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1. 发明授权

US4022788A Indane tetrol amines 失效
标题翻译：吲哚四胺
公开(公告)号：US4022788A
公开(公告)日：1977-05-10
申请号：US570911
申请日：1975-04-23
申请人： Frederic Peter Hauck , Joyce Reid , Vinayak V. Kane
发明人： Frederic Peter Hauck , Joyce Reid , Vinayak V. Kane
IPC分类号： C07D295/096 , C07D211/06 , C07D295/08 , C07D295/10
CPC分类号： C07D295/096
摘要： The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## or of the formula ##STR3## wherein (CH.sub.2) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R.sup.5 and R.sup.6 may be the same or different and may be hydrogen, alkyl, arylalkyl, and R.sup.5 and R.sup.6 together with the nitrogen to which they are attached may be pyrrolidino, piperadino or N'-alkyl piperazino;R.sup.1, r.sup.2, r.sup.3 or R.sup.4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR4## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR5## wherein R.sup.5 and R.sup.6 are as previously defined and p is 0-3; 2-, 3-, or 4-pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl;R.sup.7 and R.sup.8 may be the same or different and may be hydrogen or alkyl, and R.sup.7 and R.sup.8 taken together with the carbon atoms bearing substituents OR.sup.2 and OR.sup.4 may form a cycloalkyl ring. These compounds have been found useful in the treatment of hypertension in mammalian species, e.g., rats, as surface active agents, as in vitro antibacterial compounds and as water softeners.
摘要翻译：本发明的化合物具有式“IMAGE”，其中Y是式（IMAGE）或式（IMAGE）的基团，其中（CH 2）是直链或支链烷基，n是1-6，m是 0或1，并且R 5和R 6可以相同或不同，并且可以是氢，烷基，芳烷基和R 5和R 6与它们所连接的氮一起可以是吡咯烷子基，哌嗪基或哌嗪子基; R1，R2，R3或R4可以相同或不同，可以是氢; 烷基，三氟甲基; 烷酰基; 卤代烷酰基; 其中R是烷基的式“IMAGE”的烷氧基羰基; 烷氧基烷基其中R 5和R 6如前所定义且p为0-3; 2-，3-或4-吡啶基羰基; 苯基; 其中取代基是烷基，烷氧基，羟基，硝基，氨基或二烷基氨基; 烯酰基; 或芳酰基; R 7和R 8可以相同或不同，并且可以是氢或烷基，并且R 7和R 8与带有取代基OR 2和OR 4的碳原子一起可以形成环烷基环。已经发现这些化合物可用于治疗哺乳动物物种例如大鼠作为表面活性剂，体外抗菌化合物和软水剂中的高血压。

2. 发明授权

US3984407A Diene intermediates for indantetrol derivatives 失效
标题翻译：茚二酮衍生物的二烯中间体
公开(公告)号：US3984407A
公开(公告)日：1976-10-05
申请号：US570121
申请日：1975-04-21
申请人： Frederic Peter Hauck , Joyce Reid , Venkatachala L. Narayanan , Christopher M. Cimarusti , Rudiger D. Haugwitz , Joseph E. Sundeen
发明人： Frederic Peter Hauck , Joyce Reid , Venkatachala L. Narayanan , Christopher M. Cimarusti , Rudiger D. Haugwitz , Joseph E. Sundeen
IPC分类号： C07D211/12 , C07D211/14 , C07D211/22 , C07D295/02 , C07D295/03 , C07D295/033 , C07D295/096
CPC分类号： C07D295/096 , C07D211/12 , C07D211/14 , C07D211/22 , C07D295/03 , C07D295/033 , C07C2102/08
摘要： Compounds are provided having the structure ##SPC1##Wherein n is 1, 2 or 3, m and m' are 0, 1 or 2, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##EQU1## amido ##EQU2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##EQU3## These compounds are useful in the treatment of hypertension.
摘要翻译：提供具有下列结构的化合物：其中N为1,2或3，M和M为0，1或2，R 1，R 2，R 3和R 4可以相同或不同，并且可以是氢，低级烷基，卤代低级烷基，酰基，低级烷氧基 - 羰基O并行（ROC），酰胺基R5O PARALLEL（ANGLE NC），R6或低级烷氧基亚烷基，X为直链或支链二价脂族基，Y为R5 R5'-N ANGLE或-C ANGLE | R6 R7R6 “这些化合物可用于治疗高血压。

3. 发明授权

US4113726A Perhydrofluorenetetrol and perhydrophenanthrenetetrol derivatives 失效
标题翻译：全氢氟虫腈和全氢化蒽醌衍生物
公开(公告)号：US4113726A
公开(公告)日：1978-09-12
申请号：US446837
申请日：1974-02-28
申请人： Frederic Peter Hauck , Christopher Michael Cimarusti
发明人： Frederic Peter Hauck , Christopher Michael Cimarusti
IPC分类号： C07D295/08 , C07C17/16 , C07C57/40 , C07C61/29 , C07C67/00 , C07C213/00 , C07C215/42 , C07C217/52 , C07C233/18 , C07C233/23 , C07C233/74 , C07C239/00 , C07C239/12 , C07D211/22 , C07D211/60 , C07D295/096 , C07D295/185 , C07D307/93 , C07D295/02 , C07D295/14
CPC分类号： C07D295/185 , C07C17/16 , C07C57/40 , C07C61/29 , C07D211/22 , C07D211/60 , C07D295/096 , C07D307/93 , C07C2103/18 , C07C2103/26
摘要： Compounds are provided having the structure ##STR1## wherein n is 1 or 2, n.sup.1 is 0, 1 or 2 and n.sup.2 is 0, 1, 2 or 3, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, R can be lower alkoxy, lower alkyl or cycloalkyl, R.sub.8 can be hydrogen, lower alkyl, cycloalkyl, hydroxy, dialkylaminoalkyl or R.sub.9 O(CH.sub.2)q-. X is a single bond or a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.
摘要翻译：提供具有结构的化合物，其中n为1或2，n1为0,1或2，n2为0,1,2或3，R1，R2，R3和R4可以相同或不同，可以是氢，低级烷基，卤代低级烷基，酰基，低级烷氧基羰基，酰氨基，低级烷氧基羰基，低级烷氧基，低级烷基或环烷基，R 8可以是氢，低级烷基，环烷基，羟基，二烷基氨基烷基或 R9O（CH2）q-。 X是单键或直链或支链二价脂肪族基，Y是这些化合物可用于治疗高血压。

4. 发明授权

US4104400A Imidazo(2,1-b)thiazole derivatives, compositions containing same, and method of treating helminthiasis 失效
标题翻译：咪唑（2,1-b）噻唑衍生物，含有它们的组合物和治疗蠕虫病的方法
公开(公告)号：US4104400A
公开(公告)日：1978-08-01
申请号：US813910
申请日：1977-07-08
申请人： Frank Lee Weisenborn , Rudiger D. Haugwitz , Frederic Peter Hauck
发明人： Frank Lee Weisenborn , Rudiger D. Haugwitz , Frederic Peter Hauck
IPC分类号： A23K1/16 , C07D233/42 , C07D513/04 , A61K31/425
CPC分类号： C07D513/04 , A23K20/116 , C07C255/00 , C07D233/42
摘要： Imidazo[2,1-b]thiazole derivatives are provided having the structure ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or carboxy, and R.sup.2 is hydrogen, lower alkyl or phenyl.In addition, a method is provided for treating or inhibiting helminthiasis by parenterally, perorally or topically administering a pharmaceutical composition containing such imidazo[2,1-b]thiazole derivatives. Pharmaceutical compositions for use in the above method are also provided.
摘要翻译：提供咪唑并[2,1-b]噻唑衍生物，其具有结构，其中R 1是氢，低级烷基或羧基，R 2是氢，低级烷基或苯基。

5. 发明授权

US4082773A Tricyclic tetrahydro naphthaleneols and related compounds 失效
标题翻译：三甲基四氢萘和相关化合物
公开(公告)号：US4082773A
公开(公告)日：1978-04-04
申请号：US268300
申请日：1972-07-03
申请人： Frederic Peter Hauck
发明人： Frederic Peter Hauck
IPC分类号： C10M135/36 , A61K31/33 , A61L2/16 , C02F5/10 , C02F5/12 , C07C27/00 , C07C39/17 , C07C39/42 , C07C41/00 , C07C43/20 , C07C43/21 , C07C51/00 , C07C65/17 , C07C65/26 , C07C67/00 , C07C69/017 , C07C201/00 , C07C205/33 , C07C213/00 , C07C215/86 , C07C217/94 , C07C219/34 , C07C231/00 , C07C231/12 , C07C233/25 , C07C241/00 , C07C251/22 , C07C325/00 , C07D263/52 , C07D263/60 , C07D303/22 , C07D307/92 , C07D317/44 , C07D317/70 , C07D319/22 , C07D327/04 , C07D333/50 , C07D333/74 , C07D339/06 , C07D413/04 , C10M133/48 , C10N30/12 , C07D317/46 , A61L1/00
CPC分类号： C07D303/22 , C02F5/10 , C02F5/12 , C07C247/00 , C07D263/60 , C07D307/92 , C07D317/70 , C07D319/22 , C07D333/74 , C10M2207/044 , C10M2207/08 , C10M2207/14 , C10M2207/142 , C10M2207/281 , C10M2207/282 , C10M2207/283 , C10M2207/284 , C10M2207/285 , C10M2207/286 , C10M2207/32 , C10M2207/34 , C10M2211/00 , C10M2215/04 , C10M2215/042 , C10M2215/044 , C10M2215/14 , C10M2215/202 , C10M2215/22 , C10M2215/221 , C10M2215/225 , C10M2215/226 , C10M2215/26 , C10M2215/30 , C10M2219/00 , C10M2219/09 , Y10S514/821
摘要： Compounds are provided of the structure ##STR1## WHEREIN X--Z--Y together with two carbons of the cycloalkyl ring form a 5- or 6-membered ring, wherein R.sup.1 is hydrogen, aralkyl or acyl, n is 0, 1 or 2, and n' is 0, 1, 2 or 3, R.sup.2 is hydrogen, lower alkyl or aralkyl, R.sup.3 is hydrogen, acyl, lower alkyl, aralkyl, lower alkoxy, carboxy, halo, alkenyl, nitro, cycloalkyl, amino, acylamino, R.sup.2 O(CH.sub.2).sub.n 2 where n.sup.2 is 0, 1 or 2 or dihydroxyalkyl, X and Y may be the same or different and can be --CH.sub.2 --, .dbd.N--, --O--, --S--, --NR.sup.4 --, --O--CH.sub.2 --, --S--CH.sub.2 --, or --NR.sup.4 --CH.sub.2 -- where R.sup.4 is hydrogen, lower alkyl or aryl, Z can be ##STR2## where R.sup.5 and R.sup.6 can be hydrogen, lower alkyl, cycloalkyl, aryl, haloalkyl, amino or substituted or unsubstituted aminoalkyl; ##STR3## and --X--Z--Y-- can be taken together to form ##STR4## and ##STR5## These compounds are useful as anti-fibrillatory agents, disinfectants and water-softeners.

6. 发明授权

US3965102A 1,2,3,4,6,7,8,8A-Octahydro-6-aryl-isoquinolines and derivatives thereof 失效
标题翻译： 1,2,3,4,6,7,8,8a-八氢-6-芳基 - 异喹啉及其衍生物
公开(公告)号：US3965102A
公开(公告)日：1976-06-22
申请号：US512277
申请日：1974-10-04
申请人： Frederic Peter Hauck , Joseph E. Sundeen
发明人： Frederic Peter Hauck , Joseph E. Sundeen
IPC分类号： C07D217/04 , C07D491/048 , C07D491/04
CPC分类号： C07D491/048 , C07D217/04 , Y10S514/886
摘要： 1,2,3,4,6,7,8,8a-Octahydro-6-phenyl or substituted phenyl-isoquinolines and derivatives thereof and their methods of preparation are disclosed. These compounds are useful as anti-inflammatory agents.
摘要翻译：公开了1,2,3,4,6,7,8,8a-八氢-6-苯基或取代的苯基 - 异喹啉及其衍生物及其制备方法。这些化合物可用作抗炎剂。

7. 发明授权

US4092318A Indantetrol derivatives 失效
标题翻译：茚满醇衍生物
公开(公告)号：US4092318A
公开(公告)日：1978-05-30
申请号：US666983
申请日：1976-03-15
申请人： Frederic Peter Hauck , Joyce Reid , Venkatachala L. Narayanan , Christopher M. Cimarusti , Rudiger D. Haugwitz , Joseph E. Sundeen
发明人： Frederic Peter Hauck , Joyce Reid , Venkatachala L. Narayanan , Christopher M. Cimarusti , Rudiger D. Haugwitz , Joseph E. Sundeen
IPC分类号： C07D211/12 , C07D211/14 , C07D211/22 , C07D295/02 , C07D295/03 , C07D295/033 , C07D295/096
CPC分类号： C07D295/096 , C07D211/12 , C07D211/14 , C07D211/22 , C07D295/03 , C07D295/033 , C07C2102/08
摘要： Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1 OR 2, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.
摘要翻译：提供了具有结构式（II）的化合物，其中N为1,2或3，M和M为0，1或2，R 1，R 2，R 3和R 4可以相同或不同，并且可以是氢，低级烷基，卤代低级烷基，酰基，低级烷氧基 - 羰基或低级烷氧基亚烷基，X是直链或支链二价脂族基，Y是这些化合物可用于治疗高血压。

8. 发明授权

US4076843A 5,6,7,8-Tetrahydronaphthalene hypotensive agents 失效
标题翻译： 5,6,7,8-四氢萘降压药
公开(公告)号：US4076843A
公开(公告)日：1978-02-28
申请号：US428466
申请日：1973-12-26
申请人： Frederic Peter Hauck , Christopher M. Cimarusti , Joseph E. Sundeen
发明人： Frederic Peter Hauck , Christopher M. Cimarusti , Joseph E. Sundeen
IPC分类号： C07C69/017 , A61K31/05 , A61K31/135 , C02F5/00 , C02F5/08 , C02F5/10 , C02F5/12 , C07C27/00 , C07C39/17 , C07C39/23 , C07C39/42 , C07C41/00 , C07C43/20 , C07C45/00 , C07C47/28 , C07C49/76 , C07C51/00 , C07C65/00 , C07C67/00 , C07C201/00 , C07C213/00 , C07C215/64 , C07C217/74 , C07C219/26 , C07C233/23 , C07C233/25 , C07C233/41 , C07C233/47 , C07C241/00 , C07C247/14 , C07C253/00 , C07C255/45 , C07C255/47 , C07C255/59 , C07C313/00 , C07C323/17 , C07D203/26 , C07D295/096 , C07D303/16 , C07D303/22 , C07D317/70 , C07D319/08 , C07D331/02
CPC分类号： C07D295/096 , C07C247/00 , C07C323/00 , C07D203/26 , C07D303/16 , C07D303/22 , C07D319/08 , C07D331/02 , C07C2102/08 , C07C2102/10
摘要： 5,6,7,8-Tetrahydronaphthalenes having the structure ##STR1## and the pharmaceutically acceptable salts thereof, are useful as blood pressure lowering agents. In the above formula R.sub.1 can be hydrogen or alkyl; R.sub.2 is alkyl; R.sub.3 and R.sub.4 can each be hydrogen, hydroxyl, alkoxy, or arylalkoxy, but both cannot be hydroxyl. Those compounds wherein at least one of R.sub.3 and R.sub.4 is other than hydrogen are novel, and constitute a part of this invention.
摘要翻译：具有结构的5,6,7,8-四氢萘及其药学上可接受的盐可用作降压剂。在上式中，R 1可以是氢或烷基; R2是烷基; R3和R4各自可以是氢，羟基，烷氧基或芳基烷氧基，但都不能是羟基。那些其中R 3和R 4中的至少一个不是氢的那些化合物是新的，构成本发明的一部分。

9. 发明授权

US4044040A 4,7-Dihydroindanyl alkanols, analogues thereof and their corresponding tosylates 失效
标题翻译： 4,7-二氢茚基烷醇，其类似物及其相应的甲苯磺酸酯
公开(公告)号：US4044040A
公开(公告)日：1977-08-23
申请号：US667003
申请日：1976-03-15
申请人： Frederic Peter Hauck , Joyce Reid , Venkatachala L. Narayanan , Christopher M. Cimarusti , Rudiger D. Haugwitz , Joseph E. Sundeen
发明人： Frederic Peter Hauck , Joyce Reid , Venkatachala L. Narayanan , Christopher M. Cimarusti , Rudiger D. Haugwitz , Joseph E. Sundeen
IPC分类号： C07C33/34 , C07C33/38 , C07C309/73 , C07D211/12 , C07D211/14 , C07D211/22 , C07D213/30 , C07D295/096 , C07C143/68 , C07C33/02 , C07C35/32 , C07C35/36
CPC分类号： C07D213/30 , C07C309/73 , C07C33/34 , C07C33/38 , C07D211/12 , C07D211/14 , C07D211/22 , C07D295/096 , C07C2102/08
摘要： Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1, OR 2, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.
摘要翻译：提供了具有结构式为N，N，N，Y，Y，Y，Y和Y的结构的化合物，其中R 1，R 2，R 3和R 4可以相同或不同，可以是氢，低级烷基卤代低级烷基，酰基，低级烷氧基 - 羰基，或低级烷氧基亚烷基，X是直链或支链二价脂肪族基，Y是这些化合物可用于治疗高血压。

10. 发明授权

US3984419A Perhydrofluorenetetrol and perhydro-phenanthrenetetrol derivatives 失效
标题翻译：全氢氟乙腈和全氢菲咯酸衍生物
公开(公告)号：US3984419A
公开(公告)日：1976-10-05
申请号：US447000
申请日：1974-02-28
申请人： Frederic Peter Hauck , Christopher Michael Cimarusti
发明人： Frederic Peter Hauck , Christopher Michael Cimarusti
IPC分类号： C07C17/16 , C07C22/04 , C07C57/26 , C07C61/39 , C07D295/02 , C07D295/033 , C07D295/096 , C07D295/185 , C07D307/93 , C07D295/08 , C07D295/10
CPC分类号： C07D295/185 , C07C17/16 , C07C22/04 , C07C57/26 , C07C61/39 , C07D295/033 , C07D295/096 , C07D307/93 , C07C2103/18 , C07C2103/26
摘要： Compounds are provided having the structure ##SPC1##Wherein n is 1 or 2, n.sup.1 is 0, 1 or 2 and n.sup.2 is 0, 1, 2 or 3, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##EQU1## amido ##EQU2## or lower alkoxyalkylene, R can be lower alkoxy, lower alkyl or cycloalkyl, R.sub.8 can be hydrogen, lower alkyl, cycloalkyl, hydroxy, dialkylaminoalkyl or R.sub.9 O(CH.sub.2)q--. X is a single bond or a straight or branched bivalent aliphatic radical and Y is ##EQU3## These compounds are useful in the treatment of hypertension.
摘要翻译：提供化合物，其结构为：其中N为1或2，N1为0,1或2，N 2为0,1,2或3，R 1，R 2，R 3和R 4可以相同或不同，并且可以是氢，低级烷基，卤代低级烷基，酰基，低级烷氧基 - 羰基O并列R1OC，酰氨基O R5和平角NC，R6或低级烷氧基亚烷基，R可以是低级烷氧基，低级烷基或环烷基，R8可以是氢，低级烷基，环烷基，羟基，二烷基氨基烷基或R9O（CH2）q-。 X是单键或直链或支链二价脂肪族基，Y是R 5 -N ANGLE R6这些化合物可用于治疗高血压。

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