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1. 发明授权

US07491312B2 Identifying therapeutic compounds based on their physical-chemical properties 有权
标题翻译：根据物理化学性质鉴定治疗化合物
公开(公告)号：US07491312B2
公开(公告)日：2009-02-17
申请号：US10696752
申请日：2003-10-29
申请人： Sylvain Gilat , Gary Binyamin , Guy Miller
发明人： Sylvain Gilat , Gary Binyamin , Guy Miller
IPC分类号： G01N27/26
CPC分类号： G01N33/6896 , G01N33/6893 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed to rapid and efficient methods of identifying therapeutic compounds by allowing only the most favorable molecules initially selected based on their physical-chemical profile falling within a range predefined by the physical-chemical/biological relationship of a previously tested small subset of compounds of same core structure to be assayed; and to the therapeutic compositions identified by said methods.
摘要翻译：本发明涉及快速和有效的方法，通过仅允许最初选择的最有利的分子基于它们的物理化学特征落入由先前测试的小子集的物理化学/生物学关系预定的范围内来确定治疗化合物要测定的相同核心结构的化合物; 以及通过所述方法鉴定的治疗组合物。

2. 发明申请

US20050142155A1 Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods 审中-公开
标题翻译：细胞保护化合物，药物和化妆品制剂及方法
公开(公告)号：US20050142155A1
公开(公告)日：2005-06-30
申请号：US11055895
申请日：2005-02-10
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07D295/18 , A61K8/00 , A61K8/30 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/122 , A61K31/15 , A61K31/166 , A61K31/18 , A61K31/192 , A61K31/21 , A61K31/235 , A61K31/277 , A61K31/28 , A61K31/30 , A61K31/315 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4425 , A61K31/444 , A61K31/4453 , A61K31/5375 , A61K31/555 , A61K31/662 , A61K31/7024 , A61K33/32 , A61P1/04 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/16 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/06 , A61P43/00 , A61Q19/00 , A61Q19/02 , C07C39/21 , C07C39/373 , C07C39/44 , C07C43/215 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C49/747 , C07C50/34 , C07C69/007 , C07C69/76 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/15 , C07C255/36 , C07C255/53 , C07C255/54 , C07C311/29 , C07C317/22 , C07D213/30 , C07D213/53 , C07D231/22 , C07D231/26 , C07D233/24 , C07D233/64 , C07D235/08 , C07D277/20 , C07D277/24 , C07D277/30 , C07D277/34 , C07D295/22 , C07D295/26 , C07D307/83 , C07D311/72 , C07D317/62 , C07D333/16 , C07F1/08 , C07F9/40 , C07H13/08 , A61K7/42 , A61K31/4152 , A61K31/42 , C07D231/08 , C07D261/12
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
摘要翻译：细胞保护性化合物，其中许多是以具有某些缀合键的取代苯酚为特征的酚类衍生物，可用于治疗某些缺血性或炎症性疾病，包括但不限于中风，心肌梗死，充血性心力衰竭和特征为炎症或氧化损伤。它们也可用于制造用于治疗这些病症的药物和化妆品制剂。

3. 发明授权

US07629375B2 Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods 有权
标题翻译：细胞保护化合物，药物和化妆品制剂及方法
公开(公告)号：US07629375B2
公开(公告)日：2009-12-08
申请号：US11015198
申请日：2004-12-16
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： A61K31/415 , A01N43/56
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
摘要翻译：细胞保护性化合物，其中许多是以具有某些缀合键的取代苯酚为特征的酚类衍生物，可用于治疗某些缺血性或炎症性疾病，包括但不限于中风，心肌梗死，充血性心力衰竭和特征为炎症或氧化损伤。它们也可用于制造用于治疗这些病症的药物和化妆品制剂。

4. 发明申请

US20050113416A1 Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods 有权
公开(公告)号：US20050113416A1
公开(公告)日：2005-05-26
申请号：US11015198
申请日：2004-12-16
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Del Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07D295/18 , A61K8/00 , A61K8/30 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/085 , A61K31/09 , A61K31/10 , A61K31/122 , A61K31/15 , A61K31/166 , A61K31/18 , A61K31/192 , A61K31/21 , A61K31/235 , A61K31/277 , A61K31/28 , A61K31/30 , A61K31/315 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/4184 , A61K31/426 , A61K31/4425 , A61K31/444 , A61K31/4453 , A61K31/5375 , A61K31/555 , A61K31/662 , A61K31/7024 , A61K33/32 , A61P1/04 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/16 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/06 , A61P43/00 , A61Q19/00 , A61Q19/02 , C07C39/21 , C07C39/373 , C07C39/44 , C07C43/215 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C49/747 , C07C50/34 , C07C69/007 , C07C69/76 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/15 , C07C255/36 , C07C255/53 , C07C255/54 , C07C311/29 , C07C317/22 , C07D213/30 , C07D213/53 , C07D231/22 , C07D231/26 , C07D233/24 , C07D233/64 , C07D235/08 , C07D277/20 , C07D277/24 , C07D277/30 , C07D277/34 , C07D295/22 , C07D295/26 , C07D307/83 , C07D311/72 , C07D317/62 , C07D333/16 , C07F1/08 , C07F9/40 , C07H13/08 , A61K31/445 , A61K31/165 , A61K31/185 , A61K31/40
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

5. 发明申请

US20060178356A1 Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods 审中-公开
公开(公告)号：US20060178356A1
公开(公告)日：2006-08-10
申请号：US11387507
申请日：2006-03-22
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07F1/08 , A61K31/555 , A61K31/426 , A61K31/4152 , A61K31/444
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

6. 发明申请

US20060106014A1 Methods for treating diabetes 审中-公开
标题翻译：治疗糖尿病的方法
公开(公告)号：US20060106014A1
公开(公告)日：2006-05-18
申请号：US11251423
申请日：2005-10-13
申请人： Sekhar Boddupalli , David Liebowitz , Guy Miller
发明人： Sekhar Boddupalli , David Liebowitz , Guy Miller
IPC分类号： A61K31/5377 , A61K31/52 , A61K31/506 , A61K31/497 , A61K31/501 , A61K31/452 , A61K31/473 , A61K31/407 , A61K31/404 , A61K31/4015 , A61K31/353
CPC分类号： A61K31/05 , A61K31/353 , A61K31/355 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/452 , A61K31/47 , A61K31/473 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377
摘要： Disclosed are methods for the treatment of diabetes by administering a composition comprising a pharmaceutically acceptable amount of a dual inhibitor of both 5-lipoxygenase (5-LO) and 12/15-lipoxygenase (12/15-LO) enzymes or of both 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) enzymes. The invention is also directed to methods of controlling blood glucose level in diabetic patients with a dual inhibitor of both 5-lipoxygenase (5-LO) and 12/15-lipoxygenase (12/15-LO) enzymes or of both 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) enzymes.
摘要翻译：公开了通过施用包含可药用量的5-脂氧合酶（5-LO）和12 / 15-脂肪氧合酶（12/15-LO）酶的双重抑制剂或两者的5- 脂氧合酶（5-LO）和15-脂肪氧合酶（15-LO）酶。本发明还涉及在具有5-脂氧合酶（5-LO）和12 / 15-脂肪氧合酶（12/15-LO）酶的双重抑制剂或5-脂肪氧合酶（12）的双重抑制剂的糖尿病患者中控制血糖水平的方法， 5-LO）和15-脂氧合酶（15-LO）酶。

7. 发明申请

US20050183540A1 Apparatus for driving an accessory gearbox in a gas turbine engine 审中-公开
公开(公告)号：US20050183540A1
公开(公告)日：2005-08-25
申请号：US10784926
申请日：2004-02-25
申请人： Guy Miller
发明人： Guy Miller
IPC分类号： F02C7/32 , F02C7/36 , F16H1/14 , F16H37/06
CPC分类号： F02C7/32 , F02C7/36 , F05D2260/4031 , F05D2260/53 , Y10T74/19084
摘要： A mechanical drive system for an accessory gearbox of a gas turbine engine is provided. The engine has a high-pressure drive shaft and a low-pressure drive shaft. The mechanical drive system includes a first tower shaft, a second tower shaft, a first lay shaft, and a second lay shaft. The first tower shaft is driven by the high-pressure drive shaft. The second tower shaft is driven by the low-pressure drive shaft. The first lay shaft is driven by the first tower shaft, and is connected to the accessory gearbox. The second lay shaft is driven by the second tower shaft, and is connected to the accessory gearbox.

8. 发明申请

US20050183529A1 Apparatus for driving an accessory gearbox in a gas turbine engine 有权
标题翻译：用于驱动燃气涡轮发动机中的附件齿轮箱的装置
公开(公告)号：US20050183529A1
公开(公告)日：2005-08-25
申请号：US10785502
申请日：2004-02-25
申请人： Guy Miller
发明人： Guy Miller
IPC分类号： F02B61/06 , F02C7/32 , F02C7/36 , F16H1/14
CPC分类号： F02C7/32 , F02C7/36 , F05D2260/4031 , F05D2260/53 , Y10T74/19674
摘要： A mechanical drive system for an accessory gearbox of a gas turbine engine is provided. The engine has a high-pressure drive shaft and a low-pressure drive shaft. The mechanical drive system includes a first tower shaft, a second tower shaft, a first lay shaft, and a second lay shaft. The first tower shaft is driven by the high-pressure drive shaft. The second tower shaft is driven by the low-pressure drive shaft. The first lay shaft is driven by the first tower shaft, and is connected to the accessory gearbox. The second lay shaft is driven by the second tower shaft, and is connected to the accessory gearbox.
摘要翻译：提供了一种用于燃气涡轮发动机的附件齿轮箱的机械驱动系统。发动机具有高压驱动轴和低压驱动轴。机械驱动系统包括第一塔轴，第二塔轴，第一副轴和第二副轴。第一塔轴由高压驱动轴驱动。第二塔轴由低压驱动轴驱动。第一副轴由第一塔轴驱动，并连接到附件齿轮箱。第二副轴由第二塔轴驱动，并连接到附件齿轮箱。

9. 发明授权

US06426362B1 Formulations of tocopherols and methods of making and using them 有权
标题翻译：生育酚的制剂及其使用方法
公开(公告)号：US06426362B1
公开(公告)日：2002-07-30
申请号：US09684588
申请日：2000-10-06
申请人： Guy Miller , Lesley A. Brown
发明人： Guy Miller , Lesley A. Brown
IPC分类号： A61K3135
CPC分类号： A61K31/355 , A61K45/06
摘要： Non-naturally-occuring compositions for use in amelioration of disruption of energy metabolism secondary to stress are described. The compositions comprise a tocopherol and/or a derivative thereof, and a synergist, and are particularly suited for use as nutritional supplements. Synergists include, but are not limited to, flavonoids and lactoferrin and/or derivatives thereof. Compositions comprising an optimized formulation comprising a tocopherol and an additional compound such as daidzein or biochanin A are also described. Methods of making these compositions and methods of ameliorating injury(ies) or disruption of energy metabolism secondary to stress, comprising administering such compositions, are also disclosed.
摘要翻译：描述了用于改善继发于应力的能量代谢破坏的非天然存在的组合物。组合物包含生育酚和/或其衍生物和增效剂，并且特别适合用作营养补充剂。协同增效剂包括但不限于类黄酮和乳铁蛋白和/或其衍生物。还描述了包含包含生育酚和附加化合物如黄豆苷原或鸟角素A的优化制剂的组合物。还公开了制备这些组合物的方法和改善继发于应激的能量代谢的损伤或破坏的方法，包括施用这样的组合物。

10. 发明授权

US08150740B1 Electronic commerce integration 有权
公开(公告)号：US08150740B1
公开(公告)日：2012-04-03
申请号：US09791331
申请日：2001-02-23
申请人： Guy Miller
发明人： Guy Miller
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0623 , G06Q30/00 , G06Q30/0601 , G06Q30/0625 , G06Q30/0639 , G06Q30/0641
摘要： An information system environment is described that, among other things, facilitates integration of electronic commerce and physical store front retailer selling channels. In some realizations, the system includes a shopper accessible kiosk co-located with a physical store front retailer and an electronic commerce information service accessible from locations external to the physical store front retailer. Both access inventory information supplied from a suitable information service. The shopper accessible kiosk allows a user thereof to access inventory information particular to the physical store front retailer, while the electronic commerce information service allows a user thereof to order items from out of stock of the physical store front retailer.

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