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1. 发明授权

US08838439B2 Entity recognition 有权
标题翻译：实体识别
公开(公告)号：US08838439B2
公开(公告)日：2014-09-16
申请号：US13156622
申请日：2011-06-09
申请人： Jonathan D. Butters , Fabio Ciravegna , Colin Cadas , Andrew Harrison
发明人： Jonathan D. Butters , Fabio Ciravegna , Colin Cadas , Andrew Harrison
IPC分类号： G06F17/20 , G06F17/27 , G06F17/30
CPC分类号： G06F17/278 , G06F17/30672
摘要： The invention relates to a method of querying technical domains that recognizes the concepts represented by strings of characters, rather than merely comparing strings. It can be used to compute conceptual similarity between terms, The method employs string distance metrics and a cyclic progression of lexical processing to recognize constituent term concepts that are then combined to form full-term concepts by means of a grammar. Terms can be extracted and identified as being conceptually similar (or dissimilar) to other terms even if they have never previously been encountered. A key advantage is the ability to extract terms from documents based on the combination of a limited number of sub-concepts, This avoids the need for the prior identification of all possible terms that current methods require. A second key advantage is the ability to introduce or remove concepts and synonyms individually without the need to alter terms which the concept or synonym constitutes.
摘要翻译：本发明涉及一种查询识别由字符串表示的概念的技术领域的方法，而不是仅仅比较字符串。它可以用于计算术语之间的概念相似度。该方法使用字符串距离度量和词法处理的循环进程来识别组合术语概念，然后通过语法组合以形成全文概念。术语可以被提取并被识别为在概念上与其他术语相似（或不相似），即使它们从未曾遇到过。一个关键的优点是能够根据有限数量的子概念的组合从文档中提取术语。这避免了对当前方法所需的所有可能术语的先前识别的需要。第二个关键优点是能够单独引入或删除概念和同义词，而无需改变概念或同义词构成的术语。

2. 再颁专利

USRE45096E1 Voice response system 有权
标题翻译：语音应答系统
公开(公告)号：USRE45096E1
公开(公告)日：2014-08-26
申请号：US12458605
申请日：2009-07-16
申请人： Michael Andrew Harrison , Paul Ian Popay , Neil Lewis Watton
发明人： Michael Andrew Harrison , Paul Ian Popay , Neil Lewis Watton
IPC分类号： H04M11/00 , H04M1/64
摘要： With interactive voice response services, it can be frustrating for a user to become stuck in a dialogue where the same question is asked repetitively. Here the wording of questions used by the system are varied throughout the dialogue depending upon how many times a user has visited a particular dialogue state during the call history. Furthermore the wording of the question is also varied in dependence upon the way in which the question was asked the last time the user was in a particular dialogue state.
摘要翻译：使用交互式语音响应服务，用户可能会遇到困扰同一问题重复的对话。这里，系统使用的问题的措辞在整个对话中是不同的，这取决于用户在通话历史期间访问特定对话状态的次数。此外，问题的措辞也是根据上一次用户在特定对话状态下问问题的方式而变化的。

3. 发明申请

US20070037277A1 Pharmacokinetic-based culture system with biological barriers 审中-公开
标题翻译：基于药物动力学的生物屏障培养体系
公开(公告)号：US20070037277A1
公开(公告)日：2007-02-15
申请号：US11436100
申请日：2006-05-17
申请人： Michael Shuler , Gregory Baxter , Aaron Sin , Andrew Harrison , Scott Meyers , Robert Freedruan
发明人： Michael Shuler , Gregory Baxter , Aaron Sin , Andrew Harrison , Scott Meyers , Robert Freedruan
IPC分类号： C12M3/00
CPC分类号： C12M23/34 , B01L3/5027 , C12M21/08 , C12M23/16 , C12M23/44 , C12M29/04
摘要： Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions with drug compounds in one or more fluidic flows. Such fluidic systems can include, by way of examples, gastrointestinal flow, blood flow, bile flow, urinary flow, and brain fluid flow. Interactions between fluidic systems can be simulated by a microscale permeable member. In one example, blood-biliary interaction can be simulated by a microscale permeable material having hepatocytes bound to a permeable substrate via a binder.
摘要翻译：公开了用于微量药代动力学的系统和方法。各种器官及其与药物化合物的相互作用可以通过使用可通过微量通道相互连接的微小室进行体外模拟。与器官相关的细胞或细胞材料可以在这些隔室中培养以允许与一种或多种流体流中药物化合物的相互作用。这样的流体系统可以包括例如胃肠道流动，血流量，胆汁流量，尿流量和脑液流量。流体系统之间的相互作用可以通过微量可渗透构件进行模拟。在一个实例中，可以通过具有通过粘合剂结合到可渗透底物的肝细胞的微量可渗透材料来模拟血液 - 胆汁相互作用。

4. 发明授权

US06215002B1 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase 失效
标题翻译：吡咯并吡咯啉酮衍生物作为嗜中性粒细胞弹性蛋白酶抑制剂
公开(公告)号：US06215002B1
公开(公告)日：2001-04-10
申请号：US09517963
申请日：2000-03-03
申请人： Michael Dennis Dowle , Harry Finch , Lee Andrew Harrison , Graham George Inglis , Martin Redpath Johnson , Simon John Fawcett MacDonald , Pritom Shah , Robin Andrew Smith
发明人： Michael Dennis Dowle , Harry Finch , Lee Andrew Harrison , Graham George Inglis , Martin Redpath Johnson , Simon John Fawcett MacDonald , Pritom Shah , Robin Andrew Smith
IPC分类号： C07D48704
CPC分类号： C07D487/04 , C07D207/14
摘要： There are described according to the invention, processes for making compounds of formula (XXVIII)3 (relative stereochemistry indicated), wherein P2 is as defined in the specification.
摘要翻译：根据本发明描述了制备式（XXVIII）3化合物的方法（所示的相对立体化学），其中P2如说明书中所定义。

5. 发明授权

US09273276B2 Devices and methods for pharmacokinetic-based cell culture system 有权
标题翻译：基于药物动力学的细胞培养系统的装置和方法
公开(公告)号：US09273276B2
公开(公告)日：2016-03-01
申请号：US13301261
申请日：2011-11-21
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
IPC分类号： C12M1/34 , C12M3/06 , C12M3/00 , C12M1/36 , G01N33/50 , C12N5/071 , C12N5/00
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： A cell culture method using an in vitro microscale cell culture device having a first microscale chamber containing cells attached to an inner surface of the chamber and cell culture medium in contact with the cells. The cells are maintained in culture in the in vitro microscale cell culture device while flowing culture medium through the first chamber at a controlled rate to provide a liquid residence time value for the cells in the first chamber of the in vitro microscale cell culture device that is comparable to a liquid residence time value obtained with respect to comparable cells in vivo, such that metabolism by the cells in culture in the in vitro microscale cell culture device is comparable to metabolism by comparable cells in vivo.
摘要翻译：一种使用体外微细胞培养装置的细胞培养方法，所述培养装置具有包含连接于所述腔室内表面的细胞的第一微量室和与细胞接触的细胞培养基。将细胞在体外微量细胞培养装置中保持培养，同时以受控的速率流过培养基通过第一室，以提供体外微量细胞培养装置的第一室中的细胞的液体停留时间值，其为相当于在体内相当的细胞获得的液体停留时间值，使得体外微量细胞培养装置中培养物中的细胞的代谢与体内相当的细胞的代谢相当。

6. 发明申请

US20100304355A1 DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEM 审中-公开
标题翻译：用于药物动力学细胞培养系统的装置和方法
公开(公告)号：US20100304355A1
公开(公告)日：2010-12-02
申请号：US11530400
申请日：2006-09-08
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
IPC分类号： C12M3/02 , C12M3/00
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
摘要翻译：提供了用于微量细胞培养类似（CCA）装置的装置，体外细胞培养物，系统和方法。

7. 发明授权

US06177425B1 Pyrrolopyrrolone derivatives 失效
标题翻译：吡咯并吡咯啉衍生物
公开(公告)号：US06177425B1
公开(公告)日：2001-01-23
申请号：US09508314
申请日：2000-05-05
申请人： Michael Dennis Dowle , Harry Finch , Lee Andrew Harrison , Graham George Adam Inglis , Martin Redpath Johnson , Simon John Fawcett MacDonald , Pritom Shah
发明人： Michael Dennis Dowle , Harry Finch , Lee Andrew Harrison , Graham George Adam Inglis , Martin Redpath Johnson , Simon John Fawcett MacDonald , Pritom Shah
IPC分类号： A61K31407
CPC分类号： C07D487/04
摘要： According to the invention there are provided Hexahydro-Pyrrolo[3,4-b]pyrrol-2-one compounds of formula (1), (relative stereochemistry indicated), wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (1) are useful inter alia in the treatment or chronic bronchitis.
摘要翻译：根据本发明，提供式（1）的六氢 - 吡咯并[3,4-b]吡咯-2-酮化合物（所示的相对立体化学），其中R1，R2和R3如说明书中所定义。式（1）的化合物尤其可用于治疗或慢性支气管炎。

8. 发明申请

US20090090748A1 Self opening pour spout and rotating nozzle 审中-公开
标题翻译：自开口喷嘴和旋转喷嘴
公开(公告)号：US20090090748A1
公开(公告)日：2009-04-09
申请号：US11906525
申请日：2007-10-03
申请人： Albert Andrew Harrison
发明人： Albert Andrew Harrison
IPC分类号： B67D3/00
CPC分类号： B65D5/746 , B65D47/305
摘要： I, Albert Harrison has, invented a pour spout with rotating nozzle that is affixed to a gable top carton, as set forth in the enclosed substitute specification.
摘要翻译：我，阿尔伯特·哈里森（Albert Harrison）发明了一种倾斜喷嘴，其上安装有旋转喷嘴，该喷嘴固定在山形顶板上，如附带的替代规范所述。

9. 发明授权

US07288405B2 Devices and methods for pharmacokinetic-based cell culture system 有权
标题翻译：基于药物动力学的细胞培养系统的装置和方法
公开(公告)号：US07288405B2
公开(公告)日：2007-10-30
申请号：US10133977
申请日：2002-04-25
申请人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory T. Baxter , Aaron Sin , Robert Andrew Harrison , Scott Meyers
IPC分类号： C12M3/00 , C12M1/34
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.
摘要翻译：提供了用于微量细胞培养类似（CCA）装置的装置，体外细胞培养物，系统和方法。

10. 发明申请

US20070015275A1 DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEMS 审中-公开
公开(公告)号：US20070015275A1
公开(公告)日：2007-01-18
申请号：US11533607
申请日：2006-09-20
申请人： Michael Shuler , Gregory Baxter , Aaron Sin , Andrew Harrison , Scott Meyers
发明人： Michael Shuler , Gregory Baxter , Aaron Sin , Andrew Harrison , Scott Meyers
IPC分类号： C12M3/00 , C12M1/34
CPC分类号： C12M41/46 , C12M23/16 , C12M23/44 , C12M41/48 , C12N5/0062 , C12N5/0671 , G01N33/5008 , G01N33/5067
摘要： Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.

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