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1. 发明申请

US20110059987A1 Co-Crystals and Pharmaceutical Compositions Comprising the Same 失效
标题翻译：共晶体和药物组合物组成
公开(公告)号：US20110059987A1
公开(公告)日：2011-03-10
申请号：US12528977
申请日：2008-02-27
申请人： Patrick R. Connelly , Irina Kadiyala , Kathy Stavropolus , Yuegang Zhang , Steve Johnston , Govinda Rao Bhisetti , Valdas Jurkauskas , Peter Rose
发明人： Patrick R. Connelly , Irina Kadiyala , Kathy Stavropolus , Yuegang Zhang , Steve Johnston , Govinda Rao Bhisetti , Valdas Jurkauskas , Peter Rose
IPC分类号： A61K31/497 , A61P31/14
CPC分类号： C07K5/0812 , C07D403/12
摘要： The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of 4-hydroxybenzoic acid, 4-amino salicylic acid, phenylalanine, threonline, tartaric acid, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthranilic acid, and d-Biotin. Also within the scope of this invention are methods of making and using the same.
摘要翻译：本发明涉及各自包含VX-950和选自4-羟基苯甲酸，4-氨基水杨酸，苯丙氨酸，苏氨酸，酒石酸，己二酸，琥珀酸乙酯，脯氨酸，4-羟基苯甲酸甲酯，邻氨基苯甲酸和d-生物素。在本发明的范围内也是制造和使用本发明的方法。

2. 发明授权

US06403675B1 Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same 失效
标题翻译：包含聚（脂环族磷酸酯）化合物的生物可降解组合物，制品及其使用方法
公开(公告)号：US06403675B1
公开(公告)日：2002-06-11
申请号：US09070204
申请日：1998-04-30
申请人： Wenbin Dang , Hai-quan Mao , Irina Kadiyala , Kam W. Leong , Zhong Zhao , James P. English
发明人： Wenbin Dang , Hai-quan Mao , Irina Kadiyala , Kam W. Leong , Zhong Zhao , James P. English
IPC分类号： A61K3180
CPC分类号： C08G79/04 , A61K47/34 , A61L27/18 , A61L31/06 , Y10S623/924 , C08L85/02
摘要： Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.
摘要翻译：描述了可生物降解的，可流动的或柔性的聚合物组合物，其包含具有式I所示的重复单体单元的聚合物：其中：R和R'各自独立地为未取代的或被一个或多个非干扰取代基取代的直链或支链亚烷基; L是二价脂环族基团; R“选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; andn为5至1,000，其中所述生物可降解聚合物在生物降解之前和之后是生物相容的。在一个实施方案中，R，R'或R“中的一个或多个是生物活性物质。还描述了除了聚合物之外含有生物活性物质的无定形组合物以及使用该组合物可控地释放生物活性物质的方法。

3. 发明授权

US07659240B2 Mucin immobilized chromatography 有权
标题翻译：粘蛋白固定色谱
公开(公告)号：US07659240B2
公开(公告)日：2010-02-09
申请号：US10345453
申请日：2003-01-14
申请人： Irina Kadiyala , Riccardo Panicucci
发明人： Irina Kadiyala , Riccardo Panicucci
IPC分类号： C07K14/00
CPC分类号： G01N33/538 , C07K14/4727 , C07K17/00 , G01N2333/4725
摘要： An in vitro high-throughput screening method that models the absorption of drugs across the epithelial mucosa is provided. The invention discloses an in vitro mucin immobilized chromatography model to estimate drug permeability coefficients. The invention describes compositions for mucin immobilized chromatography media and methods to prepare this media. The invention also discloses a method to estimate in vitro drug permeability coefficients using mucin immobilized chromatography media. The invention also discloses methods to determine absorption processes in the digestive system and discloses methods of use for mucin chromatography media in column, batch, assay, diagnostic, or high-throughput screening analyses.
摘要翻译：提供了一种模拟通过上皮粘膜吸收药物的体外高通量筛选方法。本发明公开了一种用于估计药物渗透系数的体外粘蛋白固定化色谱模型。本发明描述了用于粘蛋白固定的色谱介质的组合物和制备该介质的方法。本发明还公开了使用粘蛋白固定化色谱介质估计体外药物渗透系数的方法。本发明还公开了确定消化系统中吸收过程的方法，并公开了在柱，批，测定，诊断或高通量筛选分析中使用粘蛋白色谱介质的方法。

4. 发明授权

US08217172B2 Solid forms of 1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea 失效
标题翻译：固体形式的1-乙基-3-（5-（5-氟吡啶-3-基）-7-（嘧啶-2-基）-1H-苯并[d]咪唑-2-基）脲
公开(公告)号：US08217172B2
公开(公告)日：2012-07-10
申请号：US12329179
申请日：2008-12-05
申请人： Rossitza Alargova , Irina Kadiyala , Arnaud Le Tiran , Dainius Macikenas , Yeugang Zhang
发明人： Rossitza Alargova , Irina Kadiyala , Arnaud Le Tiran , Dainius Macikenas , Yeugang Zhang
IPC分类号： C07D401/08
CPC分类号： C07D401/14
摘要： Solid forms of crystalline1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea, compositions containing solid forms of crystalline1 -ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea and methods of using the same are described.
摘要翻译：结晶1-乙基-3-（5-（5-氟吡啶-3-基）-7-（嘧啶-2-基）-1H-苯并[d]咪唑-2-基）脲的固体形式，含有固体形式的组合物的结晶1-乙基-3-（5-（5-氟吡啶-3-基）-7-（嘧啶-2-基）-1H-苯并[d]咪唑-2-基）脲及其使用方法描述。

5. 发明申请

US20100063284A1 SOLID FORMS OF 1-ethyl-3-(5-(5-FLUOROPYRIDIN-3-YL)-7-(PYRIMIDIN-2-YL)-1H-BENZO[D]IMIDAZOL-2-YL)UREA 失效
标题翻译： 1-乙基-3-（5-（5-氟吡啶-3-基）-7-（吡咯烷-2-基）-1H-苯并[d]咪唑烷-2-基）尿素的固体形式
公开(公告)号：US20100063284A1
公开(公告)日：2010-03-11
申请号：US12329179
申请日：2008-12-05
申请人： Rossitza Alargova , Irina Kadiyala , Arnaud Le Tiran , Dainius Macikenas , Yuegang Zhang
发明人： Rossitza Alargova , Irina Kadiyala , Arnaud Le Tiran , Dainius Macikenas , Yuegang Zhang
IPC分类号： C07D401/14
CPC分类号： C07D401/14
摘要： Solid forms of crystalline1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea, compositions containing solid forms of crystalline1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea and methods of using the same are described.
摘要翻译：结晶1-乙基-3-（5-（5-氟吡啶-3-基）-7-（嘧啶-2-基）-1H-苯并[d]咪唑-2-基）脲的固体形式，含有固体形式的组合物的结晶1-乙基-3-（5-（5-氟吡啶-3-基）-7-（嘧啶-2-基）-1H-苯并[d]咪唑-2-基）脲及其使用方法描述。

6. 发明申请

US20070225339A1 Compositions and methods for treating rheumatoid arthritis 审中-公开
标题翻译：类风湿关节炎的组合物和方法
公开(公告)号：US20070225339A1
公开(公告)日：2007-09-27
申请号：US11715028
申请日：2007-03-07
申请人： Ramon Mohanlal , Robert Kauffman , John Alam , Christopher Godfrey , Irina Kadiyala
发明人： Ramon Mohanlal , Robert Kauffman , John Alam , Christopher Godfrey , Irina Kadiyala
IPC分类号： A61K31/44
CPC分类号： A61K31/519 , A61K31/44 , A61K31/455 , A61K39/395 , Y02A50/412 , A61K2300/00
摘要： The present invention relates to methods and compositions for treating RA in subjects in need thereof. The invention also relates to kits and pharmaceutical packs comprising compositions and dosage forms.
摘要翻译：本发明涉及在有需要的受试者中治疗RA的方法和组合物。本发明还涉及包含组合物和剂型的试剂盒和药物包装。

7. 发明申请

US20080070972A1 Controlled release formulations 审中-公开
标题翻译：控释制剂
公开(公告)号：US20080070972A1
公开(公告)日：2008-03-20
申请号：US11807706
申请日：2007-05-30
申请人： Irina Kadiyala , Wu Lin , Patricia Hurter
发明人： Irina Kadiyala , Wu Lin , Patricia Hurter
IPC分类号： A61K31/4025 , A61P17/06 , A61P29/00 , C07D405/12
CPC分类号： A61K9/1688 , A61K9/2077 , A61K9/2095 , A61K31/401
摘要： The invention relates to a controlled release formulation for an oral cytokine inhibitor of interleukin-1 beta converting enzyme.
摘要翻译：本发明涉及一种用于白细胞介素-1β转换酶的口服细胞因子抑制剂的控释制剂。

8. 发明授权

US06800672B2 Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same 有权
标题翻译：包含聚（脂环族磷酸酯）化合物的生物可降解组合物，制品及其使用方法
公开(公告)号：US06800672B2
公开(公告)日：2004-10-05
申请号：US10011570
申请日：2001-12-04
申请人： Wenbin Dang , Irina Kadiyala , Zhong Zhao , James P. English , Hai-quan Mao , Kam W. Leong
发明人： Wenbin Dang , Irina Kadiyala , Zhong Zhao , James P. English , Hai-quan Mao , Kam W. Leong
IPC分类号： A61K3180
CPC分类号： C08G79/04 , A61K47/34 , A61L27/18 , A61L31/06 , Y10S623/924 , C08L85/02
摘要： Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.
摘要翻译：描述了可生物降解的，可流动的或柔性的聚合物组合物，其包含具有式I所示的重复单体单元的聚合物：其中：R和R'各自独立地为未取代的或被一个或多个非干扰取代基取代的直链或支链亚烷基; L为二价脂环族基团; R“选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; andn为5至1,000，其中所述生物可降解聚合物在生物降解之前和之后是生物相容的。在一个实施方案中，R，R'或R“中的一个或多个是生物活性物质。除聚合物之外含有生物活性物质的无定形组合物以及使用该组合物可控地释放生物活性物质的方法也是描述。

9. 发明授权

US08759353B2 Co-crystals and pharmaceutical compositions comprising the same 失效
标题翻译：包含其的共晶体和药物组合物
公开(公告)号：US08759353B2
公开(公告)日：2014-06-24
申请号：US12528977
申请日：2008-02-27
申请人： Patrick R. Connelly , Irina Kadiyala , Kathy Stavropoulos , Yuegang Zhang , Steven C. Johnston , Govinda Rao Bhisetti , Valdas Jurkauskas , Peter Rose
发明人： Patrick R. Connelly , Irina Kadiyala , Kathy Stavropoulos , Yuegang Zhang , Steven C. Johnston , Govinda Rao Bhisetti , Valdas Jurkauskas , Peter Rose
IPC分类号： A61K31/497 , A61P31/14
CPC分类号： C07K5/0812 , C07D403/12
摘要： The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of 4-hydroxybenzoic acid, 4-amino salicylic acid, phenylalanine, threonline, tartaric acid, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthranilic acid, and d-Biotin. Also within the scope of this invention are methods of making and using the same.
摘要翻译：本发明涉及各自包含VX-950和选自4-羟基苯甲酸，4-氨基水杨酸，苯丙氨酸，苏氨酸，酒石酸，己二酸，琥珀酸乙酯，脯氨酸，4-羟基苯甲酸甲酯，邻氨基苯甲酸和d-生物素。在本发明的范围内也是制造和使用本发明的方法。

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