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1. 发明申请

US20110300174A1 CONJUGATES FOR THE PREVENTION OR TREATMENT OF NICOTINE ADDICTION 有权
标题翻译：预防或治疗非裔美国人接种
公开(公告)号：US20110300174A1
公开(公告)日：2011-12-08
申请号：US13151590
申请日：2011-06-02
申请人： Alan Daniel BROWN , Heather Lynn DAVIS , David P. GERVAIS , Lyn Howard JONES , James R. MERSON , David Cameron PRYDE , David R. STEAD , Michael J. MCCLUSKIE , Jennifer Marie THORN , Paul Robert MEHELIC , Parag Ashok KOLHE , Keshab BHATTACHARYA , Jari Ilmari FINNEMAN , Erin Kristen PARSONS , Nickolas ANASTASIOU
发明人： Alan Daniel BROWN , Heather Lynn DAVIS , David P. GERVAIS , Lyn Howard JONES , James R. MERSON , David Cameron PRYDE , David R. STEAD , Michael J. MCCLUSKIE , Jennifer Marie THORN , Paul Robert MEHELIC , Parag Ashok KOLHE , Keshab BHATTACHARYA , Jari Ilmari FINNEMAN , Erin Kristen PARSONS , Nickolas ANASTASIOU
IPC分类号： A61K39/385 , A61P25/34 , C07K14/34 , C07D401/04 , C07K17/06
CPC分类号： A61K39/385 , A61K31/465 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/55561 , A61K2039/6012 , A61K2039/6037 , A61K2039/627 , C07D401/04 , C07K14/34 , Y02A50/473
摘要： The present invention relates in part to nicotine-derived hapten-carrier conjugates of the formula (III): wherein m, n, W, -(spacer)-, X* and Y are as defined in the description. In certain embodiments, said nicotine-derived hapten-carrier conjugates can be used to prepare vaccines for the treatment and/or prevention of nicotine addiction.
摘要翻译：本发明部分地涉及式（III）的尼古丁衍生的半抗原 - 载体共轭物：其中m，n，W， - （间隔基） - ，X *和Y如说明书中所定义。在某些实施方案中，所述尼古丁衍生的半抗原 - 载体缀合物可用于制备用于治疗和/或预防尼古丁成瘾的疫苗。

2. 发明授权

US5417923A Assay tray assembly 失效
标题翻译：分析盘组件
公开(公告)号：US5417923A
公开(公告)日：1995-05-23
申请号：US182956
申请日：1994-01-18
申请人： Dejan Bojanic , James R. Merson
发明人： Dejan Bojanic , James R. Merson
IPC分类号： B01L3/00 , G01N30/46 , B01L11/00
CPC分类号： B01L3/50255 , G01N30/466
摘要： An assay tray assembly and an assay tray primarily for chromatographic analysis has a plastics moulded test tray 1 mounted on a plastics moulded collection tray 72, The test tray has a spaced array of chambers 3 disposed as per a microtiter plate, Each chamber has a bottom outlet port 5 formed by a flange 8 which retains within the chamber a chromatographic medium to which test liquid deposited in the chamber is to be subjected for the percolate or eluate liquid to emerge from the respective outlet ports, The collection tray 72 has a spaced array of wells 16 disposed as per a microtiter plate to correspond with the chambers 3 and the tray 14 is mounted on the tray 72 for each chamber to communicate with a corresponding well 16. Each chamber 3 has a tubular spigot part 12 which extends into the respective well 16 to alleviate cross contamination of the liquid derived from the outlet ports 5.The depth of entry of the tubular spigots 12 into their respective wells 16 is restricted by abutment between the bottom of the test tray with the top of the collection tray, The volume of each well 16 beneath the tubular spigot it receives is adequate to accommodate all of the eluate or percolate derived from the chamber 3 with which it communicates to alleviate liquid on the spigot parts from dripping into wells with which those tubular spigots are not associated (and thereby cause cross contamination) when the trays are separated for analysis of the percolate or eluate.
摘要翻译：主要用于色谱分析的分析托盘组件和测定托盘具有安装在塑料模制收集托盘72上的塑料模制测试托盘1.测试托盘具有根据微量滴定板布置的间隔开的腔室阵列3，每个腔室具有底部出口端口5由凸缘8形成，该凸缘8在腔室内保留色谱介质，沉积在室中的测试液体将经过渗透液或洗脱液从相应的出口出口。收集托盘72具有间隔开的阵列根据微量滴定板布置以与腔室3和托盘14对应的孔16安装在托盘72上，用于每个室以与相应的孔16连通。每个腔室3具有管状插口部分12，其延伸到相应的孔井16以减轻来自出口5的液体的交叉污染。管状插口12进入其各自的孔16的深度受到邻接测试托盘的底部与收集托盘的顶部之间的每个孔16的容积在其所接收的管状插口下面的容积足以容纳所有来自腔室3的洗脱液或渗透液，其与其连通以减轻液体在这些插管部分上滴入到那些管状插口不与之相关联的孔中（并且由此引起交叉污染），当塔板被分离以分析渗滤液或洗脱液时。

3. 发明授权

US08980276B2 Conjugates for the prevention or treatment of nicotine addiction 有权
标题翻译：用于预防或治疗尼古丁成瘾的共轭物
公开(公告)号：US08980276B2
公开(公告)日：2015-03-17
申请号：US13151590
申请日：2011-06-02
申请人： Alan Daniel Brown , Heather Lynn Davis , David P. Gervais , Lyn Howard Jones , James R. Merson , David Cameron Pryde , David R. Stead , Michael J. McCluskie , Jennifer Marie Thorn , Paul Robert Mehelic , Parag Ashok Kolhe , Keshab Bhattacharya , Jari Ilmari Finneman , Erin Kristen Parsons , Nickolas Anastasiou
发明人： Alan Daniel Brown , Heather Lynn Davis , David P. Gervais , Lyn Howard Jones , James R. Merson , David Cameron Pryde , David R. Stead , Michael J. McCluskie , Jennifer Marie Thorn , Paul Robert Mehelic , Parag Ashok Kolhe , Keshab Bhattacharya , Jari Ilmari Finneman , Erin Kristen Parsons , Nickolas Anastasiou
IPC分类号： A61K39/00 , A61K47/48 , A61K31/465 , C07D401/04
CPC分类号： A61K39/385 , A61K31/465 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/55561 , A61K2039/6012 , A61K2039/6037 , A61K2039/627 , C07D401/04 , C07K14/34 , Y02A50/473
摘要： The present invention relates in part to nicotine-derived hapten-carrier conjugates of the formula (III): wherein m, n, W, -(spacer)-, X* and Y are as defined in the description. In certain embodiments, said nicotine-derived hapten-carrier conjugates can be used to prepare vaccines for the treatment and/or prevention of nicotine addiction.
摘要翻译：本发明部分地涉及式（III）的尼古丁衍生的半抗原 - 载体共轭物：其中m，n，W， - （间隔基） - ，X *和Y如说明书中所定义。在某些实施方案中，所述尼古丁衍生的半抗原 - 载体缀合物可用于制备用于治疗和/或预防尼古丁成瘾的疫苗。

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