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1. 发明申请

US20110034543A1 DNA Vaccination For Treatment of Multiple Sclerosis and Insulin-Dependent Diabetes Mellitus 有权
标题翻译：用于治疗多发性硬化症和胰岛素依赖性糖尿病的DNA疫苗接种
公开(公告)号：US20110034543A1
公开(公告)日：2011-02-10
申请号：US12754555
申请日：2010-04-05
申请人： LAWRENCE STEINMAN , PEDRO RUIZ , HIDEKI GARREN
发明人： LAWRENCE STEINMAN , PEDRO RUIZ , HIDEKI GARREN
IPC分类号： A61K31/7088 , A61P19/00 , A61P37/00
CPC分类号： C07K14/62 , A01K67/027 , A01K2227/105 , A01K2267/0325 , A61K39/00 , A61K39/0008 , A61K39/39 , A61K48/00 , A61K2039/53 , A61K2039/55527 , A61K2039/57
摘要： A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further treating by co-vaccination with a DNA encoding a Th2 cytokine, particularly encoding IL4. In response to the vaccination, the proliferation of autoantigen-reactive T cells and the secretion of Th1 cytokines, including IL-2, IFN-γ and IL-15, are reduced.
摘要翻译：通过注射到编码与自身免疫疾病相关的自身抗原的DNA的受体中，特异性地抑制促炎T细胞应答。接受者可以通过与编码Th2细胞因子的DNA（特别是编码IL4）共同接种来进一步治疗。响应于接种，自身抗原反应性T细胞的增殖和Th1细胞因子（包括IL-2，IFN-γ和IL-15）的分泌减少。

2. 发明申请

US20100160415A1 COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE DISEASE 审中-公开
标题翻译：用于治疗自身免疫疾病的组合物和方法
公开(公告)号：US20100160415A1
公开(公告)日：2010-06-24
申请号：US12089190
申请日：2006-10-04
申请人： Nanette Solvason , Michael Leviten , Hideki Garren
发明人： Nanette Solvason , Michael Leviten , Hideki Garren
IPC分类号： A61K31/7088 , A61P37/02 , C12N15/63
CPC分类号： A61K39/0008 , A61K39/0007 , A61K2039/55561 , A61K2039/55566
摘要： Disclosed are improved methods for the treatment or prevention of an autoimmune disease comprising administration of a modified self-vector encoding and capable of expressing a self-polypeptide that includes one or more pathogenic epitopes associated with the autoimmune disease. The improved method of the present invention includes the administration to a subject of a modified self-vector or self-vectors comprising a polynucleotide encoding a self-polypeptide. In one aspect, the method includes a modified self-vector that allows for increased expression of the self-polypeptide associated with an autoimmune disease in a host cell relative to the unmodified vector. In another, non-mutually exclusive aspect, the method includes a modified self-vector that allows for a secreted autoantigen associated with an autoimmune disease to be encoded as a non-secreted self-polypeptide.
摘要翻译：公开了用于治疗或预防自身免疫疾病的改进方法，包括施用编码并能够表达包含与自身免疫疾病相关的一个或多个病原性表位的自身多肽的修饰的自身载体。本发明的改进方法包括向受试者施用修饰的自身载体或包含编码自身多肽的多核苷酸的自身载体。在一个方面，该方法包括修饰的自身载体，其允许相对于未修饰的载体增加宿主细胞中与自身免疫疾病相关的自身多肽的表达。在另一方面，非相互排斥的方面，该方法包括允许与自身免疫疾病相关的分泌的自身抗原被编码为非分泌的自身多肽的修饰的自身载体。

3. 发明授权

US07867976B2 Nogo epitopic fragments for modulating immune response 有权
标题翻译： Nogo表位片段用于调节免疫应答
公开(公告)号：US07867976B2
公开(公告)日：2011-01-11
申请号：US10556756
申请日：2004-05-14
申请人： Lawrence Steinman , Hideki Garren , Paulo Fontoura
发明人： Lawrence Steinman , Hideki Garren , Paulo Fontoura
IPC分类号： A61K38/16 , A61K38/00 , C07K14/00 , C07K14/435
CPC分类号： A61K45/06 , A61K38/1709 , G01N33/564 , A61K2300/00
摘要： Epitopic fragments of Nogo, including Nogo 45-66, elicit a specific and strong T cell response, and a B cell response. T cells reactive to Nogo antigens are capable of ameliorating ongoing disease, which may be induced with other antigens. The present invention provides compositions and methods for the identification and use of Nogo epitopic fragments in the treatment of immune related disease.
摘要翻译： Nogo的异位片段，包括Nogo 45-66，引发特异性和强T细胞应答和B细胞反应。与Nogo抗原反应的T细胞能够改善正在进行的疾病，其可以用其他抗原诱导。本发明提供了用于鉴定和使用Nogo表位片段治疗免疫相关疾病的组合物和方法。

4. 发明授权

US07579328B2 DNA vaccination for treatment of multiple sclerosis and insulin-dependent diabetes mellitus 有权
标题翻译：用于治疗多发性硬化和胰岛素依赖性糖尿病的DNA疫苗接种
公开(公告)号：US07579328B2
公开(公告)日：2009-08-25
申请号：US11289226
申请日：2005-11-28
申请人： Lawrence Steinman , Pedro Ruiz , Hideki Garren
发明人： Lawrence Steinman , Pedro Ruiz , Hideki Garren
IPC分类号： A01N43/04 , C12N15/00
CPC分类号： C07K14/62 , A01K67/027 , A01K2227/105 , A01K2267/0325 , A61K39/00 , A61K39/0008 , A61K39/39 , A61K48/00 , A61K2039/53 , A61K2039/55527 , A61K2039/57
摘要： A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further treating by co-vaccination with a DNA encoding a Th2 cytokine, particularly encoding IL4. In response to the vaccination, the proliferation of autoantigen-reactive T cells and the secretion of Th1 cytokines, including IL-2, IFN-γ and IL-15, are reduced.
摘要翻译：通过注射到编码与自身免疫疾病相关的自身抗原的DNA的受体中，特异性地抑制促炎T细胞应答。接受者可以通过与编码Th2细胞因子的DNA（特别是编码IL4）共同接种来进一步治疗。响应于疫苗接种，自身抗原反应性T细胞的增殖和Th1细胞因子（包括IL-2，IFN-γ和IL-15）的分泌减少。

5. 发明申请

US20050261215A1 Methods and immune modulatory nucleic acid compositions for preventing and treating disease 有权
标题翻译：用于预防和治疗疾病的方法和免疫调节核酸组合物
公开(公告)号：US20050261215A1
公开(公告)日：2005-11-24
申请号：US10524643
申请日：2003-11-21
申请人： Hideki Garren , Peggy Ho , Lawrence Steinman
发明人： Hideki Garren , Peggy Ho , Lawrence Steinman
IPC分类号： A61K31/70 , A61K31/715 , A61K48/00
CPC分类号： A61K31/715 , A61K31/70 , A61K48/00
摘要： This invention relates to methods and compositions for treating or preventing disease comprising the administration of immune modulatory nucleic acids having one or more immune modulatory sequences (IMSs). The invention further relates to the means and methods for the identification of the IMSs for preventing or treating disease, more particularly the treatment and prevention of autoimmune or inflammatory diseases. The invention also relates to the treatment or prevention of disease comprising the administration of the immune modulatory nucleic acids alone or in combination with a polynucleotide encoding self-protein(s), -polypeptide(s) or -peptide(s). The present invention also relates to methods and compositions for treating diseases in a subject associated with one or more self-protein(s), -polypeptide(s) or -peptide(s) that are present in the subject and involved in a non-physiological state.
摘要翻译：本发明涉及用于治疗或预防疾病的方法和组合物，其包括施用具有一种或多种免疫调节序列（IMS）的免疫调节核酸。本发明还涉及用于鉴定用于预防或治疗疾病的IMS的方法和方法，更具体地涉及治疗和预防自身免疫性或炎性疾病。本发明还涉及治疗或预防疾病，其包括单独施用免疫调节性核酸或与编码自身蛋白，多肽或多肽的多核苷酸组合施用。本发明还涉及用于治疗与受试者中存在的一种或多种自身蛋白，多肽或肽的受试者相关的疾病的方法和组合物，生理状态。

6. 发明申请

US20180092991A1 COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN-DEPENDENT DIABETES MELLITUS 审中-公开
公开(公告)号：US20180092991A1
公开(公告)日：2018-04-05
申请号：US13376345
申请日：2010-06-07
申请人： Hideki Garren , Michael Leviten , Nanette Solvason
发明人： Hideki Garren , Michael Leviten , Nanette Solvason
IPC分类号： A61K48/00 , C07K14/47 , C07K14/62 , C12N15/86 , A61K9/00 , A61P3/10
CPC分类号： A61K48/0066 , A61K9/0019 , A61K48/005 , A61P3/10 , C07K14/4713 , C07K14/62 , C12N15/86 , C12N2830/001
摘要： This invention provides methods of treating insulin-dependent diabetes mellitus in a subject comprising administering to the subject a self-vector encoding human proinsulin. The invention also provides a pharmaceutical composition comprising a self-vector encoding human proinsulin, as well as treatment and maintenance regimens for administering the pharmaceutical composition to a subject.

7. 发明授权

US07785819B2 Therapeutic and diagnostic uses of antibody specificity profiles 有权
标题翻译：抗体特异性谱的治疗和诊断用途
公开(公告)号：US07785819B2
公开(公告)日：2010-08-31
申请号：US10120578
申请日：2002-04-10
申请人： William H. Robinson , David L. Hirschberg , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz , Hideki Garren
发明人： William H. Robinson , David L. Hirschberg , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz , Hideki Garren
IPC分类号： G01N33/00
CPC分类号： A61K39/0008 , G01N33/564 , G01N33/6854 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： This invention provides a method for determining the antibody specificity profile in an individual. This specificity profile reveals the individual's immune response to multiple antigens and/or epitopes of autoantigens, allergens, graft antigens, etc. The antibody specificity profile is determined through the binding of patient samples comprising antibodies to the arrays. The array can comprises antigens and epitopes. The invention also provides the means and methods for determining antigen or epitope specificity profiles that can be used in the development of either generic and individualized diagnosis and treatment for immune related diseases, including autoimmune disease, allergy and graft rejection.
摘要翻译：本发明提供了确定个体中抗体特异性谱的方法。该特异性特征揭示了个体对多种抗原和/或自身抗原，变应原，移植抗原等表位的免疫应答。通过将包含抗体的患者样品与阵列的结合来确定抗体特异性谱。阵列可以包括抗原和表位。本发明还提供了用于确定抗原或表位特异性谱的方法和方法，所述抗原或表位特异性特征可用于开发针对免疫相关疾病的通用和个体化诊断和治疗，包括自身免疫疾病，变态反应和移植排斥反应。

8. 发明申请

US20090264515A1 POLYNUCLEOTIDE THERAPY 审中-公开
标题翻译：多核苷酸治疗
公开(公告)号：US20090264515A1
公开(公告)日：2009-10-22
申请号：US12467866
申请日：2009-05-18
申请人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
发明人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
IPC分类号： A61K31/7088 , A61P21/00
CPC分类号： A61K39/001 , A61K38/2026 , A61K39/0007 , A61K39/0008 , A61K48/00 , A61K2039/53 , A61K2039/55522 , A61K2039/55561 , C07K2319/30
摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
摘要翻译：本发明提供了一种治疗或预防与一种或多种自身蛋白，多肽或肽存在或参与非生理过程的一种或多种自身相关的动物疾病的方法，所述动物包括向所述动物施用包含编码与所述疾病相关的自身蛋白质多肽或多肽的多核苷酸的自身载体。施用包含编码自身蛋白，多肽或多肽的多核苷酸的自身载体调节对自身蛋白质的多肽或肽的免疫应答（s）表示自我向量的管理。本发明还提供了一种组合物，其包含编码一种或多种自身蛋白质，多肽或多肽或多肽的多核苷酸，所述多肽或多肽在治疗动物中非生理性地存在，可用于治疗或预防相关疾病其中存在于动物的非生理过程的和/或靶中的自身蛋白质，多肽或多肽。

9. 发明申请

US20080108585A1 DNA VACCINATION FOR TREATMENT OF AUTOIMMUNE DISEASE 有权
标题翻译：用于治疗自身免疫疾病的DNA疫苗
公开(公告)号：US20080108585A1
公开(公告)日：2008-05-08
申请号：US11923139
申请日：2007-10-24
申请人： Lawrence Steinman , Pedro Ruiz , Hideki Garren
发明人： Lawrence Steinman , Pedro Ruiz , Hideki Garren
IPC分类号： A61K48/00
CPC分类号： C07K14/62 , A01K67/027 , A01K2227/105 , A01K2267/0325 , A61K39/00 , A61K39/0008 , A61K39/39 , A61K48/00 , A61K2039/53 , A61K2039/55527 , A61K2039/57
摘要： A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further treating by co-vaccination with a DNA encoding a Th2 cytokine, particularly encoding IL4. In response to the vaccination, the proliferation of autoantigen-reactive T cells and the secretion of Th1 cytokines, including IL-2, IFN-γ and IL-15, are reduced.
摘要翻译：通过注射到编码与自身免疫疾病相关的自身抗原的DNA的受体中，特异性地抑制促炎T细胞应答。接受者可以通过与编码Th2细胞因子的DNA（特别是编码IL4）共同接种来进一步治疗。响应于疫苗接种，自身抗原反应性T细胞的增殖和Th1细胞因子（包括IL-2，IFN-γ和IL-15）的分泌减少。

10. 发明申请

US20070280954A1 Novel Immunomodulating Peptide 有权
标题翻译：新型免疫调节肽
公开(公告)号：US20070280954A1
公开(公告)日：2007-12-06
申请号：US10556756
申请日：2004-05-14
申请人： Lawrence Steinman , Hideki Garren , Paulo Fontoura
发明人： Lawrence Steinman , Hideki Garren , Paulo Fontoura
IPC分类号： A61K39/00 , A61P37/02 , G01N33/53
CPC分类号： A61K45/06 , A61K38/1709 , G01N33/564 , A61K2300/00
摘要： Epitopic fragments of Nogo, including Nogo 45-66, elicit a specific and strong T cell response, and a B cell response. T cells reactive to Nogo antigens are capable of ameliorating ongoing disease, which may be induced with other antigens. The present invention provides compositions and methods for the identification and use of Nogo epitopic fragments in the treatment of immune related disease.
摘要翻译： Nogo的异位片段，包括Nogo 45-66，引发特异性和强T细胞应答和B细胞反应。与Nogo抗原反应的T细胞能够改善正在进行的疾病，其可以用其他抗原诱导。本发明提供用于鉴定和使用Nogo表位片段治疗免疫相关疾病的组合物和方法。

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