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1. 发明申请

US20120115752A1 Method for Generating Aptamers with Improved Off-Rates 有权
标题翻译：用改进的脱离率产生适配器的方法
公开(公告)号：US20120115752A1
公开(公告)日：2012-05-10
申请号：US13382493
申请日：2010-07-09
申请人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold , Thale C. Jarvis , Jeffrey D. Carter
发明人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold , Thale C. Jarvis , Jeffrey D. Carter
IPC分类号： C40B30/04 , C12Q1/68 , C12Q1/70 , C07H21/00 , C12Q1/02 , B82Y15/00
CPC分类号： C12N15/1048 , C12N15/115 , C12N2310/16 , C12Q1/6811 , G01N33/5308 , C12Q2525/117 , C12Q2525/205 , C12Q2541/101
摘要： The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods. Specifically, the present disclosure describes methods for the identification and use of aptamers to one or more targets within a histological or cytological sample, which have slow rates of dissociation. The aptamers may be used to assess localization, relative density, and presence or absence of one or more targets in cytological and histological samples. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. The aptamers may also be used to introduce target specific signal moieties. In addition to target identification, the aptamers may be used to amplify signal generation through a variety of methods.
摘要翻译：本公开描述了具有比使用先前描述的方法获得的那些更快的解离速率常数的适配体和光致抗体的鉴定和使用。具体地，本公开描述了用于鉴定和使用适配体到组织学或细胞学样品中的一种或多种目标的方法，其具有缓慢的解离速率。适配体可用于评估细胞学和组织学样品中的一种或多种靶标的定位，相对密度和存在或不存在。可以选择对于样品收集的给定疾病状态的特异性和诊断性的靶标。适体也可以用于引入目标特异性信号部分。除目标识别之外，适体可用于通过各种方法放大信号产生。

2. 发明申请

US20130325488A1 METHODS AND SYSTEMS FOR PROVIDING COST INFORMATION FOR HEALTH CARE SERVICES 审中-公开
标题翻译：为卫生服务提供成本信息的方法和系统
公开(公告)号：US20130325488A1
公开(公告)日：2013-12-05
申请号：US13486844
申请日：2012-06-01
申请人： Jeffrey D. Carter , Andrew J. Hall
发明人： Jeffrey D. Carter , Andrew J. Hall
IPC分类号： G06Q50/22 , G06Q40/08
CPC分类号： G06Q40/08 , G06F19/328 , G06Q50/22
摘要： Methods and systems for providing cost information for health care services enable, among other things, health care users to make more informed and cost-effective decisions regarding their use of health care services, and/or health care providers to compete against one another on the basis of cost. According to an exemplary embodiment, a method includes: receiving, via a device, a user input requesting cost information for a health care service for a user; and providing, via the device and in response to the user input, a display including one or more health care providers and cost information for each of the one or more health care providers for providing the health care service for the user.
摘要翻译：为卫生保健服务提供成本信息的方法和系统使医疗保健用户能够就其使用保健服务做出更明智且具有成本效益的决策，和/或医疗保健提供者在成本的基础。根据示例性实施例，一种方法包括：经由设备接收为用户提供医疗保健服务的请求成本信息的用户输入; 以及经由所述设备并且响应于所述用户输入提供包括一个或多个医疗保健提供者的显示器以及用于为所述用户提供所述保健服务的所述一个或多个医疗保健提供者中的每一个的费用信息。

3. 发明申请

US20110275794A1 5-POSITION MODIFIED PYRIMIDINES AND THEIR USE 审中-公开
标题翻译： 5位改性吡啶并及其用途
公开(公告)号：US20110275794A1
公开(公告)日：2011-11-10
申请号：US13085256
申请日：2011-04-12
申请人： John Rohloff , Nebojsa Janjic , Jeffrey D. Carter , Catherine Fowler
发明人： John Rohloff , Nebojsa Janjic , Jeffrey D. Carter , Catherine Fowler
IPC分类号： C07H21/04 , C07H19/10 , C07H19/073
CPC分类号： C07H19/10 , C07H19/06 , C07H21/04 , C12N15/115 , C12N2310/335
摘要： The present disclosure relates to the field of nucleic acid chemistry, specifically to 5-position modified uridines as well as phosphoramidite and triphosphate derivatives thereof. The present disclosure also relates to methods of making and using the same.
摘要翻译：本公开内容涉及核酸化学领域，特别涉及5-位修饰的尿苷以及其亚磷酰胺和三磷酸衍生物。本公开还涉及制备和使用该方法。

4. 发明授权

US5694541A System console terminal for fault tolerant computer system 失效
标题翻译：容错计算机系统的系统控制台
公开(公告)号：US5694541A
公开(公告)日：1997-12-02
申请号：US546347
申请日：1995-10-20
申请人： John D. Service , Walter A. Jones, Jr. , Richard Urmston , Arthur J. Beaverson , Charles J. Horvath , Matthew A. Trask , John T. Vachon , Jeffrey D. Carter
发明人： John D. Service , Walter A. Jones, Jr. , Richard Urmston , Arthur J. Beaverson , Charles J. Horvath , Matthew A. Trask , John T. Vachon , Jeffrey D. Carter
IPC分类号： G06F11/20 , G06F11/273 , G06F11/30 , H04L29/14 , G06F15/02
CPC分类号： G06F11/3006 , G06F11/3055 , H04L69/40 , G06F11/16 , G06F11/2294 , G06F11/2736
摘要： A console terminal arrangement is disclosed for use in connection with a fault-tolerant computer system including a plurality of processing modules, at least some of the processing modules including an operator input/output interface for receiving operator input from an operator input device and operator display output on an operator display device. The console terminal arrangement facilitates management of all of the processing modules by a single operator from a single location. The arrangement includes a console terminal and a plurality of processing module interfaces interconnected by a network. The console terminal includes an operator input device and an operator display device, and generates operator input messages including processing module management information generated by the operator input device in response to inputs provided by an operator and an address identifying one of the processing modules to be managed by the console terminal. The console terminal further generates and displays video images in response to video image data received in messages from the processing modules. Each processing module interface receives operator input messages generated by the console terminal which include an address identifying the processing module connected to the processing module interface and provide the processing module management information to the operator input/output interface to control the processing module. In addition, each processing module interface receives video information from the associated processing module's operator input output device and generates a message including the video information and an address identifying the console terminal. The network carries messages generated by the console terminal and the processing module interfaces in accordance with the addresses contained in the respective messages.
摘要翻译：公开了一种用于与包括多个处理模块的容错计算机系统结合使用的控制台终端装置，至少一些处理模块包括操作员输入/输出接口，用于从操作员输入装置接收操作者输入和操作者显示在操作者显示设备上输出。控制台终端装置便于单个操作员从单个位置管理所有处理模块。该装置包括控制台终端和由网络互连的多个处理模块接口。控制终端包括操作员输入装置和操作者显示装置，并且响应于由操作者提供的输入和识别要管理的处理模块之一的地址，生成包括由操作者输入装置产生的处理模块管理信息的操作者输入消息由控制台终端。控制台终端还响应于在处理模块的消息中接收的视频图像数据，生成和显示视频图像。每个处理模块接口接收由控制台终端产生的操作员输入消息，其包括标识连接到处理模块接口的处理模块的地址，并将处理模块管理信息提供给操作员输入/输出接口以控制处理模块。此外，每个处理模块接口从相关联的处理模块的操作员输入设备接收视频信息，并产生包括视频信息和标识控制台终端的地址的消息。该网络根据包含在相应消息中的地址携带由控制台终端和处理模块接口产生的消息。

5. 发明授权

US08975026B2 Method for generating aptamers with improved off-rates 有权
标题翻译：用于产生具有改善的脱离率的适配体的方法
公开(公告)号：US08975026B2
公开(公告)日：2015-03-10
申请号：US13382493
申请日：2010-07-09
申请人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold , Thale C. Jarvis , Jeffrey D. Carter
发明人： Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold , Thale C. Jarvis , Jeffrey D. Carter
IPC分类号： C12N15/115
CPC分类号： C12N15/1048 , C12N15/115 , C12N2310/16 , C12Q1/6811 , G01N33/5308 , C12Q2525/117 , C12Q2525/205 , C12Q2541/101
摘要： The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods. Specifically, the present disclosure describes methods for the identification and use of aptamers to one or more targets within a histological or cytological sample, which have slow rates of dissociation. The aptamers may be used to assess localization, relative density, and presence or absence of one or more targets in cytological and histological samples. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. The aptamers may also be used to introduce target specific signal moieties. In addition to target identification, the aptamers may be used to amplify signal generation through a variety of methods.
摘要翻译：本公开描述了具有比使用先前描述的方法获得的那些更快的解离速率常数的适配体和光致抗体的鉴定和使用。具体地，本公开描述了用于鉴定和使用适配体到组织学或细胞学样品中的一种或多种目标的方法，其具有缓慢的解离速率。适配体可用于评估细胞学和组织学样品中的一种或多种靶标的定位，相对密度和存在或不存在。可以选择对于样品收集的给定疾病状态的特异性和诊断性的靶标。适体也可以用于引入目标特异性信号部分。除目标识别之外，适体可用于通过各种方法放大信号产生。

6. 发明申请

US20120065994A1 Methods and systems for utilizing electronic medical records to track and manage radiation doses 审中-公开
标题翻译：利用电子医疗记录跟踪和管理辐射剂量的方法和系统
公开(公告)号：US20120065994A1
公开(公告)日：2012-03-15
申请号：US12807743
申请日：2010-09-13
申请人： Jeffrey D. Carter , Andrew J. Hall
发明人： Jeffrey D. Carter , Andrew J. Hall
IPC分类号： G06Q50/00 , G06Q10/00
CPC分类号： G06Q50/24 , G06Q10/10
摘要： Methods and systems for utilizing electronic medical records are operative to track and manage radiation doses provided to patients through various different types of radiation-emitting medical procedures. According to an exemplary embodiment, one such method includes receiving an electronic medical record for a patient, the electronic medical record comprising data indicating a cumulative past amount of radiation exposure for the patient; detecting if the cumulative past amount of radiation exposure for the patient is above a threshold before performing a radiation-emitting medical procedure on the patient; and providing a pre-defined output message in response to detecting that the cumulative past amount of radiation exposure for the patient is above the threshold.
摘要翻译：利用电子医疗记录的方法和系统可操作以通过各种不同类型的辐射发射医疗程序来跟踪和管理提供给患者的放射剂量。根据示例性实施例，一种这样的方法包括接收患者的电子医疗记录，所述电子医疗记录包括指示患者的累积过去辐射暴露量的数据; 在对患者执行辐射发射医疗程序之前，检测患者的累积过去辐射暴露量是否高于阈值; 以及提供预定义的输出消息以响应于检测到患者的累积过去辐射暴露量高于阈值。

7. 发明授权

US5182125A Product produced by process of freezing and ice glazing broccoli 失效
标题翻译：通过冷冻和冰釉西兰花的方法生产的产品
公开(公告)号：US5182125A
公开(公告)日：1993-01-26
申请号：US691381
申请日：1991-04-25
申请人： Dean H. Lockwood , William G. Schmidt , Jeffrey D. Carter
发明人： Dean H. Lockwood , William G. Schmidt , Jeffrey D. Carter
IPC分类号： A23B7/04 , A23B7/05
CPC分类号： A23B7/0433 , A23B7/05
摘要： A product produced by the process of forming an ice glazing within the canopy of broccoli florets to preserve the floret structure and reduce fines loss is disclosed. The process includes the steps of individually freezing the broccoli florets, and immersing the florets in water at a water temperature and for an amount of time sufficient to form an ice glazing within the structure of the floret. The floret is then refrozen. The product has a glazing which preserves the structure of the floret during processing and subsequently handling. A frozen broccoli floret having an ice glazing within the crevices of the floret is also disclosed.
摘要翻译：公开了通过在西兰花小花冠中形成冰盖玻璃以保持小花结构并减少细粉损失而产生的产品。该方法包括以下步骤：单独冷冻西兰花，并将小花浸入水中，并在足以在小花结构内形成冰盖的时间。小花然后被重新冷冻。该产品具有玻璃窗，其在处理和随后处理期间保留小花的结构。还公开了在小花的裂缝内具有冰玻璃的冷冻的西兰花小花。

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