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1. 发明授权

US08911815B2 Thin film processing apparatuses for adjustable volume accommodation 有权
标题翻译：用于可调节容积的薄膜处理设备
公开(公告)号：US08911815B2
公开(公告)日：2014-12-16
申请号：US13509785
申请日：2010-11-15
申请人： Brian Howard Kram , Kevin David Marshall , Christine Tse , Timothy James Keller , Austin Micheil Ashby
发明人： Brian Howard Kram , Kevin David Marshall , Christine Tse , Timothy James Keller , Austin Micheil Ashby
IPC分类号： A61L33/00 , G01N1/28 , G01N1/31
CPC分类号： G01N1/312 , G01N1/2813
摘要： An apparatus can be used to apply and remove fluid substances for processing biological samples. The fluid substances can be delivered between a first substrate and a second substrate. One substrate carries a specimen. A layer of the fluid substance is retained in a gap defined by the first and second substrates. One substrate is moved with respect to the second substrate to disperse the fluid substance in the gap.
摘要翻译：可以使用一种装置来施加和去除用于处理生物样品的流体物质。流体物质可以在第一基底和第二基底之间递送。一个衬底携带一个样本。流体物质的一层被保持在由第一和第二基底限定的间隙中。一个衬底相对于第二衬底移动以将流体物质分散在间隙中。

2. 发明授权

US08340905B2 Vehicle guidance and sensor bias determination 有权
标题翻译：车辆指导和传感器偏差确定
公开(公告)号：US08340905B2
公开(公告)日：2012-12-25
申请号：US13338114
申请日：2011-12-27
申请人： Peter James Roberts , William James Keller
发明人： Peter James Roberts , William James Keller
IPC分类号： G01C21/00
CPC分类号： G01C21/00 , G05D1/0259 , G05D1/027 , G05D1/0278 , G05D2201/0201 , G05D2201/0202
摘要： Systems and methods for guiding a vehicle and vehicle sensor bias determination methods are disclosed. A method for guiding a vehicle includes a primary antenna of a primary survey-grade GNSS-receiver and a secondary antenna of a secondary GNSS-receiver mounted to the vehicle, which are at least temporarily receiving GNSS-signals of a global positioning system. A plurality of physical sensors mounted to the vehicle generate physical data indicative of respective measured physical parameters of at least part of the vehicle. The method includes de-biasing the physical data and applying a recursive statistical estimator, such as a Kalman filter, to the de-biased physical data and an output of the primary and secondary GNSS-receivers to determine a position and velocity of the vehicle.
摘要翻译：公开了用于引导车辆和车辆传感器偏置确定方法的系统和方法。一种用于引导车辆的方法包括主要测量级GNSS接收机的主天线和安装到车辆的辅助GNSS接收机的辅助天线，其至少暂时接收全球定位系统的GNSS信号。安装到车辆的多个物理传感器产生指示车辆的至少一部分的相应测量物理参数的物理数据。该方法包括对物理数据进行去偏置并将递归统计估计器（例如卡尔曼滤波器）应用于去偏置物理数据和主GNSS和接收机的输出以确定车辆的位置和速度。

3. 发明授权

US08025240B2 Radiant heat flooring system 有权
标题翻译：辐射热地板系统
公开(公告)号：US08025240B2
公开(公告)日：2011-09-27
申请号：US11550977
申请日：2006-10-19
申请人： James Keller
发明人： James Keller
IPC分类号： F24D3/14 , F24D3/12
CPC分类号： F24D3/127 , F24D3/142
摘要： A flooring system for radiant heating includes a top floor portion and a subfloor portion. The top portion is releasably connectable to the subfloor portion in a vertical direction substantially perpendicular to a walking surface of the top portion. The top portion includes a bottom side and top channel portion downwardly depending from the bottom side. The subfloor portion includes a top side and a bottom channel portion extending upwardly from the top side. The top channel portion and the bottom channel portion bound a channel for receiving a heating conduit. The channel extends longitudinally relative to the top floor portion and the subfloor portion.
摘要翻译：用于辐射加热的地板系统包括顶层部分和底层地板部分。顶部可在基本上垂直于顶部的行走表面的垂直方向上可释放地连接到底层地板部分。顶部包括从底侧向下悬垂的底侧和顶部通道部分。底层部分包括从顶侧向上延伸的顶侧和底通道部分。顶部通道部分和底部通道部分限定了用于接收加热导管的通道。通道相对于顶层部分和底层部分纵向延伸。

4. 发明授权

US07346078B2 Processing of received data within a multiple processor device 有权
标题翻译：处理多处理器设备内的接收数据
公开(公告)号：US07346078B2
公开(公告)日：2008-03-18
申请号：US10356324
申请日：2003-01-31
申请人： Manu Gulati , Laurent Moll , James Keller
发明人： Manu Gulati , Laurent Moll , James Keller
IPC分类号： H04J3/22
CPC分类号： G06F13/4247
摘要： A multiple processor device stores a stream of data as a plurality of data segments, which includes multiplexed data fragments from at least one of a plurality of virtual channels. The data segments that comprise the stream of data correspond to the multiplexed data fragments from the virtual channels. The multiple processor device then decodes at least one data segment in accordance with one of a plurality of transmission protocols to produce a decoded data segment. The multiple processor device then stores the decoded data segment to align it in accordance with a data path segment size. The multiple processor device then interprets the stored decoded data segment with respect to a corresponding one of the plurality of virtual channels to determine a destination of the stored decoded data segment. The multiple processor device then stores the decoded data segment as part of reassembled data.
摘要翻译：多处理器设备将数据流存储为多个数据段，其包括来自多个虚拟通道中的至少一个的多路复用数据片段。构成数据流的数据段对应于来自虚拟通道的复用数据片段。多处理器设备然后根据多个传输协议之一对至少一个数据段进行解码，以产生解码的数据段。然后，多处理器设备存储解码的数据段，以根据数据路径段大小进行对准。然后，多处理器设备相对于多个虚拟通道中的相应一个解码存储的解码数据段，以确定存储的解码数据段的目的地。然后，多处理器设备将解码的数据段存储为重新组装的数据的一部分。

5. 发明申请

US20070271402A1 Partially Populated, Hierarchical Crossbar 有权
标题翻译：部分填充，分层交叉
公开(公告)号：US20070271402A1
公开(公告)日：2007-11-22
申请号：US11832841
申请日：2007-08-02
申请人： Sridhar Subramanian , James Keller , George Yiu , Ruchi Wadhawan
发明人： Sridhar Subramanian , James Keller , George Yiu , Ruchi Wadhawan
IPC分类号： G06F13/00
CPC分类号： G06F13/364 , G06F13/4022 , Y02D10/14 , Y02D10/151
摘要： In various embodiments, an apparatus comprises a plurality of agents and an interconnect. In one embodiment, the plurality of agents includes first through fourth agents. The interconnect comprises a plurality of segments that are switchable (e.g. using a plurality of selection circuits) to form communication paths between the agents, and a first segment is included in a first communication path from the first agent to the second agent, and is also included in a second communication path from the third agent to the fourth agent. In another embodiment, each segment is driven by a selection circuit. At least one selection circuit has at least one segment and an output from at least one agent as inputs. In yet another embodiment, an arbiter is configured to determine a communication path on the interconnect for each requesting agent to the destination agent over the segments. The arbiter is configured to arbitrate among a subset of requests for which each segment in the corresponding communication path is available.
摘要翻译：在各种实施例中，装置包括多个代理和互连。在一个实施方案中，多种试剂包括第一至第四试剂。互连包括可切换的多个段（例如，使用多个选择电路）以形成代理之间的通信路径，并且第一段包括在从第一代理到第二代理的第一通信路径中，并且还包括在从第三代理到第四代理的第二通信路径中。在另一实施例中，每个段由选择电路驱动。至少一个选择电路具有至少一个段和来自至少一个代理的输出作为输入。在另一个实施例中，仲裁器被配置为确定每个请求代理在该互连上的通信路径到该段上的目的地代理。仲裁器被配置为在对应的通信路径中的每个段可用的请求的子集之间进行仲裁。

6. 发明授权

US07204105B2 Tamper-proof latch cover 有权
标题翻译：防撬盖
公开(公告)号：US07204105B2
公开(公告)日：2007-04-17
申请号：US10955019
申请日：2004-09-30
申请人： James Edward Hooper , G. James Keller
发明人： James Edward Hooper , G. James Keller
IPC分类号： E05B13/00
CPC分类号： E05B17/142 , E05B67/383 , Y10S70/30 , Y10T70/30 , Y10T70/5739 , Y10T70/5779 , Y10T292/1086 , Y10T292/31
摘要： A latch in a door is protected from an unauthorized entry by forming a first bracket that fits around the latch, and a second bracket that is rotatably connected to the first latch. The second bracket covers the latch when rotated to be in a first position, and exposes the latch when rotated to be in a second position.
摘要翻译：通过形成围绕闩锁配合的第一支架，保护门中的闩锁免受未经授权的进入，以及可旋转地连接到第一闩锁的第二支架。当旋转到第一位置时，第二支架覆盖闩锁，并且当旋转到第二位置时使闩锁暴露。

7. 发明授权

US5945293A Protein-colloidal metal-aminodextran coated particle and methods of preparation and use 失效
标题翻译：蛋白胶体金属 - 氨基糊精包被颗粒及其制备和使用方法
公开(公告)号：US5945293A
公开(公告)日：1999-08-31
申请号：US947811
申请日：1997-10-09
申请人： Olavi Siiman , Kristie Gordon , Carlos M. Rodriguez , Alexander Burshteyn , John A. Maples , James Keller Whitesell
发明人： Olavi Siiman , Kristie Gordon , Carlos M. Rodriguez , Alexander Burshteyn , John A. Maples , James Keller Whitesell
IPC分类号： G01N33/49 , G01N33/50 , G01N33/543 , G01N33/548 , G01N33/553 , G01N33/53
CPC分类号： G01N33/5094 , G01N33/54313 , G01N33/54353 , G01N33/54393 , G01N33/548 , G01N33/553 , Y10T428/2982 , Y10T428/2991
摘要： A stable colloidal particle comprises a colloidal-sized core substrate having amine-reactive functional groups thereon with an aminodextran coating over its peripheral surface and a layer of colloidal-sized metallic solid overlaying the aminodextran coating. A linker comprising aminotrithiolate attached to the metallic solid has a free amino group to which a protein is attached by covalent bonding to the free amino group. Such novel particles are useful in flow cytometry, particularly useful in the simultaneous analyses of subpopulations of leukocytes. Methods of preparation of such particles, as well as methods of use are provided. These conjugates enable the simultaneous analyses of at least two different mutually exclusive subsets of white blood cells, based on the binding affinity of the conjugated protein.
摘要翻译：稳定的胶体颗粒包括其上具有胺反应性官能团的胶体尺寸的核心底物，其外周表面上具有氨基葡聚糖涂层，和覆盖氨基葡聚糖涂层的胶体尺寸的金属固体层。包含与金属固体连接的氨基三硫醇盐的连接体具有游离氨基，通过与游离氨基的共价键连接有蛋白质。这种新型颗粒可用于流式细胞术，特别适用于同时分析白细胞亚群。提供了这种颗粒的制备方法以及使用方法。基于缀合蛋白的结合亲和力，这些缀合物能够同时分析至少两种不同的相互排斥的白细胞亚群。

8. 发明授权

US4089657A Stabilized suspension of carbon in hydrocarbon fuel and method of preparation 失效
标题翻译：碳氢燃料中碳的稳定悬浮液和制备方法
公开(公告)号：US4089657A
公开(公告)日：1978-05-16
申请号：US797414
申请日：1977-05-16
申请人： Leonard James Keller
发明人： Leonard James Keller
IPC分类号： C23F14/02 , C02F5/00 , C02F5/08 , C02F5/10 , C02F5/12 , C10L1/32 , C10L9/10
CPC分类号： C10L9/10 , C10L1/322
摘要： A method of preparing a stabilized suspension of carbon in hydrocarbon fuel characterized by comminuting coal to form predetermined sized particles and coating the particles with at least a coating of an alcohol having 1-4 carbon atoms and thereafter admixing the alcohol coated particles with a liquid hydrocarbon to form the substantially uniform admixture for serving as a fuel. In a preferred embodiment, coal particles are first compacted and comminuted to the predetermined size range to form an abundance of platey, lenticular, irregular and angular particles for forming a stabilized suspensoid that exhibits the property of shear thinning so as to be pumpable with a lower apparent viscosity than the at rest viscosity of the slurry of carbon in hydrocarbon. Also disclosed are specific details of the method and preferred embodiments, including the fuel composition, per se.
摘要翻译：一种制备碳氢化合物燃料中稳定的碳悬浮液的方法，其特征在于粉碎煤以形成预定尺寸的颗粒，并用至少一种具有1-4个碳原子的醇的涂层涂覆颗粒，然后将醇涂覆的颗粒与液体烃混合以形成用作燃料的基本均匀的混合物。在优选的实施方案中，煤颗粒首先被压实并粉碎至预定的尺寸范围以形成大量的板状，透镜状，不规则和有角度的颗粒，用于形成稳定的悬浮体，其表现出剪切稀化的性质，以便可以用较低的表观粘度比碳在烃中的浆液的静止粘度。还公开了本方法和优选实施方案的具体细节，包括燃料组合物本身。

9. 发明授权

US08962808B2 EGFR-related polypeptides and methods of use 有权
标题翻译： EGFR相关多肽和使用方法
公开(公告)号：US08962808B2
公开(公告)日：2015-02-24
申请号：US13696291
申请日：2011-05-05
申请人： Edward L. Chan , James Keller
发明人： Edward L. Chan , James Keller
IPC分类号： C07K16/00 , C12Q1/68 , C07K14/71 , G01N33/574 , C07K16/40 , C12N9/12 , G01N33/74
CPC分类号： C12Q1/6886 , C07K14/71 , C07K16/40 , C07K2319/00 , C07K2319/23 , C07K2319/42 , C07K2319/43 , C07K2319/60 , C12N9/12 , G01N33/57407 , G01N33/74 , G01N2333/71 , G01N2800/56
摘要： Described herein are truncated EGF receptor polypeptides, nucleic acids encoding them, and methods of using them to help select a method of treatment for an EGFR-related cancer, to predict clinical outcome, and to detect micrometastases or minimal residual disease. High EGFR expression and phosphorylated EGFR predicts poor survival in head and neck cancer patients, but does not correlate with advanced stage disease. In our studies, we determined that clinical biological correlates are likely to be more accurate when different aspects of EGFR are evaluated in combination. We analyzed EGFR phosphorylation, expression and mutations in 60 primary head and neck tumors. We not only found that head and neck tumors with either truncated or activated EGFR tend to have higher tumor and nodal stage, but also discovered three EGFR truncations.
摘要翻译：本文描述的是截短的EGF受体多肽，编码它们的核酸，以及使用它们帮助选择EGFR相关癌症的治疗方法，预测临床结果以及检测微转移或微小残留疾病的方法。高EGFR表达和磷酸化EGFR预测头颈癌患者的生存率差，但与晚期阶段疾病无关。在我们的研究中，我们确定临床生物相关性可以更准确地评估EGFR的不同方面。我们分析了60例原发性头颈部肿瘤中的EGFR磷酸化，表达和突变。我们不仅发现具有截短或活化的EGFR的头颈部肿瘤倾向于具有较高的肿瘤和淋巴结阶段，而且还发现三个EGFR截短。

10. 发明申请

US20130052331A1 THIN FILM PROCESSING APPARATUSES FOR ADJUSTABLE VOLUME ACCOMMODATION 有权
公开(公告)号：US20130052331A1
公开(公告)日：2013-02-28
申请号：US13509785
申请日：2010-11-15
申请人： Brian Howard Kram , Kevin David Marshall , Christine Tse , Timothy James Keller , Austin Micheil Ashby
发明人： Brian Howard Kram , Kevin David Marshall , Christine Tse , Timothy James Keller , Austin Micheil Ashby
IPC分类号： B05C11/02 , B05D5/00
CPC分类号： G01N1/312 , G01N1/2813
摘要： An apparatus can be used to apply and remove fluid substances for processing biological samples. The fluid substances can be delivered between a first substrate and a second substrate. One substrate carries a specimen. A layer of the fluid substance is retained in a gap defined by the first and second substrates. One substrate is moved with respect to the second substrate to disperse the fluid substance in the gap.

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