专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07674614B2 Method of optically resolving racemic alcohols with a bicyclooxaoctane or a bicycooxaoctene resolving reagents 有权
标题翻译：用双环氧辛烷或二氧杂辛烷拆分试剂旋光拆分外消旋醇的方法
公开(公告)号：US07674614B2
公开(公告)日：2010-03-09
申请号：US11683322
申请日：2007-03-07
申请人： Hisao Nemoto , Masayuki Shibuya
发明人： Hisao Nemoto , Masayuki Shibuya
IPC分类号： C12P41/00
CPC分类号： C07D307/935 , C07B2200/07 , C12C11/02 , Y10T436/204165
摘要： An optical resolving reagent comprising at least one of compounds represented by the following formulae (1) and (2) (1) (2) (wherein R1 to R8 each represents hydrogen or C1-20 alkyl; R9 represents optionally substituted C1-20 alkyl, optionally substituted C1-20 alkenyl, formyl, or acyl; and R10 represents C1-6 alkyl; provided that the molecule represented by the formula (1) is of the cis configuration with respect to R9 and OR10); and a method of optically resolving with the optical resolving reagent an alcohol having an asymmetric carbon atom in the molecule and represented by the formula (3): (R11)(R12)(R13)COH (wherein R11, R12, and R13 each represents hydrogen or optionally substituted C1-20 alkyl, provided that at least one of R11, R12, and R13 is not hydrogen). The method of optical resolution is highly suitable for general purposes. By the method, a mixture of optical isomers of any of various alcohols can be optically resolved easily and industrially advantageously.
摘要翻译：包含由下式（1）和（2）（1）（2）表示的化合物中的至少一种的光学拆分试剂（其中R 1至R 8各自表示氢或C 1-20烷基; R 9表示任选取代的C 1-20烷基，任选取代的C 1-20烯基，甲酰基或酰基; R 10表示C 1-6烷基;条件是由式（1）表示的分子相对于R9和OR10为顺式构型; （3）表示的具有不对称碳原子的醇：（R11）（R12）（R13）COH（其中R11，R12和R13各自表示氢或任选取代的C 1-20烷基，条件是R 11，R 12和R 13中的至少一个不是氢）。光学分辨率的方法非常适合于一般用途。通过该方法，可以容易且工业上有利地光学拆分各种醇的光学异构体的混合物。

2. 发明申请

US20080287695A1 Agent For Optical Resolution, Process For Producing Optically Active Substance and 1,5-Substituted Bicyclo [3.3.0] -2-Oxaoctane Compound 审中-公开
标题翻译：光学拆分剂，用于制备光学活性物质和1,5-取代的双环[3.3.0] -2-氧杂辛烷化合物
公开(公告)号：US20080287695A1
公开(公告)日：2008-11-20
申请号：US10588994
申请日：2005-02-18
申请人： Hisao Nemoto
发明人： Hisao Nemoto
IPC分类号： C07D307/935
CPC分类号： C07B57/00 , C07C45/294 , C07D307/935 , C07C49/697
摘要： An agent for optical resolution comprising a bicyclo[3.3.0]-2-oxaoctane compound represented by the formula [1], [2] or [3] a process for producing an optically active substance comprising obtaining a mixture of diastereomers by reaction of the agent with a mixture of optically active substances having active hydrogen atom, resolving the mixture of diastereomers into each diastereomer and obtaining an (R) optically active substance or an (S) optically active substance by decomposition of the diastereomer; and compounds represented by the above formulae in which R11 represents fluorenylmethyl group, fluorenylidenemethyl group, bis(4-cyclohexylphenyl)methyl group, 4-(9-phenanthryl)phenyl group, 4-(1-pyrenyl)phenyl group, 4-(5-acenaphthenyl)phenyl group or 4-(9-anthryl)phenyl group, are disclosed. A useful optically active substance having a very high purity can be produced efficiently by using the agent of the present invention.
摘要翻译：一种用于光学拆分的试剂，其包含由式[1]，[2]或[3]表示的双环[3.3.0] -2-氧代辛烷化合物，其是制备光学活性物质的方法，包括通过具有活性氢原子的光学活性物质的混合物的试剂，将非对映异构体的混合物分解成各个非对映异构体并通过分解非对映体得到（S）光学活性物质或（S）光学活性物质; 由上式表示的化合物，其中R 11表示芴基甲基，芴基亚甲基，双（4-环己基苯基）甲基，4-（9-菲基）苯基，4-（1-芘基））苯基，4-（5-苊基）苯基或4-（9-蒽基）苯基。通过使用本发明的试剂可以有效地制备具有非常高纯度的有用的光学活性物质。

3. 发明申请

US20050208015A1 Glycerol derivative 失效
标题翻译：甘油衍生物
公开(公告)号：US20050208015A1
公开(公告)日：2005-09-22
申请号：US10529216
申请日：2003-09-02
申请人： Hisao Nemoto , Motoo Yamasaki , Toshiyuki Suzawa , Hiroyuki Yamaguchi
发明人： Hisao Nemoto , Motoo Yamasaki , Toshiyuki Suzawa , Hiroyuki Yamaguchi
IPC分类号： A61K47/48 , A61P43/00 , C07C233/78 , C07C237/22 , C07C323/60 , C07D207/40 , C07D207/404 , A61K38/54 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/48
CPC分类号： C07D207/404 , A61K47/54 , A61K47/6949 , B82Y5/00 , C07C233/78 , C07C237/22 , C07C323/60
摘要： (wherein R represents a residue comprising a reactive group or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: R1s each represent a hydrogen atom or a group capable of being transformed into a hydrogen atom, and 6 or more of R1s may be the same or different) The compound represented by the above formula (1), which is capable of modifying a physiologically active polypeptide or a derivative thereof, or a low molecular compound while maintaining the physiological activity, or which is useful for improving the stability or water-solubility of the low molecular compound, are provided.
摘要翻译：（其中R表示包含反应性基团或能够转化成反应性基团的残基的残基; n表示3以上的整数，X表示能够具有以下结构的残基：n为数：R < > 1个各自表示氢原子或能够转化成氢原子的基团，并且6个或更多个R 1可以相同或不同，由能够在保持生理活性的同时修饰生理活性多肽或其衍生物或低分子化合物的上述式（1），或可用于提高低分子化合物的稳定性或水溶性的上述式（1）被提供。

4. 发明授权

US5714591A Gadolinium-DTPA complex containing carborane unit, intermediates thereof and method of synthesizing them 失效
标题翻译：含有碳硼烷单元的钆-DTPA复合物，其中间体和合成它们的方法
公开(公告)号：US5714591A
公开(公告)日：1998-02-03
申请号：US682004
申请日：1996-07-16
申请人： Yoshinori Yamamoto , Hisao Nemoto
发明人： Yoshinori Yamamoto , Hisao Nemoto
IPC分类号： A61K49/00 , B01J23/44 , C07B61/00 , C07F5/02 , C07F5/00 , A61K51/00
CPC分类号： C07F5/027
摘要： The present invention provides a gadolinium-DTPA complex containing a carborane unit having structural formula (1) given below and an intermediate thereof, i.e., carborane-containing DTPA derivative represented by formula (2) given below. ##STR1## The present invention also provides a method of synthesizing the compound (1), which comprises reacting an ester derivative of DTPA with a carborane derivative in the presence of a palladium catalyst, deesterifying by treatment with an acid, reacting with gadolinium trichloride hexahydrate, and treating with an alkali to give the desired compound (1).
摘要翻译：本发明提供了含有下述结构式（1）的碳硼烷单元及其中间体的钆-DTPA络合物，即由下式（2）表示的含碳硼烷的DTPA衍生物。（1）本发明还提供合成化合物（1）的方法，其包括在钯催化剂存在下使DTPA的酯衍生物与碳硼烷衍生物反应，通过处理进行脱酯化与酸反应，与三氯化钆六水合物反应，并用碱处理得到所需化合物（1）。

5. 发明授权

US09931705B2 Process for fabricating inductive heated solder cartridge 有权
公开(公告)号：US09931705B2
公开(公告)日：2018-04-03
申请号：US14032616
申请日：2013-09-20
申请人： Mitsuhiko Miyazaki , Hisao Nemoto
发明人： Mitsuhiko Miyazaki , Hisao Nemoto
IPC分类号： B23K3/03 , B23K3/047 , F27D7/06
CPC分类号： B23K3/0353 , B23K3/03 , B23K3/0369 , B23K3/0475 , F27D7/06 , Y10T29/4902 , Y10T29/49885
摘要： A method or process of fabricating a solder cartridge and solder cartridge made according to the process is disclosed. The solder cartridge made according to the process provides a self-temperature regulating solder tip for an inductive current soldering station having improved heater quality and stability with reduced manufacturing costs.

6. 发明申请

US20100172967A1 COMPOUND MODIFIED WITH GLYCEROL DERIVATIVE 审中-公开
标题翻译：用甘油衍生物修饰的化合物
公开(公告)号：US20100172967A1
公开(公告)日：2010-07-08
申请号：US12708714
申请日：2010-02-19
申请人： Hisao Nemoto , Masahiro Yamauchi , Hiroko Kusano , Yasuki Kato , Motoo Yamasaki , Toshiyuki Suzawa
发明人： Hisao Nemoto , Masahiro Yamauchi , Hiroko Kusano , Yasuki Kato , Motoo Yamasaki , Toshiyuki Suzawa
IPC分类号： A61K9/127 , C07C237/06 , C07F9/06 , C07F9/02 , C07K2/00 , A61K9/107
CPC分类号： C07D207/452 , A61K47/00 , A61K47/54 , A61K47/6911 , B82Y5/00 , C07C323/60 , C07F9/10 , C07K5/0202
摘要： Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like. The present invention provides a compound in which a substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, is modified with a glycerol derivative represented by the following formula (1): wherein R represents a residue comprising a reactive group for the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance or for a spacer capable of binding the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, to R—X, or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: directly or via the spacer, or a salt thereof; a fine particle comprising the same; and the like.
摘要翻译：本发明的目的是提供一种可用作生产药物载体等的表面改性剂或其盐的化合物; 包含该颗粒的细颗粒; 等等。本发明提供一种化合物，其中选自由两亲物质和疏水性物质组成的组中的被改性物质用下式（1）表示的甘油衍生物进行改性：其中R表示残基包括选自两亲物质和疏水性物质的待修饰物质的反应性基团或能够与被修饰物质结合的间隔基，其选自两亲物质和疏水性物质，R-X或能够转化为反应性基团的基团; n表示3以上的整数， X表示可以直接或经由间隔基或其盐具有n数的以下结构的残基：包含该颗粒的细颗粒; 等等。

7. 发明授权

US07696359B2 Compound modified with glycerol derivative 失效
标题翻译：用甘油衍生物修饰的化合物
公开(公告)号：US07696359B2
公开(公告)日：2010-04-13
申请号：US10570623
申请日：2004-09-03
申请人： Hisao Nemoto , Masahiro Yamauchi , Hiroko Kusano , Yasuki Kato , Motoo Yamasaki , Toshiyuki Suzawa
发明人： Hisao Nemoto , Masahiro Yamauchi , Hiroko Kusano , Yasuki Kato , Motoo Yamasaki , Toshiyuki Suzawa
IPC分类号： C07D207/46 , C07F9/09
CPC分类号： C07D207/452 , A61K47/00 , A61K47/54 , A61K47/6911 , B82Y5/00 , C07C323/60 , C07F9/10 , C07K5/0202
摘要： Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like. The present invention provides a compound in which a substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, is modified with a glycerol derivative represented by the following formula (1): wherein R represents a residue comprising a reactive group for the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance or for a spacer capable of binding the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, to R-X, or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: directly or via the spacer, or a salt thereof; a fine particle comprising the same; and the like.
摘要翻译：本发明的目的是提供一种可用作生产药物载体等的表面改性剂或其盐的化合物; 包含该颗粒的细颗粒; 等等。本发明提供一种化合物，其中选自由两亲物质和疏水性物质组成的组中的被改性物质用下式（1）表示的甘油衍生物进行改性：其中R表示残基包括选自两亲物质和疏水性物质的待修饰物质的反应性基团或能够与被修饰物质结合的间隔基，其选自两亲物质和疏水性物质，至RX或能够转化为反应性基团的基团; n表示3以上的整数， X表示可以直接或经由间隔基或其盐具有n数的以下结构的残基：包含该颗粒的细颗粒; 等等。

8. 发明授权

US07524978B2 2-oxabicyclo[3.3.0]octane compounds, process for producing the same, optical resolver, method of separating diastereomer mixture, and method of optically resolving alcohol 失效
标题翻译： 2-氧杂双环[3.3.0]辛烷化合物，其制备方法，光学旋变变压器，分离非对映体混合物的方法和光学拆分醇的方法
公开(公告)号：US07524978B2
公开(公告)日：2009-04-28
申请号：US10520282
申请日：2003-08-22
申请人： Kei Sakamoto , Yasushi Nakano , Yoshihisa Kondou , Toshiro Yamada , Hisao Nemoto
发明人： Kei Sakamoto , Yasushi Nakano , Yoshihisa Kondou , Toshiro Yamada , Hisao Nemoto
IPC分类号： C07D307/937
CPC分类号： C07D307/935 , C07B2200/07 , Y02P20/582
摘要： 2-Oxabicyclo[3.3.0]octane compounds represented by the following formula (1) (compound (1)); an optical resolver comprising at least one of the compounds (1); a process for producing the compounds (1) which comprises reacting a compound (2) or compound (3) with an alcohol (5) in the presence of an acid catalyst; a method of separating a diastereomer mixture of a compound (1); and a method of optically resolving an alcohol with the optical resolver. [In the formulae, R1 to R10 each represents hydrogen atom, etc.; R11 represents an alkyl group, etc.; R12 represents a hydrocarbon group, etc.; R13 represents a hydrocarbon group, etc.; and A represents acetyl group, etc.]
摘要翻译：由下式（1）表示的2-氧杂双环[3.3.0]辛烷化合物（化合物（1））; 包括化合物（1）中的至少一种的光学旋光器; 一种制备化合物（1）的方法，包括在酸催化剂存在下使化合物（2）或化合物（3）与醇（5）反应; 分离化合物（1）的非对映异构体混合物的方法; 以及用光学旋转变光器光学拆分醇的方法。 [式中，R 1〜R 10各自表示氢原子等。 R11表示烷基等。 R12表示烃基等; R13表示烃基等。 A代表乙酰基等]

9. 发明申请

US20070155994A1 OPTICAL RESOLVER AND METHOD OF OPTICALLY RESOLVING ALCOHOL WITH THE SAME 有权
标题翻译：光学分辨率和光学解决醇的方法
公开(公告)号：US20070155994A1
公开(公告)日：2007-07-05
申请号：US11683322
申请日：2007-03-07
申请人： Hisao NEMOTO , Masayuki Shibuya
发明人： Hisao NEMOTO , Masayuki Shibuya
IPC分类号： C07C29/74 , C07D307/87
CPC分类号： C07D307/935 , C07B2200/07 , C12C11/02 , Y10T436/204165
摘要： An optical resolving reagent comprising at least one of compounds represented by the following formulae (1) and (2) (1) (2) (wherein R1 to R8 each represents hydrogen or C1-20 alkyl; R9 represents optionally substituted C1-20 alkyl, optionally substituted C1-20 alkenyl, formyl, or acyl; and R10 represents C1-6 alkyl; provided that the molecule represented by the formula (1) is of the cis configuration with respect to R9 and OR10); and a method of optically resolving with the optical resolving reagent an alcohol having an asymmetric carbon atom in the molecule and represented by the formula (3): (R11) (R12) (R13)COH (wherein R11, R12, and R13 each represents hydrogen or optionally substituted C1-20 alkyl, provided that at least one of R11, R12, and R13 is not hydrogen) The method of optical resolution is highly suitable for general purposes By the method, a mixture of optical isomers of any of various alcohols can be optically resolved easily and industrially advantageously.
摘要翻译：一种光学拆分试剂，其包含由下式（1）和（2）（1）（2）表示的化合物中的至少一种（其中R 1〜R 8各自独立地表示氢或C 1-20烷基; R 9表示任选取代的C 1-20烷基，任选取代的C 1-20 烯基，甲酰基或酰基; R 10表示C 1-6烷基;条件是由式（1）表示的分子是顺式相对于R 9和OR 10的构型）; 以及用光学拆分试剂在分子中具有不对称碳原子的醇进行光学拆分的方法，由式（3）代表：（R 11）（R 12））（R 13）COH（其中R 11，R 12和R 12各自表示氢或任选取代的C 1-12烷基，条件是R 11，R 12和R 13中的至少一个 >不是氢）光学拆分的方法非常适合于一般目的通过该方法，各种醇中的任何一种的光学异构体的混合物可以容易且工业上有利地光学拆分。

10. 发明授权

US5780670A DTPA derivatives modified with non-ester bond and a process for synthesizing them 失效
标题翻译：用非酯键修饰的DTPA衍生物及其合成方法
公开(公告)号：US5780670A
公开(公告)日：1998-07-14
申请号：US680611
申请日：1996-07-16
申请人： Yoshinori Yamamoto , Hisao Nemoto
发明人： Yoshinori Yamamoto , Hisao Nemoto
IPC分类号： A61K49/00 , A61K51/04 , B01J23/44 , B01J31/22 , C07B61/00 , C07C227/18 , C07C229/16 , C07C229/24 , C07C229/30 , C07C229/00
CPC分类号： C07C229/30 , A61K51/048 , C07C229/24
摘要： Provided are DTPA derivatives having five carbonyl groups, represented by the following formula (1). Further provided is a process for synthesizing a compound (1a) represented by the formula of a compound (1) in which R.sub.2 is 2-alkenyl group (R.sub.4). The process comprises the steps of performing esterification of DTPA, introducing an alkoxycarbonyl group and reacting with 2-alkenyl alkoxyformate in the presence of a palladium catalyst, thereby obtaining the compound (1a). ##STR1##
摘要翻译：提供具有五个羰基的DTPA衍生物，由下式（1）表示。进一步提供一种合成由式为其中R 2为2-链烯基（R 4）的化合物（1）表示的化合物（1a）的方法。该方法包括以下步骤：在钯催化剂存在下，进行DTPA的酯化，引入烷氧基羰基和与烷氧基甲酸2-链烯基酯反应，从而得到化合物（1a）。（1）（1a）

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式