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1. 发明授权

US08608697B2 Insertion indicator for needle 失效
标题翻译：插针指针
公开(公告)号：US08608697B2
公开(公告)日：2013-12-17
申请号：US13041284
申请日：2011-03-04
申请人： Pelu Tran , Khang Trong Dinh , Andrew Pipathsouk , Benjamin Chung , Hongbin Li
发明人： Pelu Tran , Khang Trong Dinh , Andrew Pipathsouk , Benjamin Chung , Hongbin Li
IPC分类号： A61M5/178 , A61M1/00 , A61M5/00
CPC分类号： A61M13/00
摘要： A method and apparatus are provided for a fluid level insertion indicator that provides immediate feedback to a surgeon by draining when a tip of a needle has entered a body lumen, such as peritoneal cavity. An apparatus includes a handle connected to a hollow needle and a hollow stylet that extends through the hollow needle and has a blunt distal end that includes an opening for passing fluid. A spring biases the stylet to extend past the sharp distal end of the needle absent resistance by tissue against the stylet. An at least partially translucent pressure chamber configured to hold a quantity of fluid under pressure is connected to the proximal end of the stylet. The pressure chamber and stylet form a conduit for passing fluid through the opening in the blunt distal end when the stylet extends past the sharp distal end of the hollow needle.
摘要翻译：提供了一种用于液位插入指示器的方法和装置，其通过在针的尖端进入体腔（例如腹膜腔）时通过排水而向外科医生提供即时反馈。一种装置包括连接到中空针的手柄和延伸穿过中空针的空心探针并具有钝的远端，该远端包括用于使流体通过的开口。弹簧偏压探针以延伸穿过针尖的尖端，组织抵抗探针而没有阻力。构造成在压力下保持一定量的流体的至少部分半透明的压力室连接到通球针的近端。当探针延伸穿过中空针的尖锐远端时，压力室和探针形成一个导管，用于使流体通过钝头远端的开口。

2. 发明授权

US08880210B2 Methods and apparatus for processing substrates using model-based control 有权
标题翻译：使用基于模型的控制处理基板的方法和装置
公开(公告)号：US08880210B2
公开(公告)日：2014-11-04
申请号：US13183520
申请日：2011-07-15
申请人： Keith Brian Porthouse , John W. Lane , Mariusch Gregor , Nir Merry , Michael R. Rice , Alex Minkovich , Hongbin Li , Dmitry A. Dzilno
发明人： Keith Brian Porthouse , John W. Lane , Mariusch Gregor , Nir Merry , Michael R. Rice , Alex Minkovich , Hongbin Li , Dmitry A. Dzilno
IPC分类号： G06F19/00 , G05B17/02 , H01L21/67 , G05D16/20
CPC分类号： G05D16/2046 , G05B17/02 , H01L21/67017 , H01L21/67253
摘要： Methods and apparatus are disclosed herein. In some embodiments, methods of controlling process chambers may include predetermining a relationship between pressure in a processing volume and a position of an exhaust valve as a function of a process parameter; setting the process chamber to a first state having a first pressure in the processing volume and a first value of the process parameter, wherein the exhaust valve is set to a first position based on the predetermined relationship to produce the first pressure at the first value; determining a pressure control profile to control the pressure as the process chamber is changed to a second state having a second pressure and a second process parameter value from the first state; and applying the pressure control profile to control the pressure by varying the position of the exhaust valve while changing the process chamber to the second state.
摘要翻译：本文公开了方法和装置。在一些实施例中，控制处理室的方法可以包括根据处理参数预先确定处理容积中的压力与排气门的位置之间的关系; 将所述处理室设定为处理容积中具有第一压力的第一状态和所述处理参数的第一值，其中所述排气阀基于所述预定关系设定在第一位置以产生所述第一值的所述第一压力; 当所述处理室改变为具有来自所述第一状态的第二压力和第二过程参数值的第二状态时，确定压力控制曲线以控制所述压力; 以及通过在将处理室改变到第二状态的同时改变排气门的位置来施加压力控制曲线来控制压力。

3. 发明授权

US08431593B2 Heteroaryl amide derivatives 失效
标题翻译：杂芳酰胺衍生物
公开(公告)号：US08431593B2
公开(公告)日：2013-04-30
申请号：US12516480
申请日：2007-11-27
申请人： Alan J. Hutchison , Hongbin Li , Jianmin Mao , David J. Wustrow , Jun Yuan , He Zhao
发明人： Alan J. Hutchison , Hongbin Li , Jianmin Mao , David J. Wustrow , Jun Yuan , He Zhao
IPC分类号： A61K31/44 , A01N43/42 , C07D221/02
CPC分类号： C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/113 , C07D519/00
摘要： Heteroaryl amide derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供了以下分子式的杂芳酰胺衍生物：其中变量如本文所述。这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

4. 发明申请

US20110218485A1 Insertion Indicator for Needle 失效
标题翻译：针插入指示器
公开(公告)号：US20110218485A1
公开(公告)日：2011-09-08
申请号：US13041284
申请日：2011-03-04
申请人： Pelu Tran , Khang Trong Dinh , Andrew Pipathsouk , Benjamin Chung , Hongbin Li
发明人： Pelu Tran , Khang Trong Dinh , Andrew Pipathsouk , Benjamin Chung , Hongbin Li
IPC分类号： A61M13/00
CPC分类号： A61M13/00
摘要： A method and apparatus are provided for a fluid level insertion indicator that provides immediate feedback to a surgeon by draining when a tip of a needle has entered a body lumen, such as peritoneal cavity. An apparatus includes a handle connected to a hollow needle and a hollow stylet that extends through the hollow needle and has a blunt distal end that includes an opening for passing fluid. A spring biases the stylet to extend past the sharp distal end of the needle absent resistance by tissue against the stylet. An at least partially translucent pressure chamber configured to hold a quantity of fluid under pressure is connected to the proximal end of the stylet. The pressure chamber and stylet form a conduit for passing fluid through the opening in the blunt distal end when the stylet extends past the sharp distal end of the hollow needle.
摘要翻译：提供了一种用于液位插入指示器的方法和装置，其通过在针的尖端进入体腔（例如腹膜腔）时通过排水而向外科医生提供即时反馈。一种装置包括连接到中空针的手柄和延伸穿过中空针的空心探针并具有钝的远端，该远端包括用于使流体通过的开口。弹簧偏压探针以延伸穿过针尖的尖端，组织抵抗探针而没有阻力。构造成在压力下保持一定量的流体的至少部分半透明的压力室连接到通球针的近端。当探针延伸穿过中空针的尖锐远端时，压力室和探针形成一个导管，用于使流体通过钝头远端的开口。

5. 发明申请

US20100292236A1 5-Membered Heterocyclic Amides And Related Compounds 审中-公开
标题翻译： 5元杂环酰胺及相关化合物
公开(公告)号：US20100292236A1
公开(公告)日：2010-11-18
申请号：US12669308
申请日：2008-07-21
申请人： Hongbin Li , Jun Yuan , Rajagopal Bakthavatchalam , Kevin J. Hodgetts , Scott M. Capitosti , Jianmin Mao , David J. Wustrow , Qin Guo
发明人： Hongbin Li , Jun Yuan , Rajagopal Bakthavatchalam , Kevin J. Hodgetts , Scott M. Capitosti , Jianmin Mao , David J. Wustrow , Qin Guo
IPC分类号： A61K31/5377
CPC分类号： C07D487/04 , C07D231/14 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/04 , C07D417/04 , C07D417/14
摘要： 5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供了5-组杂环酰胺和相关化合物，其具有如下所述的变体：这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

6. 发明申请

US20130018500A1 METHODS AND APPARATUS FOR PROCESSING SUBSTRATES USING MODEL-BASED CONTROL 有权
标题翻译：使用基于模型的控制处理基板的方法和装置
公开(公告)号：US20130018500A1
公开(公告)日：2013-01-17
申请号：US13183520
申请日：2011-07-15
申请人： KEITH BRIAN PORTHOUSE , JOHN W. LANE , MARIUSCH GREGOR , NIR MERRY , MICHAEL R. RICE , ALEX MINKOVICH , HONGBIN LI , DMITRY A. DZILNO
发明人： KEITH BRIAN PORTHOUSE , JOHN W. LANE , MARIUSCH GREGOR , NIR MERRY , MICHAEL R. RICE , ALEX MINKOVICH , HONGBIN LI , DMITRY A. DZILNO
IPC分类号： G05D16/20 , G06F17/11 , G05B13/04
CPC分类号： G05D16/2046 , G05B17/02 , H01L21/67017 , H01L21/67253
摘要： Methods and apparatus are disclosed herein. In some embodiments, methods of controlling process chambers may include predetermining a relationship between pressure in a processing volume and a position of an exhaust valve as a function of a process parameter; setting the process chamber to a first state having a first pressure in the processing volume and a first value of the process parameter, wherein the exhaust valve is set to a first position based on the predetermined relationship to produce the first pressure at the first value; determining a pressure control profile to control the pressure as the process chamber is changed to a second state having a second pressure and a second process parameter value from the first state; and applying the pressure control profile to control the pressure by varying the position of the exhaust valve while changing the process chamber to the second state.
摘要翻译：本文公开了方法和装置。在一些实施例中，控制处理室的方法可以包括根据处理参数预先确定处理容积中的压力与排气门的位置之间的关系; 将所述处理室设定为处理容积中具有第一压力的第一状态和所述处理参数的第一值，其中所述排气阀基于所述预定关系设定在第一位置以产生所述第一值的所述第一压力; 当所述处理室改变为具有来自所述第一状态的第二压力和第二过程参数值的第二状态时，确定压力控制曲线以控制所述压力; 以及通过在将处理室改变到第二状态的同时改变排气门的位置来施加压力控制曲线来控制压力。

7. 发明申请

US20100216763A1 Heteroaryl Amide Derivatives 失效
标题翻译：杂芳基酰胺衍生物
公开(公告)号：US20100216763A1
公开(公告)日：2010-08-26
申请号：US12516480
申请日：2007-11-27
申请人： Alan J. Hutchison , Hongbin Li , Jianmin Mao , David J. Wustrow , Jun Yuan , He Zhao
发明人： Alan J. Hutchison , Hongbin Li , Jianmin Mao , David J. Wustrow , Jun Yuan , He Zhao
IPC分类号： A61K31/397 , C07D471/04 , A61K31/437 , C07D403/14 , A61K31/496 , C07D413/14 , A61K31/5377 , C07D223/04 , A61K31/55 , C07D221/20 , A61K31/438 , C07D295/15 , A61K31/4995 , C07D243/08 , A61K31/551 , C07D221/22 , A61K31/439 , C07D417/14 , A61K31/541 , C07D281/06 , A61K31/553 , A61P29/00 , A61P25/24 , A61P25/22 , A61P25/18
CPC分类号： C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/113 , C07D519/00
摘要： Heteroaryl amide derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供了以下分子式的杂芳酰胺衍生物：其中变量如本文所述。这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

8. 发明申请

US20070078135A1 Substituted heteroaryl CB1 antagonists 审中-公开
标题翻译：取代的杂芳基CB1拮抗剂
公开(公告)号：US20070078135A1
公开(公告)日：2007-04-05
申请号：US11406532
申请日：2006-04-18
申请人： Jun Yuan , Qin Guo , He Zhao , Shaojing Hu , Darren Whitehouse , Wallace Pringle , Jianmin Mao , George Maynard , Jack Hammer , David Wustrow , Hongbin Li
发明人： Jun Yuan , Qin Guo , He Zhao , Shaojing Hu , Darren Whitehouse , Wallace Pringle , Jianmin Mao , George Maynard , Jack Hammer , David Wustrow , Hongbin Li
IPC分类号： A61K31/53 , A61K31/497 , A61K31/4965 , C07D403/02
CPC分类号： C07D403/14 , C07D213/28 , C07D213/61 , C07D213/74 , C07D239/42 , C07D239/54 , C07D241/12 , C07D241/20 , C07D241/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds of Formula I are provided. In which the variables are as described herein. Such compounds may be used to modulate CB1 activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CB1 modulation in humans, domesticated companion animals and livestock animals, including appetite disorders, obesity and addictive disorders. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies and various in vitro assays.
摘要翻译：提供式I化合物。其中变量如本文所述。这种化合物可用于体内或体外调节CB1活性，并且特别可用于治疗对人类，家养伴侣动物和家畜中的CB1调节有反应的病症，包括食欲障碍，肥胖症和成瘾性疾病。还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究和各种体外测定的方法。

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