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1. 发明申请

US20120253442A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：影响患者神经功能变化的方法和装置
公开(公告)号：US20120253442A1
公开(公告)日：2012-10-04
申请号：US13438513
申请日：2012-04-03
申请人： Bradford Evan Gliner , Brad Fowler , Andrew D. Firlik , Jeffrey Balzer , Alan J. Levy , Kent Leyde
发明人： Bradford Evan Gliner , Brad Fowler , Andrew D. Firlik , Jeffrey Balzer , Alan J. Levy , Kent Leyde
IPC分类号： A61N1/05
CPC分类号： A61N1/32 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/375 , A61N1/3756 , A61N1/40
摘要： A device and method for intracranial electrical stimulation to effectuate a change in neural-functions of a patient, by electrical stimulating the brain at a site where neuroplasticity is occurring or is expected to occur, where the stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity is related to the neural-function occurs in the brain, identifying the location where such neuroplasticity is present or expected to occur. Where neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. The methods can use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
摘要翻译：用于颅内电刺激的装置和方法，通过在发生或预期发生神经可塑性的部位电刺激脑，刺激部位可能不同于神经活动通常存在以根据脑的功能组织执行特定神经功能的脑。在脑中发生神经功能与神经功能相关的一个实施方案中，鉴定存在或预期发生这种神经可塑性的位置。在脑中不发生神经可塑性的情况下，另一方面是在预期发生的刺激部位诱导神经可塑性。这些方法可以使用电脉冲，其将刺激部位的神经元的静息膜电位增加到亚阈值水平。

2. 发明申请

US20100145427A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：影响患者神经功能变化的方法和装置
公开(公告)号：US20100145427A1
公开(公告)日：2010-06-10
申请号：US12710964
申请日：2010-02-23
申请人： Bradford Evan Gliner , Brad Fowler , Andrew D. Firlik , Jeffrey Balzer , Alan J. Levy , Kent Leyde
发明人： Bradford Evan Gliner , Brad Fowler , Andrew D. Firlik , Jeffrey Balzer , Alan J. Levy , Kent Leyde
IPC分类号： A61N1/05
CPC分类号： A61N1/32 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/375 , A61N1/3756 , A61N1/40
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring or is expected to occur. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present or expected to occur. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
摘要翻译：以下公开内容描述了用于治疗或以其他方式实现患者神经功能变化的颅内电刺激的几种方法和装置。根据本发明的方法的某些实施方案在神经可塑性发生或预期发生的刺激部位电刺激脑。刺激部位可能不同于大脑中通常存在神经活动的区域，以根据脑的功能组织来执行特定的神经功能。在与神经功能相关的神经可塑性发生在脑中的一个实施方案中，该方法可以包括鉴定存在或预期发生这种神经可塑性的位置。在脑中不发生神经可塑性的替代实施方案中，替代方面是在预期发生的刺激位点处诱导神经可塑性。预期对刺激部位的预期神经活动产生持久影响的这些方法的若干实施方案使用增加刺激部位的神经元的静息膜电位至亚阈值水平的电脉冲。

3. 发明授权

US07672730B2 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 有权
标题翻译：用于实现患者神经功能持续变化的方法和装置
公开(公告)号：US07672730B2
公开(公告)日：2010-03-02
申请号：US10606202
申请日：2003-06-24
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy
IPC分类号： A61N1/18
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/36021 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
摘要翻译：用于治疗患者脑部受损的神经功能的方法和装置。在一个实施方案中，用于治疗患者脑部神经功能的方法包括确定要执行多个治疗期间以恢复与神经功能相对应的功能能力的治疗期。该方法通过识别与神经功能相关联的患者的脑中或其上的刺激部位，并且将电极定位至少接近所识别的刺激部位来继续。然后通过向刺激部位提供电刺激治疗来治疗患者。治疗可以包括在治疗期间向电极传送电刺激信号。在治疗期满后，该方法包括防止电刺激信号传递到刺激部位。

4. 发明申请

US20090171416A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 有权
标题翻译：影响患者神经功能变化的方法和装置
公开(公告)号：US20090171416A1
公开(公告)日：2009-07-02
申请号：US12343454
申请日：2008-12-23
申请人： Andrew D. Firlik , Jeffrey Balzer , Alan J. Levy , Bradford Evan Gliner , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Alan J. Levy , Bradford Evan Gliner , Katrina S. Firlik
IPC分类号： A61N1/18
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/36021 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
摘要翻译：用于治疗患者脑部受损的神经功能的方法和装置。在一个实施方案中，用于治疗患者脑部神经功能的方法包括确定要执行多个治疗期间以恢复与神经功能相对应的功能能力的治疗期。该方法通过识别与神经功能相关联的患者的脑中或其上的刺激部位，并且将电极定位至少接近所识别的刺激部位来继续。然后通过向刺激部位提供电刺激治疗来治疗患者。治疗可以包括在治疗期间向电极传送电刺激信号。在治疗期满后，该方法包括防止电刺激信号传递到刺激部位。

5. 发明申请

US20080215112A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
公开(公告)号：US20080215112A1
公开(公告)日：2008-09-04
申请号：US11834638
申请日：2007-08-06
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

6. 发明申请

US20080161880A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
公开(公告)号：US20080161880A1
公开(公告)日：2008-07-03
申请号：US11834642
申请日：2007-08-06
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61N1/362
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

7. 发明申请

US20080161879A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
公开(公告)号：US20080161879A1
公开(公告)日：2008-07-03
申请号：US11834621
申请日：2007-08-06
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61B1/05
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

8. 发明授权

US07146217B2 Methods and apparatus for effectuating a change in a neural-function of a patient 有权
公开(公告)号：US07146217B2
公开(公告)日：2006-12-05
申请号：US10072700
申请日：2002-02-07
申请人： Andrew D. Firlik , Alan J. Levy , Bradford Evan Gliner
发明人： Andrew D. Firlik , Alan J. Levy , Bradford Evan Gliner
IPC分类号： A61N1/18
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/375 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

9. 发明申请

US20120316630A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
公开(公告)号：US20120316630A1
公开(公告)日：2012-12-13
申请号：US13587607
申请日：2012-08-16
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).

10. 发明授权

US07577481B2 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 有权
标题翻译：用于实现患者神经功能持续变化的方法和装置
公开(公告)号：US07577481B2
公开(公告)日：2009-08-18
申请号：US11355038
申请日：2006-02-15
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner , Alan J. Levy , Carlton B. Morgan , Katrina S. Firlik
IPC分类号： A61N1/18
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes a method for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain).
摘要翻译：以下公开描述了一种用于颅内电刺激治疗或以其他方式实现患者神经功能变化的方法。几个实施例旨在增强或以其他方式诱导神经活动的持续变化以实现特定的神经功能。这种神经活动的持续变化被定义为“神经可塑性”。这些方法可用于治疗脑损伤（例如卒中，创伤等），脑部疾病（如阿尔茨海默病，皮克病，帕金森病等）和/或脑部疾病（例如癫痫，抑郁症等）。该方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或控制感觉功能（例如疼痛）。

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