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1. 发明申请

US20050261215A1 Methods and immune modulatory nucleic acid compositions for preventing and treating disease 有权
标题翻译：用于预防和治疗疾病的方法和免疫调节核酸组合物
公开(公告)号：US20050261215A1
公开(公告)日：2005-11-24
申请号：US10524643
申请日：2003-11-21
申请人： Hideki Garren , Peggy Ho , Lawrence Steinman
发明人： Hideki Garren , Peggy Ho , Lawrence Steinman
IPC分类号： A61K31/70 , A61K31/715 , A61K48/00
CPC分类号： A61K31/715 , A61K31/70 , A61K48/00
摘要： This invention relates to methods and compositions for treating or preventing disease comprising the administration of immune modulatory nucleic acids having one or more immune modulatory sequences (IMSs). The invention further relates to the means and methods for the identification of the IMSs for preventing or treating disease, more particularly the treatment and prevention of autoimmune or inflammatory diseases. The invention also relates to the treatment or prevention of disease comprising the administration of the immune modulatory nucleic acids alone or in combination with a polynucleotide encoding self-protein(s), -polypeptide(s) or -peptide(s). The present invention also relates to methods and compositions for treating diseases in a subject associated with one or more self-protein(s), -polypeptide(s) or -peptide(s) that are present in the subject and involved in a non-physiological state.
摘要翻译：本发明涉及用于治疗或预防疾病的方法和组合物，其包括施用具有一种或多种免疫调节序列（IMS）的免疫调节核酸。本发明还涉及用于鉴定用于预防或治疗疾病的IMS的方法和方法，更具体地涉及治疗和预防自身免疫性或炎性疾病。本发明还涉及治疗或预防疾病，其包括单独施用免疫调节性核酸或与编码自身蛋白，多肽或多肽的多核苷酸组合施用。本发明还涉及用于治疗与受试者中存在的一种或多种自身蛋白，多肽或肽的受试者相关的疾病的方法和组合物，生理状态。

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