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1. 发明授权

US07659240B2 Mucin immobilized chromatography 有权
标题翻译：粘蛋白固定色谱
公开(公告)号：US07659240B2
公开(公告)日：2010-02-09
申请号：US10345453
申请日：2003-01-14
申请人： Irina Kadiyala , Riccardo Panicucci
发明人： Irina Kadiyala , Riccardo Panicucci
IPC分类号： C07K14/00
CPC分类号： G01N33/538 , C07K14/4727 , C07K17/00 , G01N2333/4725
摘要： An in vitro high-throughput screening method that models the absorption of drugs across the epithelial mucosa is provided. The invention discloses an in vitro mucin immobilized chromatography model to estimate drug permeability coefficients. The invention describes compositions for mucin immobilized chromatography media and methods to prepare this media. The invention also discloses a method to estimate in vitro drug permeability coefficients using mucin immobilized chromatography media. The invention also discloses methods to determine absorption processes in the digestive system and discloses methods of use for mucin chromatography media in column, batch, assay, diagnostic, or high-throughput screening analyses.
摘要翻译：提供了一种模拟通过上皮粘膜吸收药物的体外高通量筛选方法。本发明公开了一种用于估计药物渗透系数的体外粘蛋白固定化色谱模型。本发明描述了用于粘蛋白固定的色谱介质的组合物和制备该介质的方法。本发明还公开了使用粘蛋白固定化色谱介质估计体外药物渗透系数的方法。本发明还公开了确定消化系统中吸收过程的方法，并公开了在柱，批，测定，诊断或高通量筛选分析中使用粘蛋白色谱介质的方法。

2. 发明授权

US06280775B1 Antimicrobial oral composition and method of use 有权
标题翻译：抗微生物口服成分及使用方法
公开(公告)号：US06280775B1
公开(公告)日：2001-08-28
申请号：US09575351
申请日：2000-05-19
申请人： Joseph Alan Sasson , Riccardo Panicucci
发明人： Joseph Alan Sasson , Riccardo Panicucci
IPC分类号： A61K3340
CPC分类号： A61K33/40 , A61K33/00 , A61K33/04 , A61K33/14 , Y10S514/835 , Y10S514/90 , Y10S514/901 , Y10S514/902 , Y10S514/974 , A61K2300/00
摘要： This invention provides a liquid antimicrobial composition that is particularly useful as a mouthwash for treating or reducing the risk of dental disease. The composition is prepared by mixing a first solution comprising a water soluble metal chlorite compound with a second solution comprising sodium persulfate and hydrogen peroxide. The resulting composition, containing chlorine dioxide, is preferably used at the time of preparation by applying the composition to the locus where treatment is desired.
摘要翻译：本发明提供了一种液体抗微生物组合物，其特别可用作治疗或降低牙科疾病风险的漱口水。通过将包含水溶性金属亚氯酸盐化合物的第一溶液与包含过硫酸钠和过氧化氢的第二溶液混合来制备组合物。含有二氧化氯的所得组合物优选在制备时通过将组合物施用于需要处理的场所来使用。

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