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1. 发明授权

US5869349A Immobilization of acid-treated antibodies on siliceous support 失效
标题翻译：酸处理抗体固定在硅质载体上
公开(公告)号：US5869349A
公开(公告)日：1999-02-09
申请号：US626367
申请日：1990-12-12
申请人： Jinn-Nan Lin , Joseph D. Andrade , I-Nan Chang
发明人： Jinn-Nan Lin , Joseph D. Andrade , I-Nan Chang
IPC分类号： C07K16/44 , C07K17/14 , G01N33/543 , G01N33/53 , C07K16/00
CPC分类号： C07K17/14 , C07K16/44 , G01N33/54393
摘要： The antigen-binding activity of an antibody immobilized on a siliceous support can be increased by pretreatment of the antibody with acid prior to its immobilization.
摘要翻译：通过在固定之前用酸预处理抗体可以增加固定在硅质载体上的抗体的抗原结合活性。

2. 发明授权

US06501549B1 Method of measuring chemical concentration based on spatial separation and resolution of luminescence 失效
标题翻译：基于空间分离和发光分辨率测量化学浓度的方法
公开(公告)号：US06501549B1
公开(公告)日：2002-12-31
申请号：US09077694
申请日：1998-12-03
申请人： Joseph D. Andrade , Chung-Yih Wang , Vladimir Hlady , Philip M. Triolo , Robert J. Scheer
发明人： Joseph D. Andrade , Chung-Yih Wang , Vladimir Hlady , Philip M. Triolo , Robert J. Scheer
IPC分类号： G01B1100
CPC分类号： G01N21/763 , G01N21/6456 , G01N21/76
摘要： A method and associated apparatus for measuring chemical concentration in a liquid sample based on spatial separation and resolution of light is disclosed. The method is preferably applied to sensitive, quantitative, luminescence-based biosensors which reads the analyte concentration via spatial distribution of the emitted light. The detection of light is used to assess the spatial position, rather than the intensity or wavelength, of emitted light. A bioluminescent or chemiluminescent reaction requiring, for example, ATP, NADPH or NADH as a specific, and sensitive co-factor is used. ATP or NADH concentration is modulated, “tuned,” and/or regulated via, for example, an enzyme which consumes (“consumase”) ATP, NADPH, or NADH, thereby producing a spatial distribution of ATP or NADH and a spatial distribution in the emitted light. By appropriate control of the consumase or “synthase” activity and kinetics, a sensitive, specific, and easily readable luminescent pattern is produced, permitting detection.
摘要翻译：公开了一种基于空间分离和光分辨率来测量液体样品中化学浓度的方法和相关装置。该方法优选地应用于通过发射光的空间分布读取分析物浓度的灵敏的，定量的，基于发光的生物传感器。光的检测用于评估发射光的空间位置，而不是强度或波长。使用需要例如ATP，NADPH或NADH作为特异性和敏感辅因子的生物发光或化学发光反应。 ATP或NADH浓度通过例如消耗（“消耗”）ATP，NADPH或NADH的酶“调节”和/或调节，由此产生ATP或NADH的空间分布和空间分布发出的光。通过适当控制消耗或“合成酶”活性和动力学，产生敏感，特异且容易读取的发光图案，允许检测。

3. 发明授权

US07473244B2 Active needle devices with integrated functionality 有权
标题翻译：具有集成功能的主动针装置
公开(公告)号：US07473244B2
公开(公告)日：2009-01-06
申请号：US10258011
申请日：2001-06-01
申请人： A. Bruno Frazier , Joseph D. Andrade , Daniel A. Bartholomeusz , John D. Brazzle
发明人： A. Bruno Frazier , Joseph D. Andrade , Daniel A. Bartholomeusz , John D. Brazzle
IPC分类号： A61M5/32 , A61B5/05
CPC分类号： A61M37/0015 , A61M2037/003 , A61M2037/0038 , A61M2037/0053
摘要： An active needle device for fluid injection or extraction includes at least one hollow elongated shaft defining at least one channel. The channel provides communication between at least one input port and at least one output port of the needle device. At least one active component such as a sensor or actuator is placed or integrated into the elongated shaft. The needle device can include a macroneedle, a microneedle, or an array of macroneedles or microneedles. The microneedles can be fabricated on a substrate which can remain attached to the microneedles or be subsequently removed. The active component can facilitate biochemical, optical, electrical, or physical measurements of a fluid injected or extracted by the needle device.
摘要翻译：用于流体注射或提取的主动针装置包括限定至少一个通道的至少一个中空细长轴。通道提供至少一个输入端口和针装置的至少一个输出端口之间的通信。至少一个有源部件，例如传感器或致动器被放置或集成到细长轴中。针装置可以包括一个大针，一个微针，或一个大针或微针的阵列。微针可以在可以保持连接到微针上或随后去除的基底上制造。活性组分可促进由针装置注入或提取的流体的生物化学，光学，电学或物理测量。

4. 发明授权

US4368047A Process for conducting fluorescence immunoassays without added labels and employing attenuated internal reflection 失效
标题翻译：用于进行荧光免疫测定而没有添加标记并使用衰减内反射的方法
公开(公告)号：US4368047A
公开(公告)日：1983-01-11
申请号：US257838
申请日：1981-04-27
申请人： Joseph D. Andrade , Richard Van Wagenen
发明人： Joseph D. Andrade , Richard Van Wagenen
IPC分类号： G01N21/64 , G01N33/58 , G01N33/54 , G01N31/06
CPC分类号： G01N33/582 , G01N33/58 , Y10S436/805 , Y10S436/815 , Y10S436/816 , Y10S436/817
摘要： A process is presented for conducting fluorescence immunoassays without the use of added labels by utilizing ultraviolet radiation and internal reflection optics to activate fluorescent groups present in the molecules of interest. The assay is accomplished by directing a beam of light having wavelengths in the ultraviolet region to a solid liquid interface which (1) has a material X immobilized thereon, and (2) is contacted with an assay solution containing in unknown Y which contains intrinsic tyrosine, tryptophan, nucleic acid or related fluorescence groups which are activated by wavelengths in the ultraviolet region; X and Y may be in the relationship of antibody and antigen in that one had the ability of recognizing the particular spatial and polar configuration of the other and is attracted to and bound to such configuration, said beam of ultraviolet light being projected under such conditions that there is internal reflection at the interface, and then measuring the amount of fluorescence emitted from the surface of the interface, the amount of the fluorescence emission being a function of the amount of the unknown Y being detected. In the event that Y is not fluorescent, the X-Y sandwich can be further exposed to a solution containing X, to form XYX sandwich. The observed fluorescence of X is proportional to the amount of bound Y which is in turn related to the solution concentration of Y.
摘要翻译：呈现用于进行荧光免疫测定的方法，而不使用通过利用紫外线辐射和内部反射光学器件来添加目标分子中的荧光基团的添加的标记物。该测定通过将具有紫外线区域的波长的光束引导到固体液体界面来实现，该固体液体界面（1）具有固定在其上的材料X，和（2）与含有未知Y的测定溶液接触，所述测定溶液含有内在酪氨酸，色氨酸，核酸或由紫外线区域中的波长激活的相关荧光基团; X和Y可以是抗体和抗原的关系，因为它们具有识别另一个的特定空间和极性构型并被吸引并结合到这种构型的能力，所述紫外线束在以下条件下投射：在界面处存在内部反射，然后测量从界面的表面发射的荧光量，荧光发射量是被检测的未知Y的量的函数。在Y不是荧光的情况下，可以将X-Y三明治进一步暴露于含有X的溶液中以形成XYX三明治。观察到的X的荧光与结合的Y的量成比例，这又与Y的溶液浓度有关。

5. 发明授权

US5075400A Polymer supersurfactants for protein resistance and protein removal 失效
标题翻译：聚合物超表面活性剂用于蛋白质抗性和蛋白质去除
公开(公告)号：US5075400A
公开(公告)日：1991-12-24
申请号：US493215
申请日：1990-03-14
申请人： Joseph D. Andrade , Jindrich Kopecek , Jin H. Lee
发明人： Joseph D. Andrade , Jindrich Kopecek , Jin H. Lee
IPC分类号： C08F220/18 , C08F20/22 , C08F20/52 , C08F26/10 , C08F220/28 , C08F220/56 , C08F226/10 , C08F290/00 , C08F299/02
CPC分类号： C08F220/28
摘要： The invention discloses the processes and materials for treating materials to minimize the deposition of proteins and other molecules, and for removing proteins and other molecules from materials. New copolymers containing polyethylene oxide sidechains called supersurfactants have the ability to bind themselves to interfaces to provide a stable protein-resistant interface. A process is presented to treat and modify interfaces with the new copolymers.
摘要翻译：本发明公开了用于处理材料以最小化蛋白质和其他分子的沉积以及从材料中去除蛋白质和其它分子的方法和材料。含有称为超表面活性剂的聚环氧乙烷侧链的新共聚物具有将其自身与界面结合以提供稳定的蛋白质抗性界面的能力。提出了一种处理和修饰与新共聚物的界面的方法。

6. 发明申请

US20090069697A1 ACTIVE MICRONEEDLES AND MICRONEEDLE ARRAYS 审中-公开
标题翻译：主动麦克风和麦克风阵列
公开(公告)号：US20090069697A1
公开(公告)日：2009-03-12
申请号：US12273470
申请日：2008-11-18
申请人： A. Bruno Frazier , Joseph D. Andrade , Daniel A. Bartholomeusz , John D. Brazzle
发明人： A. Bruno Frazier , Joseph D. Andrade , Daniel A. Bartholomeusz , John D. Brazzle
IPC分类号： A61B6/00 , A61M5/32
CPC分类号： A61M37/0015 , A61M2037/003 , A61M2037/0038 , A61M2037/0053
摘要： An active needle device for fluid injection or extraction includes at least one hollow elongated shaft defining at least one channel. The channel provides communication between at least one input port and at least one output port of the needle device. At least one active component such as a sensor or actuator is placed or integrated into the elongated shaft. The needle device can include a macroneedle, a microneedle, or an array of macroneedles or microneedles. The microneedles can be fabricated on a substrate which can remain attached to the microneedles or be subsequently removed. The active component can facilitate biochemical, optical, electrical, or physical measurements of a fluid injected or extracted by the needle device.
摘要翻译：用于流体注射或提取的主动针装置包括限定至少一个通道的至少一个中空细长轴。通道提供至少一个输入端口和针装置的至少一个输出端口之间的通信。至少一个有源部件，例如传感器或致动器被放置或集成到细长轴中。针装置可以包括一个大针，一个微针，或一个大针或微针的阵列。微针可以在可以保持连接到微针上或随后去除的基底上制造。活性组分可促进由针装置注入或提取的流体的生物化学，光学，电学或物理测量。

7. 再颁专利

USRE34153E Molecular gas analysis by Raman scattering in intracavity laser configuration 失效
公开(公告)号：USRE34153E
公开(公告)日：1992-12-29
申请号：US560027
申请日：1990-07-25
申请人： Robert E. Benner , Joseph D. Andrade , Richard A. Van Wagenen , Dwayne R. Westenskow
发明人： Robert E. Benner , Joseph D. Andrade , Richard A. Van Wagenen , Dwayne R. Westenskow
IPC分类号： G01J3/12 , G01J3/44 , G01N21/39 , G01N21/65
CPC分类号： G01N21/65 , G01J2003/123 , G01J3/44 , G01N2021/391
摘要： The concentration of multiple polyatomic gases are determined almost simultaneously by Raman scattering. The gas sample is placed in a sampling cell located in the resonance cavity of a laser and a polarized laser beam having sufficient intensity to produce detectable signals of Raman scattered light is passed through the cell. The scattered light is captured and redirected by means of a reflection mirror located parallel to the axis of the laser beam adjacent to and outside of the cell. Signals of both inelastic Raman scattered light and elastic laser scattered light are collected by a collection lens means opposite the reflection mirror and outside the gas cell. The collection lens is also parallel to the axis of the laser beam. The collected scattered signals are directed onto a laser line rejection filter where the scattered elastic laser signals are filtered out and the inelastic Raman scattered signals are transmitted to come in contact with a rotating filter wheel containing a series of interference filters with each filter being specific to the transmission of one Raman line. The Raman lines passing through the rotating filters are sensed sequentially by a single detector means and amplified and converted into digital electrical pulses which are processed and converted into visual readouts indicative of the concentration of each of the polyatomic molecules in the gas being determined.

8. 发明授权

US5135876A Method and apparatus for the regulation of complex binding 失效
标题翻译：用于调节复合物结合的方法和装置
公开(公告)号：US5135876A
公开(公告)日：1992-08-04
申请号：US100935
申请日：1987-09-24
申请人： Joseph D. Andrade , James Herron
发明人： Joseph D. Andrade , James Herron
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , Y10S436/805
摘要： A reusable biosensor is disclosed. A molecule containing a moiety of an antibody-antigen complex and photosensitive polymers are bonded to an optical conduit. When placed in a solution, the presence or absence of a second complementary moiety of an antibody-antigen complex can be determined by sensing whether or not the first moiety is complexed. The first moiety of an antibody-antigen complex can then be regenerated by transmitting light through the optical conduit which alters the structure of the photosensitive polymers to cause interference with said complex, thereby dissociating the second complementary moiety from the first moiety. The ability to regulate and control specific binding has applications can be useful in information storage devices, bioorganic electronic devices, and optical devices.
摘要翻译：公开了可重复使用的生物传感器。含有抗体 - 抗原复合物部分和感光性聚合物的分子被结合到光导管上。当置于溶液中时，抗体 - 抗原复合物的第二互补部分的存在或不存在可以通过检测第一部分是否复合来确定。抗体 - 抗原复合物的第一部分然后可以通过透过光导管来再生，该光导管改变光敏聚合物的结构以引起与所述复合物的干扰，从而使第二互补部分与第一部分解离。调节和控制特异性结合的能力可用于信息存储设备，生物有机电子设备和光学设备中。

9. 发明授权

US4648714A Molecular gas analysis by Raman scattering in intracavity laser configuration 失效
标题翻译：通过拉曼散射在腔内激光配置中的分子气体分析
公开(公告)号：US4648714A
公开(公告)日：1987-03-10
申请号：US774643
申请日：1985-09-11
申请人： Robert E. Benner , Joseph D. Andrade , Richard A. Van Wagenen , Dwayne R. Westenskow
发明人： Robert E. Benner , Joseph D. Andrade , Richard A. Van Wagenen , Dwayne R. Westenskow
IPC分类号： G01J3/12 , G01J3/44 , G01N21/39 , G01N21/65 , H01S3/108
CPC分类号： H01S3/1086 , G01N21/65 , G01J2003/123 , G01J3/44 , G01N2021/391
摘要： The concentration of multiple polyatomic gases are determined almost simultaneously by Raman scattering. The gas sample is placed in a sampling cell located in the resonance cavity of a laser and a polarized laser beam having sufficient intensity to produce detectable signals of Raman scattered light is passed through the cell. The scattered light is captured and redirected by means of a reflection mirror located parallel to the axis of the laser beam adjacent to and outside of the cell. Signals of both inelastic Raman scattered light and elastic laser scattered light are collected by a collection lens means opposite the reflection mirror and outside the gas cell. The collection lens is also parallel to the axis of the laser beam. The collected scattered signals are directed onto a laser line rejection filter where the scattered elastic laser signals are filtered out and the inelastic Raman scattered signals are transmitted to come in contact with a rotating filter wheel containing a series of interference filters with each filter being specific to the transmission of one Raman line. The Raman lines passing through the rotating filters are sensed sequentially by a single detector means and amplified and converted into digital electrical pulses which are processed and converted into visual readouts indicative of the concentration of each of the polyatomic molecules in the gas being determined.
摘要翻译：多重多原子气体的浓度几乎同时由拉曼散射确定。将气体样品放置在位于激光器的共振腔中的采样单元中，并且具有足够强度以产生可拉曼散射光的可检测信号的偏振激光束通过该单元。散射光被平行于与电池相邻并且在电池外部的激光束的轴线平行的反射镜捕获并重定向。无弹性拉曼散射光和弹性激光散射光的信号通过与反射镜相对的收集透镜装置和气室的外部收集。收集透镜也平行于激光束的轴线。收集的散射信号被引导到激光线抑制滤波器，其中散射的弹性激光信号被滤出，并且非弹性拉曼散射信号被传输以与包含一系列干涉滤光器的旋转滤光轮接触，每个滤光器特定于一条拉曼线的传输。通过旋转滤波器的拉曼线路被单个检测器装置依次检测，并被放大并转换成数字电脉冲，这些电脉冲被处理并转换成指示所确定的气体中每个多原子分子的浓度的视觉读数。

10. 发明授权

US4508606A Process for treating polymer surfaces to reduce their friction resistance characteristics when in contact with non-polar liquid, and resulting products 失效
标题翻译：用于处理聚合物表面以在与非极性液体接触时产生的摩擦阻力特性以及所得产物的方法降低
公开(公告)号：US4508606A
公开(公告)日：1985-04-02
申请号：US495209
申请日：1983-05-16
申请人： Joseph D. Andrade , Philip M. Triolo , Lee M. Smith , Frank J. Miller
发明人： Joseph D. Andrade , Philip M. Triolo , Lee M. Smith , Frank J. Miller
IPC分类号： B29C59/14 , C08J5/16
CPC分类号： C08J7/123 , B29C59/14
摘要： Surfaces of hydrophobic polymers are treated to reduce their friction resistance characteristics when in contact with an aqueous environment by exposing the surfaces to an oxidation treatment, preferably by use of radio frequency glow discharge. This oxidation is followed by exposure to atmospheric air, until there is a substantial reduction in the air-water contact angle of the surfaces. The reduced friction resistance characteristics are important in aqueous applications where there is movement between the surfaces of two polymeric materials, such as in double slideable catheters and similar medical products. This process also provides lower coefficients of friction for general polymeric products in contact with water and aqueous solutions.
摘要翻译：处理疏水性聚合物的表面以通过将表面暴露于氧化处理（优选通过使用射频辉光放电）与水性环境接触来降低其摩擦阻力特性。这种氧化之后是暴露于大气中，直到表面的空气 - 水接触角显着降低。降低的摩擦阻力特性在水性应用中是重要的，其中在两个聚合物材料的表面之间存在运动，例如在双滑动导管和类似医疗产品中。该方法还为与水和水溶液接触的一般聚合物产品提供较低的摩擦系数。

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