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1. 发明授权

US4705081A System for sensing and forming objects such as leads of electronic components 失效
标题翻译：用于感测和形成诸如电子部件的引线的物体的系统
公开(公告)号：US4705081A
公开(公告)日：1987-11-10
申请号：US832481
申请日：1986-02-21
申请人： John Birk , Heinz Breu , William Gong , Charles C. Morehouse , Sidney Liebes, Jr.
发明人： John Birk , Heinz Breu , William Gong , Charles C. Morehouse , Sidney Liebes, Jr.
IPC分类号： B23P21/00 , H05K3/30 , H05K13/02 , H05K13/04 , H05K13/08
CPC分类号： H05K13/023 , H05K13/0421 , H05K13/043 , H05K13/08 , Y10T29/49139 , Y10T29/53183
摘要： An automatic lead sensing and fine-forming system is disclosed for preparing the leads of electronic compnents so that they are ready to be inserted by robots into holes on printed circuit boards. The positions of the lead tips and the positions of the holes are sensed and compared to determine if any leads need to be bent. These leads are then bent and the force on the leads and their displacement are sensed and recorded during the process. The data recorded is then used for subsequent bendings, where necessary, for bending the leads to the target locations so that all the leads fit simultaneously into the holes. To simplify image processing, the lead tips are illuminated by light originating from substantially isotropic directions from locations substantially coplanar with the region of the lead tips. A telecentric lens system is used in the optical sensing of the position of the lead tips so that measurement of the distances between leads is unaffected by variations in the separation between the lead tips and the sensing device.
摘要翻译：公开了一种自动引线感测和精细成形系统，用于制备电子元件的引线，使得它们准备好被机器人插入印刷电路板上的孔中。检测并比较引线尖端和孔的位置的位置，以确定是否需要弯曲引线。然后，这些引线被弯曲，并且在该过程期间感测和记录引线上的力及其位移。然后记录的数据用于随后的弯曲，在必要时，用于将引线弯曲到目标位置，使得所有引线同时并入孔中。为了简化图像处理，引线尖端由来自基本上各向同性方向的光照射，该位置基本上与引线尖端的区域共面。远心透镜系统用于光学感测引线尖端的位置，使得引线之间的距离的测量不受引线尖端和感测装置之间的间隔的变化的影响。

2. 发明授权

US09342651B2 Computational methods for translating a sequence of multi-base color calls to a sequence of bases 有权
标题翻译：用于将多基色调序列转换为基序的计算方法
公开(公告)号：US09342651B2
公开(公告)日：2016-05-17
申请号：US13106998
申请日：2011-05-13
申请人： Heinz Breu , Danwei Guo
发明人： Heinz Breu , Danwei Guo
IPC分类号： G06F19/22 , G06F15/00 , C12Q1/68
CPC分类号： C12Q1/6869 , G06F19/22 , C12Q2535/131 , C12Q2565/1025
摘要： Disclosed are systems and methods for resequencing using color calls. A DNA sample is encoded and sequenced according to a multi-base code producing a string of read color calls for a fragment of the sample. A reference sequence is obtained. The string of read color calls is mapped to the reference sequence. A base sequence is extracted from the reference sequence. The base sequence is encoded as a string of reference color codes according to the multi-base code. The string of read color calls is aligned with the string of reference color codes and mismatches in the alignment are detected. One or more mismatches of the string of read color calls are annotated as inconsistent. The one or more inconsistent mismatches of the string of read color calls are corrected. The string of corrected read color calls is decoded to bases producing a read sequence.
摘要翻译：公开了使用颜色调用重新测序的系统和方法。 DNA样本根据多基因码进行编码和测序，产生样本片段的一系列读取颜色调用。得到参考序列。读取颜色调用的字符串映射到参考序列。从参考序列中提取碱基序列。基本序列根据多基本码被编码为参考颜色码串。读取颜色调用的字符串与参考颜色代码的字符串对齐，并且检测到对齐中的不匹配。读取颜色调用字符串的一个或多个不匹配被注释为不一致。读取颜色调用串的一个或多个不一致的不匹配被更正。将经校正的读取颜色调用的字符串解码为产生读取序列的基准。

3. 发明授权

US5023916A Method for inspecting the leads of electrical components on surface mount printed circuit boards 失效
标题翻译：用于检查表面贴装印刷电路板上电气元件引线的方法
公开(公告)号：US5023916A
公开(公告)日：1991-06-11
申请号：US399688
申请日：1989-08-28
申请人： Heinz Breu
发明人： Heinz Breu
IPC分类号： G01R31/04 , B23K31/12 , G01N21/956 , G06T1/00 , G06T7/00 , H05K3/34 , H05K13/08
CPC分类号： G06T7/001 , B23K31/12 , G01N21/95684 , H05K13/08 , G06T2207/20136 , G06T2207/30152
摘要： A method of inspecting solder joints that connect surface-mount electronic components to printed circuit boards is provided. Preferably, the method includes the steps of obtaining an image of a plurality of the leads of the electronic component, for each obtained image, representing segments of the image that correspond to each of the leads by polygons, projecting pixel intensity values within each polygon each onto an axial dimension to provide a measured waveform, comparing the measured waveform for each lead with a corresponding model waveform, and, classifying each lead as being either satisfactory or unsatisfactory on the basis of said comparisons.
摘要翻译：提供了一种检查将表面贴装电子部件连接到印刷电路板的焊点的方法。优选地，该方法包括以下步骤：对于每个获得的图像，获得电子部件的多个引线的图像，表示通过多边形对应于每个引线的图像的段，在每个多边形内投影像素强度值在轴向尺寸上提供测量波形，将每个引线的测量波形与相应的模型波形进行比较，并且根据所述比较将每个引线分类为满意的或不令人满意的。

4. 发明申请

US20110295514A1 Computational Methods For Translating A Sequence Of Multi-Base Color Calls To A Sequence Of Bases 有权
标题翻译：用于将多基色彩调用序列翻译成基本序列的计算方法
公开(公告)号：US20110295514A1
公开(公告)日：2011-12-01
申请号：US13106998
申请日：2011-05-13
申请人： Heinz Breu , Danwei Guo
发明人： Heinz Breu , Danwei Guo
IPC分类号： G06F19/10
CPC分类号： C12Q1/6869 , G06F19/22 , C12Q2535/131 , C12Q2565/1025
摘要： Disclosed are systems and methods for resequencing using color calls. A DNA sample is encoded and sequenced according to a multi-base code producing a string of read color calls for a fragment of the sample. A reference sequence is obtained. The string of read color calls is mapped to the reference sequence. A base sequence is extracted from the reference sequence. The base sequence is encoded as a string of reference color codes according to the multi-base code. The string of read color calls is aligned with the string of reference color codes and mismatches in the alignment are detected. One or more mismatches of the string of read color calls are annotated as inconsistent. The one or more inconsistent mismatches of the string of read color calls are corrected. The string of corrected read color calls is decoded to bases producing a read sequence.
摘要翻译：公开了使用颜色调用重新测序的系统和方法。 DNA样本根据多基因码进行编码和测序，产生样本片段的一系列读取颜色调用。得到参考序列。读取颜色调用的字符串映射到参考序列。从参考序列中提取碱基序列。基本序列根据多基本码被编码为参考颜色码串。读取颜色调用的字符串与参考颜色代码的字符串对齐，并且检测到对齐中的不匹配。读取颜色调用字符串的一个或多个不匹配被注释为不一致。读取颜色调用串的一个或多个不一致的不匹配被更正。将经校正的读取颜色调用的字符串解码为产生读取序列的基准。

5. 发明申请

US20110257031A1 Nucleic acid, biomolecule and polymer identifier codes 审中-公开
标题翻译：核酸，生物分子和聚合物识别码
公开(公告)号：US20110257031A1
公开(公告)日：2011-10-20
申请号：US13026046
申请日：2011-02-11
申请人： John BODEAU , Heinz BREU , Kathleen PERRY , Adam HARRIS , Patrick GILLES , Miho Gilles
发明人： John BODEAU , Heinz BREU , Kathleen PERRY , Adam HARRIS , Patrick GILLES , Miho Gilles
IPC分类号： C40B30/04 , C07H21/04 , C40B40/06
CPC分类号： C12Q1/6869 , C12N15/1065 , C12Q1/6876 , C12Q2600/166 , C12Q2565/102 , C12Q2533/107 , C12Q2563/179 , C12Q2565/514
摘要： Provided herein are systems, compositions and methods for tracking, sorting and/or identifying sample polynucleotides using nucleic acid barcodes. The barcodes provided herein are oligonucleotides that are designed to be uniquely identifiable. The nucleic acid barcodes have properties that permit them to be sequenced with high accuracy and/or reduced error rates. In some embodiments, the nucleic acid barcodes are designed to have certain nucleotide sequences that make up overlapping dibase color positions (also called color positions). The order of the overlapping dibase color positions can be determined using fluorophore-encoded dibase probes in a fluorophore color calling scheme to give high fidelity reads.
摘要翻译：本文提供了使用核酸条形码跟踪，分选和/或鉴定样品多核苷酸的系统，组合物和方法。本文提供的条形码是被设计为唯一可识别的寡核苷酸。核酸条形码具有允许它们以高精度和/或降低的错误率进行排序的性质。在一些实施方案中，将核酸条形码设计为具有构成重叠二碱基色位置（也称为颜色位置）的某些核苷酸序列。可以使用荧光团编码的二酶探针在荧光团颜色调用方案中确定重叠二碱基色素位置的顺序，以提供高保真读数。

6. 发明授权

US4813255A System for sensing and forming objects such as leads of electronic components 失效
标题翻译：用于感测和形成诸如电子部件的引线的物体的系统
公开(公告)号：US4813255A
公开(公告)日：1989-03-21
申请号：US89719
申请日：1987-08-26
申请人： John Birk , Heinz Breu , William Gong , Charles C. Morehouse , Sidney Liebes, Jr.
发明人： John Birk , Heinz Breu , William Gong , Charles C. Morehouse , Sidney Liebes, Jr.
IPC分类号： H05K13/02 , H05K13/04 , H05K13/08 , B21D7/12
CPC分类号： H05K13/0421 , H05K13/023 , H05K13/043 , H05K13/08 , Y10S72/702
摘要： An automatic lead sensing and fine-forming system is disclosed for preparing the leads of electronic components so that they are ready to be inserted by robots into holes on printed circuit boards. The positions of the lead tips and the positions of the holes are sensed and compared to determine if any leads need to be bent. These leads are then bent and the force on the leads and their displacement are sensed and recorded during the process. The data recorded is then used for subsequent bendings, where necessary, for bending the leads to the target locations so that all the leads fit simultaneously into the holes. To simplify image processing, the lead tips are illuminated by light originating from substantially isotropic directions from locations substantially coplanar with the region of the lead tips. A telecentric lens system is used in the optical sensing of the position of the lead tips so that measurement of the distances between leads is unaffected by variations in the separation between the lead tips and the sensing device.
摘要翻译：公开了一种用于制备电子元件引线的自动引线感测和精细成形系统，使得它们准备好被机器人插入印刷电路板上的孔中。检测并比较引线尖端和孔的位置的位置，以确定是否需要弯曲引线。然后，这些引线被弯曲，并且在该过程期间感测和记录引线上的力及其位移。然后记录的数据用于随后的弯曲，在必要时，用于将引线弯曲到目标位置，使得所有引线同时并入孔中。为了简化图像处理，引线尖端由来自基本上各向同性方向的光照射，该位置基本上与引线尖端的区域共面。远心透镜系统用于光学感测引线尖端的位置，使得引线之间的距离的测量不受引线尖端和感测装置之间的间隔的变化的影响。

7. 发明申请

US20110270532A1 Systems And Methods For Identifying Exon Junctions From Single Reads 审中-公开
标题翻译：用于从单次读取中识别外显子结的系统和方法
公开(公告)号：US20110270532A1
公开(公告)日：2011-11-03
申请号：US13097328
申请日：2011-04-29
申请人： Paolo VATTA , Onur Sakarya , Heinz Breu , Liviu Popescu , Asim Siddiqui , Fiona Hyland
发明人： Paolo VATTA , Onur Sakarya , Heinz Breu , Liviu Popescu , Asim Siddiqui , Fiona Hyland
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G16B30/00
摘要： Systems and methods are used to identify an exon junction from a single read of a transcript. A transcript sample is interrogated and a read sequence is produced using a nucleic acid sequencer. A first exon sequence and a second exon sequence are obtained using the processor. The first exon sequence is mapped to a prefix of the read sequence using the processor. The second exon sequence is mapped to a suffix of the read sequence using the processor. A sum of a number of sequence elements of the first exon sequence that overlap the prefix of the read sequence, of a number of sequence elements of the second exon sequence that overlap the suffix of the read sequence, and of a constant is calculated using the processor. If the sum equals a length of the read sequence, a junction is identified in the read using the processor.
摘要翻译：系统和方法用于从单次阅读誊本中鉴定出外显子连接。询问转录物样品，并使用核酸测序仪产生读序列。使用处理器获得第一外显子序列和第二外显子序列。使用处理器将第一个外显子序列映射到读取序列的前缀。第二个外显子序列使用处理器映射到读序列的后缀。与第一外显子序列的序列元素的数量重叠，读取序列的前缀，与重写序列的后缀重叠的第二外显子序列的多个序列元件的数目和一个常数的序列元素的总和是使用处理器。如果总和等于读取序列的长度，则使用处理器在读取中识别结。

8. 发明申请

US20100129810A1 METHODS AND SYSTEMS FOR NUCLEIC ACID SEQUENCING VALIDATION, CALIBRATION AND NORMALIZATION 审中-公开
标题翻译：用于核酸序列确认，校准和正常化的方法和系统
公开(公告)号：US20100129810A1
公开(公告)日：2010-05-27
申请号：US12555549
申请日：2009-09-08
申请人： Douglas P. GREINER , Carmen GJERSTAD , Janet S. ZIEGLE , Lee W. JONES , Min-Yi SHEN , Chen-Shan CHIN , Heinz BREU
发明人： Douglas P. GREINER , Carmen GJERSTAD , Janet S. ZIEGLE , Lee W. JONES , Min-Yi SHEN , Chen-Shan CHIN , Heinz BREU
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2545/101 , C12Q2563/149
摘要： A system for performing quality control for nucleic acid sample sequencing is disclosed. The system has a set of solid supports, each support having attached thereto a plurality of nucleic acid sequences. The set has plural groups of solid supports and each group contains solid supports having the same nucleic acid sequences attached thereto. The nucleic acid sequences of each group differ from each other. The nucleic acid sequences are synthetically derived. A method of preparing a quality control for performing nucleic acid sample sequencing and a method of validating a nucleic acid sequencing instrument are also disclosed.
摘要翻译：公开了一种用于进行核酸样品测序的质量控制的系统。该系统具有一组固体支持物，每个载体附着有多个核酸序列。该组具有多组固体支持物，每组含有与其相连的相同核酸序列的固体支持体。各组的核酸序列彼此不同。核酸序列是合成衍生的。还公开了一种制备用于进行核酸样品测序的质量控制的方法和验证核酸测序仪的方法。

9. 发明授权

US5023920A Method for finding the medial axis transform of an image 失效
标题翻译：用于找到图像的中轴变换的方法
公开(公告)号：US5023920A
公开(公告)日：1991-06-11
申请号：US400211
申请日：1989-08-28
申请人： Heinz Breu
发明人： Heinz Breu
IPC分类号： G06K9/44
CPC分类号： G06K9/44
摘要： An improved method for constructing the medial axis transform of an image is disclosed. The method requires only that one line of the image be held in memory at any given time. The method runs in a time of order N, where N is the number of pixels in the image.
摘要翻译：公开了一种用于构建图像的中轴变换的改进方法。该方法仅需要在任何给定时间将图像的一行保持在存储器中。该方法在N阶的时间运行，其中N是图像中的像素数。

10. 发明授权

US4821157A System for sensing and forming objects such as leads of electronic components 失效
标题翻译：用于感测和形成诸如电子部件的引线的物体的系统
公开(公告)号：US4821157A
公开(公告)日：1989-04-11
申请号：US89651
申请日：1987-08-26
申请人： John Birk , Heinz Breu , William Gong , Charles C. Morehouse , Sidney Liebes, Jr.
发明人： John Birk , Heinz Breu , William Gong , Charles C. Morehouse , Sidney Liebes, Jr.
IPC分类号： H05K13/02 , H05K13/04 , H05K13/08 , F21V11/00
CPC分类号： H05K13/043 , H05K13/023 , H05K13/0421 , H05K13/08
摘要： An automatic lead sensing and fine-forming system is disclosed for preparing the leads of electronic components so that they are ready to be inserted by robots into holes on printed circuit boards. The positions of the lead tips and the positions of the holes are sensed and compared to determine if any leads need to be bent. These leads are then bent and the force on the leads and their displacement are sensed and recorded during the process. The data recorded in then used for subsequent bendings, where necessary, for bending the leads to the target locations so that all the leads fit simultaneously into the holes. To simplify image processing, the lead tips are illuminated by light originating from substantially isotropic directions from locations substantially coplanar with the region of the lead tips. A telecentric lens system is used in the optical sensing of the position of the lead tips so that measurement of the distances between leads is unaffected by variations in the separation between the lead tips and the sensing device.
摘要翻译：公开了一种用于制备电子元件引线的自动引线感测和精细成形系统，使得它们准备好被机器人插入印刷电路板上的孔中。检测并比较引线尖端和孔的位置的位置，以确定是否需要弯曲引线。然后，这些引线被弯曲，并且在该过程期间感测和记录引线上的力及其位移。所记录的数据随后用于随后的弯曲，必要时用于将引线弯曲到目标位置，使得所有引线同时并入孔中。为了简化图像处理，引线尖端由来自基本上各向同性方向的光照射，该位置基本上与引线尖端的区域共面。远心透镜系统用于光学感测引线尖端的位置，使得引线之间的距离的测量不受引线尖端和感测装置之间的间隔的变化的影响。

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