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1. 发明授权

US06953958B2 Electronic gain cell based charge sensor 有权
标题翻译：基于电子增益单元的电荷传感器
公开(公告)号：US06953958B2
公开(公告)日：2005-10-11
申请号：US10393515
申请日：2003-03-19
申请人： Gregory T. Baxter , Sandip Tiwari
发明人： Gregory T. Baxter , Sandip Tiwari
IPC分类号： G11C11/54 , G11C13/02 , H01L23/58
CPC分类号： G11C13/0014 , B82Y10/00 , G11C11/54 , G11C13/02 , G11C2216/08 , H01L2924/0002 , H01L2924/00
摘要： A gated metal oxide semiconductor field effect transistor (MOSFET) gain cell is formed with a flow channel for molecule flow. The flow channel is formed under the gate, and between a source and drain of the transistor. The molecule flow modulates a gain of the transistor. Current flowing between the source and drain is representative of charges on the molecules flowing through the flow channel. A plurality of individually addressable gain cells are coupled between chambers containing samples to measure charges on molecules in the samples passing through the gain cells.
摘要翻译：栅极金属氧化物半导体场效应晶体管（MOSFET）增益单元形成有用于分子流的流动通道。流通道形成在栅极下方，并在晶体管的源极和漏极之间。分子流调制晶体管的增益。在源极和漏极之间流动的电流代表流过流动通道的分子上的电荷。多个可单独寻址的增益单元耦合在包含样本的室之间以测量通过增益单元的样品中的分子上的电荷。

2. 发明授权

US06383813B1 Microfabrication of a nuclear transfer array for high-throughput animal cloning 失效
标题翻译：用于高通量动物克隆的核转移阵列的微加工
公开(公告)号：US06383813B1
公开(公告)日：2002-05-07
申请号：US09662342
申请日：2000-09-14
申请人： Gregory T. Baxter , Richard C. Kuo
发明人： Gregory T. Baxter , Richard C. Kuo
IPC分类号： C12N1563
CPC分类号： C12M35/00
摘要： A micro-machined nuclear transfer array (NTA) provides high-throughput transfer of nuclei between two cells. Donor cells containing the nuclei to be transferred are placed in microwells positioned adjacent to microwells containing the recipient biological cell. The microwells are contained within an upper chamber patterned with parallel rows of microwells of the diameter of the cell of interest. An injection port is formed in the bottom of the microwells through which nuclei may pass during transfer. The NTA also contains a lower chamber having a second array of capture wells of similar dimension and in register with the upper chamber for receiving the nuclei removed from the cell in the upper chamber. Nuclei are removed from the donor cells in the upper chamber, transferred to capture wells in the lower chamber, and inserted into the recipient biological cells of the upper chamber. The upper tray moves relative to the lower chamber so that the nuclei in the capture well are transferred to the recipient biological cell to complete the nuclear transfer process.
摘要翻译：微加工核转移阵列（NTA）提供了两个细胞之间的高通量核转移。将含有待转移核的供体细胞置于邻近含有受体生物细胞的微孔的微孔中。微孔被包含在图案化的具有感兴趣的细胞直径的平行微孔的上室中。注入口形成在微孔的底部，核在转移过程中通过该端口。 NTA还包含具有类似尺寸的捕获阱的第二阵列的下室，并且与上室对准，用于接收从上腔室中的细胞移除的核。将核从上室中的供体细胞中移出，转移到下腔室中的捕获孔中，并插入上腔室的受体生物细胞。上托盘相对于下室移动，使得捕获阱中的核转移到受体生物细胞以完成核转移过程。

3. 发明申请

US20160281048A1 DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEM 审中-公开
标题翻译：用于药物动力学细胞培养系统的装置和方法
公开(公告)号：US20160281048A1
公开(公告)日：2016-09-29
申请号：US15055385
申请日：2016-02-26
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
IPC分类号： C12M1/34
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
摘要翻译：提供了用于微量细胞培养类似（CCA）装置的装置，体外细胞培养物，系统和方法。

4. 发明申请

US20120214189A1 Devices and Methods for Pharmacokinetic-Based Cell Culture System 审中-公开
标题翻译：基于药物动力学的细胞培养系统的装置和方法
公开(公告)号：US20120214189A1
公开(公告)日：2012-08-23
申请号：US13301261
申请日：2011-11-21
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
IPC分类号： C12M1/24 , C12Q1/02
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
摘要翻译：提供了用于微量细胞培养类似（CCA）装置的装置，体外细胞培养物，系统和方法。

5. 发明授权

US08030061B2 Devices and methods for pharmacokinetic-based cell culture system 有权
标题翻译：基于药物动力学的细胞培养系统的装置和方法
公开(公告)号：US08030061B2
公开(公告)日：2011-10-04
申请号：US11530381
申请日：2006-09-08
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
IPC分类号： C12M3/00 , C12M1/34
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
摘要翻译：提供了用于微量细胞培养类似（CCA）装置的装置，体外细胞培养物，系统和方法。

6. 发明申请

US20080166794A1 Devices and Methods for Pharmacokinetic-Based Cell Culture System 审中-公开
标题翻译：基于药物动力学的细胞培养系统的装置和方法
公开(公告)号：US20080166794A1
公开(公告)日：2008-07-10
申请号：US11925677
申请日：2007-10-26
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
IPC分类号： C12M1/00
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
摘要翻译：提供了用于微量细胞培养类似（CCA）装置的装置，体外细胞培养物，系统和方法。

7. 发明申请

US20080064088A1 DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEM 审中-公开
标题翻译：用于药物动力学细胞培养系统的装置和方法
公开(公告)号：US20080064088A1
公开(公告)日：2008-03-13
申请号：US11530363
申请日：2006-09-08
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Andrew Harrison , Scott Meyers
IPC分类号： C12M3/00
CPC分类号： C12M23/16 , C12M21/08 , C12M23/44
摘要： Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
摘要翻译：提供了用于微量细胞培养类似（CCA）装置的装置，体外细胞培养物，系统和方法。

8. 发明申请

US20080166795A1 Devices and Methods for Pharmacokinetic-Based Cell Culture System 审中-公开
公开(公告)号：US20080166795A1
公开(公告)日：2008-07-10
申请号：US11925687
申请日：2007-10-26
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
IPC分类号： C12M1/00
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.

9. 发明授权

US09273276B2 Devices and methods for pharmacokinetic-based cell culture system 有权
标题翻译：基于药物动力学的细胞培养系统的装置和方法
公开(公告)号：US09273276B2
公开(公告)日：2016-03-01
申请号：US13301261
申请日：2011-11-21
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
IPC分类号： C12M1/34 , C12M3/06 , C12M3/00 , C12M1/36 , G01N33/50 , C12N5/071 , C12N5/00
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： A cell culture method using an in vitro microscale cell culture device having a first microscale chamber containing cells attached to an inner surface of the chamber and cell culture medium in contact with the cells. The cells are maintained in culture in the in vitro microscale cell culture device while flowing culture medium through the first chamber at a controlled rate to provide a liquid residence time value for the cells in the first chamber of the in vitro microscale cell culture device that is comparable to a liquid residence time value obtained with respect to comparable cells in vivo, such that metabolism by the cells in culture in the in vitro microscale cell culture device is comparable to metabolism by comparable cells in vivo.
摘要翻译：一种使用体外微细胞培养装置的细胞培养方法，所述培养装置具有包含连接于所述腔室内表面的细胞的第一微量室和与细胞接触的细胞培养基。将细胞在体外微量细胞培养装置中保持培养，同时以受控的速率流过培养基通过第一室，以提供体外微量细胞培养装置的第一室中的细胞的液体停留时间值，其为相当于在体内相当的细胞获得的液体停留时间值，使得体外微量细胞培养装置中培养物中的细胞的代谢与体内相当的细胞的代谢相当。

10. 发明申请

US20100304355A1 DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEM 审中-公开
标题翻译：用于药物动力学细胞培养系统的装置和方法
公开(公告)号：US20100304355A1
公开(公告)日：2010-12-02
申请号：US11530400
申请日：2006-09-08
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
IPC分类号： C12M3/02 , C12M3/00
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
摘要翻译：提供了用于微量细胞培养类似（CCA）装置的装置，体外细胞培养物，系统和方法。

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