内置结果报告的分析物测定的设备和方法
公开(公告)号：US07297502B2
公开(公告)日：2007-11-20
申请号：US11016371
申请日：2004-12-17
申请人： Fei Gao , Shujiang Wu , Huikang Chen , DengFeng Xiong , Jinn-nan Lin , James McMenamy
发明人： Fei Gao , Shujiang Wu , Huikang Chen , DengFeng Xiong , Jinn-nan Lin , James McMenamy
IPC分类号： B01L3/00 , G01N15/06 , G01N21/77 , G01N33/53 , G01N33/543 , G01N33/558 , G01N33/566 , C12M1/34 , C12M3/00 , C12Q1/00
CPC分类号： G01N33/558 , Y10S436/808 , Y10S436/81
摘要： The present invention provides devices, methods and kits for detecting the presence of an analyte in a liquid sample. The invention provides devices having a positive control area covered with an opaque, movable material, such as an ink, dye, or other material, that is moved on the device by the flow of liquid sample, thereby exposing the positive control area underneath. Using the interaction of colored signals from the positive control area and the analyte binding area, a recognizable symbol is revealed on the device that correlates with the test results, and appears as the test is conducted.
摘要翻译：本发明提供用于检测液体样品中分析物的存在的装置，方法和试剂盒。本发明提供了具有被不透明的可移动材料（例如墨水，染料或其他材料）覆盖的正面控制区域的装置，其通过液体样品流动在装置上移动，从而暴露下面的正面控制区域。使用来自阳性对照区域和分析物结合区域的彩色信号的相互作用，在与测试结果相关的设备上显示可识别的符号，并且在进行测试时出现。

7. 发明授权

US06759190B2 Test strip for detection of analyte and methods of use 有权
标题翻译：用于检测分析物的试纸和使用方法
公开(公告)号：US06759190B2
公开(公告)日：2004-07-06
申请号：US10173457
申请日：2002-06-15
申请人： Jinn-Nan Lin , Chia-Lin Wang
发明人： Jinn-Nan Lin , Chia-Lin Wang
IPC分类号： C12Q100
CPC分类号： G01N33/525 , C12Q1/54 , Y10S435/968 , Y10S435/97
摘要： One aspect of the present invention is a reagent test strip that includes: a) a top support layer including a sample aperture; b) a membrane that includes a reagent system for indicating the concentration of a target; c) a spreading layer; d) a bottom support layer including a measuring port in substantial alignment or approximate alignment with the sample aperture. Preferably, the membrane is affixed to the top support layer. Preferably, the membrane is positioned between the top support layer and the bottom support layer. Preferably, the spreading layer is positioned above the top support layer and in substantial or approximate alignment with the sample aperture. Preferably, a fluid applied to the spreading layer, passes through the sample aperture and contacts the membrane.
摘要翻译：本发明的一个方面是试剂测试条，其包括：a）包括样品孔的顶部支撑层; b）膜，其包括用于指示靶的浓度的试剂系统; c）扩散层; d）底部支撑层，其包括基本对准或与样品孔近似对准的测量口。优选地，膜固定到顶部支撑层。优选地，膜位于顶部支撑层和底部支撑层之间。优选地，扩散层位于顶部支撑层上方并且与样本孔基本上或近似对准。优选地，施加到铺展层的流体通过样品孔并接触膜。

8. 发明授权

US5869349A Immobilization of acid-treated antibodies on siliceous support 失效
标题翻译：酸处理抗体固定在硅质载体上
公开(公告)号：US5869349A
公开(公告)日：1999-02-09
申请号：US626367
申请日：1990-12-12
申请人： Jinn-Nan Lin , Joseph D. Andrade , I-Nan Chang
发明人： Jinn-Nan Lin , Joseph D. Andrade , I-Nan Chang
IPC分类号： C07K16/44 , C07K17/14 , G01N33/543 , G01N33/53 , C07K16/00
CPC分类号： C07K17/14 , C07K16/44 , G01N33/54393
摘要： The antigen-binding activity of an antibody immobilized on a siliceous support can be increased by pretreatment of the antibody with acid prior to its immobilization.
摘要翻译：通过在固定之前用酸预处理抗体可以增加固定在硅质载体上的抗体的抗原结合活性。

9. 发明授权

US07807043B2 Microfluidic test device 有权
标题翻译：微流控测试装置
公开(公告)号：US07807043B2
公开(公告)日：2010-10-05
申请号：US11064524
申请日：2005-02-22
申请人： Fu Hsiung Tsai , Jinn-nan Lin , Chia-Lin Wang
发明人： Fu Hsiung Tsai , Jinn-nan Lin , Chia-Lin Wang
IPC分类号： G01N27/327
CPC分类号： C12Q1/006 , B01L3/5023 , G01N27/3272 , G01N33/5438
摘要： The present invention provides biosensor test devices for measuring the presence or amount of an analyte in a biological fluid. The devices have a base plate that has an electrode system embedded therein, and a hydrophilic porous material situated on the base plate. A hydrophobic protective layer is situated on the hydrophilic porous material, and a cover is placed on the hydrophobic protective layer to complete the device. Some embodiments also use an insulating layer, which can be situated between the base layer and the hydrophilic porous material. The cover of the device has an opening present therein, situated over the electrodes, so that the electrodes communicate with the exterior of the device through the groove. The insulating layer can also have a groove situated therein, which in one embodiment is placed to align with the groove in the cover. The invention also provides methods of manufacturing the devices, and methods of using them.
摘要翻译：本发明提供用于测量生物流体中分析物的存在或量的生物传感器测试装置。这些装置具有嵌入其中的电极系统的基板和位于基板上的亲水性多孔材料。疏水性保护层位于亲水性多孔材料上，并且将覆盖物放置在疏水性保护层上以完成该装置。一些实施例还使用可以位于基底层和亲水性多孔材料之间的绝缘层。该装置的盖具有位于电极上方的开口，使得电极通过凹槽与装置的外部连通。绝缘层还可以具有位于其中的凹槽，其在一个实施例中被放置成与盖中的凹槽对准。本发明还提供了制造装置的方法及其使用方法。

10. 发明申请

US20050234492A1 Lancet device and method of use 审中-公开
标题翻译：柳叶刀装置及使用方法
公开(公告)号：US20050234492A1
公开(公告)日：2005-10-20
申请号：US11081791
申请日：2005-03-15
申请人： Fu Tsai , Jinn-nan Lin , Chia-Lin Wang
发明人： Fu Tsai , Jinn-nan Lin , Chia-Lin Wang
IPC分类号： A61B5/15 , A61B17/32
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150183 , A61B5/150259 , A61B5/150282 , A61B5/150412 , A61B5/150824 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/1519
摘要： The present invention is directed to spring-activated devices and methods for lancing the skin to obtain a small amount of blood for metabolic testing. In one embodiment, the depth penetration of the lancet needle can be seen by the patient during lancing the skin. In another embodiment, the device has only five moving parts for cocking and firing, a plunger, two springs, a slider and a button. In order to reduce manufacturing costs, the number of parts used in the device has been reduced and their configuration has been simplified to reduce construction time, and thereby save on labor costs.
摘要翻译：本发明涉及弹簧激活装置和用于穿刺皮肤以获得少量用于代谢测试的血液的方法。在一个实施例中，在穿刺皮肤期间，患者可以看到柳叶刀针的深度穿透。在另一个实施例中，该装置仅具有五个用于起动和击发的移动部件，一个柱塞，两个弹簧，滑块和按钮。为了降低制造成本，已经减少了装置中使用的部件的数量，并且简化了它们的构造以减少施工时间，从而节省了劳动力成本。

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