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1. 发明授权

US06893655B2 Transdermal delivery devices 有权
标题翻译：透皮递送装置
公开(公告)号：US06893655B2
公开(公告)日：2005-05-17
申请号：US10263413
申请日：2002-10-02
申请人： Peggy-Jean P. Flanigan , Hye-ok Choi
发明人： Peggy-Jean P. Flanigan , Hye-ok Choi
IPC分类号： A61K9/06 , A61K9/08 , A61K9/10 , A61K9/12 , A61K9/14 , A61K9/66 , A61K9/70 , A61K31/21 , A61K31/4168 , A61K31/4468 , A61K31/465 , A61K31/565 , A61K31/568 , A61F13/02 , A61F13/00 , A61L15/16
CPC分类号： A61K9/703 , A61K9/7084 , A61K9/7092 , A61K31/21 , A61K31/465 , A61K31/565 , B33Y80/00
摘要： A transdermal delivery device including at least one pressure sensitive adhesive layer having a first major surface and a second major surface, wherein at least one of the first and second major surfaces is a structured surface; a cap layer in contact with the structured surface of an adhesive layer; and, at least one medicinal ingredient between the adhesive layer and the cap layer.
摘要翻译：一种透皮递送装置，其包括具有第一主表面和第二主表面的至少一个压敏粘合剂层，其中所述第一和第二主表面中的至少一个是结构化表面; 与粘合剂层的结构化表面接触的盖层; 以及在粘合剂层和盖层之间的至少一种药用成分。

2. 发明授权

US06312715B1 Adhesive microsphere drug delivery composition 失效
标题翻译：胶粘剂微球药物输送组合物
公开(公告)号：US06312715B1
公开(公告)日：2001-11-06
申请号：US09071667
申请日：1998-05-01
申请人： Adam S. Cantor , Hye-ok Choi , Joaquin Delgado , Chan U. Ko , Thu-Van Tran
发明人： Adam S. Cantor , Hye-ok Choi , Joaquin Delgado , Chan U. Ko , Thu-Van Tran
IPC分类号： A61F1302
CPC分类号： A61K9/7061 , A61K9/1617 , A61K9/1635 , A61K9/7092 , C08L2205/18 , C08L2666/28 , C09J133/06
摘要： Transdermal drug delivery compositions comprising pressure sensitive adhesive microspheres that contain a softening agent and/or a drug. Typically the microspheres contain at least 10 wt-% of a softening agent. The drug and/or softening agent can be incorporated into the microspheres during or after their formation.
摘要翻译：透皮药物递送组合物包含含有软化剂和/或药物的压敏粘合剂微球。通常，微球含有至少10重量％的软化剂。药物和/或软化剂可在其形成期间或之后并入微球中。

3. 发明申请

US20120315345A1 FUNCTIONAL FOOD AND PHARMACEUTICAL COMPOSITIONS FOR ANTI-OBESITY COMPRISING CAPSANTHIN AND FATTY-ACYL ESTER OF CAPSANTHIN HAVING ANTI-ADIPOGENIC ACTIVITY 审中-公开
标题翻译：功能性食品和药物组合物，用于包含抗坏血酸和含有抗体活性的芹菜素的脂肪酸酯
公开(公告)号：US20120315345A1
公开(公告)日：2012-12-13
申请号：US13481995
申请日：2012-05-29
申请人： Byung-Hoon HAN , Jeong-Won KIM , Sung-Jun JO , Hye-Ok CHOI , Jung-Hwan KIM , Moo-Kang KIM , Il-Kwon PARK , Seung-Hwan LEE
发明人： Byung-Hoon HAN , Jeong-Won KIM , Sung-Jun JO , Hye-Ok CHOI , Jung-Hwan KIM , Moo-Kang KIM , Il-Kwon PARK , Seung-Hwan LEE
IPC分类号： A61K31/12 , A23L2/38 , A23G3/48 , A61P3/04 , A21D13/00 , A23L1/16 , C07C49/573 , A61K36/81 , A23L1/30 , A23L1/10
CPC分类号： A61K36/81 , A23L33/105 , A23V2002/00 , A61K31/12 , A61K31/21 , A61K36/67 , C07C403/14 , A23V2200/332 , A23V2250/211 , A61K2300/00
摘要： One or more embodiments of the present invention describe a novel use of capsanthin and/or fatty-acyl ester of capsanthin to inhibit both the differentiation of pre-adipocytes to adipocytes and the accumulation of fat in the adipocytes. One or more embodiments of the present invention are based on findings that capsanthin contained in some natural products such as red pepper, paprika, bell pepper, etc. have anti-adipogenic activity by inhibiting both the differentiation of pre-adipocyte into adipocyte and the accumulation of fat in adipocytes, Therefore, this findings provide a functional food and a pharmaceutical composition wherein capsanthins and the extract of any natural products containing the same components are included in the functional food and the pharmaceutical composition, to offer obesity prevention and/or treatment effects.
摘要翻译：本发明的一个或多个实施方案描述了辣椒红和/或辣椒红的脂肪酰基酯的新用途，以抑制前脂肪细胞与脂肪细胞的分化以及脂肪细胞中脂肪的积累。本发明的一个或多个实施方案基于以下发现：一些天然产物如红辣椒，辣椒红，甜椒等中所含的辣椒红含有通过抑制前脂肪细胞分化成脂肪细胞和积累的脂肪生成活性脂肪细胞中的脂肪。因此，该发现提供功能性食品和药物组合物，其中将功能性食品和药物组合物中包含辣椒红和含有相同组分的任何天然产物的提取物，以提供肥胖预防和/或治疗效果。

4. 发明授权

US5508060A Method of polymer impregnation 失效
标题翻译：聚合物浸渍方法
公开(公告)号：US5508060A
公开(公告)日：1996-04-16
申请号：US193170
申请日：1994-09-19
申请人： Craig A. Perman , Joanne M. Bartkus , Hye-Ok Choi , Manfred E. Riechert , Kelvin J. Witcher , Richard C. Kao , James S. Stefely , John E. Gozum
发明人： Craig A. Perman , Joanne M. Bartkus , Hye-Ok Choi , Manfred E. Riechert , Kelvin J. Witcher , Richard C. Kao , James S. Stefely , John E. Gozum
IPC分类号： A61K9/00 , A61K9/16 , A61K47/32 , A61K47/34 , A61L17/00 , A61L29/16 , A61L31/16 , C08J3/20 , C08J7/06 , D06M23/10 , D06P1/94 , B05D3/12
CPC分类号： D06P1/94 , A61K9/1647 , A61K9/1658 , A61K9/1694 , A61L17/005 , C08J7/065 , D06M23/105 , A61L2300/252 , A61L2300/406 , A61L2300/43 , A61L2300/442 , A61L2300/622 , Y02P20/544
摘要： Methods of impregnating various polymer substrates with an impregnation additive, by simultaneously contacting the polymer substrate with an impregnation additive, carrier liquid, and supercritical fluid are provided. The impregnation additive is substantially insoluble in the supercritical fluid, and the carrier liquid is preferably substantially insoluble in the supercritical fluid.
摘要翻译： PCT No.PCT / US94 / 01557 Sec。 371日期1994年9月19日 102（e）1994年9月19日PCT 1994年2月10日PCT PCT。出版物WO94 / 18264 日期：1994年8月18日。提供了用浸渍添加剂浸渍各种聚合物基材，同时使聚合物基材与浸渍添加剂，载体液体和超临界流体接触的方法。浸渍添加剂基本上不溶于超临界流体，载体液体优选基本上不溶于超临界流体。

5. 发明申请

US20080051699A1 Method Of Using A Film To Coat A Microneedle Array 有权
标题翻译：使用薄膜涂覆微针阵列的方法
公开(公告)号：US20080051699A1
公开(公告)日：2008-02-28
申请号：US11718474
申请日：2005-11-18
申请人： Hye-Ok Choi , Gordon Knutson , Moses David
发明人： Hye-Ok Choi , Gordon Knutson , Moses David
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023
摘要： A method of coating a microneedle array by applying a coating fluid using a flexible film in a brush-like manner. A method of coating a microneedle array comprising: providing a microneedle array having a substrate and a plurality of microneedles; providing a flexible film; providing a coating solution comprising a carrier fluid and a coating material; applying the coating solution onto a first major surface of the flexible film; providing a coating solution comprising a carrier fluid and a coating material; applying the coating solution onto a first major surface of the flexible film; performing a transfer step of bringing the first major surface of the flexible film into contact with the microneedles and removing the flexible film from contact with the microneedles; and allowing the carrier fluid to evaporate.
摘要翻译：通过以类似刷子的方式使用柔性膜施加涂布液来涂布微针阵列的方法。一种涂覆微针阵列的方法，包括：提供具有基底和多个微针的微针阵列; 提供柔性膜; 提供包含载体流体和涂层材料的涂层溶液; 将涂布溶液施加到柔性膜的第一主表面上; 提供包含载体流体和涂层材料的涂层溶液; 将涂布溶液施加到柔性膜的第一主表面上; 执行将柔性膜的第一主表面与微针接触并移除柔性膜以与微针接触的转印步骤; 并允许载体液体蒸发。

6. 发明申请

US20080102192A1 Masking Method for Coating a Microneedle Array 有权
标题翻译：用于涂覆微针阵列的掩模方法
公开(公告)号：US20080102192A1
公开(公告)日：2008-05-01
申请号：US11718737
申请日：2005-11-18
申请人： Peter R. Johnson , Maria R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel c. Duan , Moses M. David , Hye-Ok Choi
发明人： Peter R. Johnson , Maria R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel c. Duan , Moses M. David , Hye-Ok Choi
IPC分类号： A61L33/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： A method of coating a microneedle array comprising: providing a microneedle array having a substrate and at least one needle; providing a removable masking layer on the microneedle array such that the substrate is at least partially covered by the masking layer and the at least one needle remains at least partially exposed; and applying a coating material to at least a portion of the exposed portion of the microneedle array.
摘要翻译：一种涂覆微针阵列的方法，包括：提供具有基底和至少一个针的微针阵列; 在所述微针阵列上提供可移除的掩模层，使得所述基底至少部分地被所述掩蔽层覆盖，并且所述至少一个针保持至少部分地暴露; 以及将涂层材料施加到所述微针阵列的暴露部分的至少一部分。

7. 发明授权

US06576263B2 Delivery systems using preformed biodegradable polymer compositions and methods 有权
标题翻译：使用预制的生物可降解聚合物组合物和方法的递送系统
公开(公告)号：US06576263B2
公开(公告)日：2003-06-10
申请号：US09784934
申请日：2001-02-16
申请人： Myhanh T. Truong , Kaveh Pournoor , Hye-ok Choi , David J. Velasquez , Richard H. Ferber , Stephanie F. Bernatchez
发明人： Myhanh T. Truong , Kaveh Pournoor , Hye-ok Choi , David J. Velasquez , Richard H. Ferber , Stephanie F. Bernatchez
IPC分类号： A61K914
CPC分类号： C08G65/329 , A61K9/1658 , A61K9/2063 , A61K47/643 , A61K47/65
摘要： A preformed object for delivering an active agent for a subject, the preformed object including crosslinked protein, and methods of making and using.
摘要翻译：用于递送受试者的活性剂的预成型物体，所述预成型物体包括交联的蛋白质，以及制备和使用方法。

8. 发明授权

US08057842B2 Method of contact coating a microneedle array 有权
标题翻译：接触涂布微针阵列的方法
公开(公告)号：US08057842B2
公开(公告)日：2011-11-15
申请号：US11718474
申请日：2005-11-18
申请人： Hye-Ok Choi , Gordon P. Knutson , Moses M. David
发明人： Hye-Ok Choi , Gordon P. Knutson , Moses M. David
IPC分类号： B05D3/02 , G01N1/00 , A61B17/20 , A61M37/00 , A61M5/32
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023
摘要： A method of coating a microneedle array by applying a coating fluid using a flexible film in a brush-like manner. A method of coating a microneedle array comprising: providing a microneedle array having a substrate and a plurality of microneedles; providing a flexible film; providing a coating solution comprising a carrier fluid and a coating material; applying the coating solution onto a first major surface of the flexible film; performing a transfer step of bringing the first major surface of the flexible film into contact with the microneedles and removing the flexible film from contact with the microneedles; and allowing the carrier fluid to evaporate. Also, a method of coating a microneedle array by applying a coating solution onto a first major surface of a coating substrate to form a layer of applied coating solution having a thickness equal to or less than the height of at least one of the microneedles and performing a transfer step of bringing the first major surface of the coating substrate into contact with the microneedles and removing the coating substrate from contact with the microneedles, thereby transferring at least a portion of the coating solution to the microneedle array.
摘要翻译：通过以类似刷子的方式使用柔性膜施加涂布液来涂布微针阵列的方法。一种涂覆微针阵列的方法，包括：提供具有基底和多个微针的微针阵列; 提供柔性膜; 提供包含载体流体和涂层材料的涂层溶液; 将涂布溶液施加到柔性膜的第一主表面上; 执行将柔性膜的第一主表面与微针接触并移除柔性膜以与微针接触的转印步骤; 并允许载体液体蒸发。此外，通过将涂布溶液涂覆在涂布基材的第一主表面上以形成具有等于或小于至少一个微针的高度的涂覆涂层溶液的层并涂覆微针阵列的方法，并执行将涂布基板的第一主表面与微针接触并移除涂布基板与微针接触的转印步骤，从而将至少一部分涂布溶液转印到微针阵列上。

9. 发明授权

US07846488B2 Masking method for coating a microneedle array 有权
标题翻译：用于涂布微针阵列的掩模方法
公开(公告)号：US07846488B2
公开(公告)日：2010-12-07
申请号：US11718737
申请日：2005-11-18
申请人： Peter R. Johnson , Marla R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel C. Duan , Moses M. David , Hye-Ok Choi
发明人： Peter R. Johnson , Marla R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel C. Duan , Moses M. David , Hye-Ok Choi
IPC分类号： A61L33/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： A method of coating a microneedle array comprising: providing a microneedle array having a substrate and at least one needle; providing a removable masking layer on the microneedle array such that the substrate is at least partially covered by the masking layer and the at least one needle remains at least partially exposed; and applying a coating material to at least a portion of the exposed portion of the microneedle array.
摘要翻译：一种涂覆微针阵列的方法，包括：提供具有基底和至少一个针的微针阵列; 在所述微针阵列上提供可移除的掩模层，使得所述基底至少部分地被所述掩蔽层覆盖，并且所述至少一个针保持至少部分地暴露; 以及将涂层材料施加到所述微针阵列的暴露部分的至少一部分。

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