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1. 发明授权

US09393255B2 Pharmaceutical compositions of cytidine analogs and methods of use thereof 有权
标题翻译：胞苷类似物的药物组合物及其使用方法
公开(公告)号：US09393255B2
公开(公告)日：2016-07-19
申请号：US13363008
申请日：2012-01-31
申请人： Anthony Tutino , Mei Lai , Jeffrey B. Etter
发明人： Anthony Tutino , Mei Lai , Jeffrey B. Etter
IPC分类号： A61K31/706 , A61P35/00 , A61P35/02 , A61K9/00
CPC分类号： A61K31/706 , A61K9/0019
摘要： The present disclosure provides pharmaceutical compositions comprising cytidine analogs for parenteral administration. Also provided are methods of preparing the compositions and methods of treating diseases and disorders using the compositions provided herein.
摘要翻译：本公开提供了包含用于肠胃外给药的胞苷类似物的药物组合物。还提供了使用本文提供的组合物制备治疗疾病和病症的组合物和方法的方法。

2. 发明授权

US07847120B2 Compositions of allosteric hemoglobin modifiers and methods of making the same 有权
标题翻译：变构血红蛋白修饰剂的组成及其制备方法
公开(公告)号：US07847120B2
公开(公告)日：2010-12-07
申请号：US11112389
申请日：2005-04-22
申请人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
发明人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
IPC分类号： C07C229/00 , C07C65/03
CPC分类号： A61K31/195
摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.
摘要翻译：本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。本发明还包括用于纯化通过本发明方法形成的产品的改进方法。新颖的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）提取粗组合物以降低杂质量，特别是聚合物杂质。还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

3. 发明授权

US07153651B1 Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof 失效
标题翻译：提供流体样品层流的流通光学测定装置及其构造方法
公开(公告)号：US07153651B1
公开(公告)日：2006-12-26
申请号：US08950963
申请日：1997-10-15
申请人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
发明人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
IPC分类号： C12Q1/68 , C12M1/00 , G01N15/06
CPC分类号： G01N33/54373 , G01N21/7703
摘要： An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the sample through layers of the device, an attachment layer positioned on the optically functional layer, and an analyte specific receptive layer positioned on the attachment layer.
摘要翻译：一种用于检测样品中感兴趣分析物的光学测定装置，包括含有通道的载体，位于载体上的光学功能层，使得光学功能层和载体允许样品层流流过该装置的层，位于光学功能层上的附着层和位于附着层上的分析物特异性接收层。

4. 发明授权

US06933112B1 Device for mass transport assisted optical assays 失效
标题翻译：大容量传输辅助光学测定装置
公开(公告)号：US06933112B1
公开(公告)日：2005-08-23
申请号：US09675518
申请日：2000-09-29
申请人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
发明人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
IPC分类号： G01N31/22 , C12M1/00 , C12Q1/68 , G01N21/27 , G01N21/77 , G01N33/543 , G01N33/553 , G01N15/06
CPC分类号： G01N33/54373 , G01N21/7703
摘要： An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the sample through layers of the device, an attachment layer positioned on the optically functional layer, and an analyte specific receptive layer positioned on the attachment layer.
摘要翻译：一种用于检测样品中感兴趣分析物的光学测定装置，包括含有通道的载体，位于载体上的光学功能层，使得光学功能层和载体允许样品层流流过该装置的层，位于光学功能层上的附着层和位于附着层上的分析物特异性接收层。

5. 发明授权

US06875441B2 Composition for delivery of hematopoietic growth factor 失效
标题翻译：用于输送造血生长因子的组合物
公开(公告)号：US06875441B2
公开(公告)日：2005-04-05
申请号：US09893339
申请日：2001-06-26
申请人： Gary J. Rosenthal , Jeffrey B. Etter
发明人： Gary J. Rosenthal , Jeffrey B. Etter
IPC分类号： A61K9/00 , A61K9/52 , A61K38/18 , A61K38/19 , A61K38/20 , A61K47/10 , A61K47/36 , A61K47/38 , C12N5/02 , A61K38/00
CPC分类号： A61K9/0024 , A61K31/505 , A61K31/513 , A61K35/545 , A61K38/18 , A61K38/193 , A61K38/2046 , A61K47/10 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the first biocompatible polymer and the liquid vehicle. The second biocompatible polymer helps to protect the first biocompatible polymer from being dissolved in vivo following administration to a host.
摘要翻译：造血生长因子递送组合物包括造血生长因子，液体载体，第一生物相容性聚合物和第二生物相容性聚合物。由于第一生物相容性聚合物和液体载体之间的相互作用，该组合物显示出反向热粘性行为。第二生物相容性聚合物有助于保护第一生物相容性聚合物在施用于宿主后在体内溶解。

6. 发明申请

US20150290228A1 ORAL FORMULATIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF 审中-公开
标题翻译： CYDIDINE ANALOG的口服制剂及其使用方法
公开(公告)号：US20150290228A1
公开(公告)日：2015-10-15
申请号：US14594045
申请日：2015-01-09
申请人： Jay T. BACKSTROM , Jeffrey B. ETTER , Mei LAI
发明人： Jay T. BACKSTROM , Jeffrey B. ETTER , Mei LAI
IPC分类号： A61K31/706 , A61K31/573 , A61K31/704 , A61K31/475 , A61K39/395 , A61K31/675
CPC分类号： A61K31/7068 , A61K9/20 , A61K9/2013 , A61K9/2018 , A61K9/2846 , A61K9/2886 , A61K9/48 , A61K31/282 , A61K31/475 , A61K31/573 , A61K31/675 , A61K31/704 , A61K31/706 , A61K39/3955 , A61K45/06
摘要： The present disclosure provides pharmaceutical compositions comprising cytidine analogs for oral administration, wherein the compositions release the cytidine analog substantially in the stomach. Also provided are methods of diffuse large B-cell lymphoma, follicular lymphoma, or mantel cell lymphoma, which comprises administering to a human having diffuse large B-cell lymphoma, follicular lymphoma, or mantel cell lymphoma a therapeutically effective amount of 5-azacytidine, or a pharmaceutically acceptable salt, solvate or hydrate thereof, and optionally administering therapeutically effective amounts of one or more additional active agents.
摘要翻译：本公开提供了包含用于口服给药的胞苷类似物的药物组合物，其中所述组合物基本上在胃中释放胞苷类似物。还提供了扩散性大B细胞淋巴瘤，滤泡淋巴瘤或壁细胞淋巴瘤的方法，其包括向具有弥漫性大B细胞淋巴瘤，滤泡淋巴瘤或壁细胞淋巴瘤的人施用治疗有效量的5-氮杂胞苷，或其药学上可接受的盐，溶剂合物或水合物，以及任选地施用治疗有效量的一种或多种另外的活性剂。

7. 发明授权

US08846628B2 Oral formulations of cytidine analogs and methods of use thereof 有权
标题翻译：胞苷类似物的口服制剂及其使用方法
公开(公告)号：US08846628B2
公开(公告)日：2014-09-30
申请号：US12466213
申请日：2009-05-14
申请人： Jeffrey B. Etter , Mei Lai , Jay Thomas Backstrom
发明人： Jeffrey B. Etter , Mei Lai , Jay Thomas Backstrom
IPC分类号： A01N43/04 , A61K31/70 , C07H19/12 , A61K9/28 , A61K9/20 , A61K31/706 , A61K31/7068
CPC分类号： A61K31/706 , A61K9/2013 , A61K9/2018 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/7068 , A61K47/10
摘要： The present disclosure provides pharmaceutical compositions comprising cytidine analogs, for example, 5-azacytidine or decitabine, for oral administration, wherein the compositions release the cytidine analog, for example, 5-azacytidine or decitabine, substantially in the stomach. Also provided are methods of treating diseases and disorders using the oral formulations provided herein.
摘要翻译：本公开提供了包含胞苷类似物（例如5-氮杂胞苷或地西他滨）用于口服给药的药物组合物，其中所述组合物基本上在胃中释放胞苷类似物，例如5-氮杂胞苷或地西他滨。还提供了使用本文提供的口服制剂治疗疾病和病症的方法。

8. 发明申请

US20080057086A1 COLON-TARGETED ORAL FORMULATIONS OF CYTIDINE ANALOGS 审中-公开
标题翻译： CYTIDINE ANALOGS的定向口服制剂
公开(公告)号：US20080057086A1
公开(公告)日：2008-03-06
申请号：US11849958
申请日：2007-09-04
申请人： Jeffrey B. Etter
发明人： Jeffrey B. Etter
IPC分类号： A61K9/00 , A61K31/7068 , A61P43/00
CPC分类号： A61K31/7068 , A61K9/2846 , A61K9/2886 , A61K9/4891
摘要： The present invention provides an oral formulation of a cytidine analog, including, 5-azacytidine, for delivery to the lower gastrointestinal tract, including, the large intestine; methods to treat diseases associated with abnormal cell proliferation by treatment with the oral formulations of the present invention; and methods to increase the bioavailability of a cytidine analog upon administration to a patient by providing an oral formulation of the present invention.
摘要翻译：本发明提供了包含5-氮杂胞苷的胞苷类似物的口服制剂，用于递送至下胃肠道，包括大肠; 用本发明的口服制剂治疗与异常细胞增殖相关的疾病的方法; 以及通过提供本发明的口服制剂在给予患者时增加胞苷类似物的生物利用度的方法。

9. 发明授权

US06669960B2 Particulate drug-containing products and method of manufacture 有权
标题翻译：颗粒含药产品及其制造方法
公开(公告)号：US06669960B2
公开(公告)日：2003-12-30
申请号：US09740573
申请日：2000-12-18
申请人： Jeffrey B. Etter
发明人： Jeffrey B. Etter
IPC分类号： A61K914
CPC分类号： A61K9/0075 , A61K9/14 , A61K9/1617 , A61K9/1647 , A61K9/1694 , A61K38/00 , A61K48/00
摘要： Provided is a compressed anti-solvent technique for manufacture of drug-containing powders for pulmonary delivery. The drug is processed in a cosolvent system including two or more mutually soluble organic solvents. Also provided are powders manufacturable by the manufacture method, including powders of substantially pure drug and powders including a biocompatible polymer for pulmonary sustained drug release applications. Also provided are packaged products including drug-containing powder in a container that is receivable by and operable with a dry powder inhaler to produce an aerosol including dispersed drug-containing particles when the inhaler is actuated.
摘要翻译：提供了用于制造用于肺部递送的含药粉末的压缩反溶剂技术。该药物在包含两种或多种相互溶解的有机溶剂的助溶剂体系中进行处理。还提供了可通过制造方法制造的粉末，包括基本上纯的药物和粉末的粉末，其包括用于肺持续药物释放应用的生物相容性聚合物。还提供了包含药物的粉末在包装容器中的包装产品，该容器能够通过干粉吸入器接收和操作，以在吸入器致动时产生包含分散的含药颗粒的气溶胶。

10. 发明授权

US08372798B2 High-concentration protein formulations and method of manufacture 有权
公开(公告)号：US08372798B2
公开(公告)日：2013-02-12
申请号：US10271832
申请日：2002-10-16
申请人： John F. Carpenter , Jeffrey B. Etter , Adrian C. Samaniego
发明人： John F. Carpenter , Jeffrey B. Etter , Adrian C. Samaniego
IPC分类号： A61K49/14
CPC分类号： A61K49/14 , A61K9/0019 , A61K9/146 , A61K39/39591 , A61K47/10 , A61K47/26
摘要： Provided is a pharmaceutical composition involving a concentrated mixture of a precipitated protein and a liquid medium and a method for manufacturing the concentrated mixture. The concentrated mixture is manufacturable by precipitation of a protein with a biocompatible polymer precipitating agent, followed by removal of sufficient liquid to concentrate the resulting mixture to the desired degree. The precipitated protein can be stored for a significant time in the concentrated mixture, such as intermediate between processing stages during manufacture operations.

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