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    • 3. 发明授权
    • Method of contact coating a microneedle array
    • 接触涂布微针阵列的方法
    • US08057842B2
    • 2011-11-15
    • US11718474
    • 2005-11-18
    • Hye-Ok ChoiGordon P. KnutsonMoses M. David
    • Hye-Ok ChoiGordon P. KnutsonMoses M. David
    • B05D3/02G01N1/00A61B17/20A61M37/00A61M5/32
    • A61M37/0015A61K9/0021A61M2037/0023
    • A method of coating a microneedle array by applying a coating fluid using a flexible film in a brush-like manner. A method of coating a microneedle array comprising: providing a microneedle array having a substrate and a plurality of microneedles; providing a flexible film; providing a coating solution comprising a carrier fluid and a coating material; applying the coating solution onto a first major surface of the flexible film; performing a transfer step of bringing the first major surface of the flexible film into contact with the microneedles and removing the flexible film from contact with the microneedles; and allowing the carrier fluid to evaporate. Also, a method of coating a microneedle array by applying a coating solution onto a first major surface of a coating substrate to form a layer of applied coating solution having a thickness equal to or less than the height of at least one of the microneedles and performing a transfer step of bringing the first major surface of the coating substrate into contact with the microneedles and removing the coating substrate from contact with the microneedles, thereby transferring at least a portion of the coating solution to the microneedle array.
    • 通过以类似刷子的方式使用柔性膜施加涂布液来涂布微针阵列的方法。 一种涂覆微针阵列的方法,包括:提供具有基底和多个微针的微针阵列; 提供柔性膜; 提供包含载体流体和涂层材料的涂层溶液; 将涂布溶液施加到柔性膜的第一主表面上; 执行将柔性膜的第一主表面与微针接触并移除柔性膜以与微针接触的转印步骤; 并允许载体液体蒸发。 此外,通过将涂布溶液涂覆在涂布基材的第一主表面上以形成具有等于或小于至少一个微针的高度的涂覆涂层溶液的层并涂覆微针阵列的方法,并执行 将涂布基板的第一主表面与微针接触并移除涂布基板与微针接触的转印步骤,从而将至少一部分涂布溶液转印到微针阵列上。
    • 4. 发明授权
    • Fluorinated composition, method of coating the composition, and article thereby
    • 氟化组合物,涂覆组合物的方法和由此制成的制品
    • US08664323B2
    • 2014-03-04
    • US13111504
    • 2011-05-19
    • Suresh S. IyerRichard M. FlynnMoses M. David
    • Suresh S. IyerRichard M. FlynnMoses M. David
    • C09D181/02
    • G02B1/14C08G77/24C08G77/28C09D4/00C09D183/08G02B1/10G02B1/18G02B27/0006
    • A fluorinated composition includes: a polyfluoropolyether silane represented by the formula: RfaO(CF(CF3)CF2O)pCF(CF3)CH2OZ1Si(Y1)3; and a polyfluoropolyether silane represented by the formula: Rfb[R5CH2OZ2Si(Y2)3]2 Rfa represents a perfluoroalkyl group having from 1 to 12 carbon atoms, optionally substituted with at least one catenated oxygen atom or —NR8— group, wherein R8 represents a perfluoroalkyl group; Z1 represents —R1SR2—, —R1S(═O)R2—, or —R1S(═O)2R2, wherein R1 and R2 independently represent alkylene groups having from 1 to 12 carbon atoms; each Y1 independently represents a hydrolyzable group; and p is a number in a range of from 3 to 50; Z2 independently represents —R3SR4—, —R3S(═O)R4—, or —R3S(═O)2R4, wherein R3 and R4 independently represent alkylene groups having from 1 to 12 carbon atoms; Y2 independently represents a hydrolyzable group; Rfb represents a perfluoroalkylene group having at least 3 carbon atoms, optionally substituted with at least one catenated oxygen atom or —NR6— group, wherein R6 represents a perfluoroalkyl group; R5 independently represents a covalent bond, or —(OR7)b—, and wherein R7 independently represents a branched perfluoroalkylene group, and b independently represents a number greater than or equal to one.
    • 氟化组合物包括:由式:RfaO(CF(CF 3)CF 2 O)pCF(CF 3)CH 2 OZ 1 Si(Y 1)3表示的多氟聚醚硅烷; 和由式Rfb [R5CH2OZ2Si(Y2)3] 2表示的多氟聚醚硅烷,Rfa表示任选被至少一个连接的氧原子或-NR 8 - 基团取代的具有1至12个碳原子的全氟烷基,其中R 8表示 全氟烷基 Z1表示-R1SR2-,-R1S(= O)R2-或-R1S(= O)2R2,其中R1和R2独立地表示具有1至12个碳原子的亚烷基; 每个Y1独立地表示可水解基团; 并且p是3至50范围内的数字; Z2独立地表示-R3SR4​​-,-R3S(= O)R4-或-R3S(= O)2R4,其中R3和R4独立地表示具有1至12个碳原子的亚烷基; Y2独立地表示可水解基团; Rfb表示具有至少3个碳原子的全氟亚烷基,任选被至少一个连接的氧原子或-NR 6 - 基团取代,其中R 6表示全氟烷基; R5独立地表示共价键,或 - (OR7)b-,其中R7独立地表示支链全氟亚烷基,b独立地表示大于或等于1的数。
    • 8. 发明申请
    • FLUORINATED COMPOSITION, METHOD OF COATING THE COMPOSITION, AND ARTICLE THEREBY
    • 氟化组合物,涂料组合物的方法及其制品
    • US20110319546A1
    • 2011-12-29
    • US13111504
    • 2011-05-19
    • Suresh S. IyerRichard M. FlynnMoses M. David
    • Suresh S. IyerRichard M. FlynnMoses M. David
    • C09D181/02C09D183/16B05D1/38
    • G02B1/14C08G77/24C08G77/28C09D4/00C09D183/08G02B1/10G02B1/18G02B27/0006
    • A fluorinated composition includes: a polyfluoropolyether silane represented by the formula: RfaO(CF(CF3)CF2O)pCF(CF3)CH2OZ1Si(Y1)3; and a polyfluoropolyether silane represented by the formula: Rfb[R5CH2OZ2Si(Y2)3]2 Rfa represents a perfluoroalkyl group having from 1 to 12 carbon atoms, optionally substituted with at least one catenated oxygen atom or —NR8— group, wherein R8 represents a perfluoroalkyl group; Z1 represents —R1SR2—, —R1S(═O)R2—, or —R1S(═O)2R2, wherein R1 and R2 independently represent alkylene groups having from 1 to 12 carbon atoms; each Y1 independently represents a hydrolyzable group; and p is a number in a range of from 3 to 50; Z2 independently represents —R3SR4—, —R3S(═O)R4—, or —R3S(═O)2R4, wherein R3 and R4 independently represent alkylene groups having from 1 to 12 carbon atoms; Y2 independently represents a hydrolyzable group; Rfb represents a perfluoroalkylene group having at least 3 carbon atoms, optionally substituted with at least one catenated oxygen atom or —NR6— group, wherein R6 represents a perfluoroalkyl group; R5 independently represents a covalent bond, or —(OR7)b—, and wherein R7 independently represents a branched perfluoroalkylene group, and b independently represents a number greater than or equal to one.
    • 氟化组合物包括:由式:RfaO(CF(CF 3)CF 2 O)pCF(CF 3)CH 2 OZ 1 Si(Y 1)3表示的多氟聚醚硅烷; 和由式Rfb [R5CH2OZ2Si(Y2)3] 2表示的多氟聚醚硅烷,Rfa表示任选被至少一个连接的氧原子或-NR 8 - 基团取代的具有1至12个碳原子的全氟烷基,其中R 8表示 全氟烷基 Z1表示-R1SR2-,-R1S(= O)R2-或-R1S(= O)2R2,其中R1和R2独立地表示具有1至12个碳原子的亚烷基; 每个Y1独立地表示可水解基团; 并且p是3至50范围内的数字; Z 2独立地表示-R 3 SR 4 - , - R 3 S(= O)R 4 - 或-R 3 S(= O)2 R 4,其中R 3和R 4独立地表示具有1至12个碳原子的亚烷基; Y2独立地表示可水解基团; Rfb表示具有至少3个碳原子的全氟亚烷基,任选被至少一个连接的氧原子或-NR 6 - 基团取代,其中R 6表示全氟烷基; R5独立地表示共价键,或 - (OR7)b-,其中R7独立地表示支链全氟亚烷基,b独立地表示大于或等于1的数。