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1. 发明授权

US09278085B2 Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers 有权
标题翻译：用于治疗线粒体疾病和其他条件的氧化还原活性治疗剂的侧链变体和能量生物标志物的调节
公开(公告)号：US09278085B2
公开(公告)日：2016-03-08
申请号：US11710042
申请日：2007-02-22
申请人： Guy M. Miller , Sidney M. Hecht , Orion D. Jankowski , Kieron E. Wesson , Paul Mollard
发明人： Guy M. Miller , Sidney M. Hecht , Orion D. Jankowski , Kieron E. Wesson , Paul Mollard
IPC分类号： A61K31/355 , A61K31/05 , C07C39/08 , C07C39/11 , C07C39/19 , C07C39/24 , C07C50/02 , C07C50/06 , C07C50/24 , C07C50/28 , C07C215/56 , C07C403/04 , C07C403/08 , C07C403/18
CPC分类号： C07C50/04 , A61K31/05 , A61K31/355 , C07C39/08 , C07C39/11 , C07C39/19 , C07C39/245 , C07C43/225 , C07C43/23 , C07C47/277 , C07C50/02 , C07C50/06 , C07C50/24 , C07C50/28 , C07C69/608 , C07C69/618 , C07C215/56 , C07C233/27 , C07C233/32 , C07C255/37 , C07C403/04 , C07C403/08 , C07C403/18 , C07C2601/16
摘要： Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
摘要翻译：公开了治疗或抑制线粒体疾病如弗里德里希共济失调（FRDA），莱伯氏遗传性视神经病变（LHON），线粒体肌病，脑病，乳酸脱落症，中风（MELAS）或Kearns-Sayre综合征（KSS）的方法，以及可用于本发明方法的化合物。还公开了可用于治疗其它疾病的方法和化合物。还公开了可用于评估受试者的代谢状态和治疗功效的能量生物标志物。还公开了调节，归一化或增强能量生物标志物的方法以及可用于这些方法的化合物。

2. 发明申请

US20140031432A1 TREATMENT OF MITOCHONDRIAL DISEASES WITH VITAMIN K 审中-公开
标题翻译：维生素K治疗麻醉病
公开(公告)号：US20140031432A1
公开(公告)日：2014-01-30
申请号：US13814722
申请日：2011-08-04
申请人： Orion D. Jankowski , Andrew W. Hinman , Guy M. Miller
发明人： Orion D. Jankowski , Andrew W. Hinman , Guy M. Miller
IPC分类号： A61K31/122
CPC分类号： A61K31/122
摘要： Methods of treating, preventing or suppressing symptoms associated with mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), dominant optic atrophy (DOA); mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Leigh syndrome or Kearns-Sayre Syndrome (KSS) with vitamin K are disclosed.
摘要翻译：治疗，预防或抑制与线粒体疾病相关的症状的方法，如弗里德里希共济失调（FRDA），莱伯氏遗传性视神经病变（LHON），显性视神经萎缩（DOA）; 公布了线粒体肌病，脑病，乳酸酸中毒（MELAS），Leigh综合征或Kearns-Sayre综合征（KSS）与维生素K的关系。

3. 发明申请

US20130109759A1 FORMULATIONS OF QUINONES FOR THE TREATMENT OF OPHTHALMIC DISEASES 审中-公开
标题翻译：用于治疗眼底疾病的喹诺酮配方
公开(公告)号：US20130109759A1
公开(公告)日：2013-05-02
申请号：US13643542
申请日：2011-04-26
申请人： Guy M. Miller
发明人： Guy M. Miller
IPC分类号： A61K31/122
CPC分类号： A61K31/122
摘要： A formulation comprising an ophthalmically effective amount of one or more quinones of Formula I. Use of a formulation comprising one or more quinones of Formula I for the prevention, reduction, amelioration or treatment of ophthalmic disorders that are associated with a neurodegenerative or trauma disorder is also discussed. A method of treating or controlling the ocular symptoms associated with neurodegenerative diseases or trauma with a formulation comprising one or more quinones of Formula I is also discussed. A method of treating or controlling the ocular symptoms associated with mitochondrial myopathies with a formulation comprising one or more quinones of Formula I is also discussed.
摘要翻译：包含眼睛有效量的一种或多种式I的醌的制剂。包含一种或多种式I醌的制剂的用途用于预防，减少，改善或治疗与神经变性或创伤病症相关的眼科疾病是也讨论过。还讨论了用包含一种或多种式I醌的制剂治疗或控制与神经变性疾病或创伤相关的眼部症状的方法。还讨论了用包含一种或多种式I醌的制剂治疗或控制与线粒体肌病相关的眼部症状的方法。

4. 发明申请

US20110142834A1 TREATMENT OF HEARING AND BALANCE IMPAIRMENTS USING COMPOUNDS HAVING ERYTHROPOIETIN ACTIVITY 审中-公开
标题翻译：使用具有抗坏血酸活性的化合物治疗听力和平衡障碍
公开(公告)号：US20110142834A1
公开(公告)日：2011-06-16
申请号：US12991909
申请日：2009-05-13
申请人： Guy M. Miller
发明人： Guy M. Miller
IPC分类号： A61K39/395 , A61K38/18 , A61P27/16 , A61P25/00
CPC分类号： A61K38/1816
摘要： Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing or balance impairments involving neuronal damage, loss, or degeneration, preferably of spiral ganglion neurons, by administration of a therapeutically effective amount of one or more molecules having erythropoietin activity selected from EPO, or a biosimilar, a variant, or a mutant thereof; a protein or peptide mimetic of EPO; a small molecule mimetic of EPO and an erythropoiesis stimulating agent. Also provided are improved compositions and methods for treatments of ototoxicity requiring administration of a pharmaceutical having an ototoxic side-effect in combination with a therapeutically effective amount of a molecule having erythropoietin activity.
摘要翻译：提供了组合物和方法，用于通过施用治疗有效量的一种或多种具有促红细胞生成素活性的分子来预防或治疗哺乳动物用于听力或平衡涉及神经元损伤，损失或变性，优选螺旋神经节神经元的损伤 EPO或其生物仿制药，变体或突变体; EPO的蛋白质或肽模拟物; EPO和红细胞生成刺激剂的小分子模拟物。还提供了改善的组合物和治疗耳毒性的方法，其需要施用具有耳毒性副作用的药物与治疗有效量的具有促红细胞生成素活性的分子的组合。

5. 发明申请

US20110046156A1 TREATMENT OF HEARING AND BALANCE IMPAIRMENTS WITH REDOX-ACTIVE THERAPEUTICS 审中-公开
标题翻译：用抗氧化活性治疗方法治疗听力和平衡障碍
公开(公告)号：US20110046156A1
公开(公告)日：2011-02-24
申请号：US12919004
申请日：2009-03-04
申请人： Guy M. Miller
发明人： Guy M. Miller
IPC分类号： A61K31/495 , A61K31/445 , A61K31/122 , A61K31/355 , A61P27/16 , A61P25/00
CPC分类号： A61K31/495 , A61K31/122 , A61K31/16 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing or balance impairments involving neuronal damage, loss, or degeneration, by administration of a therapeutically effective amount of a redox-active therapeutic. Also provided are improved compositions and methods for treatments requiring administration of a pharmaceutical having an ototoxic side-effect in combination with a therapeutically effective amount of a redox-active therapeutic to treat the ototoxicity.
摘要翻译：提供组合物和方法，用于通过施用治疗有效量的氧化还原活性治疗剂来预防或治疗哺乳动物的听力或平衡损伤，包括神经元损伤，损失或变性。还提供了改进的组合物和方法，其需要施用具有耳毒性副作用的药物与治疗有效量的氧化还原活性治疗剂组合以治疗耳毒性。

6. 发明申请

US20100273894A1 TREATMENT OF LEBER'S HEREDITARY OPTIC NEUROPATHY AND DOMINANT OPTIC ATROPHY WITH TOCOTRIENOL QUINONES 审中-公开
标题翻译：用TOCOTRIENOL QUINONES治疗眼部视神经病变和主要光学ATROPHY
公开(公告)号：US20100273894A1
公开(公告)日：2010-10-28
申请号：US12768565
申请日：2010-04-27
申请人： Guy M. MILLER
发明人： Guy M. MILLER
IPC分类号： A61K31/122 , A61P27/02 , C07C50/28
CPC分类号： A61K31/122 , A61K9/0048 , A61K9/0053 , A61K31/05
摘要： The present invention relates to methods of treating Leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones, including alpha-tocotrienol quinone, in order to alleviate symptoms of the disease.
摘要翻译：本发明涉及利用生育三烯酚醌（包括α-生育三烯酚醌）治疗Leber遗传性视神经病变和显性视神经萎缩的方法，以减轻该疾病的症状。

7. 发明申请

US20100273892A1 FORMULATIONS OF TOCOTRIENOL QUINONES FOR THE TREATMENT OF OPHTHALMIC DISEASES 审中-公开
标题翻译：用于治疗眼病的TOCOTRIENOL喹诺酮配方
公开(公告)号：US20100273892A1
公开(公告)日：2010-10-28
申请号：US12768554
申请日：2010-04-27
申请人： Guy M. MILLER , William D. Shrader , Viktoria Kheifets
发明人： Guy M. MILLER , William D. Shrader , Viktoria Kheifets
IPC分类号： A61K31/12 , A61P27/02 , A61P25/28 , A61P27/06 , A61P25/16 , A61P7/10
CPC分类号： A61K31/122 , A61K9/0048 , A61K9/0053 , A61K31/353 , A61K47/44
摘要： A formulation, comprising an ophthalmically effective amount of one or more tocotrienol quinones, particularly of alpha-tocotrienol quinone is disclosed. Use of a formulation comprising one or more tocotrienol quinones for the prevention, reduction, amelioration or treatment of ophthalmic disorders that are associated with a neurodegenerative or trauma disorder is also discussed. A method of treating or controlling the ocular symptoms associated with neurodegenerative diseases or trauma with a formulation comprising one or more tocotrienol quinones is also discussed. A method of treating or controlling the ocular symptoms associated with mitochondrial myopathies with a formulation comprising one or more tocotrienol quinones is also discussed.
摘要翻译：公开了包含眼睛有效量的一种或多种生育三烯酚醌，特别是α-生育三烯酚醌的制剂。还讨论了包含一种或多种生育三烯酚醌的制剂用于预防，减少，改善或治疗与神经退行性或创伤性病症相关的眼科疾病的用途。还讨论了用包含一种或多种生育三烯酚醌的制剂治疗或控制与神经变性疾病或创伤相关的眼部症状的方法。还讨论了用包含一种或多种生育三烯酚醌的制剂治疗或控制与线粒体肌病相关的眼部症状的方法。

8. 发明申请

US20100063161A1 TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS WITH REDOX-ACTIVE THERAPEUTICS 有权
标题翻译：用REDOX-ACTIVE治疗方法治疗恶性发展障碍
公开(公告)号：US20100063161A1
公开(公告)日：2010-03-11
申请号：US12555700
申请日：2009-09-08
申请人： Guy M. MILLER , Viktoria KHEIFETS
发明人： Guy M. MILLER , Viktoria KHEIFETS
IPC分类号： A61K31/122 , A61K31/05 , A61P25/00
CPC分类号： A61K31/122 , A23L33/10 , A23L33/40 , A23V2002/00 , A61K31/05 , C07C39/08 , C07C50/02 , C07C50/06
摘要： Methods of treating or suppressing pervasive developmental disorders (PDDs) including; autistic disorder, Asperger's syndrome, childhood disintegrative disorder (CDD), Rett's disorder, and PDD-not otherwise specified (PDD-NOS) or attention deficit/hyperactivity disorder (ADHD) comprising administering to a subject in need thereof a therapeutically effective amount of one or more compounds as disclosed herein.
摘要翻译：治疗或抑制普遍发育障碍（PDD）的方法包括：自闭症，阿斯伯格综合症，儿童分裂障碍（CDD），雷特氏症（Rett's disorder）和PDD（未另外规定）（PDD-NOS）或注意力缺陷/多动症（ADHD），包括向有需要的受试者施用治疗有效量的一种或更多的化合物。

9. 发明授权

US10039722B2 Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells 有权
公开(公告)号：US10039722B2
公开(公告)日：2018-08-07
申请号：US13123496
申请日：2009-10-13
申请人： Guy M. Miller
发明人： Guy M. Miller
IPC分类号： A61K31/122 , A61K31/00 , A61K31/025
摘要： Methods of treating or suppressing oxidative stress diseases and symptoms related to oxidative stress affecting normal electron flow in the cells or caused by reactive oxygen species with redox-active therapeutics. Use of redox-active therapeutics for the reduction, suppression or treatment of oxidative stress induced by chemical agents such as contrast agents and other nephrotoxic agents, by radiation exposure, and by disruptions in the transport of oxygen to tissues, is disclosed.

10. 发明申请

US20150057363A1 TREATMENT OF METHYLMALONIC ACIDURIA, ISOVALERIC ACIDURIA, AND OTHER ORGANIC ACIDURIAS WITH TOCOTRIENOL QUINONES 审中-公开
标题翻译：甲氧基乳酸，碘代酸和其他有机酸的处理
公开(公告)号：US20150057363A1
公开(公告)日：2015-02-26
申请号：US14130903
申请日：2012-07-05
申请人： Guy M. Miller , Carlo Dionisi-Vici , Enrico Bertini , Diego Martinelli
发明人： Guy M. Miller , Carlo Dionisi-Vici , Enrico Bertini , Diego Martinelli
IPC分类号： A61K31/122
CPC分类号： A61K31/122 , A61K31/05 , A61P3/00
摘要： The present invention relates to methods of treating methylmalonic aciduria and other organic acidurias with tocotrienol quinones, including alpha-tocotrienol quinone, in order to alleviate symptoms of the disease.
摘要翻译：本发明涉及使用生育三烯酚醌（包括α-生育三烯酚醌）治疗甲基丙二酸尿症和其它有机酸尿的方法，以减轻疾病的症状。

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