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1. 发明申请

US20090162890A1 IDENTIFYING THERAPEUTIC COMPOUNDS BASED ON THEIR PHYSICAL-CHEMICAL PROPERTIES 审中-公开
公开(公告)号：US20090162890A1
公开(公告)日：2009-06-25
申请号：US12336449
申请日：2008-12-16
申请人： Sylvain GILAT , Gary BINYAMIN , Guy M. MILLER
发明人： Sylvain GILAT , Gary BINYAMIN , Guy M. MILLER
IPC分类号： C12Q1/02
CPC分类号： G01N33/6896 , G01N33/6893 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed to rapid and efficient methods of identifying therapeutic compounds by allowing only the most favorable molecules initially selected based on their physical-chemical profile falling within a range predefined by the physical-chemical/biological relationship of a previously tested small subset of compounds of same core structure to be assayed; and to the therapeutic compositions identified by said methods.

2. 发明申请

US20090163529A1 IDENTIFYING THERAPEUTIC COMPOUNDS BASED ON THEIR PHYSICAL-CHEMICAL PROPERTIES 审中-公开
标题翻译：基于其物理化学性质鉴定治疗化合物
公开(公告)号：US20090163529A1
公开(公告)日：2009-06-25
申请号：US12344025
申请日：2008-12-24
申请人： Sylvain GILAT , Gary Binyamin , Guy M. Miller
发明人： Sylvain GILAT , Gary Binyamin , Guy M. Miller
IPC分类号： A61K31/473 , A61K31/05 , A61K31/352 , A61P25/28
CPC分类号： G01N33/6896 , G01N33/6893 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed to rapid and efficient methods of identifying therapeutic compounds by allowing only the most favorable molecules initially selected based on their physical-chemical profile falling within a range predefined by the physical-chemical/biological relationship of a previously tested small subset of compounds of same core structure to be assayed; and to the therapeutic compositions identified by said methods.
摘要翻译：本发明涉及快速和有效的方法，通过仅允许最初选择的最有利的分子基于它们的物理化学特征落入由先前测试的小子集的物理化学/生物学关系预定的范围内来确定治疗化合物要测定的相同核心结构的化合物; 以及通过所述方法鉴定的治疗组合物。

3. 发明授权

US07491312B2 Identifying therapeutic compounds based on their physical-chemical properties 有权
标题翻译：根据物理化学性质鉴定治疗化合物
公开(公告)号：US07491312B2
公开(公告)日：2009-02-17
申请号：US10696752
申请日：2003-10-29
申请人： Sylvain Gilat , Gary Binyamin , Guy Miller
发明人： Sylvain Gilat , Gary Binyamin , Guy Miller
IPC分类号： G01N27/26
CPC分类号： G01N33/6896 , G01N33/6893 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed to rapid and efficient methods of identifying therapeutic compounds by allowing only the most favorable molecules initially selected based on their physical-chemical profile falling within a range predefined by the physical-chemical/biological relationship of a previously tested small subset of compounds of same core structure to be assayed; and to the therapeutic compositions identified by said methods.
摘要翻译：本发明涉及快速和有效的方法，通过仅允许最初选择的最有利的分子基于它们的物理化学特征落入由先前测试的小子集的物理化学/生物学关系预定的范围内来确定治疗化合物要测定的相同核心结构的化合物; 以及通过所述方法鉴定的治疗组合物。

4. 发明申请

US20070198045A1 System to Facilitate the Use of a Surgical Instrument 审中-公开
标题翻译：促进手术器械使用的系统
公开(公告)号：US20070198045A1
公开(公告)日：2007-08-23
申请号：US11677514
申请日：2007-02-21
申请人： John Morton , Jessica Connor , Gary Binyamin
发明人： John Morton , Jessica Connor , Gary Binyamin
IPC分类号： A61M29/00
CPC分类号： A61M29/00 , A61B17/3439 , A61B2017/00477 , A61B2017/320044
摘要： The dilating device of the preferred embodiments includes a three dimensional dilating surface that functions to dilate an orifice, an alignment surface that functions to align and center the dilating device to the orifice, a coupling element that functions to couple the dilating device to the surgical instrument, a removal element that functions to facilitate the removal of the dilating device from the surgical site such as a hole and/or a grasping surface. The dilating device is preferably designed to dilate an orifice to the size of a surgical instrument, thereby facilitating the use of a surgical instrument during surgery and, more specifically, facilitating the use of a circular stapler in laparoscopic surgery. The dilating device, however, may be alternatively used in any suitable environment and for any suitable reason.
摘要翻译：优选实施例的扩张装置包括用于扩张孔的三维扩张表面，用于使扩张装置对准和对准孔的功能的对准表面，用于将扩张装置连接到手术器械的联接元件，用于促进从外科手术部位（例如孔和/或抓握表面）移除扩张装置的移除元件。膨胀装置优选地被设计成将孔扩张到手术器械的尺寸，从而便于手术中使用外科器械，更具体地，便于在腹腔镜手术中使用圆形缝合器。然而，扩张装置可以替代地在任何合适的环境中使用，并且由于任何合适的原因。

5. 发明申请

US20070144534A1 System to prevent airway obstruction 审中-公开
标题翻译：系统阻止气道阻塞
公开(公告)号：US20070144534A1
公开(公告)日：2007-06-28
申请号：US11607669
申请日：2006-11-30
申请人： Carlos Mery , Bilal Shafi , Gary Binyamin , Jessica Connor , John White
发明人： Carlos Mery , Bilal Shafi , Gary Binyamin , Jessica Connor , John White
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F2/02 , A61F5/56
摘要： Devices and methods are provided for the treatment of obstructive sleep apnea. An implantable device is inserted into the tongue. The implantable device is a flexible elongated structure, which may be a curved or jointed filament; of a sufficient length and diameter to provide support, when implanted, sufficient to restrain obstructive movement of the tongue during sleep.
摘要翻译：提供了用于治疗阻塞性睡眠呼吸暂停的装置和方法。将可植入装置插入到舌头中。可植入装置是柔性细长结构，其可以是弯曲或接合的细丝; 足够的长度和直径以在植入时提供足以在睡眠期间抑制舌头的阻塞运动的支撑。

6. 发明申请

US20080065200A1 BIFURCATED PROSTHESES HAVING DIFFERENTIAL DRUG COATINGS 审中-公开
标题翻译：具有差异性药物涂层的分离性前体药物（PIFURCATED PROSTHESES HAVING DIFFERENTIGIO DRGG COATINGS）
公开(公告)号：US20080065200A1
公开(公告)日：2008-03-13
申请号：US11851643
申请日：2007-09-07
申请人： Gary Binyamin , Eitan Konstantino
发明人： Gary Binyamin , Eitan Konstantino
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/0077 , A61F2/856 , A61F2250/0067
摘要： Bifurcated stent includes a main stent body and a crown adapted to deploy it laterally into a branch vessel from the main stent body. A therapeutic agent or other material is coated on at least a portion of the crown of the stent, usually over the base of the crown adjacent to the main stent body. The main stent body is either free from coating or is coated in a different manner than is the crown portion of the stent.
摘要翻译：分支支架包括主支架主体和适于将其从主支架主体横向展开到分支容器中的表冠。治疗剂或其它材料涂覆在支架的冠部的至少一部分上，通常在与主支架主体相邻的冠部的基部上。主支架体无涂层或以与支架的冠部不同的方式涂覆。

7. 发明申请

US20080033459A1 Suturing apparatus for closing tissue defects 审中-公开
标题翻译：用于闭合组织缺陷的缝合装置
公开(公告)号：US20080033459A1
公开(公告)日：2008-02-07
申请号：US11833963
申请日：2007-08-03
申请人： Bilal Shafi , Gabriel Sanchez , Carlos Mery , Gary Binyamin , Jessica Connor
发明人： Bilal Shafi , Gabriel Sanchez , Carlos Mery , Gary Binyamin , Jessica Connor
IPC分类号： A61B17/04
CPC分类号： A61B17/0057 , A61B17/0469 , A61B17/0482 , A61B2017/00637 , A61B2017/00663 , A61B2017/0472 , A61B2017/06042
摘要： A device is provided to rapidly, safely, efficiently and effectively close tissue defects created to access operative sites in a patients body. The device comprises an elongated body with its features in profile to allow use through conduits such as trocars which can be removed over the device. The device has diametrically opposed pivoting extensions which provide a target for flexible needles to attach to suture and provide protection for all vital structures in the body. Once the pivoting extensions are past the innermost layer adjacent to the tissue defect the flexible needles are advanced through the tissue to obtain an adequate and proper amount of tissue to allow for a strong closure. The device leaves a suture behind which can then be tied to close the tissue defect.
摘要翻译：提供了一种快速，安全，有效和有效地闭合组织缺陷的装置，用于接近患者体内的手术部位。该装置包括细长主体，其特征在于轮廓，以允许通过诸如可以在装置上移除的套管针的导管使用。该装置具有径向相对的枢转延伸部，其提供用于柔性针连接到缝线并且为身体中的所有重要结构提供保护的目标。一旦枢转延伸部经过与组织缺损相邻的最内层，则柔性针通过组织前进以获得足够和适当量的组织以允许强烈的闭合。该装置留下缝合线，然后可以将其缝合以闭合组织缺损。

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