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1. 发明授权

US5955377A Methods and kits for the amplification of thin film based assays 失效
标题翻译：用于扩增基于薄膜的测定法的方法和试剂盒
公开(公告)号：US5955377A
公开(公告)日：1999-09-21
申请号：US403565
申请日：1995-04-17
申请人： Diana M. Maul , Gregory R. Bogart
发明人： Diana M. Maul , Gregory R. Bogart
IPC分类号： G01N33/543 , G01N33/547
CPC分类号： G01N33/543 , G01N33/547 , G01N2333/135 , G01N2333/162 , G01N2333/22 , G01N2333/295 , G01N2333/315 , Y10S435/808 , Y10S435/81 , Y10S436/805
摘要： Method for detecting an analyte of interest, comprising the steps of providing a detection device comprising a light reflective or transmissive substrate supporting one or more layers comprising an adhering attachment layer to which is affixed a receptive material which specifically interacts with the analyte of interest; reacting the device with a sample potentially comprising the analyte under conditions in which the analyte binds to the receptive material; and reacting bound analyte with a reagent which creates a mass change on the surface of the device.
摘要翻译：用于检测感兴趣分析物的方法，包括以下步骤：提供检测装置，所述检测装置包括支撑一层或多层的光反射或透射基底，所述层包含粘附的附着层，所述粘附附着层与感兴趣的物质特异性相互作用的受体材料固定在其上; 在所述分析物与所述受体材料结合的条件下使所述装置与潜在地包含所述分析物的样品反应; 并使结合的分析物与在装置的表面上产生质量变化的试剂反应。

2. 发明授权

US5550063A Methods for production of an optical assay device 失效
标题翻译：光学测定装置的制造方法
公开(公告)号：US5550063A
公开(公告)日：1996-08-27
申请号：US76347
申请日：1993-06-10
申请人： Gregory R. Bogart
发明人： Gregory R. Bogart
IPC分类号： G01N21/21 , G01N33/543
CPC分类号： B82Y30/00 , G01N21/211 , G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： Method for producing an optical assay device having a substrate and one or more optical layers, an attachment layer and a receptive layer, including the step of spin coating an anti-reflective layer or an attachment layer.
摘要翻译：一种用于制备具有基底和一个或多个光学层，附着层和接收层的光学测定装置的方法，包括旋转涂覆抗反射层或附着层的步骤。

3. 发明授权

US08726730B1 Optically transduced MEMS gyro device 有权
标题翻译：光导MEMS陀螺仪
公开(公告)号：US08726730B1
公开(公告)日：2014-05-20
申请号：US13325683
申请日：2011-12-14
申请人： Gregory N. Nielson , Gregory R. Bogart , Eric Langlois , Murat Okandan
发明人： Gregory N. Nielson , Gregory R. Bogart , Eric Langlois , Murat Okandan
IPC分类号： G01P3/00 , G01C19/00
CPC分类号： G01C19/5726 , G01C19/5733
摘要： A bulk micromachined vibratory gyro in which a proof mass has a bulk substrate thickness for a large mass and high inertial sensitivity. In embodiments, optical displacement transduction is with multi-layer sub-wavelength gratings for high sensitivity and low cross-talk with non-optical drive elements. In embodiments, the vibratory gyro includes a plurality of multi-layer sub-wavelength gratings and a plurality of drive electrodes to measure motion of the proof mass induced by drive forces and/or moments and induced by the Coriolis Effect when the gyro experiences a rotation. In embodiments, phase is varied across the plurality gratings and a multi-layer grating having the best performance is selected from the plurality.
摘要翻译：一种体积微加工的振动陀螺仪，其中质量块具有大的质量和高惯性灵敏度的体积衬底厚度。在实施例中，光学位移转换是与用于高灵敏度和与非光学驱动元件的低串扰的多层亚波长光栅。在实施例中，振动陀螺仪包括多个多层亚波长光栅和多个驱动电极，用于测量当陀螺仪经历旋转时由驱动力和/或力矩引起的和由科里奥利效应引起的检测质量的运动。在实施例中，在多个光栅之间改变相位，并且从多个光栅中选择具有最佳性能的多层光栅。

4. 发明授权

US5494801A Microorganism antigen extraction methods 失效
标题翻译：微生物抗原提取方法
公开(公告)号：US5494801A
公开(公告)日：1996-02-27
申请号：US162401
申请日：1993-12-03
申请人： Gregory R. Bogart , Robert J. Bilodeau , Rachel M. Ostroff , Jeffrey W. Steaffens
发明人： Gregory R. Bogart , Robert J. Bilodeau , Rachel M. Ostroff , Jeffrey W. Steaffens
IPC分类号： G01N33/569
CPC分类号： A61K39/092 , G01N33/56944 , Y10S435/961 , Y10S435/962 , Y10S435/975 , Y10S436/808 , Y10T436/25 , Y10T436/25125
摘要： Method for extracting an antigen from a micro-organism organism of the genus streptococcus contained in a sample including the steps of contacting the sample with reagents which generate hyponitrous acid, further contacting the sample with a base, or contacting the sample with hypochlorite, and neutralizing the sample.
摘要翻译：从样品中含有的链球菌属微生物生物体提取抗原的方法，包括使样品与产生亚硝酸的试剂接触的步骤，进一步使样品与碱接触或使样品与次氯酸盐接触，中和例子。

5. 发明授权

US5468606A Devices for detection of an analyte based upon light interference 失效
标题翻译：基于光干扰检测分析物的装置
公开(公告)号：US5468606A
公开(公告)日：1995-11-21
申请号：US923304
申请日：1992-07-31
申请人： Gregory R. Bogart , Garret R. Moddel , Diana M. Maul , Jeffrey B. Etter
发明人： Gregory R. Bogart , Garret R. Moddel , Diana M. Maul , Jeffrey B. Etter
IPC分类号： G01N21/21 , G01N21/45 , G01N21/47 , G01N21/77 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/545
CPC分类号： B82Y30/00 , B82Y15/00 , G01N21/211 , G01N21/4738 , G01N21/77 , G01N33/54366 , G01N33/54373 , G01N33/551 , G01N33/552 , G01N21/45 , Y10S435/808 , Y10S436/805
摘要： Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in any amount selected from 0.1 nM, 0.1 ng/ml, 50 fg, and 2.times.10.sup.3 organisms comprising the analyte.
摘要翻译：用于检测感兴趣的分析物的存在或量的装置，具有具有光学活性表面的基底，所述基底表现出响应于其上的光的第一颜色，并且显示第二颜色，其包括与第一颜色不同的光的波长的组合或者当所述分析物以选自0.1nM，0.1ng / ml，50fg和2x103生物体的任何量存在于所述表面上时，响应于所述光而包含至少一种不同于所述第一颜色的波长的光的强度，所述生物体包含分析物。

6. 发明授权

US08080280B1 Nanostructure templating using low temperature atomic layer deposition 有权
标题翻译：使用低温原子层沉积的纳米结构模板
公开(公告)号：US08080280B1
公开(公告)日：2011-12-20
申请号：US11872749
申请日：2007-10-16
申请人： Robert K. Grubbs , Gregory R. Bogart , John A. Rogers
发明人： Robert K. Grubbs , Gregory R. Bogart , John A. Rogers
IPC分类号： C23C16/00
CPC分类号： C23C16/46 , C23C16/45525
摘要： Methods are described for making nanostructures that are mechanically, chemically and thermally stable at desired elevated temperatures, from nanostructure templates having a stability temperature that is less than the desired elevated temperature. The methods comprise depositing by atomic layer deposition (ALD) structural layers that are stable at the desired elevated temperatures, onto a template employing a graded temperature deposition scheme. At least one structural layer is deposited at an initial temperature that is less than or equal to the stability temperature of the template, and subsequent depositions made at incrementally increased deposition temperatures until the desired elevated temperature stability is achieved. Nanostructure templates include three dimensional (3D) polymeric templates having features on the order of 100 nm fabricated by proximity field nanopatterning (PnP) methods.
摘要翻译：描述了用于制备在所需高温下机械，化学和热稳定的纳米结构的方法，所述纳米结构具有的稳定性温度低于所需升高的温度。所述方法包括通过使用渐变温度沉积方案的模板将在期望的高温下稳定的原子层沉积（ALD）结构层沉积到模板上。至少一个结构层在小于或等于模板的稳定温度的初始温度下沉积，随后在逐渐增加的沉积温度下进行沉积，直至实现所需的高温稳定性。纳米结构模板包括通过接近场纳米图案（PnP）方法制造的具有大约100nm的特征的三维（3D）聚合物模板。

7. 发明授权

US07153651B1 Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof 失效
标题翻译：提供流体样品层流的流通光学测定装置及其构造方法
公开(公告)号：US07153651B1
公开(公告)日：2006-12-26
申请号：US08950963
申请日：1997-10-15
申请人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
发明人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
IPC分类号： C12Q1/68 , C12M1/00 , G01N15/06
CPC分类号： G01N33/54373 , G01N21/7703
摘要： An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the sample through layers of the device, an attachment layer positioned on the optically functional layer, and an analyte specific receptive layer positioned on the attachment layer.
摘要翻译：一种用于检测样品中感兴趣分析物的光学测定装置，包括含有通道的载体，位于载体上的光学功能层，使得光学功能层和载体允许样品层流流过该装置的层，位于光学功能层上的附着层和位于附着层上的分析物特异性接收层。

8. 发明授权

US06933112B1 Device for mass transport assisted optical assays 失效
标题翻译：大容量传输辅助光学测定装置
公开(公告)号：US06933112B1
公开(公告)日：2005-08-23
申请号：US09675518
申请日：2000-09-29
申请人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
发明人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
IPC分类号： G01N31/22 , C12M1/00 , C12Q1/68 , G01N21/27 , G01N21/77 , G01N33/543 , G01N33/553 , G01N15/06
CPC分类号： G01N33/54373 , G01N21/7703
摘要： An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the sample through layers of the device, an attachment layer positioned on the optically functional layer, and an analyte specific receptive layer positioned on the attachment layer.
摘要翻译：一种用于检测样品中感兴趣分析物的光学测定装置，包括含有通道的载体，位于载体上的光学功能层，使得光学功能层和载体允许样品层流流过该装置的层，位于光学功能层上的附着层和位于附着层上的分析物特异性接收层。

9. 发明授权

US07955945B1 Weak-link capacitor 有权
标题翻译：弱连接电容
公开(公告)号：US07955945B1
公开(公告)日：2011-06-07
申请号：US12892055
申请日：2010-09-28
申请人： Shawn M. Dirk , Ross S. Johnson , David R. Wheeler , Gregory R. Bogart
发明人： Shawn M. Dirk , Ross S. Johnson , David R. Wheeler , Gregory R. Bogart
IPC分类号： H01L21/20
CPC分类号： H01G4/18 , H01G4/232 , H01G4/306
摘要： A process for making a dielectric material where a precursor polymer selected from poly(phenylene vinylene) polyacetylene, poly(p-phenylene), poly(thienylene vinylene), poly(1,4-naphthylene vinylene), and poly(p-pyridine vinylene) is energized said by exposure by radiation or increase in temperature to a level sufficient to eliminate said leaving groups contained within the precursor polymer, thereby transforming the dielectric material into a conductive polymer. The leaving group in the precursor polymer can be a chloride, a bromide, an iodide, a fluoride, an ester, an xanthate, a nitrile, an amine, a nitro group, a carbonate, a dithiocarbamate, a sulfonium group, an oxonium group, an iodonium group, a pyridinium group, an ammonium group, a borate group, a borane group, a sulphinyl group, or a sulfonyl group.
摘要翻译：一种制备介电材料的方法，其中前体聚合物选自聚（亚苯基亚乙烯基）聚乙炔，聚（对亚苯基），聚（亚苯基亚乙烯基），聚（1,4-亚萘基亚乙烯基）和聚（对 - 吡啶亚乙烯基））通过辐射曝光或者将温度升高到足以消除前体聚合物中包含的所述离去基团的水平，从而将电介质材料转化为导电聚合物而被激发。前体聚合物中的离去基团可以是氯化物，溴化物，碘化物，氟化物，酯，黄原酸酯，腈，胺，硝基，碳酸酯，二硫代氨基甲酸酯，锍基，氧鎓基，碘鎓基，吡啶鎓基，铵基，硼酸酯基，硼烷基，亚磺酰基或磺酰基。

10. 发明授权

US5552272A Detection of an analyte by fluorescence using a thin film optical device 失效
标题翻译：使用薄膜光学装置通过荧光检测分析物
公开(公告)号：US5552272A
公开(公告)日：1996-09-03
申请号：US76348
申请日：1993-06-10
申请人： Gregory R. Bogart
发明人： Gregory R. Bogart
IPC分类号： G01N33/543 , G01N33/58
CPC分类号： B82Y30/00 , B82Y15/00 , G01N33/54353 , G01N33/582 , Y10S435/808 , Y10S435/81 , Y10S436/805 , Y10S436/807
摘要： Device for detecting the presence or amount of an analyte of interest, comprising a reflective solid, optical support and a label capable of generating fluorescent signal upon excitation with a suitable light source wherein said support comprises an attachment layer comprising a chemical selected from the group consisting of dendrimers, star polymers, molecular self-assembling polymers, polymeric siloxanes, and film forming latexes wherein the support provides an enhanced level of exciting photons to the immobilized fluorescent label compound, and wherein the support also increases the capture of fluorescent signal.
摘要翻译：用于检测感兴趣分析物的存在或量的装置，包括反射固体，光学载体和能够在用合适的光源激发时产生荧光信号的标签，其中所述载体包括附着层，所述附着层包含选自以下的化学物质：树枝状聚合物，星形聚合物，分子自组装聚合物，聚合物硅氧烷和成膜胶乳，其中载体提供增强水平的激发光子到固定的荧光标记化合物，并且其中载体也增加荧光信号的捕获。

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