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1. 发明授权

US06531604B2 Benzothiepine derivatives, their production and use 失效
标题翻译：苯并噻吩衍生物，其生产和使用
公开(公告)号：US06531604B2
公开(公告)日：2003-03-11
申请号：US10044787
申请日：2002-01-11
申请人： Tsuneo Yasuma , Haruhiko Makino , Akira Mori
发明人： Tsuneo Yasuma , Haruhiko Makino , Akira Mori
IPC分类号： C07D21140
CPC分类号： C07D263/44 , C07D211/88 , C07D233/74 , C07D277/04 , C07D295/135 , C07D495/04
摘要： The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0-3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.
摘要翻译：本发明提供下式的化合物：其中环A是任选取代的苯环; R1是任选取代的非芳族杂环基; R2和R3独立地为氢原子或任选取代的烃基; n为0-3的整数; 或其盐，其可用作具有成骨促进作用的药物和软骨素促进作用。本发明涉及具有抑制淀粉样蛋白b蛋白的产生和/或分泌的优异效果的胺化合物及其制备和用途。特别地，对于预防和/或治疗例如神经变性疾病，淀粉样血管病，由脑血管障碍引起的神经障碍等是有效的。

2. 发明授权

US06403606B1 Thienopyridine derivatives and their use 失效
标题翻译：噻吩并吡啶衍生物及其用途
公开(公告)号：US06403606B1
公开(公告)日：2002-06-11
申请号：US09506010
申请日：2000-02-17
申请人： Takashi Sohda , Haruhiko Makino , Atsuo Baba
发明人： Takashi Sohda , Haruhiko Makino , Atsuo Baba
IPC分类号： A61K314353
CPC分类号： C07D495/14
摘要： There is disclosed a compound of the formula (A): wherein W is C—G or C—G′ (G is optionally esterified carboxyl; and G′ is halogen); X is oxygen, optionally oxidized sulfur or —(CH2)q—, (q is 0 to 5); R is optionally substituted amino or heterocyclic group; the ring B is optionally substituted nitrogen-containing 5- to 7-membered ring; L is hydrogen, optionally substituted hydrocarbon residue, optionally substituted acyl, optionally substituted carbamoyl, optionally substituted thiocarbamoyl or optionally substituted sulfonyl provided that, when W is C—G, L is hydrogen, optionally substituted acyl, optionally substituted carbamoyl, optionally substituted alkoxycarbonyl, optionally substituted thiocarbamoyl or optionally substituted sulfonyl; n is 0 or 1; the ring A may have a substituent. A process for producing the compound (A) and a pharmaceutical composition containing the compound (A) are also disclosed. The pharmaceutical composition is useful for an anti-inflammatory drug, particularly, a drug for preventing or treating arthritis, a drug for inhibiting bone resorption, immunosuppressant or the like.
摘要翻译：公开了式（A）的化合物：其中W是C-G或C-G'（G任选被酯化的羧基，G'是卤素）; X为氧，任选氧化硫或 - （CH 2）q - ，（q为0至5）; R是任选取代的氨基或杂环基; 环B为任选取代的含氮5至7元环; L是氢，任选取代的烃残基，任选取代的酰基，任选取代的氨基甲酰基，任选取代的硫代氨基甲酰基或任选取代的磺酰基，条件是当W为CG时，L为氢，任选取代的酰基，任选取代的氨基甲酰基，任选取代的烷氧基羰基，硫代氨基甲酰基或任选取代的磺酰基; n为0或1; 环A可以具有取代基。还公开了制备化合物（A）的方法和含有化合物（A）的药物组合物。药物组合物可用于抗炎药物，特别是用于预防或治疗关节炎的药物，用于抑制骨吸收的药物，免疫抑制剂等。

3. 发明授权

US5948782A Pharmaceutical composition containing quinoline and quinazoline derivatives and novel compounds therefor 失效
标题翻译：含喹啉和喹唑啉衍生物的药物组合物及其新型化合物
公开(公告)号：US5948782A
公开(公告)日：1999-09-07
申请号：US049500
申请日：1993-04-21
申请人： Takashi Sohda , Haruhiko Makino , Atsuo Baba
发明人： Takashi Sohda , Haruhiko Makino , Atsuo Baba
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/50 , A61K31/505 , A61K31/517 , A61P19/02 , A61P25/00 , C07D215/54 , C07D239/74 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/056 , C07D513/04 , A01N43/54 , A01N43/42 , C07D215/38 , C07D239/72
CPC分类号： C07D401/12 , A61K31/47 , A61K31/50 , A61K31/505 , C07D215/54 , C07D239/74 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/10 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D513/04
摘要： There is disclosed an anti-inflammatory agent comprising a compound of the formula (I): ##STR1## The quinoline compounds included in the compound (I) are novel and there is also disclosed processes for producing them.
摘要翻译：公开了包含式（I）化合物的抗炎剂：化合物（I）中包括的喹啉化合物是新颖的，并且还公开了制备它们的方法。

4. 发明授权

US5770602A Quinoline or quinazoline derivatives, their production and use 失效
标题翻译：喹啉或喹唑啉衍生物，其生产和使用
公开(公告)号：US5770602A
公开(公告)日：1998-06-23
申请号：US436629
申请日：1995-05-08
申请人： Takashi Sohda , Haruhiko Makino , Atsuo Baba
发明人： Takashi Sohda , Haruhiko Makino , Atsuo Baba
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/505 , A61K31/517 , A61P29/00 , C07D215/60 , C07D239/74 , C07D401/06 , C07D403/06 , C07D521/00 , C07D215/58 , C07D239/72
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D401/06 , C07D403/06
摘要： A compound represented by the general formula: ##STR1## wherein Y represents a nitrogen atom or C--G (G represents a carboxyl group which may be esterified); ring R is a nitrogen-containing unsaturated heterocyclic group which may be substituted for; each of rings A and B may have a substituent; n represents an integer from 1 to 4; k represents the integer 0 or 1, or a salt thereof, which serves well as an anti-inflammatory agent, particularly a therapeutic agent for arthritis.
摘要翻译：由下式通式表示的化合物：其中Y表示氮原子或C-G（G表示可被酯化的羧基）。环R是可以被取代的含氮不饱和杂环基; 环A和B各自可以具有取代基; n表示1〜4的整数， k表示整数0或1，或其盐，其用作抗炎剂，特别是用于关节炎的治疗剂。

5. 发明授权

US5641788A Quinoline derivatives and pharmaceutical composition containing them 失效
标题翻译：喹啉衍生物和含有它们的药物组合物
公开(公告)号：US5641788A
公开(公告)日：1997-06-24
申请号：US460776
申请日：1995-06-02
申请人： Takashi Sohda , Haruhiko Makino , Atsuo Baba
发明人： Takashi Sohda , Haruhiko Makino , Atsuo Baba
IPC分类号： C07D215/20 , C07D401/06 , C07D401/12 , C07D521/00 , A61K31/47 , C07D215/14 , C07D215/60
CPC分类号： C07D249/08 , C07D215/20 , C07D231/12 , C07D233/56 , C07D401/06 , C07D401/12
摘要： The present invention provides a novel quinoline derivative useful as an anti-inflammatory agent, particularly an agent for treating arthritis, or a salt thereof. The present invention also provides a composition, particularly an anti-inflammatory composition for pharmaceutical use, comprising the novel quinoline compound of formula (I): ##STR1## wherein G is an acyl group, optionally protected hydroxyalkyl group, amidated carboxyl group or halogen atom;X is an oxygen atom, optionally oxidized sulfur atom or --(CH.sub.2).sub.q -- in which q is an integer of 0 to 5;R is an optionally substituted amino group or optionally substituted heterocyclic group;each of the ring A and ring B may optionally be substituted; andk is 0 or 1.
摘要翻译：本发明提供可用作抗炎剂，特别是治疗关节炎的药剂的新型喹啉衍生物或其盐。本发明还提供一种组合物，特别是用于药物用途的抗炎组合物，其包含式（I）的新喹啉化合物：具有羟基烷基，酰胺化的羧基或卤素原子; X是氧原子，任选地被氧化的硫原子或 - （CH 2）q-，其中q是0-5的整数; R是任选取代的氨基或任选取代的杂环基; 环A和环B中的每一个可以任选地被取代; k为0或1。

6. 发明授权

US06576984B2 Semiconductor apparatus and electronic system 失效
标题翻译：半导体装置及电子系统
公开(公告)号：US06576984B2
公开(公告)日：2003-06-10
申请号：US09212386
申请日：1998-12-16
申请人： Hideyuki Takahashi , Haruhiko Makino
发明人： Hideyuki Takahashi , Haruhiko Makino
IPC分类号： H01L23495
CPC分类号： H01L24/32 , H01L23/293 , H01L23/3128 , H01L24/48 , H01L2224/32145 , H01L2224/48091 , H01L2224/48247 , H01L2224/8592 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01029 , H01L2924/01033 , H01L2924/01082 , H01L2924/181 , H01L2924/3025 , H01L2924/351 , H01L2924/3512 , H01L2924/00 , H01L2924/00012 , H01L2224/45015 , H01L2924/207 , H01L2224/45099 , H01L2224/05599 , H01L2224/85399
摘要： A semiconductor apparatus includes a semiconductor device and a wiring member having an insulating resin base, wiring layers connected to the individual electrodes of the semiconductor device, and external terminals. The semiconductor device or a reinforcing plate placed around the semiconductor device and the wiring member are bonded to each other with an insulating elastic material therebetween. The insulating elastic material retains rubber elasticity under the environmental conditions of the fabrication process and of use. An electronic system includes a semiconductor apparatus as described above.
摘要翻译：半导体装置包括半导体器件和具有绝缘树脂基底的布线构件，连接到半导体器件的各个电极的布线层和外部端子。放置在半导体器件和布线部件周围的半导体器件或加强板之间以绝缘弹性材料彼此接合。绝缘弹性材料在制造工艺和使用的环境条件下保持橡胶弹性。电子系统包括如上所述的半导体装置。

7. 发明授权

US06214838B1 Thienodipyridine derivatives, production and use thereof 失效
标题翻译：噻吩二吡啶衍生物，其生产和使用
公开(公告)号：US06214838B1
公开(公告)日：2001-04-10
申请号：US09355218
申请日：1999-07-23
申请人： Takashi Sohda , Haruhiko Makino , Atsuo Baba , Taihei Yamane
发明人： Takashi Sohda , Haruhiko Makino , Atsuo Baba , Taihei Yamane
IPC分类号： A61K314365
CPC分类号： C07D495/14
摘要： A compound of the formula (I): wherein R is hydrogen or C2-6 alkanoyl; X is halogen; and ring A is benzene ring which is optionally substituted by 1 to 4 substituents selected from {circle around (1)} halogen, {circle around (2)} hydroxy, {circle around (3)} C1-6 alkoxy optionally substituted by halogen or phenyl, {circle around (4)} C1-6 alkylthio optionally substituted by halogen or phenyl, {circle around (5)} C1-6 alkyl optionally substituted by halogen, {circle around (6)} C2-6 alkanoylamino or {circle around (7)} carboxy optionally esterified by C1-6 alkyl, or a salt thereof; which can be used for preventing or treating inflammatory disease, arthritis, chronic rheumatoid arthritis, autoimmune diseases, or rejection after organ transplantation.
摘要翻译：式（I）的化合物：其中R是氢或C 2-6烷酰基; X是卤素; 并且环A是苯环，其任选被1至4个选自{（1）}周围的环，（2）}羟基周围的环，[（3）周围的环（任选被卤素取代）的C 1-6烷氧基或苯基，（任选被（4）周围的环）被卤素或苯基任意取代的C 1-6烷硫基，（（5）周围的环）任选被卤素取代的C 1-6烷基，（绕（6）周围的C 2-6烷酰基氨基或{ （7）}羧基，其任选被C 1-6烷基酯化，或其盐; 其可用于预防或治疗炎症性疾病，关节炎，慢性类风湿性关节炎，自身免疫性疾病或器官移植后的排斥反应。

8. 发明授权

US07067527B2 Thienopyridine derivatives, their production and use 失效
标题翻译：噻吩并吡啶衍生物，其生产和使用
公开(公告)号：US07067527B2
公开(公告)日：2006-06-27
申请号：US10662165
申请日：2003-09-03
申请人： Tsuneo Yasuma , Atsuo Baba , Haruhiko Makino , Isao Aoki , Toshiaki Nagata
发明人： Tsuneo Yasuma , Atsuo Baba , Haruhiko Makino , Isao Aoki , Toshiaki Nagata
IPC分类号： C07D495/14 , A61K31/38
CPC分类号： C07D495/04 , C07D495/14
摘要： The present invention provides thienopyridine derivatives, which are useful as anti-inflammatory drugs, particularly as remedies for arthritis; processes for producing them, and pharmaceutical compositions containing them. The thienopyridine derivatives are represented by the formula (I): wherein G is a halogen atom, hydroxyl group, an optionally substituted amino group, etc.; alk is an optionally substituted lower alkylene group; X is O, S, —(CH2)q—, etc.; R is an optionally substituted amino group, etc.; ring B is an optionally substituted Y-containing 5- to 8-membered ring whose ring constituent atoms contain no nitrogen atom; Y is O, S, a group of (wherein Ra, Rb and Rc are the same or different and, each is H, a halogen atom, an optionally substituted hydrocarbon group, etc.), etc.; and ring A may be substituted.
摘要翻译：本发明提供可用作抗炎药物的噻吩并吡啶衍生物，特别是作为关节炎的补救剂; 制备它们的方法和含有它们的药物组合物。噻吩并吡啶衍生物由式（I）表示：其中G是卤素原子，羟基，任选取代的氨基等; 烷基是任选取代的低级亚烷基; X是O，S， - （CH 2 CH 2）q - 等; R是任选取代的氨基等; 环B是任选取代的含有Y的5至8元环，其环组成原子不含氮原子; Y是O，S，（其中Ra，Rb和Rc相同或不同，并且各自为H，卤素原子，任选取代的烃基等）等; 并且环A可以被取代。

9. 发明授权

US06660941B2 Electronic parts mounting board and production method thereof 失效
公开(公告)号：US06660941B2
公开(公告)日：2003-12-09
申请号：US10080313
申请日：2002-02-21
申请人： Sakan Iwashita , Haruhiko Makino , Hidetoshi Kusano
发明人： Sakan Iwashita , Haruhiko Makino , Hidetoshi Kusano
IPC分类号： H05K100
CPC分类号： H05K3/4658 , H01L21/2885 , H01L21/4853 , H01L21/486 , H01L21/68 , H01L23/49827 , H01L2224/16 , H01L2224/83101 , H01L2924/01078 , H01L2924/01079 , H01L2924/3011 , H05K1/113 , H05K3/205 , H05K3/4617 , H05K2201/09845 , H05K2203/0733 , H05K2203/1189 , Y10T29/49147 , Y10T29/49155 , Y10T29/49156
摘要： An electronic parts mounting board includes an electrode circuit base member having electrodes on at least one surface; projecting electrodes bonded to the electrodes of the electrode circuit base member; an insulating member provided on the electrode circuit base member in such a manner as to insulate the electrodes of the electrode circuit base member and the projecting electrodes; and circuit electrode patterns provided on the insulating member and the projecting electrodes. In this mounting board, the projecting electrodes are formed by forming specific projecting conductive members at specific positions of the circuit electrode patterns by plating, and pressing the projecting conductive members in the insulating member so as to pass through the insulating member and reach the electrodes of the electrode circuit base member. The mounting board is capable of connecting circuit electrode patterns to a specific electrode base member via small contacts comparable to those obtained by a photo via process at a high positional accuracy, and improving the flatness and adhesive force of the circuit electrode patterns, without use of an expensive laser system for drilling.

10. 发明授权

US06563202B1 Lead frame, manufacturing method of a lead frame, semiconductor device, assembling method of a semiconductor device, and electronic apparatus 失效
标题翻译：引线框架，引线框架的制造方法，半导体器件，半导体器件的组装方法和电子设备
公开(公告)号：US06563202B1
公开(公告)日：2003-05-13
申请号：US09491444
申请日：2000-01-26
申请人： Kenji Ohsawa , Hidetoshi Kusano , Haruhiko Makino , Hideyuki Takahashi
发明人： Kenji Ohsawa , Hidetoshi Kusano , Haruhiko Makino , Hideyuki Takahashi
IPC分类号： H01L23495
CPC分类号： H01L21/4821 , H01L23/13 , H01L23/24 , H01L23/49816 , H01L2224/32245 , H01L2224/73269 , H01L2924/15311
摘要： Metal films (for instance, gold films or palladium films) to constitute bumps are formed on a metal base by electrolytic plating. Then, a circuit wiring including inner leads is formed by electrolytic plating with a metal so that the inner leads are connected to the respective metal films.
摘要翻译：通过电解电镀在金属基体上形成构成凸块的金属膜（例如，金膜或钯膜）。然后，通过用金属进行电解电镀形成包括内部引线的电路布线，使得内部引线连接到各个金属膜。

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