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    • 1. 发明申请
    • Outer layer material having entanglement of hydrophobic polymer host blended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest
    • 具有与马来酸化疏水性聚合物共主体共混的疏水性聚合物主体的缠结的外层材料和亲水性聚合物客体
    • US20080318022A1
    • 2008-12-25
    • US12148598
    • 2008-04-21
    • Susan P. JamesMin ZhangGuy BeauregardRachael Kurkowski Oldinski
    • Susan P. JamesMin ZhangGuy BeauregardRachael Kurkowski Oldinski
    • B32B3/26C07H3/00C07K14/00C08F10/00C07K14/52
    • C08J3/246A61L31/048C08B37/00C08B37/0072C08J9/42C08J2323/06C08J2405/08C08L5/08Y10T428/249953C08L2666/02C08L101/00C08L2666/26
    • An outer layer material having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. Prior to intermingling with the guest, a host blend may be produced to include a physical blend of a hydrophobic polymer host and a maleated hydrophobic co-host (preferably, an anhydride functionalized hydrophobic polymer, whereby the polymer so functionalized, is the same as that selected for the host). The intermingling of the guest and host, or host-co-host blend, includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer material having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host, or host blend, (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer with or without additional crosslinking of the host to the host.
    • 具有缠结的外层材料,其包含掩蔽的亲水性客体和疏水性聚合物主体的混合物,其中客体的分子彼此交联。 在某些情况下,使用客人的复合物可能是理想的或甚至是必需的。 在与客体混合之前,可以制备主体共混物以包括疏水性聚合物主体和马来酸化疏水性共主体的物理共混物(优选为酸酐官能化的疏水性聚合物,由此使官能化的聚合物与之相同) 为主机选择)。 客体和宿主或宿主 - 共同宿主混合物的混合包括物理缠结,不管其是否还包括通过其间的初次键合(例如,化学/共价键合)的交联。 还有一种制造具有这种缠结的外层材料的方法,包括以下步骤:暂时掩蔽客体的至少一部分亲水基团; 通过将具有掩蔽基团的客体扩散到结构的孔的至少一部分中来将具有多孔聚合物结构的至少一部分掩蔽组混合; 在孔内,与客体交联客体的至少一部分分子; 并去除隐形。 掩蔽可以通过甲硅烷基化或酰化进行。 混合可以通过生产客体和主体或主体混合物的混合物(无论是溶液,粉末状,颗粒状等)形式进行; 接下来,进行客人与其自身的交联; 然后,将该混合物模塑到外层中,该主体与主体有或没有额外的交联。
    • 3. 发明授权
    • Outer layer material having entanglement of hydrophobic polymer hostblended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest
    • 外层材料具有与马来酸化疏水性聚合物共主体共混的疏水性聚合物和亲水性聚合物客体的缠结
    • US08524884B2
    • 2013-09-03
    • US12148598
    • 2008-04-21
    • Susan P. JamesMin ZhangGuy BeauregardRachael Kurkowski Oldinski
    • Susan P. JamesMin ZhangGuy BeauregardRachael Kurkowski Oldinski
    • C07H5/04C07H1/00
    • C08J3/246A61L31/048C08B37/00C08B37/0072C08J9/42C08J2323/06C08J2405/08C08L5/08Y10T428/249953C08L2666/02C08L101/00C08L2666/26
    • An outer layer material having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. Prior to intermingling with the guest, a host blend may be produced to include a physical blend of a hydrophobic polymer host and a maleated hydrophobic co-host (preferably, an anhydride functionalized hydrophobic polymer, whereby the polymer so functionalized, is the same as that selected for the host). The intermingling of the guest and host, or host-co-host blend, includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer material having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host, or host blend, (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer with or without additional crosslinking of the host to the host.
    • 具有缠结的外层材料,其包含掩蔽的亲水性客体和疏水性聚合物主体的混合物,其中客体的分子彼此交联。 在某些情况下,使用客人的复合物可能是理想的或甚至是必需的。 在与客体混合之前,可以制备主体共混物以包括疏水性聚合物主体和马来酸化疏水性共主体的物理共混物(优选为酸酐官能化的疏水性聚合物,由此使官能化的聚合物与之相同) 为主机选择)。 客体和宿主或宿主 - 共同宿主混合物的混合包括物理缠结,不管其是否还包括通过其间的初次键合(例如,化学/共价键合)的交联。 还有一种制造具有这种缠结的外层材料的方法,包括以下步骤:暂时掩蔽客体的至少一部分亲水基团; 通过将具有掩蔽基团的客体扩散到结构的孔的至少一部分中来将具有多孔聚合物结构的至少一部分掩蔽组混合; 在孔内,与客体交联客体的至少一部分分子; 并去除隐形。 掩蔽可以通过甲硅烷基化或酰化进行。 混合可以通过生产客体和主体或主体混合物的混合物(无论是溶液,粉末状,颗粒状等)形式进行; 接下来,进行客人与其自身的交联; 然后,将该混合物模塑到外层中,该主体与主体有或没有额外的交联。
    • 4. 发明申请
    • OUTER LAYER HAVING ENTANGLEMENT OF HYDROPHOBIC POLYMER HOST AND HYDROPHILIC POLYMER GUEST
    • 具有疏水性聚合物主体和聚合物聚合物接头的外层
    • US20100150983A1
    • 2010-06-17
    • US12705753
    • 2010-02-15
    • Susan P. JAMESMin ZHANGGuy BEAUREGARD
    • Susan P. JAMESMin ZHANGGuy BEAUREGARD
    • A61K9/70A61K9/00B32B9/04B32B9/00B32B27/30B05D3/00A61P43/00
    • C08J9/42B05D5/00B29C67/24C08B37/00C08B37/0072C08L5/08C08L101/00Y10T428/249953Y10T428/31504Y10T428/31855Y10T428/31971C08L2666/02C08L2666/26
    • An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer.
    • 具有缠结的外层,其包含掩蔽的亲水客体和疏水性聚合物主体的混合物,其中客体的分子彼此交联。 在某些情况下,使用客人的复合物可能是理想的或甚至是必需的。 客人和主持人的混合包括物理缠结,无论其是否还包括通过其间的初次键合(例如,化学/共价键合)的交联。 还有一种制造具有这种缠结的外层的方法,包括以下步骤:暂时隐藏客人的至少一部分亲水基团; 通过将具有掩蔽基团的客体扩散到结构的孔的至少一部分中来将具有多孔聚合物结构的至少一部分掩蔽组混合; 在孔内,与客体交联客体的至少一部分分子; 并去除隐形。 掩蔽可以通过甲硅烷基化或酰化进行。 混合可以通过生产客体和主机的混合物(无论是溶液,粉末,颗粒等)形式进行; 接下来,进行客人与其自身的交联; 然后将混合物模塑成外层。
    • 5. 发明授权
    • Outer layer having entanglement of hydrophobic polymer host and hydrophilic polymer guest
    • 外层具有疏水聚合物主体和亲水聚合物客体的缠结
    • US07662954B2
    • 2010-02-16
    • US10283760
    • 2002-10-29
    • Susan P. JamesMin ZhangGuy Beauregard
    • Susan P. JamesMin ZhangGuy Beauregard
    • C07H5/04C07H1/00
    • C08J9/42B05D5/00B29C67/24C08B37/00C08B37/0072C08L5/08C08L101/00Y10T428/249953Y10T428/31504Y10T428/31855Y10T428/31971C08L2666/02C08L2666/26
    • An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer.
    • 具有缠结的外层,其包含掩蔽的亲水客体和疏水性聚合物主体的混合物,其中客体的分子彼此交联。 在某些情况下,使用客人的复合物可能是理想的或甚至是必需的。 客人和主持人的混合包括物理缠结,无论其是否还包括通过其间的初次键合(例如,化学/共价键合)的交联。 还有一种制造具有这种缠结的外层的方法,包括以下步骤:暂时隐藏客人的至少一部分亲水基团; 通过将具有掩蔽基团的客体扩散到结构的孔的至少一部分中来将具有多孔聚合物结构的至少一部分掩蔽组混合; 在孔内,与客体交联客体的至少一部分分子; 并去除隐形。 掩蔽可以通过甲硅烷基化或酰化进行。 混合可以通过生产客体和主机的混合物(无论是溶液,粉末,颗粒等)形式进行; 接下来,进行客人与其自身的交联; 然后将混合物模塑成外层。
    • 6. 发明授权
    • Process for producing a powder containing crystalline particles of maltitol
    • 制造含有麦芽糖醇结晶粒子的粉末的方法
    • US06458401B1
    • 2002-10-01
    • US09713539
    • 2000-11-15
    • Guy BeauregardMike JorgensonBen MoserTom Parady
    • Guy BeauregardMike JorgensonBen MoserTom Parady
    • A23L1236
    • C07H15/04A21D2/181
    • The invention concerns a process for the manufacture of a powder containing crystalline particles of maltitol, which includes continuously mixing maltitol syrup having a dry matter content of at least 70% by weight and a maltitol content of at least 85% by weight on a dry matter basis, the mixing being effected by simultaneously dispersing the maltitol syrup and maltitol containing seeds into an open rotating receptacle containing maltitol based granules whereby the maltitol syrup and maltitol containing seeds are mixed at the surface of the maltitol based granules contained in the receptacle, collecting maltitol based granules from the receptacle and crystallizing maltitol contained in said granules, the maltitol based granules in the receptacle being maintained in motion by the rotation of the receptacle.
    • 本发明涉及一种制造含有麦芽糖醇结晶颗粒的粉末的方法,其包括将干物质含量至少为70%重量的麦芽糖醇含量连续混合至至少85重量%的麦芽糖醇糖浆 基础上,通过将包含麦芽糖醇的麦芽糖醇糖浆和麦芽糖醇的麦芽糖醇同时分散在包含麦芽糖醇基颗粒的开放旋转容器中进行混合,由此将麦芽糖醇糖浆和含麦芽糖醇的种子混合在容纳在容器中的麦芽糖醇基颗粒的表面,收集麦芽糖醇 来自容器的基于颗粒的颗粒和包含在所述颗粒中的结晶麦芽糖醇,容器中的麦芽糖醇基颗粒通过容器的旋转保持运动。