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    • 1. 发明授权
    • Mucin immobilized chromatography
    • 粘蛋白固定色谱
    • US07659240B2
    • 2010-02-09
    • US10345453
    • 2003-01-14
    • Irina KadiyalaRiccardo Panicucci
    • Irina KadiyalaRiccardo Panicucci
    • C07K14/00
    • G01N33/538C07K14/4727C07K17/00G01N2333/4725
    • An in vitro high-throughput screening method that models the absorption of drugs across the epithelial mucosa is provided. The invention discloses an in vitro mucin immobilized chromatography model to estimate drug permeability coefficients. The invention describes compositions for mucin immobilized chromatography media and methods to prepare this media. The invention also discloses a method to estimate in vitro drug permeability coefficients using mucin immobilized chromatography media. The invention also discloses methods to determine absorption processes in the digestive system and discloses methods of use for mucin chromatography media in column, batch, assay, diagnostic, or high-throughput screening analyses.
    • 提供了一种模拟通过上皮粘膜吸收药物的体外高通量筛选方法。 本发明公开了一种用于估计药物渗透系数的体外粘蛋白固定化色谱模型。 本发明描述了用于粘蛋白固定的色谱介质的组合物和制备该介质的方法。 本发明还公开了使用粘蛋白固定化色谱介质估计体外药物渗透系数的方法。 本发明还公开了确定消化系统中吸收过程的方法,并公开了在柱,批,测定,诊断或高通量筛选分析中使用粘蛋白色谱介质的方法。