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1. 发明授权

US07442754B2 Molecular imprinting of small particles, and production of small particles from solid state reactants 失效
标题翻译：分子印迹的小颗粒，并从固态反应物生产小颗粒
公开(公告)号：US07442754B2
公开(公告)日：2008-10-28
申请号：US10682432
申请日：2003-10-10
申请人： Gary Tepper , Dmitry Pestov , Natalia Levit , Gary Wnek
发明人： Gary Tepper , Dmitry Pestov , Natalia Levit , Gary Wnek
IPC分类号： C08F20/04 , C08J9/26
CPC分类号： B01J20/285 , A61K9/5089 , B01J2/04 , B01J20/26 , B01J20/268 , B01J20/281 , B01J20/3057 , B01J2220/54 , B82Y10/00 , B82Y40/00 , G01N30/48 , G03F7/0002 , Y02C10/08 , Y10T428/2991
摘要： Small particles of polymeric material are produced by expansion of a mixture of monomers and a propellant. The size and shape of the particles can be precisely tailored by materials selection and expansion conditions. Particles of 10 nanometers to 100 microns can be produced. If monomers exhibiting solid state reactivity are utilized, the particles thus formed can be polymerized at any time after formation. The particles produced by this method can be molecularly imprinted by incorporating a template into the particle prior to fully curing the particle, in a manner which allows selective extraction of the template from the cured particle after formation without deformation of the imprint site. A two step polymerization process allows the particles to be deposited on and adhered to a wide variety of substrates without additional agents. The molecularly imprinted particles can be used in a wide variety of applications including the selective binding of analyte from a sample, where the analyte is the same as the template or is of substantially the same size and has a similar arrangement of chemical functional groups. Imprinted molecularly imprinted particles can be used for targeted delivery of agents in biological applications. Non-imprinted particles formed by the expansion technique using monomers of solid state reactivity can be used in optical data storage systems.
摘要翻译：通过膨胀单体和推进剂的混合物来生产聚合物材料的小颗粒。颗粒的尺寸和形状可以通过材料选择和膨胀条件精确地定制。可以生产10纳米至100微米的颗粒。如果使用表现出固态反应性的单体，则由此形成的颗粒可以在形成后的任何时间聚合。通过该方法制备的颗粒可以通过在完全固化颗粒之前将模板并入颗粒中以可以在形成后从固化颗粒中选择性提取而不使压印位点变形的方式来分子印迹。两步聚合方法允许颗粒沉积在各种基材上并粘附到多种基材上，而不需要额外的试剂。分子印迹的颗粒可以用于各种应用，包括分析物与样品的选择性结合，其中分析物与模板相同或具有基本相同的尺寸并且具有类似的化学官能团排列。印迹分子印迹颗粒可用于生物应用中的试剂的靶向递送。通过使用固态反应性单体的膨胀技术形成的非印刷粒子可用于光学数据存储系统。

2. 发明申请

US20080242820A1 MOLECULAR IMPRINTING OF SMALL PARTICLES, AND PRODUCTION OF SMALL PARTICLES FROM SOLID STATE REACTANTS 失效
标题翻译：小颗粒的分子印迹和来自固体状态反应物的小颗粒的生产
公开(公告)号：US20080242820A1
公开(公告)日：2008-10-02
申请号：US10682432
申请日：2003-10-10
申请人： Gary Tepper , Dmitry Pestov , Natalia Levit , Gary Wnek
发明人： Gary Tepper , Dmitry Pestov , Natalia Levit , Gary Wnek
IPC分类号： C08F20/04
CPC分类号： B01J20/285 , A61K9/5089 , B01J2/04 , B01J20/26 , B01J20/268 , B01J20/281 , B01J20/3057 , B01J2220/54 , B82Y10/00 , B82Y40/00 , G01N30/48 , G03F7/0002 , Y02C10/08 , Y10T428/2991
摘要： Small particles of polymeric material are produced by expansion of a mixture of monomers and a propellant. The size and shape of the particles can be precisely tailored by materials selection and expansion conditions. Particles of 10 nanometers to 100 microns can be produced. If monomers exhibiting solid state reactivity are utilized, the particles thus formed can be polymerized at any time after formation. The particles produced by this method can be molecularly imprinted by incorporating a template into the particle prior to fully curing the particle, in a manner which allows selective extraction of the template from the cured particle after formation without deformation of the imprint site. A two step polymerization process allows the particles to be deposited on and adhered to a wide variety of substrates without additional agents. The molecularly imprinted particles can be used in a wide variety of applications including the selective binding of analyte from a sample, where the analyte is the same as the template or is of substantially the same size and has a similar arrangement of chemical functional groups. Imprinted molecularly imprinted particles can be used for targeted delivery of agents in biological applications. Non-imprinted particles formed by the expansion technique using monomers of solid state reactivity can be used in optical data storage systems.
摘要翻译：通过膨胀单体和推进剂的混合物来生产聚合物材料的小颗粒。颗粒的尺寸和形状可以通过材料选择和膨胀条件精确地定制。可以生产10纳米至100微米的颗粒。如果使用表现出固态反应性的单体，则由此形成的颗粒可以在形成后的任何时间聚合。通过该方法制备的颗粒可以通过在完全固化颗粒之前将模板并入颗粒中以可以在形成后从固化颗粒中选择性提取而不使压印位点变形的方式来分子印迹。两步聚合方法允许颗粒沉积在各种基材上并粘附到多种基材上，而不需要额外的试剂。分子印迹的颗粒可以用于各种应用，包括分析物与样品的选择性结合，其中分析物与模板相同或具有基本相同的尺寸并且具有类似的化学官能团排列。印迹分子印迹颗粒可用于生物应用中的试剂的靶向递送。通过使用固态反应性单体的膨胀技术形成的非印刷粒子可用于光学数据存储系统。

3. 发明授权

US06660176B2 Molecular imprinting of small particles, and production of small particles from solid state reactants 失效
公开(公告)号：US06660176B2
公开(公告)日：2003-12-09
申请号：US10054708
申请日：2002-01-24
申请人： Gary Tepper , Dmitry Pestov , Natalia Levit , Gary Wnek
发明人： Gary Tepper , Dmitry Pestov , Natalia Levit , Gary Wnek
IPC分类号： C08F248
CPC分类号： B01J20/285 , A61K9/5089 , B01J2/04 , B01J20/26 , B01J20/268 , B01J20/281 , B01J20/3057 , B01J2220/54 , B82Y10/00 , B82Y40/00 , G01N30/48 , G03F7/0002 , Y02C10/08 , Y10T428/2991
摘要： Small particles of polymeric material are produced by expansion of a mixture of monomers and a propellant. The size and shape of the particles can be precisely tailored by materials selection and expansion conditions. Particles of 10 nanometers to 100 microns can be produced. If monomers exhibiting solid state reactivity are utilized, the particles thus formed can be polymerized at any time after formation. The particles produced by this method can be molecularly imprinted by incorporating a template into the particle prior to fully curing the particle, in a manner which allows selective extraction of the template from the cured particle after formation without deformation of the imprint site. A two step polymerization process allows the particles to be deposited on and adhered to a wide variety of substrates without additional agents. The molecularly imprinted particles can be used in a wide variety of applications including the selective binding of analyte from a sample, where the analyte is the same as the template or is of substantially the same size and has a similar arrangement of chemical functional groups. Imprinted molecularly imprinted particles can be used for targeted delivery of agents in biological applications. Non-imprinted particles formed by the expansion technique using monomers of solid state reactivity can be used in optical data storage systems.

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