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1. 发明授权

US08906699B2 Functionalized fluorescent nanocrystal compositions and methods for their preparation 有权
标题翻译：官能化荧光纳米晶体组合物及其制备方法
公开(公告)号：US08906699B2
公开(公告)日：2014-12-09
申请号：US13597056
申请日：2012-08-28
申请人： Imad Naasani
发明人： Imad Naasani
IPC分类号： G01N21/64 , G01N33/58 , B82Y15/00
CPC分类号： G01N33/588 , B82Y15/00 , Y10T428/265 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： The present invention provides for functionalized fluorescent nanocrystal compositions and methods for making these compositions. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in the coating may form a capping layer on the fluorescent nanocrystal with the coating compounds operably bonded to the capping layer.
摘要翻译：本发明提供了功能化的荧光纳米晶体组合物和制备这些组合物的方法。组合物是涂覆有至少一种材料的荧光纳米晶体。涂层材料具有具有带有共轭电子和部分的官能团或部分的化学化合物或配体，以在水溶液中赋予涂覆的荧光纳米晶体的溶解性。涂层材料提供功能化的荧光纳米晶体组合物，其水溶性，化学稳定性，并且当用光激发时具有高量子产率和/或发光效率的光。涂层材料还可以具有化学化合物或具有用于键合到靶分子和细胞的部分的配体以及用于交联涂层的部分。在适于反应形成封盖层的试剂存在下，涂层中的化合物可以在荧光纳米晶体上形成覆盖层，其中涂层化合物可操作地结合到覆盖层。

2. 发明授权

US08221648B2 Functionalized fluorescent nanocrystal detection system 有权
标题翻译：功能化荧光纳米晶体检测系统
公开(公告)号：US08221648B2
公开(公告)日：2012-07-17
申请号：US12551991
申请日：2009-09-01
申请人： Imad Naasani
发明人： Imad Naasani
IPC分类号： C09K11/08 , G01N21/76
CPC分类号： G01N33/588 , B82Y15/00 , C12Q1/48 , G01N2333/9125 , Y10S977/774 , Y10S977/902
摘要： The present invention include fluorescent nanocrystals which have high fluorescence intensity, are water soluble, exhibit physical and chemical stability, and whose spectral properties are detectably modified as the size of functional groups bonded to the nanocrystal surface change when contacted with target molecules in a sample. The molecules in the sample add to or reduce the size of functional groups on the fluorescent nanocrystal proportional to the activity and amount of the target molecules. The present invention may be used to detect telomerase in a sample.
摘要翻译：本发明包括具有高荧光强度，水溶性，表现出物理和化学稳定性的荧光纳米晶体，并且当与样品中的靶分子接触时，结合到纳米晶体表面的官能团的尺寸发生变化，其光谱性质可被可检测地修饰。样品中的分子增加或减少荧光纳米晶体上的官能团的大小与靶分子的活性和量成比例。本发明可以用于检测样品中的端粒酶。

3. 发明申请

US20110068322A1 Semiconductor Nanoparticle-Based Materials 有权
标题翻译：半导体纳米粒子材料
公开(公告)号：US20110068322A1
公开(公告)日：2011-03-24
申请号：US12888982
申请日：2010-09-23
申请人： Nigel Pickett , Imad Naasani , James Harris
发明人： Nigel Pickett , Imad Naasani , James Harris
IPC分类号： H01L33/06 , H01B1/20 , H01L21/20
CPC分类号： H01L33/502 , C09K11/02 , C09K11/025 , C09K11/565 , C09K11/70 , C09K11/883 , H01L33/504 , H01L33/505 , H01L2933/0025 , H01L2933/0041
摘要： In various embodiments, the present invention relates to a plurality of coated primary particles, each primary particle including a primary matrix material and containing a population of semiconductor nanoparticles, wherein each primary particle is provided with a separate layer of a surface coating material. Various methods of preparing such particles are described. Composite materials and light-emitting devices incorporating such primary particles are also described.
摘要翻译：在各种实施方案中，本发明涉及多个涂覆的初级颗粒，每个初级颗粒包括主要基体材料并含有一群半导体纳米颗粒，其中每个初级颗粒设置有单独的表面涂层材料层。描述制备这种颗粒的各种方法。还描述了包含这种一次粒子的复合材料和发光器件。

4. 发明申请

US20100075437A1 Synthesis of highly luminescent colloidal particles 有权
标题翻译：高发光胶体颗粒的合成
公开(公告)号：US20100075437A1
公开(公告)日：2010-03-25
申请号：US12563900
申请日：2009-09-21
申请人： Imad NAASANI
发明人： Imad NAASANI
IPC分类号： G01N33/53
CPC分类号： B82Y15/00 , B82Y5/00 , B82Y30/00 , C09K11/02 , C09K11/565 , C09K11/883 , C30B7/005 , C30B29/605 , G01N33/588 , Y10S977/882 , Y10S977/896 , Y10T428/2991
摘要： The present invention includes compositions and methods for their used wherein the compositions include clusters of coated fluorescent nanocrystals having a select size formed by controlled aggregation of individual coated nanocrystals.
摘要翻译：本发明包括其使用的组合物和方法，其中组合物包括具有通过单个包被的纳米晶体的受控聚集形成的选择尺寸的涂覆的荧光纳米晶体簇。

5. 发明申请

US20110306079A1 WATER-DISPERSABLE NANOPARTICLES 有权
标题翻译：水分散纳米颗粒
公开(公告)号：US20110306079A1
公开(公告)日：2011-12-15
申请号：US13057504
申请日：2009-08-06
申请人： Eric Tulsky , Kari Haley , Imad Naasani , John Mauro , Roman Rozhkow , Joseph A. Treadway
发明人： Eric Tulsky , Kari Haley , Imad Naasani , John Mauro , Roman Rozhkow , Joseph A. Treadway
IPC分类号： C12Q1/02 , G01N21/75 , B82B1/00 , B82B3/00 , B82Y15/00
CPC分类号： G01N33/588 , B01J13/14 , B22F1/0022 , B22F1/02 , B82Y30/00 , G01N1/30 , G01N21/64 , G01N2001/302 , Y10S977/773 , Y10S977/81 , Y10S977/834 , Y10S977/902
摘要： Provided herein are methods for making water-soluble nanoparticles comprising a core/shell nanocrystal that is coated with a surface layer comprising enough hydrophilic ligands to render the nanoparticle water soluble or water dispersable. Methods for crosslinking molecules on the surface of a nanoparticle, which methods can be used on the above water-soluble nanoparticles also are provided. Nanoparticle compositions resulting from these methods are also provided.
摘要翻译：本文提供了制备包含核/壳纳米晶体的水溶性纳米颗粒的方法，其被包覆有包含足够亲水性配体的表面层以使纳米颗粒水溶性或水分散。还提供了在纳米颗粒表面上交联分子的方法，该方法可用于上述水溶性纳米颗粒。还提供了由这些方法得到的纳米颗粒组合物。

6. 发明申请

US20110003343A1 CONJUGATES OF BIOMOLECULES TO NANOPARTICLES 有权
标题翻译：生物分子与纳米颗粒的结合
公开(公告)号：US20110003343A1
公开(公告)日：2011-01-06
申请号：US12748355
申请日：2010-03-26
申请人： Theo Nikiforov , Daniel Mazur , Xinzhan Peng , Tommie Lloyd Lincecum, JR. , Yuri Belosludtsev , Howard Reese , Dmitriy Gremyachinskiy , Roman Rozhkov , John M. Mauro , Joseph Beechem , Eric Tulsky , Imad Naasani , Kari Haley , Joseph A. Treadway
发明人： Theo Nikiforov , Daniel Mazur , Xinzhan Peng , Tommie Lloyd Lincecum, JR. , Yuri Belosludtsev , Howard Reese , Dmitriy Gremyachinskiy , Roman Rozhkov , John M. Mauro , Joseph Beechem , Eric Tulsky , Imad Naasani , Kari Haley , Joseph A. Treadway
IPC分类号： C12P19/34 , C12N9/10
CPC分类号： C12Q1/6869 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12N9/96 , C12Q1/6818 , C12Y207/07 , C12Y207/07007 , G01N21/6428 , G01N33/582 , G01N2021/6432
摘要： Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing.
摘要翻译：本文公开了包含连接到具有生物活性并可用于多种生物应用的标签的生物分子的缀合物。例如，本文提供了聚合酶 - 纳米颗粒缀合物，其包括与纳米颗粒连接的聚合酶，其中缀合物具有聚合酶活性。这样的缀合物可以表现出减少的聚集和改进的沉淀物，其中平均生物分子：纳米颗粒比接近或等于1:1。本文还公开了制备这种缀合物的改进方法，以及在生物应用中使用这种缀合物的方法和系统，例如核苷酸掺入，引物延伸和单分子测序。

7. 发明申请

US20100105048A1 FUNCTIONALIZED FLUORESCENT NANOCRYSTAL DETECTION SYSTEM 有权
标题翻译：功能荧光纳米晶体检测系统
公开(公告)号：US20100105048A1
公开(公告)日：2010-04-29
申请号：US12551991
申请日：2009-09-01
申请人： Imad NAASANI
发明人： Imad NAASANI
IPC分类号： C12Q1/68
CPC分类号： G01N33/588 , B82Y15/00 , C12Q1/48 , G01N2333/9125 , Y10S977/774 , Y10S977/902
摘要： The present invention include fluorescent nanocrystals which have high fluorescence intensity, are water soluble, exhibit physical and chemical stability, and whose spectral properties are detectably modified as the size of functional groups bonded to the nanocrystal surface change when contacted with target molecules in a sample. The molecules in the sample add to or reduce the size of functional groups on the fluorescent nanocrystal proportional to the activity and amount of the target molecules. The present invention may be used to detect telomerase in a sample.
摘要翻译：本发明包括具有高荧光强度，水溶性，表现出物理和化学稳定性的荧光纳米晶体，并且当与样品中的靶分子接触时，结合到纳米晶体表面的官能团的尺寸发生变化，其光谱性质可被可检测地修饰。样品中的分子增加或减少荧光纳米晶体上的官能团的大小与靶分子的活性和量成比例。本发明可以用于检测样品中的端粒酶。

8. 发明申请

US20050112376A1 Nanocrystals 有权
标题翻译：纳米晶体
公开(公告)号：US20050112376A1
公开(公告)日：2005-05-26
申请号：US10952701
申请日：2004-09-29
申请人： Imad Naasani
发明人： Imad Naasani
IPC分类号： G01N33/543 , B82B1/00 , C01B19/04 , C09K11/08 , G01N33/58 , B32B5/16 , B32B9/00 , B32B18/00
CPC分类号： B82Y15/00 , G01N33/588 , Y10T428/25 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998 , Y10T428/31721
摘要： Provided herein are compositions of functionalized, fluorescent nanocrystals comprising fluorescent nanocrystals coated with an imidazole-containing compound; compositions of functionalized, fluorescent nanocrystals comprising fluorescent nanocrystals coated with an imidazole-containing compound and cross-linked with a phosphine cross-linking compound; compositions of functionalized fluorescent nanocrystals operably bound to molecular probe; a process of making functionalized, fluorescent nanocrystals; and a process of using functionalized, fluorescent nanocrystals in a detection system.
摘要翻译：本文提供了包含用含咪唑的化合物涂覆的荧光纳米晶体的官能化荧光纳米晶体的组合物; 官能化荧光纳米晶体的组成包括用含咪唑的化合物涂覆并与膦交联化合物交联的荧光纳米晶体; 可操作地结合分子探针的官能化荧光纳米晶体的组成; 制备官能化荧光纳米晶体的方法; 以及在检测系统中使用官能化的荧光纳米晶体的过程。

9. 发明授权

US09082941B2 Semiconductor nanoparticle-based materials for use in light emitting diodes, optoelectronic displays and the like 有权
标题翻译：用于发光二极管的半导体纳米颗粒基材料，光电子显示器等
公开(公告)号：US09082941B2
公开(公告)日：2015-07-14
申请号：US13485292
申请日：2012-05-31
申请人： Imad Naasani , Hao Pang , Siobhan S. Daniels , Emma Fitzgerald , Mark McCairn
发明人： Imad Naasani , Hao Pang , Siobhan S. Daniels , Emma Fitzgerald , Mark McCairn
IPC分类号： H01L33/00 , H01L33/50 , H01L33/56 , C09K11/02 , C09K11/56 , C09K11/70 , C09K11/88 , C08L33/06 , C08F222/10 , C08F220/18
CPC分类号： H01L33/507 , C08F222/1006 , C08F2220/1883 , C08L33/06 , C09K11/02 , C09K11/025 , C09K11/565 , C09K11/70 , C09K11/703 , C09K11/883 , H01L33/501 , H01L33/502 , H01L33/56 , H01L2224/48091 , H01L2224/48247 , H01L2924/16195 , H01L2933/0041 , H01L2933/005 , H01L2924/00014
摘要： A formulation incorporates nanoparticles, particularly quantum dot (QD) nanoparticles, into an optically clear medium (resin) to be used as a phosphor material in lighting and display applications, and as a down converting phosphor material in LEDs (light emitting diodes). The resin is compatible with QDs to allow high performance and stability of QD-based LEDs, lighting and display applications.
摘要翻译：制剂将纳米颗粒，特别是量子点（QD）纳米颗粒结合到用作照明和显示应用中的荧光体材料的光学透明介质（树脂）中，以及作为LED（发光二极管）中的下变换磷光体材料。该树脂与QD兼容，可实现基于QD的LED，照明和显示应用的高性能和稳定性。

10. 发明授权

US08674390B2 Semiconductor nanoparticle-containing materials and light emitting devices incorporating the same 有权
标题翻译：含有半导体纳米颗粒的材料和掺入其的发光器件
公开(公告)号：US08674390B2
公开(公告)日：2014-03-18
申请号：US13485275
申请日：2012-05-31
申请人： James Harris , Imad Naasani , Nigel Picket
发明人： James Harris , Imad Naasani , Nigel Picket
IPC分类号： H01L33/00 , H01L21/00
CPC分类号： H01L33/52 , B82Y20/00 , C09K11/02 , C09K11/565 , C09K11/70 , C09K11/883 , F21V15/00 , H01L33/48 , H01L33/507 , H01L2224/48091 , H01L2224/48247 , Y10S977/773 , H01L2924/00014
摘要： In various embodiments, the present invention provides a light emitting device cap configured for location on a light emitting device comprising or consisting essentially of a primary light source. The cap defines a well region within which is received a population of semiconductor nanoparticles such that the semiconductor nanoparticles are in optical communication with the primary light source of the light emitting device when the cap is located on the light emitting device. There is further provided a light emitting device comprising or consisting essentially of a primary light source and such a cap, as well as methods for fabricating such a cap and device.
摘要翻译：在各种实施例中，本发明提供了一种配置用于位于发光器件上的发光器件帽，该发光器件包括或基本上由主光源组成。盖限定了一个阱区域，在该区域内接收了一群半导体纳米颗粒，使得当帽位于发光器件上时，半导体纳米颗粒与发光器件的初级光源光通信。还提供了一种发光器件，其包括或基本上由初级光源和这种盖组成，以及用于制造这种帽和器件的方法。

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