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1. 发明申请

US20150079646A1 GENETICALLY ENGINEERED YEAST CELLS 有权
标题翻译：遗传工程YEAST细胞
公开(公告)号：US20150079646A1
公开(公告)日：2015-03-19
申请号：US14370959
申请日：2012-12-17
申请人： Jens Nielsen , Verena Siewers , Yun Chen , Laurent Daviet , Michel Schalk
发明人： Jens Nielsen , Verena Siewers , Yun Chen , Laurent Daviet , Michel Schalk
IPC分类号： C12N15/81 , C12P7/16 , C12N9/10 , C12N9/04 , C12N9/02 , C12N9/00 , C12P5/00 , C12P7/62
CPC分类号： C12N15/81 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/93 , C12P5/007 , C12P7/16 , C12P7/625 , C12Y101/01002 , C12Y102/01004 , C12Y203/01009 , C12Y602/01001 , Y02E50/10
摘要： The present invention relates to yeast cells producing high levels of acetoacetyl-CoA. It also relates to a method for making such yeast cells and to the use of such yeast cells in a method for producing acetyl-CoA derived products.
摘要翻译：本发明涉及产生高含量乙酰乙酰辅酶A的酵母细胞。本发明还涉及制备这种酵母细胞的方法以及在制备乙酰辅酶A衍生产物的方法中使用这种酵母细胞。

2. 发明授权

US08668702B2 Minimal access tool 有权
标题翻译：最小的访问工具
公开(公告)号：US08668702B2
公开(公告)日：2014-03-11
申请号：US12937523
申请日：2009-04-13
申请人： Shorya Awtar , Jens Nielsen , Tristan Trutna , Andrew Mansfield , Rosa Abani , James Geiger , Patrick Quigley
发明人： Shorya Awtar , Jens Nielsen , Tristan Trutna , Andrew Mansfield , Rosa Abani , James Geiger , Patrick Quigley
IPC分类号： A61B19/00
CPC分类号： A61B17/2909 , A61B34/70 , A61B34/71 , A61B34/75 , A61B34/77 , A61B2017/00323 , A61B2017/00424 , A61B2017/00442 , A61B2017/00464 , A61B2017/2917 , A61B2017/2929 , A61B2017/2931 , A61B2017/2937 , A61B2017/2939 , A61B2017/2944 , A61B2034/306
摘要： A minimal access tool includes a frame arranged to be attached to an arm of a user, a tool shaft having a proximal end and a distal end, where the tool shaft proximal end is connected to the frame. The tool further includes an input joint having a first end connected to the frame and a second end arranged to receive user input, the input joint including a virtual center-of-rotation (VC) mechanism which provides a center of rotation that generally coincides with a wrist joint of the user. An output joint is connected to the tool shaft distal end, where the output joint is coupled to the input joint via a mechanical transmission connected therebetween to correlate motion of the input joint to motion of the output joint.
摘要翻译：最小进入工具包括布置成附接到使用者的臂的框架，具有近端和远端的工具轴，其中工具轴近端连接到框架。该工具还包括具有连接到框架的第一端和布置成接收用户输入的第二端的输入接头，输入接头包括虚拟旋转中心（VC）机构，其提供与用户的腕关节。输出接头连接到工具轴远端，其中输出接头经由连接在其间的机械传动装置联接到输入接头，以将输入接头的运动与输出接头的运动相关联。

3. 发明申请

US20110268674A1 POLYAMIDE-5 COMPOUNDS IN COSMETIC PREPARATIONS 有权
标题翻译：化妆品制备中的聚酰胺-5化合物
公开(公告)号：US20110268674A1
公开(公告)日：2011-11-03
申请号：US13123740
申请日：2009-10-12
申请人： Alexander Filbry , Rainer Kroepke , Silke Heinecke , Alexandra Blohm , Jens Nielsen
发明人： Alexander Filbry , Rainer Kroepke , Silke Heinecke , Alexandra Blohm , Jens Nielsen
IPC分类号： A61K8/18 , A61Q17/04 , A61P17/00 , A61K38/00
CPC分类号： A61Q17/04 , A61K8/37 , A61K8/375 , A61K8/4966 , A61K8/88 , A61Q19/00
摘要： Polyamide-5 compounds show an increase of the care and/or efficacy properties of cosmetic or dermatological preparations, such as waterproofness, long-term stability, skin moisture and stickiness. The preparations preferably comprise one or more care agents or active ingredients selected from the group of UV filter substances, anti-wrinkle active ingredients, skin moisturizers and/or lipids.
摘要翻译：聚酰胺-5化合物显示化妆品或皮肤病学制剂的护理和/或功效性能的增加，例如防水性，长期稳定性，皮肤水分和粘性。制剂优选包含一种或多种选自紫外线过滤物质，抗皱活性成分，皮肤保湿剂和/或脂质的护理剂或活性成分。

4. 发明申请

US20100213006A1 Escape System for Emergency Evacuation 审中-公开
标题翻译：逃生逃生系统
公开(公告)号：US20100213006A1
公开(公告)日：2010-08-26
申请号：US12303699
申请日：2007-06-12
申请人： Thyge Baungaard , Jens Nielsen
发明人： Thyge Baungaard , Jens Nielsen
IPC分类号： A62B1/20
CPC分类号： A62B1/20
摘要： The invention relates to an improved escape system including a chute adapted to compensate for varying vertical distance. Elastic cords extend in a course of direction which progresses differently from vertically when the escape system has been launched and the chute is hanging vertically from the higher position to the lower position, such that tension is applied to the elastic cords. By the present invention it is realised that a longer elongation of the chute may be obtained without increasing the minimum length when the elastic cords extend in such a course of direction, because the cords hereby become longer than in a course of direction progressing straight and vertically. Since any elastic cord has a maximum strain which it may safely endure, a longer extent of such a cord subjected to maximum strain will result in a longer elongation, and hence longer maximum length while maintaining or even reducing the minimum length. One effect is therefore that the ability of the escape system to compensate for varying evacuation height is improved.
摘要翻译：本发明涉及一种改进的逃生系统，包括适于补偿不同垂直距离的斜槽。当逸出系统已经启动并且滑槽从较高位置垂直悬挂到下部位置时，弹性帘线在与垂直方向不同的方向上延伸的方向延伸，使得张力施加到弹性帘线。通过本发明，可以看出，当弹性帘线沿着这样的方向延伸时，可以获得更长的滑槽伸长率，而不会增加弹性帘线的最小长度，因为帘线比在直线和垂直方向前进的过程中长。由于任何弹性绳具有可以安全地承受的最大应变，所以经受最大应变的较长程度的帘线将导致更长的伸长率，并因此延长最大长度，同时保持或甚至减小最小长度。因此，一个效果是提高逃生系统补偿不同排空高度的能力。

5. 发明申请

US20070269704A1 INTERCONNECT DEVICE, FUEL CELL AND FUEL CELL STACK 失效
标题翻译：互连装置，燃料电池和燃料电池堆
公开(公告)号：US20070269704A1
公开(公告)日：2007-11-22
申请号：US10762477
申请日：2004-01-23
申请人： Christian Olsen , Harald Usterud , Jens Nielsen
发明人： Christian Olsen , Harald Usterud , Jens Nielsen
IPC分类号： H01M2/14
CPC分类号： H01M8/0254 , B01J2219/00783 , B01J2219/00853 , B01J2219/00869 , B01J2219/00873 , B01J2219/00891 , C01B3/38 , C01B2203/0233 , C01B2203/066 , H01M8/0258 , H01M8/0637 , H01M8/12 , H01M8/14 , H01M8/24 , H01M8/244 , H01M8/2457 , H01M8/2483 , H01M8/2484 , H01M2008/1293 , Y02E60/566
摘要： The invention provides an interconnect device for a fuel cell comprising an electrolyte, an anode and a cathode, the interconnect device comprising a channel system having a plurality of channels, each channel being closed in one end and having either an inlet side or an outlet side at the open end of the channel, each channel having an inlet side placed in alternating order with a channel having an outlet side, the inlet side of each channel placed in consecutive order on one side of the interconnect, and the outlet sides of each channel placed in consecutive order on the opposide side of the interconnect relative to the inlet side, and a second layer of channels is located on the surface of the channel system. The invention also provides a fuel cell and a fuel cell stack in which the interconnect device is used.
摘要翻译：本发明提供了一种用于包括电解质，阳极和阴极的燃料电池的互连装置，所述互连装置包括具有多个通道的通道系统，每个通道在一端封闭，并且具有入口侧或出口侧在通道的开口端处，每个通道具有与具有出口侧的通道交替排列的入口侧，每个通道的入口侧以互连的一侧连续地排列，并且每个通道的出口侧相对于入口侧在连接的反液体侧连续地排列，并且第二层通道位于通道系统的表面上。本发明还提供一种燃料电池和燃料电池堆，其中使用互连装置。

6. 发明申请

US20070092478A1 Emulsion comprising 1,2-alkanediols and polar oil components 有权
标题翻译：包含1,2-链烷二醇和极性油组分的乳液
公开(公告)号：US20070092478A1
公开(公告)日：2007-04-26
申请号：US11585217
申请日：2006-10-24
申请人： Svea Behrens , Uta Meiring , Andreas Clausen , Andreas Bleckmann , Jens Nielsen
发明人： Svea Behrens , Uta Meiring , Andreas Clausen , Andreas Bleckmann , Jens Nielsen
IPC分类号： A61K8/37
CPC分类号： A61K8/345 , A61K8/06 , A61K8/062 , A61K8/375 , A61K8/608 , A61K8/86 , A61Q19/00
摘要： An emulsion comprising (a) more than about 40% by weight, based on the total weight of the lipid phase of the emulsion, of one or more polar and/or moderately polar lipids which exhibit an interfacial tension towards water of less than about 30 mN/m and (b) one or more 1,2-alkanediols having about 4 to about 8 carbon atoms and exhibiting a Ig pow of from about −1 to about +3. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.
摘要翻译：一种乳液，其包含（a）基于所述乳液的脂质相的总重量大于约40重量％的一种或多种极性和/或中等极性的脂质，其表现出对于水的界面张力小于约30 mN / m和（b）一种或多种具有约4至约8个碳原子并具有约-1至约+3的Ig烷基的1,2-链烷二醇。本摘要不旨在限定说明书中公开的发明，也不旨在以任何方式限制本发明的范围。

7. 发明申请

US20070092459A1 Cosmetic preparation with 1,2-alkanediol and triazines 审中-公开
标题翻译：化妆品用1,2-链烷二醇和三嗪制备
公开(公告)号：US20070092459A1
公开(公告)日：2007-04-26
申请号：US11585246
申请日：2006-10-24
申请人： Andreas Bleckmann , Svea Behrens , Andreas Clausen , Uta Meiring , Jens Nielsen
发明人： Andreas Bleckmann , Svea Behrens , Andreas Clausen , Uta Meiring , Jens Nielsen
IPC分类号： A61K8/49
CPC分类号： A61K8/345 , A61K8/4966 , A61Q17/04
摘要： A cosmetic preparation which comprises one or more 1,2-alkanediols and one or more UV light-protection filters from the group of triazine derivatives. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.
摘要翻译：一种化妆品，其包含一种或多种1,2-链烷二醇和一种或多种来自三嗪衍生物的一种或多种UV光保护过滤器。本摘要不旨在限定说明书中公开的发明，也不旨在以任何方式限制本发明的范围。

8. 发明申请

US20060051847A1 Metabolically engineered cells for the production of polyunsaturated fatty acids 失效
标题翻译：用于生产多不饱和脂肪酸的代谢工程细胞
公开(公告)号：US20060051847A1
公开(公告)日：2006-03-09
申请号：US11146428
申请日：2005-06-06
申请人： Nina Gunnarsson , Jochen Forster , Jens Nielsen
发明人： Nina Gunnarsson , Jochen Forster , Jens Nielsen
IPC分类号： C12P7/64 , C12N1/18 , C12N15/74
CPC分类号： C12N15/52 , A23L33/12 , A61K8/361 , A61K8/67 , A61Q19/00 , C11B1/00 , C12N9/0083 , C12N9/1029 , C12P7/6427 , C12P7/6472 , C12P7/6481 , Y02P20/582
摘要： The present invention relates to the construction and engineering of cells, more particularly microorganisms for producing PUFAs with four or more double bonds from non-fatty acid substrates through heterologous expression of an oxygen requiring pathway. The invention especially involves improvement of the PUFA content in the host organism through fermentation optimization, e.g. decreasing the temperature and/or designing an optimal medium, or through improving the flux towards fatty acids by metabolic engineering, e.g. through over-expression of fatty acid synthases, over-expression of other enzymes involved in biosynthesis of the precursors for PUFAs, or codon optimization of the heterologous genes, or expression of heterologous enzymes involved in the biosynthesis of the precursor for PUFAs.
摘要翻译：本发明涉及细胞的构建和工程，更特别地涉及通过异氧表达需氧途径从非脂肪酸底物生产具有四个或更多个双键的PUFA的细胞的构建和工程。本发明特别涉及通过发酵优化来改善宿主生物体中的PUFA含量，例如，降低温度和/或设计最佳培养基，或通过代谢工程改善通向脂肪酸的通量。通过脂肪酸合成酶的过表达，参与PUFA前体生物合成的其他酶的过度表达，或异源基因的密码子优化，或参与PUFA前体生物合成的异源酶的表达。

9. 发明授权

US06911210B1 Stable active ingredient combinations which are effective against blemished skin and against acne and contain interface-active glucose derivatives and hydroxycarbolic acids 有权
标题翻译：稳定的活性成分组合，其有效对抗瑕疵的皮肤和抗痤疮并含有界面活性葡萄糖衍生物和羟基碳酸
公开(公告)号：US06911210B1
公开(公告)日：2005-06-28
申请号：US09557376
申请日：2000-04-25
申请人： Angelika Bormann , Jens Nielsen , Andreas Herpens , Anja Müller , Jürgen Kielholz
发明人： Angelika Bormann , Jens Nielsen , Andreas Herpens , Anja Müller , Jürgen Kielholz
IPC分类号： A61K8/365 , A61K8/60 , A61K31/19 , A61K31/70 , A61K31/74 , A61Q19/00 , A61Q19/10 , A61K7/00 , A01N43/04 , A61K6/00
CPC分类号： A61Q19/00 , A61K8/06 , A61K8/365 , A61K8/60 , A61K2800/52 , A61Q19/10 , Y10S514/846 , Y10S514/887 , Y10S514/937
摘要： Use of cosmetic and/or dermatological preparations in the form of emulsions, comprising a) an effective amount of one or more α-hydroxycarboxylic acids and/or an effective amount of one or more β-hydroxycarboxylic acids b) one or more interface-active substances, chosen from the group of glucose derivatives and, if desired, furthermore comprising (c) one or more interface-active substances chosen from the group of oligoglycerides against blemished skin or acne.
摘要翻译：使用乳剂形式的化妆品和/或皮肤病学制剂，其包含a）有效量的一种或多种α-羟基羧酸和/或有效量的一种或多种β-羟基羧酸b）一种或多种界面活性选自一组葡萄糖衍生物的物质，如果需要，还包含（c）一种或多种选自寡聚甘油酯的界面活性物质，以防止被玷污的皮肤或痤疮。

10. 发明申请

US20050064000A1 Preparation containing 2-methyl-1,3-propanediol 审中-公开
标题翻译：含有2-甲基-1,3-丙二醇的制备
公开(公告)号：US20050064000A1
公开(公告)日：2005-03-24
申请号：US10915045
申请日：2004-08-09
申请人： Rainer Kropke , Jens Nielsen
发明人： Rainer Kropke , Jens Nielsen
IPC分类号： A61K8/30 , A61K8/00 , A61K8/02 , A61K8/34 , A61K8/92 , A61Q1/02 , A61Q1/14 , A61Q5/00 , A61Q5/06 , A61Q5/08 , A61Q7/00 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C11D3/20 , C11D3/38 , A61K7/46 , A61K6/00 , A61K7/00
CPC分类号： A61K8/922 , A61K8/34 , A61Q13/00
摘要： The invention includes an aqueous, alcoholic, or aqueous-alcoholic cosmetic or dermatological preparation comprising (a) 2-methyl-1,3-propanediol in a concentration of from 0.5 to 10% by weight and (b) perfume oil in a concentration of from 0.01 to 10.0% by weight, wherein the preparation includes a dispersed phase and an external phase, and wherein the difference in the refractive indices of the dispersed phase and the external phase is greater than 0.003. The invention also includes a method of adding fragrance to a preparation and a method of improving the solubility of perfume in a preparation comprising adding 2-methyl-1,3-propanediol. The invention also includes methods of cleaning, deodorizing, or imparting fragrance by applying the preparation to the skin or to household items.
摘要翻译：本发明包括水溶性，醇类或含水醇类化妆品或皮肤病学制剂，其包含（a）浓度为0.5至10重量％的2-甲基-1,3-丙二醇和（b）浓度为 0.01至10.0重量％，其中所述制剂包括分散相和外相，并且其中所述分散相和外相的折射率差异大于0.003。本发明还包括向制剂中加入香料的方法和提高香料在包括加入2-甲基-1,3-丙二醇的制剂中的溶解度的方法。本发明还包括通过将制剂应用于皮肤或家居用品来清洁，除臭或赋予香料的方法。

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