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1. 发明申请

US20100261799A1 STABLE AND COMPATIBLE POLYMER BLENDS 有权
标题翻译：稳定和相容的聚合物共混
公开(公告)号：US20100261799A1
公开(公告)日：2010-10-14
申请号：US12664762
申请日：2008-06-24
申请人： David John Vachon , Liwei Cao , Gary Wnek
发明人： David John Vachon , Liwei Cao , Gary Wnek
IPC分类号： A61K47/32 , C08L53/00 , A61P9/00
CPC分类号： C08L53/005 , A61K47/32 , A61K47/34 , A61L15/22 , A61L31/04 , B01D71/26 , B01D71/28 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/48 , B01D71/50 , B01D71/52 , B01D71/54 , B01D71/56 , B01D71/60 , B01D71/68 , B01D71/76 , B01D71/82 , B01D2323/39 , B01D2325/14 , C08L33/08 , C08L41/00 , C08L75/00 , C08L75/04 , C08L75/06 , C08L75/08 , C08L83/00 , C08L2666/04 , C08L2666/02 , C08L2666/14 , C08L2666/24
摘要： The present invention pertains to products and processes relating to compatible polymer blends comprising at least one sulfonated polymer and at least one non-sulfonated polymer. The sulfonated polymers may be produced using a number of sulfonating agents including a coordination complex of sulfur trioxide. The polymeric blended materials described herein are useful in a variety of applications, including as coatings for medical devices, protective clothing and fabric, laboratory equipment, vascular stents and shunts, absorbent materials and separation membranes, three-dimensional constructs, devices, and other uses.
摘要翻译：本发明涉及与包含至少一种磺化聚合物和至少一种非磺化聚合物的相容性聚合物共混物相关的产品和方法。磺化聚合物可以使用包括三氧化硫的配位络合物的多种磺化剂来制备。本文所述的聚合物共混材料可用于各种应用，包括用于医疗装置，防护服和织物，实验室设备，血管支架和分流器，吸收材料和分离膜，三维结构，装置和其它用途的涂层。

2. 发明申请

US20140171518A1 STABLE AND COMPATIBLE POLYMER BLENDS 审中-公开
标题翻译：稳定和相容的聚合物共混
公开(公告)号：US20140171518A1
公开(公告)日：2014-06-19
申请号：US14075152
申请日：2013-11-08
申请人： David John Vachon , Liwei Cao , Gary Wnek
发明人： David John Vachon , Liwei Cao , Gary Wnek
IPC分类号： C08L53/00 , A61K47/32 , A61K47/34 , C08L75/04 , C08L83/00
CPC分类号： C08L53/005 , A61K47/32 , A61K47/34 , A61L15/22 , A61L31/04 , B01D71/26 , B01D71/28 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/48 , B01D71/50 , B01D71/52 , B01D71/54 , B01D71/56 , B01D71/60 , B01D71/68 , B01D71/76 , B01D71/82 , B01D2323/39 , B01D2325/14 , C08L33/08 , C08L41/00 , C08L75/00 , C08L75/04 , C08L75/06 , C08L75/08 , C08L83/00 , C08L2666/04 , C08L2666/02 , C08L2666/14 , C08L2666/24
摘要： The present invention pertains to products and processes relating to compatible polymer blends comprising at least one sulfonated polymer and at least one non-sulfonated polymer. The sulfonated polymers may be produced using a number of sulfonating agents including a coordination complex of sulfur trioxide. The polymeric blended materials described herein are useful in a variety of applications, including as coatings for medical devices, protective clothing and fabric, laboratory equipment, vascular stents and shunts, absorbent materials and separation membranes, three-dimensional constructs, devices, and other uses.
摘要翻译：本发明涉及与包含至少一种磺化聚合物和至少一种非磺化聚合物的相容性聚合物共混物相关的产品和方法。磺化聚合物可以使用包括三氧化硫的配位络合物的多种磺化剂来制备。本文所述的聚合物共混材料可用于各种应用，包括用于医疗装置，防护服和织物，实验室设备，血管支架和分流器，吸收材料和分离膜，三维结构，装置和其它用途的涂层。

3. 发明授权

US08586637B2 Stable and compatible polymer blends 有权
标题翻译：稳定和相容的聚合物共混物
公开(公告)号：US08586637B2
公开(公告)日：2013-11-19
申请号：US12664762
申请日：2008-06-24
申请人： David John Vachon , Liwei Cao , Gary Wnek
发明人： David John Vachon , Liwei Cao , Gary Wnek
IPC分类号： A61K47/32 , C08L53/00
CPC分类号： C08L53/005 , A61K47/32 , A61K47/34 , A61L15/22 , A61L31/04 , B01D71/26 , B01D71/28 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/48 , B01D71/50 , B01D71/52 , B01D71/54 , B01D71/56 , B01D71/60 , B01D71/68 , B01D71/76 , B01D71/82 , B01D2323/39 , B01D2325/14 , C08L33/08 , C08L41/00 , C08L75/00 , C08L75/04 , C08L75/06 , C08L75/08 , C08L83/00 , C08L2666/04 , C08L2666/02 , C08L2666/14 , C08L2666/24
摘要： The present invention pertains to products and processes relating to compatible polymer blends comprising at least one sulfonated polymer and at least one non-sulfonated polymer. The sulfonated polymers may be produced using a number of sulfonating agents including a coordination complex of sulfur trioxide. The polymeric blended materials described herein are useful in a variety of applications, including as coatings for medical devices, protective clothing and fabric, laboratory equipment, vascular stents and shunts, absorbent materials and separation membranes, three-dimensional constructs, devices, and other uses.
摘要翻译：本发明涉及与包含至少一种磺化聚合物和至少一种非磺化聚合物的相容性聚合物共混物相关的产品和方法。磺化聚合物可以使用包括三氧化硫的配位络合物的多种磺化剂来制备。本文所述的聚合物共混材料可用于各种应用，包括用于医疗装置，防护服和织物，实验室设备，血管支架和分流器，吸收材料和分离膜，三维结构，装置和其它用途的涂层。

4. 发明申请

US20100247544A1 Compositions and Methods for Promoting the Healing of Tissue of Multicellular Organisms 有权
标题翻译：促进多细胞生物组织愈合的组成和方法
公开(公告)号：US20100247544A1
公开(公告)日：2010-09-30
申请号：US12690081
申请日：2010-01-19
申请人： David John Vachon
发明人： David John Vachon
IPC分类号： A61K39/395 , A61K38/43 , A61K38/00 , A61K38/18 , A61K38/14 , A61K33/38 , A61K31/713 , A61K31/65 , A61K31/198 , A61K38/06 , A61K31/18 , A61K31/167 , A61K31/444 , A61P17/02 , A61P29/00 , A61P31/00 , A61P35/00
CPC分类号： A61K31/795 , A61K31/167 , A61K31/18 , A61K31/198 , A61K31/444 , A61K31/65 , A61K31/713 , A61K33/38 , A61K38/00 , A61K45/06 , A61L26/0052 , A61L26/0066 , A61L2300/434 , A61L2300/80 , A61K2300/00
摘要： Compositions are provided for promoting healing of tissue of a vertebrate organism. The compositions can be for internal administration of a therapeutically effective amount of pharmacologically active, protease inhibiting, aqueous media soluble polysulfonated materials in salt form and associated with a secondary material to reduce one or more of inflammation, bacterial proliferation, proteolytic activity, and cancerous cell growth. The compositions may additionally or alternatively be cross-linked so as to alter the solubility of these pharmacologically active salts or slow dissolution by providing biodegradable cross-linkers. Compositions for healing the tissue of a multicellular organism are provided that can include a polysulfonated material in a liquid mixture, as solid particles or constructs that may or may not biodegrade or deliver a pharmacologically relevant value. Some of the compositions are also provided for inclusion into a device for preventing infection, reducing inflammation, and preserving the activity of a protein or protein drug.
摘要翻译：提供用于促进脊椎动物生物体组织愈合的组合物。所述组合物可用于内部施用治疗有效量的盐酸形式的与药物活性的蛋白酶抑制性水溶性多磺化材料，并与次级材料缔合以减少炎症，细菌增殖，蛋白水解活性和癌细胞中的一种或多种成长。组合物可另外地或替代地交联以通过提供可生物降解的交联剂改变这些药理学活性盐的溶解度或缓慢溶解。提供了用于愈合多细胞生物体的组织的组合物，其可以包括在液体混合物中的多磺化材料，作为固体颗粒或构建体，其可以或可以不生物降解或递送药理学相关的值。还提供了一些组合物用于包含在用于预防感染，减少炎症和保持蛋白质或蛋白质药物的活性的装置中。

5. 发明授权

US08795730B2 Compositions and methods for promoting the healing of tissue of multicellular organisms 有权
标题翻译：促进多细胞生物组织愈合的组合物和方法
公开(公告)号：US08795730B2
公开(公告)日：2014-08-05
申请号：US12690081
申请日：2010-01-19
申请人： David John Vachon
发明人： David John Vachon
IPC分类号： A61K9/00 , A61K9/06 , A61K9/08 , A61K31/795
CPC分类号： A61K31/795 , A61K31/167 , A61K31/18 , A61K31/198 , A61K31/444 , A61K31/65 , A61K31/713 , A61K33/38 , A61K38/00 , A61K45/06 , A61L26/0052 , A61L26/0066 , A61L2300/434 , A61L2300/80 , A61K2300/00
摘要： Compositions are provided for promoting healing of tissue of a vertebrate organism. The compositions can be for internal administration of a therapeutically effective amount of pharmacologically active, protease inhibiting, aqueous media soluble polysulfonated materials in salt form and associated with a secondary material to reduce one or more of inflammation, bacterial proliferation, proteolytic activity, and cancerous cell growth. The compositions may additionally or alternatively be cross-linked so as to alter the solubility of these pharmacologically active salts or slow dissolution by providing biodegradable cross-linkers. Compositions for healing the tissue of a multicellular organism are provided that can include a polysulfonated material in a liquid mixture, as solid particles or constructs that may or may not biodegrade or deliver a pharmacologically relevant value. Some of the compositions are also provided for inclusion into a device for preventing infection, reducing inflammation, and preserving the activity of a protein or protein drug.
摘要翻译：提供用于促进脊椎动物生物体组织愈合的组合物。所述组合物可用于内部施用治疗有效量的盐酸形式的与药物活性的蛋白酶抑制性水溶性多磺化材料，并与次级材料缔合以减少炎症，细菌增殖，蛋白水解活性和癌细胞中的一种或多种成长。组合物可另外地或替代地交联以通过提供可生物降解的交联剂改变这些药理学活性盐的溶解度或缓慢溶解。提供了用于愈合多细胞生物体的组织的组合物，其可以包括在液体混合物中的多磺化材料，作为固体颗粒或构建体，其可以或可以不生物降解或递送药理学相关的值。还提供了一些组合物用于包含在用于预防感染，减少炎症和保持蛋白质或蛋白质药物的活性的装置中。

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