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1. 发明授权

US07344894B2 Thermal regulation of fluidic samples within a diagnostic cartridge 有权
标题翻译：诊断墨盒内流体样品的热调节
公开(公告)号：US07344894B2
公开(公告)日：2008-03-18
申请号：US09981440
申请日：2001-10-16
申请人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
发明人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
IPC分类号： G01N33/543
CPC分类号： B01L7/00 , B01L3/5027 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2300/1872
摘要： A method and miniature analytical device with thermal regulation of reactant using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes (“LED”s) and vertical cavity surface emitting lasers (“VCSEL”s), generating internal heat, such as resistive, inductive and Peltier heaters, or external heating. The miniature analytical device comprises of array of temperature-controlled zones to restrict the volume heated and localize the heating by having the localized heat source comprise an array of emitters or heaters.
摘要翻译：使用能够发射电磁辐射的局部热源的反应物的热调节方法和微型分析装置，例如发光二极管（“LED”）和垂直腔表面发射激光器（“VCSEL”），产生内部热量，例如电阻式，感应型和珀耳帖式加热器，或外部加热。微型分析装置包括温度控制区的阵列，以通过使局部热源包括发射器或加热器的阵列来限制加热的体积并定位加热。

2. 发明授权

US06176865B1 Apparatus and method for incising 有权
标题翻译：切割装置及方法
公开(公告)号：US06176865B1
公开(公告)日：2001-01-23
申请号：US09429551
申请日：1999-10-28
申请人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
发明人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
IPC分类号： A61B1732
CPC分类号： A61B10/0233 , A61B5/14514 , A61B5/150022 , A61B5/150137 , A61B5/15016 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/15121 , A61B5/15142 , A61B10/0266 , A61B17/32002 , A61B17/32053 , A61B17/32093 , A61B17/3476
摘要： A multi-shaft apparatus for incising a substrate of soft resilient material such as a body tissue. The incising apparatus includes two or more incision shafts each having a distal edge. The shafts are not affixed to each other and are allowed to slide against each other to drive the distal edges alternately against the substrate to incise the substrate. In the case of incising a body tissue, such alternate motion would result in less pain to the patient than a puncture resulting from a sharp jab by a sharp shaft of similar size to the shafts.
摘要翻译：一种用于切割诸如身体组织的软弹性材料的基底的多轴装置。切割装置包括两个或更多个切口轴，每个切口具有远端边缘。轴彼此不固定并且允许彼此滑动以将远端边缘交替地驱动抵靠基板以切割基板。在切割身体组织的情况下，这种交替运动将导致比通过与轴相似尺寸的尖锐的尖锐刺戳导致的穿刺更少的疼痛。

3. 发明授权

US07393693B2 Methods and procedures for stabilization and performance optimization of multi-layer sol-gel chemical and biochemical sensors 有权
标题翻译：多层溶胶 - 凝胶化学和生物化学传感器的稳定和性能优化的方法和程序
公开(公告)号：US07393693B2
公开(公告)日：2008-07-01
申请号：US10159301
申请日：2002-05-31
申请人： David J. Anvar , Ganapati R. Mauze , Dan-Hui Yang
发明人： David J. Anvar , Ganapati R. Mauze , Dan-Hui Yang
IPC分类号： G01N30/00
CPC分类号： G01N33/6803 , Y10T436/25 , Y10T436/2525
摘要： A sensor and method for making a sensor includes providing a substrate having an adhesion layer with a first functional group operatively associated with a sol-gel composition having a second functional group, and at least one linker material for connecting the first functional group to the second functional group. In another embodiment, a sensor and method for making the sensor includes providing a sol-gel layer operatively associated with a sol-gel precursor solution that includes at least one co-polymer and at least one solvent adapted to resist the deformation of the sol-gel layer by decreasing evaporation, decreasing cross-linking, increasing intermolecular forces, or increasing elasticity.
摘要翻译：用于制造传感器的传感器和方法包括提供具有粘附层的基底，其具有与具有第二官能团的溶胶 - 凝胶组合物操作性相关联的第一官能团，以及用于将第一官能团连接到第二官能团的至少一种连接材料功能组。在另一个实施方案中，用于制造传感器的传感器和方法包括提供可操作地与溶胶 - 凝胶前体溶液相关联的溶胶 - 凝胶层，所述溶胶 - 凝胶层包括至少一种共聚物和至少一种适于抵抗溶胶 - 凝胶前体溶液变形的溶剂 - 凝胶层通过减少蒸发，减少交联，增加分子间力或增加弹性。

4. 发明授权

US07056475B2 Fluidically isolated pumping and metered fluid delivery system and methods 失效
公开(公告)号：US07056475B2
公开(公告)日：2006-06-06
申请号：US10058797
申请日：2002-01-30
申请人： Paul Lum , Ganapati R. Mauze , Catherine K. Templin
发明人： Paul Lum , Ganapati R. Mauze , Catherine K. Templin
IPC分类号： G01N33/00
CPC分类号： B01L3/50273 , B01L2300/0816 , B01L2400/0481 , B01L2400/0633 , F04B43/043 , F04B43/082 , F04B43/1223 , G01N1/38 , Y10T436/2575
摘要： An apparatus and method for pumping and optionally mixing of small quantities of biological fluid wherein the pumping mechanism is segregated from the biological fluid being pumped. The micro-pump pushes the biological fluid by compressing a cartridge housing the blood and reagents with collapsible walls with a roller or ball bearing, synchronized perpendicular plungers, or an acutely-angled member to push the biological fluid by collapsing the walls of the cartridge in the direction of flow.

5. 发明授权

US6139562A Apparatus and method for incising 失效
标题翻译：切割装置及方法
公开(公告)号：US6139562A
公开(公告)日：2000-10-31
申请号：US50748
申请日：1998-03-30
申请人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
发明人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
IPC分类号： A61B5/151 , A61B5/15 , A61B10/00 , A61B10/02 , A61B17/32 , A61B17/34 , A61B17/14
CPC分类号： A61B10/0233 , A61B10/0266 , A61B17/32053 , A61B17/32093 , A61B5/14514 , A61B5/150022 , A61B5/150137 , A61B5/15016 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/15121 , A61B5/15142 , A61B17/32002 , A61B17/3476
摘要： A multi-shaft apparatus for incising a substrate of soft resilient material such as a body tissue. The incising apparatus includes two or more incision shafts each having a distal edge. The shafts are not affixed to each other and are allowed to slide against each other to drive the distal edges alternately against the substrate to incise the substrate. In the case of incising a body tissue, such alternate motion would result in less pain to the patient than a puncture resulting from a sharp jab by a sharp shaft of similar size to the shafts.
摘要翻译：一种用于切割诸如身体组织的软弹性材料的基底的多轴装置。切割装置包括两个或更多个切口轴，每个切口具有远端边缘。轴彼此不固定并且允许彼此滑动以将远端边缘交替地驱动抵靠基板以切割基板。在切割身体组织的情况下，这种交替运动将导致比通过与轴相似尺寸的尖锐的尖锐刺戳导致的穿刺更少的疼痛。

6. 发明授权

US07049129B2 Electro-optical devices and methods for hybridization and detection 失效
标题翻译：电光装置和杂交和检测方法
公开(公告)号：US07049129B2
公开(公告)日：2006-05-23
申请号：US10414719
申请日：2003-04-15
申请人： Ganapati R. Mauze , Dan-Hui Yang
发明人： Ganapati R. Mauze , Dan-Hui Yang
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/20 , G01N33/00
CPC分类号： C12Q1/6825 , Y10S435/81 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/607 , C12Q2563/137
摘要： The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction. The method of the invention teaches the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.
摘要翻译：本发明提供了用于检测靶分子的装置和方法。该装置包括标记有过渡金属 - 配体络合物的探针，其与靶杂交以形成初始复合物，用于掺杂初始络合物并形成最终复合物的金属离子，以及为最终复合物提供潜力的潜在手段以产生表明氧化还原反应后靶的存在的可检测信号。本发明的方法教导了将探针与附着的标记物杂交到靶标以产生初始复合物的步骤，向最初的复合物中加入金属离子以形成最终的复合物并向潜在的复合物施加潜能以产生可测量的信号。

7. 发明授权

US06974703B2 Electro-optical devices and methods for hybridization and detection 失效
标题翻译：电光装置和杂交和检测方法
公开(公告)号：US06974703B2
公开(公告)日：2005-12-13
申请号：US10798982
申请日：2004-03-11
申请人： Ganapati R. Mauze , Dan-Hui Yang
发明人： Ganapati R. Mauze , Dan-Hui Yang
IPC分类号： C07H21/04 , C12M1/34 , C12Q1/68 , G01N33/00
CPC分类号： C12Q1/6825 , Y10S435/81 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/607 , C12Q2563/137
摘要： The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction. The method of the invention teaches the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.
摘要翻译：本发明提供了用于检测靶分子的装置和方法。该装置包括标记有过渡金属 - 配体络合物的探针，其与靶杂交以形成初始复合物，用于掺杂初始络合物并形成最终复合物的金属离子，以及为最终复合物提供潜力的潜在手段以产生表明氧化还原反应后靶的存在的可检测信号。本发明的方法教导了将探针与附着的标记物杂交到靶标以产生初始复合物的步骤，向最初的复合物中加入金属离子以形成最终的复合物并向潜在的复合物施加潜能以产生可测量的信号。

8. 发明授权

US06379969B1 Optical sensor for sensing multiple analytes 有权
标题翻译：用于感测多种分析物的光学传感器
公开(公告)号：US06379969B1
公开(公告)日：2002-04-30
申请号：US09517259
申请日：2000-03-02
申请人： Ganapati R. Mauze , Bo Curry
发明人： Ganapati R. Mauze , Bo Curry
IPC分类号： G01N2164
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/77 , G01N2021/7786 , G01N2021/7793 , Y10T436/144444 , Y10T436/147777
摘要： A device for analyzing simultaneously multiple analytes in a fluid of unknown composition. The device includes a plurality of sensors, a light source for providing light to shine on the sensors, light detectors, and a processor. The sensors are exposed to a sample of the fluid of unknown composition. The plurality of sensors includes groups of sensors, each group targeting a specific analyte and including one or more sensors that contain an analyte-specific chemical that interacts more specifically with one analyte than with some other analytes to be analyzed. Each sensor in each group has a different chemical interacting with the analyte to target it. The light source shines light on the sensors of the plurality of sensors to cause light interaction with the sensors. The differences in the sensors lead to differences in the light interaction. The light detectors detects the light interaction by the sensors. The processor analyzes the light interaction by the sensors to take into account interference in light interaction among the analytes, thereby determining the concentration of each of the analytes in the fluid.
摘要翻译：用于同时分析未知组成的流体中的多种分析物的装置。该装置包括多个传感器，用于提供光照射在传感器，光检测器和处理器上的光源。传感器暴露于未知组成的流体样品。多个传感器包括传感器组，每个组针对特定分析物并且包括一个或多个传感器，其包含特异性分析物的化学物质，其与一种分析物更具体地与一种分析物相互作用。每组中的每个传感器都具有与分析物相互作用的不同的化学物质来靶向它。光源将光照射到多个传感器的传感器上，以使光与传感器相互作用。传感器的差异导致光相互作用的差异。光检测器通过传感器检测光的相互作用。处理器分析传感器的光相互作用，以考虑到分析物之间的光相互作用的干扰，从而确定流体中每种分析物的浓度。

9. 发明授权

US06210420B1 Apparatus and method for efficient blood sampling with lancet 有权
标题翻译：柳叶刀高效采血装置及方法
公开(公告)号：US06210420B1
公开(公告)日：2001-04-03
申请号：US09233298
申请日：1999-01-19
申请人： Ganapati R Mauze , J. Fleming Dias
发明人： Ganapati R Mauze , J. Fleming Dias
IPC分类号： A61B1714
CPC分类号： A61B5/15186 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150183 , A61B5/150213 , A61B5/150229 , A61B5/150412 , A61B5/150519 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15142 , A61B5/15194
摘要： A technique for efficiently sampling blood from body tissue by reducing pressure on the body tissue. In the present technique a body tissue is placed under reduced pressure to improve perfusion of blood in the body tissue before lancing. An embodiment of this apparatus includes a lancet carried by a piston slidable in a housing, a mechanism for transmitting mechanical energy internally in the apparatus for creating the reduced pressure on the body tissue. The apparatus also includes a driver that drives the lancet for lancing. The apparatus has a head in the housing for contacting the body tissue in an air-tight manner against suction forces. In the head facing the body tissue is a channel in which the air pressure can be reduced.
摘要翻译：一种通过减少身体组织上的压力来有效地从身体组织取样血液的技术。在本技术中，身体组织被放置在减压下以改善在穿刺之前身体组织中的血液灌注。该装置的一个实施例包括由可在壳体中滑动的活塞承载的刺血针，用于在用于在身体组织上产生减压的装置内部传递机械能的机构。该装置还包括驱动柳叶刀进行穿刺的驱动器。该装置在壳体中具有头部，用于以气密方式抵抗抽吸力使身体组织接触。在面向身体组织的头部是可以减小空气压力的通道。

10. 发明授权

US06171325B2 Apparatus and method for incising 有权
公开(公告)号：US06171325B2
公开(公告)日：2001-01-09
申请号：US09420988
申请日：1999-10-20
申请人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
发明人： Ganapati R. Mauze , Michael Greenstein , Edward D. Verdonk , Paul Lum
IPC分类号： A61B1732
CPC分类号： A61B10/0233 , A61B5/14514 , A61B5/150022 , A61B5/150137 , A61B5/15016 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/15121 , A61B5/15142 , A61B10/0266 , A61B17/32002 , A61B17/32053 , A61B17/32093 , A61B17/3476
摘要： A multi-shaft apparatus for incising a substrate of soft resilient material such as a body tissue. The incising apparatus includes two or more incision shafts each having a distal edge. The shafts are not affixed to each other and are allowed to slide against each other to drive the distal edges alternately against the substrate to incise the substrate. In the case of incising a body tissue, such alternate motion would result in less pain to the patient than a puncture resulting from a sharp jab by a sharp shaft of similar size to the shafts.

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