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1. 发明授权

US06358532B2 Calcium phosphate microcarriers and microspheres 有权
标题翻译：磷酸钙微载体和微球
公开(公告)号：US06358532B2
公开(公告)日：2002-03-19
申请号：US09788103
申请日：2001-02-15
申请人： L. Brian Starling , James E. Stephan
发明人： L. Brian Starling , James E. Stephan
IPC分类号： A61K914
CPC分类号： B01J20/282 , A61F2/30767 , A61F2002/2817 , A61F2002/30242 , A61F2002/3025 , A61F2230/0071 , A61F2310/00293 , A61F2310/00796 , A61K9/1611 , A61K9/501 , A61L27/12 , A61L31/026 , B01J20/048 , B01J20/28004 , B01J20/28011 , B01J20/28019 , B01J20/28021 , B01J20/2803 , B01J2220/54 , C01B25/32
摘要： The present invention provides calcium phosphate-based (CaP) microcarriers and their use, for example, in cell culturing systems, chromatography, and implantable biomedical materials.
摘要翻译：本发明提供了基于磷酸钙的（CaP）微载体及其在细胞培养系统，色谱和可植入生物医学材料中的用途。

2. 发明授权

US4374076A Method for making cast epoxy resin bodies and epoxy formulation therefor 失效
标题翻译：铸造环氧树脂体及其环氧树脂配方的制造方法
公开(公告)号：US4374076A
公开(公告)日：1983-02-15
申请号：US310170
申请日：1981-10-09
申请人： James E. Stephan , Paul A. Boduch , John A. Elverum
发明人： James E. Stephan , Paul A. Boduch , John A. Elverum
IPC分类号： C08G59/00 , A61K6/087 , A61K6/10 , B29C39/00 , B29C39/38 , B29C39/40 , C08G59/38 , C08G59/42 , C08L63/00 , B29C5/00 , A61C13/08
CPC分类号： C08G59/4223 , B29C39/006 , B29C39/38 , B29C39/40 , C08G59/38 , B29K2063/00
摘要： A method for making cast precision epoxy resin bodies and an epoxy resin formulation for use therein, the epoxy resin formulation having Component A consisting essentially of from 40 to 70% by weight epoxy novolac polymer, from 30 to 50% by weight vinyl -3-cyclohexene diepoxide and from 0 to 20% by weight 3,4 epoxy cyclohexylmethyl -3,4-epoxy cyclohexane carboxylate and Component B consisting essentially of partially hydrolyzed aryl tetracarboxylic acid dianhydride, preferably partially hydrolyzed pyromellitic acid dianhydride. In the preferred embodiments a tertiary amine catalyst is also included. These components are mixed, just before use, in a ratio of from 20 to 50 parts by weight Component B to each 100 parts by weight Component A. To make the cast precision bodies such mixture is cast in a mold of the shape desired, allowed to cure to a solid body while in the mold, and thereafter heated to cause permanent expansion thereof at least sufficient to compensate for any shrinkage occurring during the casting and hardening thereof while in the mold.
摘要翻译：一种用于制造铸造精密环氧树脂体和用于其中的环氧树脂配方的方法，所述环氧树脂制剂具有基本上由40至70重量％的环氧酚醛清漆聚合物组成的组分A，30至50重量％的乙烯基-3- 环己烯二环氧化物和0至20重量％的3,4-环氧环己基甲基-3,4-环氧环己烷羧酸酯和组分B，其基本上由部分水解的芳基四羧酸二酐组成，优选部分水解的均苯四酸二酐。在优选的实施方案中也包括叔胺催化剂。这些组分在使用前混合，比例为20至50重量份组分B与每100重量份组分A.为了使铸造精密体将这种混合物浇铸在所需形状的模具中，允许在模具中固化成固体，然后加热至其永久膨胀至少足以补偿在模具中铸造和硬化期间发生的任何收缩。

3. 发明授权

US08389017B1 Calcium-containing structures and methods of making and using the same 有权
标题翻译：含钙结构及其制造和使用方法
公开(公告)号：US08389017B1
公开(公告)日：2013-03-05
申请号：US10030578
申请日：2000-07-07
申请人： L. Brian Starling , James E. Stephan
发明人： L. Brian Starling , James E. Stephan
IPC分类号： A61K33/00 , A61K33/14 , A01N59/08
CPC分类号： A61L27/3608 , A61K9/501 , A61K33/06 , A61K35/12 , A61K45/06 , A61L27/12 , A61L27/50 , A61L27/54 , A61L2300/114 , C12N5/0075 , C12N5/0654 , C12N2533/18 , A61K31/155 , A61K31/195 , A61K2300/00
摘要： The present invention generally relates to calcium-containing structures and methods of making and using the structures. In one aspect, hollow calcium containing microstructures are used in conjunction with bone tissues/by-products to augment bone defects and extend the supply of bone tissues/by-products for bone augmentation. Bonding agents, such as calcium cements, are also used in the preparation of the hollow calcium microstructures combined with bone tissues/by-products or for use in preparing the hollow microstructures. The calcium-containing microstructures of the present invention are also useful as delivery vehicles of nitric oxide and/or nitric oxide containing or producing compounds for a variety of in vitro and in vivo uses. Calcium containing contoured substrates upon which cells/tissues can be grown in vitro for replacement and repair of tissues in vivo that conform in size and shape to the tissue surface to be replaced are also provided.
摘要翻译：本发明一般涉及含钙结构及其制造和使用方法。在一个方面，含空心钙微结构与骨组织/副产物结合使用，以增加骨缺损并延长骨组织/副产物的供应以增加骨骼。粘结剂，例如钙粘结剂，也用于制备与骨组织/副产物组合的中空钙微结构或用于制备中空微结构。本发明的含钙微结构也可用作含有或用于各种体外和体内用途的化合物的一氧化氮和/或一氧化氮的输送载体。还提供含钙成分的基质，细胞/组织可以在其上体外生长，用于体内组织的组织替换和修复，其尺寸和形状与待替换的组织表面一致。

4. 发明授权

US06346317B1 Electronic components incorporating ceramic-metal composites 失效
标题翻译：包含陶瓷 - 金属复合材料的电子元件
公开(公告)号：US06346317B1
公开(公告)日：2002-02-12
申请号：US08820164
申请日：1997-03-19
申请人： Marcus A. Ritland , Dennis W. Readey , Jack D. Sibold , James E. Stephan
发明人： Marcus A. Ritland , Dennis W. Readey , Jack D. Sibold , James E. Stephan
IPC分类号： B22F300
CPC分类号： B01D29/111 , B01D29/31 , B01D53/02 , B01D53/0438 , B01D63/061 , B01D63/066 , B01D2201/0446 , B01D2253/104 , B01D2253/112 , B01D2253/25 , B01D2253/30 , B01D2253/311 , B01D2259/4145 , B32B18/00 , C04B41/009 , C04B41/5127 , C04B41/5144 , C04B41/52 , C04B41/88 , C04B41/89 , C04B2111/00793 , C04B2237/064 , C04B2237/341 , C04B2237/343 , C04B2237/366 , C04B2237/592 , C04B2237/62 , C04B2237/68 , C22C1/1015 , C22C1/1036 , C22C29/12 , C22C2001/1063 , F01L3/02 , F01L3/22 , F01L2101/02 , F02B3/06 , F02F3/00 , F02F7/0087 , F05C2201/0415 , F05C2203/0895 , F05C2253/16 , H01L21/486 , H01L23/49827 , H01L23/5384 , H01L2924/0002 , H01L2924/09701 , H05K1/0306 , H05K3/4061 , H05K2201/0116 , H05K2203/128 , Y10S148/069 , Y10T156/1056 , Y10T428/24926 , Y10T428/249957 , Y10T428/24997 , C04B41/4523 , C04B41/4572 , C04B41/4582 , C04B41/5093 , C04B41/5133 , C04B35/10 , C04B38/0003 , H01L2924/00
摘要： The present invention relates to electronic components and in particular relates to ceramic-based electronic components wherein a portion of the component comprises a metal-infiltrated ceramic. In a preferred embodiment, the metal-infiltrated ceramic comprises copper metal.
摘要翻译：本发明涉及电子部件，特别涉及一种陶瓷基电子部件，其中该部件的一部分包括金属渗透的陶瓷。在优选实施例中，金属渗透陶瓷包括铜金属。

5. 发明授权

US06210715B1 Calcium phosphate microcarriers and microspheres 有权
标题翻译：磷酸钙微载体和微球
公开(公告)号：US06210715B1
公开(公告)日：2001-04-03
申请号：US09402308
申请日：2000-02-02
申请人： L. Brian Starling , James E. Stephan
发明人： L. Brian Starling , James E. Stephan
IPC分类号： A61K914
CPC分类号： B01J20/282 , A61F2/30767 , A61F2002/2817 , A61F2002/30242 , A61F2002/3025 , A61F2230/0071 , A61F2310/00293 , A61F2310/00796 , A61K9/1611 , A61K9/501 , A61L27/12 , A61L31/026 , B01J20/048 , B01J20/28004 , B01J20/28011 , B01J20/28019 , B01J20/28021 , B01J20/2803 , B01J2220/54 , C01B25/32
摘要： The present invention provides calcium phosphate-based (CAP) microcarriers and microspheres and their use in cell culturing systems, chromatography and implantable biomedical materials.
摘要翻译：本发明提供了基于磷酸钙的（CAP）微载体和微球及其在细胞培养系统，色谱和可植入生物医学材料中的应用。

6. 发明授权

US5614043A Method for fabricating electronic components incorporating ceramic-metal composites 失效
标题翻译：制造陶瓷 - 金属复合材料的电子元件的制造方法
公开(公告)号：US5614043A
公开(公告)日：1997-03-25
申请号：US220570
申请日：1994-03-31
申请人： Marcus A. Ritland , Dennis W. Readey , Jack D. Sibold , James E. Stephan
发明人： Marcus A. Ritland , Dennis W. Readey , Jack D. Sibold , James E. Stephan
IPC分类号： B01D29/11 , B01D53/04 , B01D63/06 , C04B37/00 , C04B37/02 , C04B41/51 , C04B41/52 , C04B41/88 , C04B41/89 , C22C1/10 , C22C29/12 , F01L3/02 , F01L3/22 , F02B3/06 , F02F3/00 , F02F7/00 , H01L21/48 , H01L23/498 , H01L23/538 , H05K1/03 , H05K3/40 , B32B31/26 , B32B31/12
CPC分类号： B01D29/111 , B01D53/02 , B01D63/061 , B01D63/066 , B32B18/00 , C04B41/009 , C04B41/5127 , C04B41/5144 , C04B41/52 , C04B41/88 , C04B41/89 , C22C1/1015 , C22C1/1036 , C22C29/12 , F01L3/02 , F01L3/22 , F02F3/00 , F02F7/0087 , H01L21/486 , H01L23/49827 , H01L23/5384 , H05K3/4061 , B01D2201/0446 , B01D2253/104 , B01D2253/112 , B01D2253/25 , B01D2253/30 , B01D2253/311 , B01D2259/4145 , B01D53/0438 , C04B2111/00793 , C04B2237/064 , C04B2237/341 , C04B2237/343 , C04B2237/366 , C04B2237/592 , C04B2237/62 , C04B2237/68 , C22C2001/1063 , F01L2101/02 , F02B3/06 , F05C2201/0415 , F05C2203/0895 , F05C2253/16 , H01L2924/0002 , H01L2924/09701 , H05K1/0306 , H05K2201/0116 , H05K2203/128 , Y10S148/069 , Y10T156/1056 , Y10T428/24926 , Y10T428/249957 , Y10T428/24997
摘要： The present invention relates to electronic components and in particular relates to ceramic-based electronic components wherein a portion of the component comprises a metal-infiltrated ceramic. In a preferred embodiment, the metal-infiltrated ceramic comprises copper metal.
摘要翻译：本发明涉及电子部件，特别涉及一种陶瓷基电子部件，其中该部件的一部分包括金属渗透的陶瓷。在优选实施例中，金属渗透陶瓷包括铜金属。

7. 发明授权

US4839215A Biocompatible particles and cloth-like article made therefrom 失效
标题翻译：生物相容性颗粒和由其制成的布状物品
公开(公告)号：US4839215A
公开(公告)日：1989-06-13
申请号：US872617
申请日：1986-06-09
申请人： L. Brian Starling , James E. Stephan , William G. Hubbard
发明人： L. Brian Starling , James E. Stephan , William G. Hubbard
IPC分类号： A61L27/00 , A61C8/00 , A61F2/00 , A61F2/28 , A61F2/30 , A61L27/02 , A61L27/12
CPC分类号： A61F2/30756 , A61C8/0012 , A61F2/0063 , A61F2/28 , A61L27/02 , A61L27/12 , A61F2002/0068 , A61F2002/30009 , A61F2002/302 , A61F2002/30235 , A61F2002/30909 , A61F2002/30914 , A61F2230/0065 , A61F2230/0069 , A61F2250/0028 , A61F2310/00293 , Y10S525/937 , Y10T428/24273 , Y10T428/24322 , Y10T428/24331 , Y10T428/25 , Y10T428/252 , Y10T428/254 , Y10T428/256 , Y10T428/2982
摘要： Biocompatible particles and an article incorporating a plurality of such particles is disclosed. The particles can have means for interconnecting such as an aperture for stringing the particles on a filament or interlocking external shape. A plurality of particles, with or without means for interconnecting, can be fashioned into an article by interconnecting the particles with a flexible material. When the particles have a means for interconnecting, the plurality of particles can also be interconnected by a rigid material. The particles or plurality of interconnected particles are useful for medical, dental or veterinary or biotechnical applications, such as bone, tooth or skin implants, including alveolar ridge augmentation, or as a growth substrate material. Any biocompatible material can be used, including ceramics such a hydroxylapatite.
摘要翻译：公开了生物相容性颗粒和包含多个这样的颗粒的制品。颗粒可以具有用于互连的装置，例如用于将颗粒缠绕在细丝上或互锁外部形状上的孔。具有或不具有互连的装置的多个颗粒可以通过将颗粒与柔性材料相互连接而形成制品。当颗粒具有用于互连的装置时，多个颗粒也可以通过刚性材料互连。颗粒或多个相互连接的颗粒可用于医疗，牙科或兽医或生物技术应用，例如骨，牙齿或皮肤植入物，包括牙槽嵴隆起或作为生长基质材料。可以使用任何生物相容性材料，包括陶瓷如羟基磷灰石。

8. 发明授权

US6143421A Electronic components incorporating ceramic-metal composites 失效
公开(公告)号：US6143421A
公开(公告)日：2000-11-07
申请号：US949227
申请日：1997-10-13
申请人： Marcus A. Ritland , Dennis W. Readey , James E. Stephan , Dean A. Rulis , Jack D. Sibold
发明人： Marcus A. Ritland , Dennis W. Readey , James E. Stephan , Dean A. Rulis , Jack D. Sibold
IPC分类号： C04B37/00 , C04B41/52 , C04B41/88 , C04B41/89 , F02F3/00 , H01L21/48 , H01L23/498 , H01L23/538 , H05K1/03 , H05K3/40 , B22F3/00
CPC分类号： C04B41/89 , C04B41/009 , C04B41/52 , C04B41/88 , C22C1/1015 , F02F3/00 , H01L21/486 , H01L23/49827 , H01L23/5384 , H05K3/4061 , C04B2111/00844 , C22C2001/1063 , F05C2201/0415 , F05C2203/0895 , F05C2253/16 , H01L2924/0002 , H01L2924/09701 , H05K1/0306 , H05K2201/0116 , H05K2203/128 , Y10T428/12007 , Y10T428/24917 , Y10T428/24926
摘要： The present invention relates to electronic components and in particular relates to ceramic-based electronic components wherein a portion of the component comprises a metal-infiltrated ceramic. In a preferred embodiment, the metal-infiltrated ceramic comprises copper metal.

9. 发明授权

US5676907A Method for making near net shape ceramic-metal composites 失效
标题翻译：制造近净形陶瓷 - 金属复合材料的方法
公开(公告)号：US5676907A
公开(公告)日：1997-10-14
申请号：US220560
申请日：1994-03-31
申请人： Marcus A. Ritland , Dennis W. Readey , James E. Stephan , Dean A. Rulis , Jack D. Sibold
发明人： Marcus A. Ritland , Dennis W. Readey , James E. Stephan , Dean A. Rulis , Jack D. Sibold
IPC分类号： B01D29/11 , B01D53/04 , B01D63/06 , C04B37/00 , C04B37/02 , C04B41/51 , C04B41/52 , C04B41/88 , C04B41/89 , C22C1/10 , C22C29/12 , F01L3/02 , F01L3/22 , F02B3/06 , F02F3/00 , F02F7/00 , H01L21/48 , H01L23/498 , H01L23/538 , H05K1/03 , H05K3/40 , B28B1/24 , B05D3/02
CPC分类号： B01D29/111 , B01D53/0407 , B01D63/061 , B01D63/066 , C04B41/009 , C04B41/5127 , C04B41/5144 , C04B41/52 , C04B41/88 , C04B41/89 , C22C1/1015 , C22C1/1036 , C22C29/12 , F01L3/02 , F01L3/22 , F02F3/00 , F02F7/0087 , H01L21/486 , H01L23/49827 , H01L23/5384 , H05K3/4061 , B01D2201/0446 , C04B2111/00793 , C22C2001/1063 , F01L2101/02 , F02B3/06 , F05C2201/0415 , F05C2203/0895 , F05C2253/16 , H01L2924/0002 , H05K1/0306 , H05K2201/0116 , H05K2203/128
摘要： A process for fabricating ceramic-metal composites having continuous ceramic and metallic phases. The process includes the steps of contacting a porous ceramic matrix material having the general shape of an article of manufacture with molten metal whereby capillary action pulls the metal into the open porosity of the ceramic matrix to substantially fill the open void space. The present invention also provides a ceramic-metal composite having continuous metal and ceramic phases.
摘要翻译：一种制备具有连续陶瓷和金属相的陶瓷 - 金属复合材料的方法。该方法包括以下步骤：将具有制品制造的一般形状的多孔陶瓷基体材料与熔融金属接触，由此毛细管作用将金属拉入陶瓷基体的开孔中，以基本上填充开放的空隙空间。本发明还提供一种具有连续的金属和陶瓷相的陶瓷 - 金属复合材料。

10. 发明授权

US4265669A Shrink-free ceramic and method and raw batch for the manufacture thereof 失效
标题翻译：无收缩陶瓷及其制造方法和原料
公开(公告)号：US4265669A
公开(公告)日：1981-05-05
申请号：US103771
申请日：1979-12-14
申请人： Lynn B. Starling , James E. Stephan , Robert D. Stroud
发明人： Lynn B. Starling , James E. Stephan , Robert D. Stroud
IPC分类号： C04B35/10 , A61C13/083 , A61K6/02 , A61K6/06 , A61K6/093 , C04B35/111 , C04B35/443 , C04B35/63 , C04B35/44 , C04B35/04
CPC分类号： A61K6/0215 , A61C13/083 , A61K6/0276 , A61K6/093 , C04B35/111 , C04B35/6316
摘要： The invention provides a hard, strong ceramic body and a ceramic raw batch and method for manufacture whereby the body, after being formed of the raw batch in the shape and size desired, can then be fired to monolithic structure without any shrinkage or distortion during the firing operation. The raw batch contains aluminum oxide, magnesium oxide, glass frit and a silicone resin, these constituents being present in a ratio such that after the firing operation the resulting monolithic body contains from about 70% to 95% by weight crystalline material and the remainder interstitial glass, the crystalline material consisting predominantly of magnesium aluminate spinel and alumina. The ceramic and method have particular utility for making dental crowns and other dental appliances where a precise fit along with high strength and wear resistance are desirable.
摘要翻译：本发明提供了一种坚硬，坚固的陶瓷体和陶瓷原料批料及其制造方法，其特征在于，在将原料形成所需的形状和尺寸之后，可将本体烧制成单块结构，而不会在射击操作。原料包含氧化铝，氧化镁，玻璃料和硅树脂，这些成分的存在比例使得在焙烧操作之后，所得到的整体体含有约70重量％至95重量％的结晶材料，其余为间隙玻璃，主要由铝酸镁尖晶石和氧化铝组成的结晶材料。陶瓷和方法具有特别的用途，用于制造具有高强度和耐磨性的精确配合的牙冠和其他牙科器具。

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