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1. 发明授权

US08083347B2 Drug delivery system and methods of use 有权
标题翻译：药物输送系统及使用方法
公开(公告)号：US08083347B2
公开(公告)日：2011-12-27
申请号：US12416802
申请日：2009-04-01
申请人： Joseph J. Bango, Jr. , Lyle Bowman , Gary Wnek , Shachar Tauber , Randall Fuerst
发明人： Joseph J. Bango, Jr. , Lyle Bowman , Gary Wnek , Shachar Tauber , Randall Fuerst
IPC分类号： G02C7/04 , G02C7/02 , A61K9/00
CPC分类号： B29D11/00048 , A61K9/0051 , A61K9/0092
摘要： Electrospun fibers are utilized to improve the mechanical characteristics of a contact lens reducing the weight and mechanical strength of the polymers from which the lenses are typically formed. Electrospun fibers are also utilized as a drug delivery system, both through direct use in the eye and by inclusion of the fibers in a contact lens. The fibers are loaded with therapeutic drugs by a variety of methods and processed by coating and cross-linking the fibers.
摘要翻译：电纺纤维用于改善隐形眼镜的机械特性，降低通常形成透镜的聚合物的重量和机械强度。电纺纤维也被用作药物递送系统，通过直接使用在眼睛中并通过将纤维包含在隐形眼镜中。纤维通过各种方法装载治疗药物并通过涂布和交联纤维进行加工。

2. 发明授权

US08012399B2 Formation of nano-or micro-scale phenolic fibers via electrospinning 有权
标题翻译：通过静电纺丝形成纳米或微尺度酚醛纤维
公开(公告)号：US08012399B2
公开(公告)日：2011-09-06
申请号：US10548203
申请日：2004-03-08
申请人： Diane Gee , Gary Wnek , John Layman , Georgios D. Karles , Mark Zhuang
发明人： Diane Gee , Gary Wnek , John Layman , Georgios D. Karles , Mark Zhuang
IPC分类号： D01F9/14 , D06M10/00 , H05B7/00
CPC分类号： D01F9/24 , A24D3/163 , C01B32/30 , D01D5/0007 , D01D5/003 , D01F1/10 , D01F6/50 , D01F6/76
摘要： Electroprocessed phenolic nanofibers, microfibers, beads, and films and materials including these electroprocessed materials are prepared using a delivery means (10), a grounded collecting means (20) and a power supply (30) for generating an electric field.
摘要翻译：使用输送装置（10），接地收集装置（20）和用于产生电场的电源（30）来制备包括这些电处理材料的电加工酚醛纳米纤维，微纤维，珠粒和薄膜和材料。

3. 发明申请

US20070035055A1 Electroprocessed phenolic materials and methods 有权
标题翻译：电加工酚醛材料及方法
公开(公告)号：US20070035055A1
公开(公告)日：2007-02-15
申请号：US10548203
申请日：2004-03-08
申请人： Diane Gee , Gary Wnek , John Layman , Georgios Karles , Mark Zhuang
发明人： Diane Gee , Gary Wnek , John Layman , Georgios Karles , Mark Zhuang
IPC分类号： H05B7/00 , D01F9/12
CPC分类号： D01F9/24 , A24D3/163 , C01B32/30 , D01D5/0007 , D01D5/003 , D01F1/10 , D01F6/50 , D01F6/76
摘要： Electroprocessed phenolic nanofibers, microfibers, beads, and films and materials including these electroprocessed materials are prepared using a delivery means (10), a grounded collecting means (20) and a power supply (30) for generating an electric field.
摘要翻译：使用输送装置（10），接地收集装置（20）和用于产生电场的电源（30）来制备包括这些电处理材料的电加工酚醛纳米纤维，微纤维，珠粒和薄膜和材料。

4. 发明授权

US06841601B2 Crosslinked polymer electrolyte membranes for heat and moisture exchange devices 有权
标题翻译：用于热和湿气交换装置的交联聚合物电解质膜
公开(公告)号：US06841601B2
公开(公告)日：2005-01-11
申请号：US10268039
申请日：2002-10-09
申请人： Joseph M. Serpico , Scott G. Ehrenberg , Gary Wnek
发明人： Joseph M. Serpico , Scott G. Ehrenberg , Gary Wnek
IPC分类号： B01D53/26 , B01D63/08 , B01D69/10 , B01D71/28 , B01D71/80 , B01D71/82 , F24F3/147 , F28D21/00 , C08L5/54
CPC分类号： B01D63/082 , B01D53/268 , B01D69/10 , B01D71/28 , B01D71/80 , B01D71/82 , B01D2325/48 , F24F3/147 , F24F2003/1435 , F28D21/0015 , Y02P20/124
摘要： A unitary humidity exchange cell (HUX) is dislosed that includes at least one composite membrane, disposed between at least one first chamber for flow of the first fluid therethrough and at least one second chamber for flow of the second fluid therethrough. The composite membrane include an at least partially sulfonated humidity-conducting polymer comprising residues derived from at least one arylvinyl monomer; and a reinforcing substrate bonded thereto. The product finds utility in a variety of physical and chemical processes and products whereby moisture or other highly polar liquid or gas transfer, exchange removal or delivery is important. A notable application is the Membrane Energy Recovery Ventilator (MERV) in which both heat, ions and moisture is transferred between two air streams, one intake and one exhaust, from an air-conditioned building.
摘要翻译：单体湿度交换单元（HUX）被包围，其包括至少一个复合膜，设置在至少一个用于第一流体流过的第一室和至少一个用于第二流体流过的第二室之间。复合膜包括至少部分磺化的导湿聚合物，其包含衍生自至少一种芳基乙烯基单体的残基; 以及与其结合的增强基板。该产品可用于各种物理和化学过程和产品，因此水分或其他高度极性的液体或气体转移，交换去除或输送是重要的。一个显着的应用是膜能量恢复呼吸机（MERV），其中热，离子和水分在空调建筑物的两个空气流（一个进气口和一个排气口）之间转移。

5. 发明申请

US20100261799A1 STABLE AND COMPATIBLE POLYMER BLENDS 有权
标题翻译：稳定和相容的聚合物共混
公开(公告)号：US20100261799A1
公开(公告)日：2010-10-14
申请号：US12664762
申请日：2008-06-24
申请人： David John Vachon , Liwei Cao , Gary Wnek
发明人： David John Vachon , Liwei Cao , Gary Wnek
IPC分类号： A61K47/32 , C08L53/00 , A61P9/00
CPC分类号： C08L53/005 , A61K47/32 , A61K47/34 , A61L15/22 , A61L31/04 , B01D71/26 , B01D71/28 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/48 , B01D71/50 , B01D71/52 , B01D71/54 , B01D71/56 , B01D71/60 , B01D71/68 , B01D71/76 , B01D71/82 , B01D2323/39 , B01D2325/14 , C08L33/08 , C08L41/00 , C08L75/00 , C08L75/04 , C08L75/06 , C08L75/08 , C08L83/00 , C08L2666/04 , C08L2666/02 , C08L2666/14 , C08L2666/24
摘要： The present invention pertains to products and processes relating to compatible polymer blends comprising at least one sulfonated polymer and at least one non-sulfonated polymer. The sulfonated polymers may be produced using a number of sulfonating agents including a coordination complex of sulfur trioxide. The polymeric blended materials described herein are useful in a variety of applications, including as coatings for medical devices, protective clothing and fabric, laboratory equipment, vascular stents and shunts, absorbent materials and separation membranes, three-dimensional constructs, devices, and other uses.
摘要翻译：本发明涉及与包含至少一种磺化聚合物和至少一种非磺化聚合物的相容性聚合物共混物相关的产品和方法。磺化聚合物可以使用包括三氧化硫的配位络合物的多种磺化剂来制备。本文所述的聚合物共混材料可用于各种应用，包括用于医疗装置，防护服和织物，实验室设备，血管支架和分流器，吸收材料和分离膜，三维结构，装置和其它用途的涂层。

6. 发明申请

US20070225631A1 Sealants for Skin and Other Tissues 审中-公开
标题翻译：皮肤和其他组织的密封剂
公开(公告)号：US20070225631A1
公开(公告)日：2007-09-27
申请号：US10588344
申请日：2003-10-06
申请人： Gary Bowlin , David Simpson , Gary Wnek , Marcus Carr , Peter Stevens , Gary Cadd , I. Cohen
发明人： Gary Bowlin , David Simpson , Gary Wnek , Marcus Carr , Peter Stevens , Gary Cadd , I. Cohen
IPC分类号： A61F13/00 , A61K38/17 , C07K1/00
CPC分类号： A61L24/102 , A61F2/105 , A61F2013/00314 , A61F2013/00472 , A61K38/363 , A61K38/39 , A61L24/106 , C07K14/78 , Y10T428/298 , A61K2300/00
摘要： The present invention relates to sealants for skin and other tissues. The sealants include an electroprocessed material. The sealants may contain more than one electroprocessed materials and may contain additional substances. The invention further relates to methods of making and using such sealants.
摘要翻译：本发明涉及用于皮肤和其它组织的密封剂。密封剂包括电加工材料。密封剂可能含有多于一种的电处理材料，并且可能含有其他物质。本发明还涉及制造和使用这种密封剂的方法。

7. 发明授权

US06592623B1 Engineered muscle 有权
标题翻译：工程肌肉
公开(公告)号：US06592623B1
公开(公告)日：2003-07-15
申请号：US09386273
申请日：1999-08-31
申请人： Gary L. Bowlin , Gary Wnek , David G. Simpson , Louis Terracio
发明人： Gary L. Bowlin , Gary Wnek , David G. Simpson , Louis Terracio
IPC分类号： A61F208
CPC分类号： A61L27/383 , A61F2/08 , A61L27/18 , A61L27/24 , A61L27/34 , A61L27/3817 , A61L27/3826 , A61L27/3873 , A61L27/507 , A61L2430/30 , C08L67/04 , C08L89/06
摘要： A muscle implant includes an extracellular matrix, tendon and muscle cells. The extracellular matrix is made of a matrix of electrospun polymer fibers. The tendon is made of extruded collagen fibers and the muscle cells are disposed on the extracellular matrix in such a manner that the combination of components will functionally and structurally act as normal muscle tissue. Cardiac and smooth muscles may be similarly formed without tendons but including the extracellular matrix and muscle cells.
摘要翻译：肌肉植入物包括细胞外基质，肌腱和肌肉细胞。细胞外基质由电纺聚合物纤维基质制成。肌腱由挤出的胶原纤维制成，并且肌细胞以这样的方式设置在细胞外基质上，使得组分的组合将在功能上和结构上作为正常肌肉组织起作用。心肌和平滑肌可以类似地形成，没有肌腱，但包括细胞外基质和肌肉细胞。

8. 发明授权

US08361492B2 Drug delivery system and methods of use 有权
标题翻译：药物输送系统及使用方法
公开(公告)号：US08361492B2
公开(公告)日：2013-01-29
申请号：US12490972
申请日：2009-06-24
申请人： Shachar Tauber , Randall Fuerst , Keela Davis , Lyle Bowman , Gary Wnek , Joseph J. Bango, Jr.
发明人： Shachar Tauber , Randall Fuerst , Keela Davis , Lyle Bowman , Gary Wnek , Joseph J. Bango, Jr.
IPC分类号： A61F13/00 , A61K9/00
CPC分类号： A61K9/0051 , A61K9/0092
摘要： Electrospun fibers are utilized to improve the mechanical characteristics of a contact lens reducing the weight and mechanical strength of the polymers from which the lenses are typically formed. Electrospun fibers are also utilized as a drug delivery system, both through direct use in the eye and by inclusion of the fibers in a contact lens. The fibers are loaded with therapeutic drugs by a variety of methods and processed by coating and cross-linking the fibers.
摘要翻译：电纺纤维用于改善隐形眼镜的机械特性，降低通常形成透镜的聚合物的重量和机械强度。电纺纤维也被用作药物递送系统，通过直接使用在眼睛中并通过将纤维包含在隐形眼镜中。纤维通过各种方法装载治疗药物并通过涂布和交联纤维进行加工。

9. 发明申请

US20130023648A1 Controlled Cross-Linking Processing of Proteins 审中-公开
标题翻译：蛋白质的控制交联处理
公开(公告)号：US20130023648A1
公开(公告)日：2013-01-24
申请号：US13430562
申请日：2012-03-26
申请人： Gary Wnek , Linghui Meng
发明人： Gary Wnek , Linghui Meng
IPC分类号： C07K1/107 , B29C47/00
CPC分类号： C07K1/1075 , A61L27/22 , C07K1/107 , C07K1/36 , C07K14/78 , D01F1/10 , D01F4/00
摘要： A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The intermediate protein structure can be cross-linked by providing for a specific ratio of chemical cross-linking agents to form the cross-linked protein structure. The solution can be prepared by adding a cross-linker of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) at a ratio of two-to-one of NHS to EDC to alcohol. PBS buffer (20X) can be added to the solution until the volume ratio of PBS buffer (20X) to alcohol is about one-to-one. About 16 percent by weight of protein can be dissolved in the solution. The solution can be electrospun to form an intermediate protein structure. After a period of time, the protein structure can be cross-linked to form the cross-linked protein structure.
摘要翻译：形成交联蛋白质结构的方法包括制备溶解在良溶剂中的蛋白质溶液并从溶液形成中间体蛋白质结构。通过提供特定比例的化学交联剂以形成交联的蛋白质结构，可以交联中间体蛋白质结构。该溶液可以通过以NHS与EDC的二对比与乙醇的比例加入N-羟基琥珀酰亚胺（NHS）和1-乙基-3-（3-二甲基氨基丙基）碳二亚胺盐酸盐（EDC）的交联剂来制备。可以将PBS缓冲液（20X）加入到溶液中，直到PBS缓冲液（20X）与醇的体积比约为1比1。约16重量％的蛋白质可以溶解在溶液中。该溶液可以静电纺丝以形成中间体蛋白质结构。一段时间后，蛋白质结构可以交联形成交联的蛋白质结构。

10. 发明授权

US07442754B2 Molecular imprinting of small particles, and production of small particles from solid state reactants 失效
标题翻译：分子印迹的小颗粒，并从固态反应物生产小颗粒
公开(公告)号：US07442754B2
公开(公告)日：2008-10-28
申请号：US10682432
申请日：2003-10-10
申请人： Gary Tepper , Dmitry Pestov , Natalia Levit , Gary Wnek
发明人： Gary Tepper , Dmitry Pestov , Natalia Levit , Gary Wnek
IPC分类号： C08F20/04 , C08J9/26
CPC分类号： B01J20/285 , A61K9/5089 , B01J2/04 , B01J20/26 , B01J20/268 , B01J20/281 , B01J20/3057 , B01J2220/54 , B82Y10/00 , B82Y40/00 , G01N30/48 , G03F7/0002 , Y02C10/08 , Y10T428/2991
摘要： Small particles of polymeric material are produced by expansion of a mixture of monomers and a propellant. The size and shape of the particles can be precisely tailored by materials selection and expansion conditions. Particles of 10 nanometers to 100 microns can be produced. If monomers exhibiting solid state reactivity are utilized, the particles thus formed can be polymerized at any time after formation. The particles produced by this method can be molecularly imprinted by incorporating a template into the particle prior to fully curing the particle, in a manner which allows selective extraction of the template from the cured particle after formation without deformation of the imprint site. A two step polymerization process allows the particles to be deposited on and adhered to a wide variety of substrates without additional agents. The molecularly imprinted particles can be used in a wide variety of applications including the selective binding of analyte from a sample, where the analyte is the same as the template or is of substantially the same size and has a similar arrangement of chemical functional groups. Imprinted molecularly imprinted particles can be used for targeted delivery of agents in biological applications. Non-imprinted particles formed by the expansion technique using monomers of solid state reactivity can be used in optical data storage systems.
摘要翻译：通过膨胀单体和推进剂的混合物来生产聚合物材料的小颗粒。颗粒的尺寸和形状可以通过材料选择和膨胀条件精确地定制。可以生产10纳米至100微米的颗粒。如果使用表现出固态反应性的单体，则由此形成的颗粒可以在形成后的任何时间聚合。通过该方法制备的颗粒可以通过在完全固化颗粒之前将模板并入颗粒中以可以在形成后从固化颗粒中选择性提取而不使压印位点变形的方式来分子印迹。两步聚合方法允许颗粒沉积在各种基材上并粘附到多种基材上，而不需要额外的试剂。分子印迹的颗粒可以用于各种应用，包括分析物与样品的选择性结合，其中分析物与模板相同或具有基本相同的尺寸并且具有类似的化学官能团排列。印迹分子印迹颗粒可用于生物应用中的试剂的靶向递送。通过使用固态反应性单体的膨胀技术形成的非印刷粒子可用于光学数据存储系统。

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